The cybersecurity landscape is moving to an AI-vs-AI world where both attackers and defenders can operate at machine speed.

In this conversation, Anne Neuberger and Sam Jones join Jai Ramaswamy to go deeper on what this shift looks like in practice. Neuberger draws on nearly two decades in government—including serving as deputy national security advisor for cyber and emerging technology—to explain how AI is transforming the threat landscape, most notably making attacks faster, cheaper, and continuous at scale. Jones brings the builder’s perspective as CEO and cofounder of Method Security, where his team is building autonomous cyber systems for both offense and defense observing firsthand how AI is accelerating everything from routine tactics to exploit development.

Together, they discuss what “cyber resilience” means in an AI world: continuous testing and red-teaming that was previously cost-prohibitive, clearer benchmarks for critical infrastructure, and faster recovery when disruptions happen.

They also walk through the policy measures that can help defenders keep pace.

Topics covered:

03:16: How AI changes the threat landscape

07:38: Net new risks in an AI-vs-AI cyber world

11:21: Building trust to deploy new technology in no-fail systems13:55: Cybercrime at machine speed

17:18: Who benefits more from AI: attackers or defenders?1

9:29: Tactics to remove friction for defenders

22:26: Real examples of incidents where AI could have changed outcomes: Colonial Pipeline and Change Healthcare

27:18: What cyber resilience means in an AI world30:57: Measuring resilience

36:59: Information sharing and antitrust: lessons from financial services and telecom compromises

44:59: The builder’s view: what Method Security is building for offense + defense

49:27: Little Tech realities of building with a small team and selling into government

52:53: The role of procurement in ensuring defensive systems keep pace with adversaries

55:32: What’s next: in-year buying flexibility and closing thoughts

Resources:

Subscribe to the a16z AI Policy Brief: https://a16zpolicy.substack.com/

Follow Jai Ramaswamy: https://www.linkedin.com/in/jai-ramaswamy-85a77675/

Follow Anne Neuberger: https://www.linkedin.com/in/anne-neuberger-13b4491b/

Follow Sam Jones: @___sjones

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit a16zpolicy.substack.com