C (26:19)
So why are people, more people being diagnosed with adhd? There are a lot of people out there who, for their own reasons, want to see something nefarious going on, that people are scamming doctors to get medications or they're drug addicts or something like that, where there's actually no evidence for that. What has happened is that people are much more aware now and recognize much more frequently the purely inattentive subtype, the quiet ADHD that otherwise goes unnoticed. It's the squeaky wheels that have gotten the grease for 50 years. Also, more people have an awareness that what they've been told in horror stories and fake opinions and things like that just isn't true. They have a personal experience of the kid down the street who was just a horror show, terribly behaved, a menacing community, but who started on ADHD medication and is now just a delightful kid. They find that all of these scares and tactics just weren't true. Because they saw it with their own eyes. Probably the big one about why people, more people are being diagnosed are that females are finally being recognized and diagnosed. So half the people with ADHD in the world were not recognized at all. So now that we are beginning, and we're only just beginning to recognize women with ADHD that doubles the number of people who are out there being diagnosed and getting medication. It is not people trying to get a little system is that we're doing a better job of recognizing it. There's also a lot less social stigma to seek treatment. ADHD is extremely common everywhere in the world. And everywhere in the world that they look for ADHD they come up with about the same problems again, something that shows that ADHD is pretty consistent all the way through the world. ADHD is the second most common neuropsychiatric condition, not just in kids, we're definitely by far the most, but at all ages with substance use disorder being the number one most frequent. This whole notion about being over diagnosed, there's no evidence for that. There are a couple of papers that show that there's small pockets around the country where the, the prevalence and number of prescriptions is much higher than the rest of the country. But in all cases it's a rural physician who's the only person who diagnoses and treats adhd. So that's what he gets, everybody goes to him or her and so he ends up writing more prescriptions. There's a study done by the National Institute of Mental Health of five US cities. Actually one of them was San Juan, Puerto Rico. And what they found was that half of children and adolescents with ADHD were missed. Again, it wasn't over diagnosed. It was a 50% failure rate to diagnose. It was so bad that the study recommended a national program to educate prescribers of all types how to recognize ADHD and treated because we were missing so many people. Now there's another study of which I was the lead author, but I didn't earn that at all. I'm basically an lead author because I want to bet the study was eight board certified adult psychiatrists who they the least amount of time they'd been out in practice was seven years and they looked at 13 patients and they videotaped every moment of interchange between the doctor and the patient looking for what it was that would trigger the thought in the clinician's head I need to consider adhd. I just need to think of it. I won the bet because I met them and said look guys, at the end of this we're not going to have any data because an American psychiatrist is not ever going to think of adult adhd. Well, I won in a big way because not only did not a single psychiatrist recognize ADHD in nine out of the 13 patients, even when the doctors were told, this is a study of adult ADHD and that's all it is, that's all these people is. Nine times they said, no, this person has a mood disorder, usually bipolar. And they refused to accept that ADHD was even a possibility. No, psychiatrists do not over diagnose it. The National Comorbidity Survey replication is a huge study, 10,000 subjects looking at the prevalence of all psychiatric conditions. It's supposed to be done every 10 years. It's done about every 15 to 20. But it's trying to figure out what demands are we going to have on the mental health system for services that Congress has absolutely no intention of funding. And what they found was, by the way, this was the first time the National Comorbidity Survey replication was bothered to include ADHD in their subjects. So it had been neglected the previous three times. They found about the same prevalence, 5.2%. If they added one thing that you didn't have to have evidence of impairments prior to the age of 12, that jumped up to 8.3%. So almost exactly what kids had. But these people were not doing well in life. 42% were in active psychotherapeutic activities. Virtually every one of these people had first been misdiagnosed with anxiety and depression. ADHD was not recognized when they looked at the people who were diagnosed. Depending on which center you looked at, somewhere between 11 and 13% of those who were diagnosed with ADHD had received any ADHD treatment in the previous 12 months. So more than a 50% miss rate and even then 80% non treatment. Again, there is nothing to believe or support the fact that the assertion that ADHD is either over diagnosed or over treated, everything points exactly in the other direction, dramatically. So now it should be incredibly easy to get people to consider giving a try to ADHD medications. First of all, the most effective medication in all of psychiatry, we measure effectiveness by what we call an effect size. An antidepressant, for instance, has an effect size of about 0.5. Just about everything in medicine is between 0.4 and 1. The stimulants, if they're fine tuned to the unique individual, get an effect size of 1.88. In other words, triple the effectiveness of antidepressant medications. They are the most thoroughly studied Medications with last now more than 8,000 studies, they're safe. These medications have been around for 80 years. They're approved down to age of three. They're approved for use in pregnant women. They are the treatment of choice in every standard of care in the world. Unfortunately, they're usually treated as a treatment, last resort. And yet people, parents especially, agonize over the decision of whether or not to try medication for years. So why should somebody try it? Well, ADHD is a serious condition. I had one colleague refer to ADHD as an optional disorder. As far as he was concerned, it was optional whether you looked for it, and if you found it, it was optional whether you treated it. On average, a person with untreated ADHD lowers their life expectancy in general 12.7 years, almost 13 years less life. To put that in perspective, that's about the same loss of life expectancy that you see in type 1 diabetes. ADHD is a very serious, potentially lethal entity. So what are the biggest risks out there? Well, substance use disorder is a big one. The diagnosis of substance use disorder is 400% higher in people with untreated ADHD than in the general population. Next comes serious injuries, injuries severe enough to have produced a hospital record, and that goes up fourfold. And accidents are the leading cause of death. Until you're 44, I'm not sure that I would want my kid quadrupling his risk of a serious accident, especially if he's driving my car. Another big one is involvement in the justice system, especially the juvenile justice system. Somebody with untreated ADHD is five times more likely to be arrested. If they are arrested, they are nine times more likely to be convicted and incarcerated. Now, this is mostly due to oppositional defiant disorder, which also significantly improves with stimulants. Treatment of ADHD in prison makes a huge difference. In one study that I know of personally here In Colorado, the 3 year recidivism rate, in other words, they're released from prison, but they're back incarcerated again within the next three years, dropped from 56% to 13%. This makes a huge difference in how well people with ADHD do after they are released from prison. Now, we all know about the problems with schools. You triple your rate of being retained in grade, you quadruple your risk of being suspended, but it's the dropout rate, 32% versus 0%. And we all know that if you don't have a high school diploma, the best jobs you can get require you to say, do you want fries with that? Retreating also is equally Important is the effect that untreated ADHD has on making and keeping friendships. McConnell's work looked at third graders and what he found was that 70% of children with ADHD untreated ADHD reported that they did not have a single friend. As adults, people with ADHD have twice the rate of separation and twice the rate of divorce. When I have parents cry in my office, it's not because the kids flunking out, it's because they were never invited to a birthday party. You can get an education anytime in your life, but it's in these early years where you're learning how to get along with other people and whether other people like you that you can't go back and do over again. So it's important for children, if only for their ability to learn social skills and get friendships that enough all alone enough for me to recommend getting on medication and staying there. In terms of sexual lives, I have a longest running study. The Milwaukee study looked at ADHD versus controls. People with ADHD had two and a half times as many sexual partners, almost 10 times more pregnancies, most of which were unplanned. They had four times as many sexually transmitted diseases. And of the 42 children born to study subjects, 41 were born to the ADHD group, only one was born to the control group. What's most disturbing is that 22 of the children, half had already been removed from the parents custody. ADHD is a disorder that affects not only the person who has it, but everybody in the family. So this is one of the things I really want to emphasize is that the impairments of ADHD continue throughout childhood and into adult life. ADHD does not go away. But what happens is that while the impairments continue, the consequences of those impairments get worse and get worse for more people. For instance, multiple injuries. An 8 year old who rides his bicycle into a tree is going to have consequences, but a 28 year old who drives his car into that same tree is going to have more severe consequences or for more people. Self medication, experimentation, substance use disorders get progressively worse when they're untreated and so on. So this is not something that you should wait for it to go away. It's only going to get worse. ADHD is a genetic disorder and since no other genetic disorders go away with age, it is foolishness of the first rank to think that ADHD is going to go away with time. So what makes it so hard to consider just trying an ADHD medication? The problem is baseless fears almost entirely. And there are four Major sources. First one is not accessing reliable information. There's a nice article looking at TikTok, which is one of the main sources of information for adolescents of every age. And what they found was that half of the postings on ADHD were wrong, completely wrong, and another fourth were termed misleading. In other words, they had the facts in there, but they draw the wrong conclusion. So we really need for many reasons to guide our children away from bad sources of information such as TikTok. They have fears about problems with the medication. They're real, but they are also correctable problems. There are no side effects of ADHD medications that can be fixed today. We also have to deal with intentionally false information. And there are still bad actors out there that do that with a really big one. The stubborn clog in the pipe is the lack of medical training. Half of all pediatricians admit that they were not prepared to treat adhd. They did not feel prepared to handle even an uncomplicated case of ADHD. When you look at adult psychiatry training programs, 93% do not mention ADHD. They just don't acknowledge its existence. I know my residency didn't. Consequently, we have plenty of patients. We have plenty of good medication treatments. The stubborn clot in the pipe are the prescribers, or rather the lack thereof. It's very, very hard to find somebody who knows what they're doing. So we're all out there being forced to balance what are the risks of treating ADHD versus not. So let's do the low hanging fruit medication side effects different. What we'll call the rule. The right molecule at the right dose for that unique individual should normalize behavior without significant side effects. Now, if you're having side effects, the dose is too high or it's the wrong molecule. You or your child's personality should not change. The goal is always to find the best version of you. You'll get better at what you're doing. Just about every international standard of care agrees. The two minor stimulant class medications, amphetamine and methylphenidate, are the treatment of choice, period. And a wavering about that and that both should be tried before moving on to a second or third line agent. Unfortunately, nothing predicts in advance which one a person is going to get their best response from. It doesn't run in families. So you can have one child on an amphetamine product and the parent on a methylphenidate product. You just have to try the medications to see which one works best for that unique individual. Side effects are well known there's the Starbucks syndrome. Imagine what somebody would look like if they rolled out of Starbucks after five double espressos. They'd be revved up. They'd be jittery, restless, irritable, have nausea, et cetera. There's the reverse autonomy syndrome. Loss of facial expression. They're lost initially. They're just sort of bland. They're no longer disruptive, but they're also not there. Both of these are caused by the dose being too high. All of the stimulant side effects are minor, harmless. But the most important thing is they are reversible within just a few hours. Why should this matter? It's an important distinction to make. It's not that these medications are inherently difficult or hard to use. The problem is that establishment medical education has done virtually nothing to teach physicians how to use these medications. They're actually very easy medications to use with virtually no side effects. If you have been trained on how to do them, it's not the fault of the medications. Unfortunately, it is hard to find somebody. So we need to go through the major FDA warnings because they are the FDA probably biggest source of bad information that I can think of. It's very rare that the FDA gets anything right. For instance, 25 years ago, they put a black box warning on all the stimulants, even though they had no evidence that they were dangerous for cardiovascular diseases. And despite the fact that their advisory committee voted unanimously not to do it, they basically did it because they had a baseless fear that somehow ADHD medications were dangerous for the cardiovascular system. And they acted on that baseless fear. And what they did was they scared people away. The risk of cardiovascular problems is due to the ADHD itself. If you have adhd, your risk of having anything wrong with your heart is determined almost entirely by the adhd, whether it's treated or not. Consequently, all this fear mongering by the FDA has left in people's minds a very odd belief that it's the treatment of ADHD that is dangerous and not the disorder itself. There are also fears of misuse, abuse, addiction and diversion. Yes, there is substance abuse. If you have untreated ADHD, your risk of at some time being diagnosed is 60%. The risk is out there. But use of ADHD medications does not increase that risk. In some reports it actually lowers it. So what makes people think it's abusable? It beats me. Amphetamine was first synthesized 148 years ago. Methylphenidate was synthesized in 1939, 86 years ago. So these are not unknown to us, we know these medications. For the first decades they were over the counter medications. You could just walk in and buy them in treatment of asthma. And there was no significant notable misuse or abuse. So they were used a minimum of 20 years with no trouble at all. Then in the late, in 1958, they made them a C4, which is the least restricted category, so they can monitor them. It was more than 20 years after that, in 1978, that the country suddenly discovered cocaine and methamphetamine, which is a real public health problem. And the DEA just arbitrarily, without asking anybody, lumped the ADHD medications into the same class as cocaine. It was not that these medications were a problem or being abused. It was just an administrative poor decision. So many studies, the majority of studies show that adhd, if it's being treated with stimulant medications, usually the stimulation, the substance use gets much better because the substance use was really self medication and usually trying to medicate the impulsive hyperactive component. There are some studies that found neither protection nor increased later use, but there have been no studies to show that the ADHD stimulants made it worse. Now we all should have known this just from common sense. In my practice when I was talking to parents about this, I would go up to the whiteboard and I would tell mom, dad, tell me what you know about drugs of abuse. And they would give me that list on the left pretty much every time. People take them to feel good, get high, users crave the drug. There's a large and ready market out there for them and it's a struggle to get their kids off of these medications. Good mom and dad, tell me what you know about the medications for adhd. Well, you feel nothing or you feel bad if the dose is even just a little bit too high. The biggest problem is patients commonly forget to take the medications. They don't like how they feel if the dose is too high while they are readily available because they're out there. Long term use is very low, less than a half of 1%. And it's a struggle to get kids to take the medications. So once you literally see the handwriting on the wall that the medications for ADHD are exactly the opposite of drugs of abuse, you start wondering exactly why they ended up that way and continue to be that way. So think for yourself on this. Do drugs that are described this way really have a high potential for abuse and dependence? There really is very little evidence for that because there was very little evidence for putting him in category Two, and they were put there strictly for political reasons. The DEA felt like they had to be doing something. And it's also why they're going to remain controlled substances, because nobody's going to expend any political capital to do the right thing and put them in Schedule 4, where they began. Once again, ADHDers pay the ADHD tax. They pay a penalty for the misbehavior of others. So let's real quickly go through the other baseless fears so we have time for some questions. One of the big ones is retardation of growth. That one's been around since 1970 and it really depends on what your training is. If you can prescribe medications, you tend not to find ADHD loss of growth, and if you can't prescribe medications, you tend to find it every time. Even if the growth problems were real, they would be inconsequential compared to the massive risks of not trying medications. The loss in all the reported studies that said there was one was less than 2 centimeters. That's less than the width of your index finger. Nobody is going to notice less than 2 cm. Whereas the risk of not taking ADHD as we just talked, is huge. There was the Adduce study, ADHD drugs used in chronic effects in Europe. It was a two year study and what they found was that methylphenidate especially was not associated with any effects on growth and development. This study also looked at a whole bunch of other things and it was interesting. What they didn't find. They didn't find any neurological problems. They didn't find any developmental problems. They didn't see an increase in psychiatric symptoms or problems. There was no increase in seizure disorders. The only thing they found was extremely minor changes in blood pressure and pulse. We're talking about 4 millimeters of mercury and 2 beats per minute. In other words, something that is not even noticeable. A lot of people worry to wring their hands. We don't know what these drugs are doing to a developing nervous system. The answer is yes, we do. These medications have been around for a long time and we've kept registries for more than 50 years. Unfortunately, all of these registries, without exception, lumped the use of ADHD stimulants in with drug abuse studies. But even when you do that, they can't find any problems with pregnancy, not with getting conception, birth defects, delivery or post delivery have ever been found. They seem to be utterly neutral. Consequently, even the FDA says it's a decision that is left up to the parents and their doctor. We don't Know what these medications do over a lifetime? Yes, we do. The longest data we have is for people who've taken amphetamine for narcolepsy. It's been the drug of choice for narcolepsy for 85 years and thus far no problems have been found with long term use. So these are medications that millions of people take every day, all day, with a lot of success. The longest study, the longest study was now out 57 years. The subjects are now in their mid-60s. All the life problems these people experience were from not taking the medication, not from taking it. Appetite suppression. Adults do not complain of appetite suppression. And you'll hear it from about 30, maybe 40% of children. They just won't be eating as much, but they won't have any clinical significance. They may not be eating as much, but they're not losing weight, not failing to gain weight, et cetera. The only time it has clinical significance, if somebody fits the slide, it just disappeared. The only clinical significance of it was that it was found in about 6% of kids. And these were kids who started off being real thin to begin with. There we go. So there are things that you can do. A lot of ducks will switch molecules 40% of the time. People have appetite suppression on one molecule, will not have it on the other. Also supraheptadine, which is an antihistamine medication designed for children. It's been around since I was a child, works about 90% of the time at the very lowest dose of 4 milligrams, half to one tablet, about 30 minutes before the meal. Its benefits last for about six hours. And it works like a charm for the vast majority of people. And you can stop it every once in a while to see if the child has become used to it. If that doesn't work, we then go to mirtazolepine. A lot of people worry, since anxiety is the most common coexisting condition, that adding stimulant will make anxiety worse. There's a nice study of studies that found that looked at 23 studies where people who were already anxious had a stimulant medication added. And what they found was that in 22 of the 23 studies it dramatically lowered the level of anxiety and that higher stimulant doses tend to lower anxiety more than lower doses. So this turns out just not to be a problem. So in summary, ADHD is a seriously impairing neurologic and genetic condition. It's their lifelong. It's not going to go away if you do nothing that everyone, adults Parents, clinicians should base their decisions on decided science, the things about which there is no ambiguity, and not on their fears, their ignorance or disinformation. Virtually all of the adverse risks, 99%, come from not treating ADHD. There's virtually no problem with a trial of ADHD medication, just to see what they have to offer and then making your decision based on real information. Also, treatment is protective against later impairments, and the earlier you start the treatment, the better. So I hope this has been helpful. We're going to have some discussion now, but there are a lot of things on the Attitude website, which is, in my opinion, the very best source of information on ADHD that's out there and available to the general public. It's also real helpful if you advocate for yourself with your physician. Remember that you will probably know more about ADHD than your doctor does, and they are not. Many doctors are not going to go out and spend the time getting up to speed with adhd. But you can print things off from Attitude especially and thrust it into their hands and say, I want you to read this. It is important to me because it's important to my child. It's important for you to know this for my child and for everybody else. You also need to help them see you are already treating ADHD. Statistically speaking, the average physician will see 40 people every day with ADHD. Now, they may not recognize it, but they're there. And they can't just walk away and pretend that it's not there. If you're a mental health professional, 20 to 25% of the people that walk into your office every day is going to have adhd. And so you need to confront your doctors because remember, psychiatrists are just as poorly trained as anybody else. You have to say, look, I want you to evaluate me for adult adhd, and if you can't do it, refer me to someone who can. You must advocate for yourself because no one will do it for you. Passive people get bad medical care. That's an axiom I've never seen the exception to. So with that, we'll open things up and Carol will come back on.