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A single scientific insight can open up an entire pipeline, and that’s what makes this conversation with Noxopharm Limited so compelling. We’re joined by CEO Olivier Laczka to talk about Sofra™, the company’s RNA technology platform built on a breakthrough discovery about how the immune system triggers inflammation, developed alongside the Hudson Institute of Medical Research in Melbourne and published in a leading journal. If you care about where ASX biotech is heading, this is a clear look at how platform science turns into real drug programs.

We dig into SOF-SKN™, Noxopharm’s lead asset aimed at cutaneous lupus, a skin disease with a growing global market and no specific designed treatments. Olivier explains why a topical cream that blocks lupus-linked inflammation could be a meaningful shift for patients, and he shares the latest progress including a completed safety trial in healthy volunteers and the practical next step of moving into a trial with lupus patients. We also touch on how the same approach could expand into broader inflammatory skin diseases and chronic conditions where inflammation drives long-term damage.

Then we move into immuno-oncology, where Sofra™ isn’t used to dampen inflammation but to deliberately boost targeted immune activation for cancer treatment. Olivier walks us through newly released breakthrough data, including a 200-fold increase in immune activation when combined with a clinical stage TLR8 agonist in human skin biopsies ex vivo, plus supportive animal model results, and why IP protection and US patents matter when scaling a platform globally. Finally, we cover validation through an Australian Government MRFF grant linked to pelvic floor disorders and birth injury repair, and the key 6 to 12 month milestones investors watch: manufacturing, FDA engagement for IND preparation, cancer program progress, and growing international partnerships.

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