← Biohacking Beauty: The Anti-Aging Skincare Podcast
Biohacking Beauty: The Anti-Aging Skincare Podcast
Can Vampire Exosomes Really Rebuild Aging Skin? Here’s the Science
00:56:57
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- [00:01]
A
Before we dive into today's episode, I want to pause and thank all of you who've taken the time to leave.
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B
A rating and review.
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A
It might seem like a small thing, but those reviews actually make a huge difference in helping this podcast grow and reach more people. To show our gratitude, we're starting a weekly giveaway. Each week we'll pick one reviewer to receive a free product. This week's shout out goes to Kitten Puppies on Apple Podcasts for their generous five star review. Here's what they said. Upping my Skincare game Love every product from Young Goose I've tried and diving into the education behind them through this podcast. Thank you to Amitai and Anastasia. I am a fan. My face is glowing and I'm excited.
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B
To follow you on the skin Biohacking journey.
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A
Thank you so much, Kitten Puppies. Please send us a DM on Instagram to confirm this was your review and we'll get your free product mailed out to you. Welcome back to Biohacking Beauty, the show where we cut through the noise and trends and focus on the real, real science of aging. Younger I'm Amitay.
- [01:25]
C
And I'm Anastasia. We're the founders of Yango Skincare, and if you've been listening, you know our mission is to redefine what aging looks like by upgrading biology, not just covering symptoms.
- [01:38]
A
Exactly. Mainstream skincare loves surface fixes. A cream here, a random procedure there. But that ignores the upstream drivers of aging mitochondrial decline, senescent zombie cells, collagen breakdown. Our biohacking approach is to intervene at the root level so skin behaves like it's younger.
- [02:03]
C
Which is why today's episode is a deep dive into PRP derived exosomes, AKA vampire exosomes. They're not just hype, they're nanoscale messengers that deliver repair instructions from platelets directly to your skin cells.
- [02:19]
A
Think of them as the next generation of PRP with standardized potency and daily usability. And what's exciting is that early human data show that they can reduce senescence markers as zombie cells restore collagen signals and improve tone, redness and fine lines.
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C
Within weeks, we'll unpack what exosomes are, how platelet origin makes them unique, what human biopsy data reveal at 12 weeks, and where they fit alongside tools like retinoids, lasers, or even Botox.
- [02:56]
A
And we'll get into the stack. We're most excited about pairing vampire exosomes with NAD precursors and boosters and activators to raise the energy budget for repair in your skin that's the systems level thinking that makes biohacking and biohackers different.
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C
Yes. And a quick reminder before we dive in, if you want to try Yangoos products for yourself, head over to yangoos.com and use the code PODCAST10 at checkout. You'll get 10% off your first order.
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A
Okay, so biohacking beauty, Yangu Skincare, real strategy for younger acting skin. Let's dive in.
- [03:41]
C
Let's do it.
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A
Okay, so basically we did it. We, we've designed it like, kind of like a Q and A where we're asking a question, then we're going to talk about it. So maybe I'll ask a question first and you'll.
- [03:52]
C
Yeah.
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A
Kind of go. So let's talk about what exactly are exosomes and why are they so talked about in regenerative medicine in general, but also in skin health?
- [04:06]
C
Absolutely. Exosomes definitely became such a buzz, and it feels like everyone's talking about them. And exosomes are nanoscale extracellular vesicles, think 40 to 150 nanometers, lipid envelopes that cells release to deliver proteins, lipids and nucleic acids to. To other cells. So really there are messengers. And the important thing to understand is that all cells release them to communicate with each other. And the message can be very different. So this is where it gets interesting. When people hear exosomes and automatically connect them to skin care and improving skin health, they connect it to this positive message of renewal and repair. And, and we'll get into more details of how can we ensure that that's the exact message that the exosomes contain, because not all exosomes contain that message. Yeah. And so they're really the body's ways to coordinate healing and remodeling, which is why they're central in wound repair, fibrosis resolution, angiogenesis, and immune calibration. Yeah, I was going to talk a little bit about, you know, that reviews in dermatology and bioengineering over the last 18 months summarize rapid progress across skin, aging, scarring in wound care models. And that's really when we're talking about, again, those exosomes that have that exact message. Because not all exosomes will result in this. Some exosomes, matter of fact, can signal, like, cell death, because that's just a message.
- [05:44]
A
All right, you're going to ask the next question.
- [05:46]
C
Why is the skincare world so focused on them for repair and rejuvenation?
- [05:51]
A
I would say because in pre clinical and early clinical work, exosomes can downshift inflammation. They can re energize fibroblasts. They also can stimulate collagen, elastin, remodeling, hyaluronic acid production, core levers behind texture laxity, hydration and photo damage. I would say there are still experts that also call out hype or inconsistent standardization and regulatory like gray zones in cosmetics. So I think it's important to anchor on sources with actual human data and clear manufacturing controls. In other words. So that was kind of a disclaimer. Okay. Like there are no FDA approved exosome drugs. Any, you know, disease treating claims need trials and approvals. So, you know, within the talk about topical positioning, they're positioned as cosmetics. They must stick to how skin, how they modulate skin appearance rather than like resolve, you know, like skin conditions. Having said that, so what are exosomes? What do exosomes do really? So exosomes, as you said, they're in every, every communication relies on exosomes in the body, for that matter, between cells or it's one of the ways. It's not correct to say that every communication relies on them, but that is the body's way to communicate. Repair, remodeling, resolve inflammation, resolve things. They're a very powerful messaging tool in the body, especially in the context of renewal and responding to injury. And the way that they do it is that within exosomes there are little things that are called micro. Micrornas. They also have proteins. Yeah, they have peptides, they have growth factors. But these are all things that have existed in cosmetics for a long time and that have a very limited effect long term on the results people get. So why is the, the reason that the cosmetic world, the skincare world, the skin anti aging world, is obsessed with exosomes at the moment is because of. They have an another thing there which are those micrornas. And what micrornas are, are basically like micromanagement of youthful function in this.
- [08:12]
C
I love it. I love this. This analogy gave at a different podcast.
- [08:16]
A
So do you want to give that analogy?
- [08:19]
C
Sure. So a lot of the time, some. There is also analogies from construction sites. They just fly over my head.
- [08:25]
A
Yeah.
- [08:26]
C
Yes. But this one was close to heart because he was talking about the havoc that a toddler brings to your living room, or any room for that matter. And our toddler, who is one year and eight months, he's just on a mission to destroy everything in the house. And so what I was saying is that as we get older, suddenly there is no more order in the house. There is this disorganization and mismanagement, if you will, of the house. And it's almost like you can imagine that you have all these rowdy toddlers running around and just. Just making a mess. And so ideally, what you want to do, you want to.
- [09:08]
A
But first you need to say what normal skincare does.
- [09:12]
C
Oh, yes. And what you see. Let's go to the source of the.
- [09:19]
A
By the way, the creator of the analogy. So normal skincare is, you know, whether we talk about peptides, whether we talk about, you know, retinol, whether we talk about lasers, microneedling, anything like that, you're giving instruction to the body, but every aging process you can imagine, like you've. You've thrown another rowdy toddler into that, into the house. So when you're young and you have like one or two, that's fine, you can shout instructions around and the toddlers maybe listen, maybe not. When you're older and you have like, you know, hundreds of toddlers running around the house wreaking havoc. Ours, for example, loves to just take our plants and throw them to the ground anyway.
- [10:03]
C
So, yeah, empty the container of the plant, the pot, like, upside down. And there is just.
- [10:09]
A
And then brings.
- [10:10]
C
The plant is outside on the floor, just covered in the mud.
- [10:14]
A
Yes. And then he triumphantly, he brings us the. The thing that was in the pot, the plant. Look what I have. Anyway, but imagine one. It's fine. But if you have hundreds of them, obviously you can shout instructions, which is what conventional skincare is. Is doing. Just, you could do two things. You can have instructions. You could be like kind of modern parents, like modern parenthood, where you're saying, you know, gentle hands and stuff like that, and you're trying to calmly explain what you would like. That obviously doesn't work very well because you have hundreds of toddlers in your house.
- [10:51]
C
Doesn't work in his analogy. At our home, we're still doing gentle.
- [10:54]
A
Parenting, by the way, but we can see how well it works with our pot. Anyway, the other side is obviously like, scream crazy instructions. That would be like, you could think of your more extreme stimulators in the skin. You're just going to scream instructions around, and that's going to, what. The toddlers just are going to get more antsy. They're going to start crying, they're going to start getting very upset. So these are the two kind of options you have with conventional skincare. You can have gentle hands. That's not going to do much. That's your, you know, clean skin care. Use, you know, carrot juice extract to try to, you know, diminish wrinkles. And the other side is okay, let's stimulate renewal like just like crazy with peels and exfoliators and lasers and stuff like that. You're going to get just like irritated by function malfunctioning skin. Long term exosomes are basically like micromanagement. Like what, what do you want to do? You want to go to that baby and you know, depends how many exosomes you have, you know, but you want to have enough micromanagers, micro nannies that go to micro parents that go to those toddlers and, and can micromanage them, go say hey, do you remember last week you, you know, threw the pot to the ground and what did we do? We cleaned it together. Let's go and clean it together. Let's sit down and read a book. And you're, and you're basically slowly, slowly resolving it one toddler at a time, one aging process at a time. For that matter, when we're talking about the skin, that is what exosomes are doing. This is what MICRORNA is, can do. Microrna basically intercepts rna, so basically intercepts your epigenetics wherever they are. If you're younger then better epigenetics. If you're older, you get older epigenetics. So more, less collagen, less elastin, less hyaluronic acid, worse kind of processes that are happening in the skin. And basically it can as a last resort kind of micromanage how that cellular function, how that epigenetic is being expressed. So it's going to basically shift everything to a much more youthful state. And that's what your body is doing when there is an injury. When there is, there is an injury, your body is going to invest extra energy. Your body always wants to save energy, so it's only going to do it normally when it is under stress. It's going to invest extra energy that where repair happens. You, you have more youthful expression. It's not perfect, you're not a baby, but you have a better youthful expression of your genes. You make collagen better, or hyaluronic acid better, or elastin better. And I can go on and on, this is just names people know. I can talk about lumicans or whatever, but it expresses antioxidants better. All of those things happen better. And that's microrna. What's important to understand is going to come out, come back later in our discussion. Not all micrornas do the same thing. So you have Micrornas for collagen. You have micrornas for angiogenesis, which is how, you know, you build the blood vessels. Yeah. You have micrornas for antioxidant ability, you have microrna for elastin, et cetera, et cetera, et cetera. So as you alluded to before, not everything, not every exosome is going to behave the same. Some exosomes, by the way, are going to have no micrornas or very little. So, yeah, I guess, you know, we can, we can continue our discussion. But that's a fun example. I think I give it better at the podcast though. I think it was you, you funnier.
- [14:35]
C
At least it was more concise. Yeah, but I think that's still such a good example that I feel like everybody can relate to it in a certain level or imagine easier than I.
- [14:46]
A
Was giving it with Legos. I think that was the cool thing. Yeah, never mind.
- [14:49]
C
Okay, okay, let's, let's keep talking. First of all, you know, based on everything you said, like, sign me up for the exosomes, sign me up for the best micro RNA and give me all the diversity and all the variety that I need.
- [15:02]
A
Okay, so now that's the, that's the question. So you will, you can answer that. So we're going to talk about, specifically about kind of the, the real, what I call like the caviar of exosomes, which is PRP exosomes. So how do PRP derived exosomes. Right, because if every regenerative cell, you know, your stem cells, whatever, they all express exosomes. Why? Exosomes expressed in platelets in prp, how do they differ from exosomes? Everyone else is talking about, like exosomes from umbilical cord or from fat or from bone marrow.
- [15:44]
C
Yeah, I love that question. Okay, so exosomes is really like an umbrella and it's a vesicle, it's a, it's a vehicle that we talked about. Right. So source matters. So mesenchymal stem cell exosomes are very often talked about. There's lots of skincare brands that use them. So they skew toward immunomodulation and angiogenesis. Platelet derived exosomes, PRP exosomes, the ones that we use in vampire exosomes, serum I enriched for wound healing, growth factors and specific micro RNAs that orchestrate matrix repair. That origin specific cargo, is why platelet exosomes are being explored as more reproducible cell free successor to PRP for skin uses.
- [16:33]
A
Yeah. And I think to your Point we really, because we kind of now juxtapose like the two best sources.
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C
Yeah.
- [16:42]
A
So here's the thing. What we care about is like skin rejuvenation. That's what we care about. When we make a topical skincare product, we want to derive the messaging and again we're talking about micrornas, but we want to derive the exosomes from a process that relates to that in the most authentic fashion. So obviously we want to derive it from the response that happened when skin is being damaged or needs repair, which are platelets. That's what causes for example, scabbing when you have like a, you know, when you. Again, when you scrape your knee or something like that. That is the closest to source as far as like repair. Skin repair. Right. Mesenchymal stem cells that are, that are normally what you will see in the market in the high potency, like high medical grade. The ones that you pay thousands of dollars to get injected or to get applied topically for that matter. These are the kind of the next one in ones in line. But, but umbilical cord from babies. Let's like further away from that. When we talk about most exosome products actually have either only or a combination of exosomes that are from plants. Normally you will have a hard time also discerning. You're going to have like an oh, this has, you know, 50 billion exosomes. It's going to be very difficult for you to kind of separate. Okay, so how many of them are from human tissue? How many of them are from plants? Plant exosomes are obviously extremely far from rejuvenation response in the skin from repair response in the skin. So they do little to none within the context of that. They can, they can be like any plant extract. They can be good for, you know, inflammation or for oxidative stress, but they are not that robust. Micro RNA delivery system.
- [18:42]
C
Yeah, the way I think always about it that if you're trying to derive, you know, the, the same kind of signals from plant, plant based exosome for human body as you would from human derived exosomes, it's almost the plant exosomes speak a different language than your body. It's like if you talking to someone that speaks a different language, you might work it out, you might get to some kind of conclusion, but it's just so much harder than if you were speaking the same language.
- [19:12]
A
Yeah, they can calm you down a little bit. They can speak very softly, they can sing, they can rile you up, they can definitely annoy You. But it's going to be very difficult to create an hour lecture with them. It's be to going be very difficult to, you know, get a new discovery in science with, with, with someone that doesn't speak your language at all. Right. So yeah, yeah. I mean, it's a good, good example.
- [19:39]
B
Let's take a quick break from this episode to tell you about our new youth firming body cream. If you're tired of body lotions that just sit on the surface, it's time to upgrade to something that actually works from the inside out on an epigenetic level. Yungoos Youth body cream isn't just your typical moisturizer. We've powered it with nad Apex selviospermidine, longevity mushrooms, and ergothioneine and lemongrass extract with lipopeptides. This is a formula that literally reprograms how your skin ages. It restores cellular energy, boosts collagen production, and clears out cellular waste like senescent cells targeting those problem areas like your arms, legs, neck and decollete, where aging shows up first. Think of it as a biological reset for your entire body skin. Because when your skin gets the science it deserves, the results speak for themselves.
- [20:47]
A
Ready for your full body upgrade?
- [20:50]
B
Visit younggoose.com today and discover what happens when longevity science meets skincare. You can grab the link in the show notes below.
- [21:06]
C
Okay, I have a question.
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A
Yes.
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C
Why are they called voice vampire exosomes, the platelet derived or why we call them there?
- [21:13]
A
Yeah. So they're kind of a nod to vampire facials where autologous platelet rich plasma. So you take someone's platelet rich plasma and you are reapplying it to the skin after you did microneedling. Here we're isolating the key signaling vesicles from platelets rather than, you know, using them after microneedling or. Or injecting the platelets themselves. No one's really injecting the platelets themselves that much. Maybe a little bit. It's more about the application. So we're doing that in a more distilled version that you can kind of take home do at home. But by the way, research shows that the results are pretty comparable between doing the kind of PRP facial with microneedling and applying platelet derived exosomes at home.
- [22:05]
C
Yeah, if. If you have the right concentration and the right message inside them. Okay, okay.
- [22:11]
A
I have. Now I'm asking the question, why are vampire exosomes considered more targeted? I think we covered it a little bit, but we can Definitely talk about more about it more considered more targeted and powerful for skin health.
- [22:25]
C
Yeah, absolutely. So because they package the platelet wound healing program. So. So that includes growth factors, lipids and micrornas into vesicles that cells can internalize efficiently head to head. Preclinical work shows platelet exosomes outperform platelet lysates at reducing MMP1 and increasing collagen deposition in aging models. So really there is robust data of it to work. And it also kind of makes sense logically because when you think about the function of platelets in the body, they are the one, the first responses to injury. They're the first ones to come at the site of injury, start, you know, wound healing, start repair and renewal. And that goes back to, you know, exosome being an envelope for a message and us trying to get to the most powerful, most efficient message. So platelets just naturally have a lot like a. Yeah, A lot more chance to give it every single time.
- [23:32]
A
And I will add something since we kind of covered the same question twice, I'm going to add like another FYI. So although in general, you know, when you talk about, you know, just looking younger, the zeitgeist is okay, we want to have the skin renew faster. Although this is generally true, it actually is kind of a double edged sword because just any cell that renews more will have more mistakes which will breed aging down the line. But what's cool about you know, exosomes, but really PRP derived exosomes, vampire exosomes are that the body takes that into account. And when there is a response that in that it, that is, that is specifically for a, a state where the body is going to invest a lot of energy in renewing cells, in having cells renew themselves faster. It also builds in programs there that scavenge zombie cells, senescent cells. Why? Because senescent cells there is a, there is a compatible ratio between more cells dividing and higher rates of zombie cells. That again, as I say, unfortunately it's a double edged sword. So you get more zombie cells, the more renewal you have. The body takes that into account. And within vampire exosomes there are programs to again, MRNA other proteins. Microrna, sorry Microrna other proteins to encode removal of zombie cells, of senescent cells. Another thing is autophagy. That's where a lot of the initial study has been done on platelet derived or we're using interchangeable language here on PRP derived exosomes is how well they click on or they turn on autophagy. For the same reason is because when we're going to create a lot of new collagen, we're going to create a lot of new strut and like structural matrix in the skin. Yeah, we can definitely create it from scratch, but that's very complicated. What we can also do is take older malfunctioning collagen, elastin, hyaluronic acid, organelles like mitochondria, and basically revamp them like, like we're doing like house renovation. You're going to renovate them and that's why you want higher autophagy. So again, vampire exosomes also encode or click on more autophagy. So we're really coming full circle with this is like the best longevity skin care.
- [26:22]
C
Yeah. And there's more. But wait, there is more. They also lowered.
- [26:25]
A
But wait, there is more.
- [26:27]
C
They also lowered telomere associated DNA damage.
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A
Wow.
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C
And a 40% drop in pro inflammatory SASP signaling. So those cytokines that, you know, go ahead and signal more inflammation.
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A
So talk a little bit more about that because I think, you know, many people wouldn't understand what SASPs are or, or, you know.
- [26:47]
C
Yeah, yeah, for sure. And it goes back to what you were talking about. You know, that happens in high senescence subjects.
- [26:54]
A
Yeah.
- [26:54]
C
So it goes back to lowering senescence. And really in skin biopsies, the data showed, and skin biopsies, for you guys to understand, this is an in vivo study. This is in humans, live humans. This is not in vitro, which is done in petri dish, which a lot of breakthroughs that, you know, the market uses has only been done in in vitro in the petri dish. What we're talking about here is done in vivo. So it's much more robust data.
- [27:25]
A
Yes. Because even we do it like, even when we talk about nad, for example, like affecting skin, skin cells, a lot of the times to explain the, the overall picture, we glaze over what was done. For example, there was a new study showing like NMN being absorbed into the skin. Great. But a lot of the time we're going to talk about, you know, how apigenin and NAD work together in the skin. That was done in a petri dish. NAD on its own would have, wouldn't have actually crossed your skin barrier. So it's important to know to, to note that when we talk about this study that you applied something on the skin and not only that, you know, it absorbed, you know, it had a robust effect because you take a piece of that skin and you look at it under a microscope. Maybe not Nice.
- [28:07]
C
What the biopsies? Yeah.
- [28:08]
A
Yes. Maybe not nice to the person but, but it's very interesting to, to study real world results that way. Right?
- [28:16]
C
Yeah. And some of the study, some of the findings also included that the RNA sequencing showed up regulate collagen and elastin pathways which is, you know, obviously as we often talk about it here, that's what firms up your skin. Clinical imaging at four to six weeks showed improvements in wrinkles, redness, melanin, overall luminosity and color evenness with the standardized topical platelet exosomes serum. So that's why really platelet derived exosomes in our humble opinion is the Rolls Royce of exosomes, the ones that going to give you like the most results.
- [28:56]
A
Yeah. So really cool. So here are two things that I like about you know the. There, there are almost 10 studies, really cool, well done studies looking at specifically PRP exosomes and the way that the studies are conducted, you could really see what's going on specifically. So if anyone wants like to really nerd out about it, I'm just going to mention it by name. So P21 or P16 or INK4A are senescent cell markers that, that we can see reduction of when we use PRP derived exosomes. Just like as an example we talked about sas, which are the inflammatory aspects that we know that don't only infect other cells with senescence. So that's why zombie cells are called senescent cells are called zombie cells because they infect other cells with that behavior, with that kind of destructive behavior and they do it through SASPs. But they don't only infect other cells. They can actually hijack the skin brain axis and can actually age our brain from skin senescence. So we want reduction of those SASPs, even if all we're interested in is, is brain health. By the way, it also makes you have higher cortisol technically because it inflames the HPA axis. So if, yeah, okay.
- [30:18]
C
I mean I, I love us deep diving and I think this was great. And for anyone who came with the, with the notepads, that was a lot to write down and then go and dig out PubMed and you know, other scientific journals. Now let's talk a little bit bigger picture, like more.
- [30:37]
A
Okay, so I language that. Okay, I have a question for you which is a different type of deep dive. Okay. What are we really doing here with, with a product like this? Are we slowing down aging? Which I think is the popular discussion in, in our biohacking field. Or are we really reversing it?
- [30:59]
C
So if we were to look at some of the clinical studies and what.
- [31:04]
A
They show, which are biopsy again, which are like.
- [31:07]
C
Yeah, which is skin biopsy, then you can see things that would show you that there is actually reversal more than, you know, more than in some other modalities that you could hope for. So when it talks, when we talk about collagen and elasticity. So biopsy and transcriptonomics show ECM remodeling.
- [31:29]
A
Yeah.
- [31:29]
C
And that really make sure that, you know, the, the collagen rises and then MMP1 falls. Then when we're talking about elastic fiber pathway upregulation, there's also, we can see that, you know, more elastin is being produced and this is really, really next level. Because for a while when we thought about what we could do, right. It was always like outside in, in it was always like, hey, there is a wrinkle. So how can we remove the wrinkle from the face? Let's just use something with like 15 acids and, and just, you know, like burn it off from, from. Erase the wrinkle, burn it off at expense of, I don't know, your skin barrier and you know, whatnot. And, and really for a while there, there was this notion that if you want beautiful skin, you have to suffer. So you have to go through, you know, all of the painful procedures that in the end you will get a beautiful skin. Right. So what we're talking about now is something that people could not imagine 20, 30, 40, 50 years ago, that you could apply a product that will penetrate very, very deep and go on and turn on processes that will result in your skin acting more youthful, turn on pathways that will result in collagen production, elastin production. As if your skin is 20 years old by you could be 40, 50, 60. That is really like when I say that I have chills, like I can't believe that we've arrived.
- [33:10]
A
The AC here is too much. She has chills. I'm kidding. But yeah, and there's. So there is another study. So you were talking about the 12 week study that was done with Bioseed Liepincotte journals or whatever. But there is a six week study that with human imaging, which human. Again, human imaging outcomes really improved across many readouts. This was in Oxford academic. Whether it is through skin arithmetic, wrinkles, pigment, that's another study. I think there's again, there are a few studies that are really impressive as far as, you know, again, telomere length, different SASPs signaling you mentioned ECM.
- [33:58]
C
Yeah. There is also like early clinical support for faster RE epithelization and scar appearance improvements. We are anti inflammatory and pro angiogenic signaling.
- [34:11]
A
Yeah.
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C
I mean the least that's by the way. Yeah.
- [34:14]
A
But just to people who are unfamiliar with RE epithelialization, this is after you've had something that removes your, your first skin layer. So that would be laser, that would be, you know, many lasers and peels. Really?
- [34:28]
C
Yeah, yeah, yeah. And that's why I think also like all of these types of applications that we just talked about, that's why there is so much buzz around exosomes. They have all of that potential. If you have the correct exosome containing the correct message, we will stress it every single time we talk about it because it's just so important. So I have another question for you. Where do vampire exosomes outperform traditional treatments?
- [34:55]
A
Okay, we kind of touched on it before, but I'll try to give it a different spin.
- [35:01]
C
We didn't compare it to traditional ingredients like retinoids. We didn't talk about fillers or Botox. Let's, let's compare it to those treatments again.
- [35:10]
A
So yeah, comparing it to that, like I say, holy trinity of, of your, your, your nurse practitioner telling you what you should do. Which no offense, of course we work with many beautiful great nurse practitioners. But like neuromodulators, like Botox, fillers and retinoids, I think like we hear it all the time. So really how do they compare? They do not replace those, they don't replace everything that I just said. But they can accelerate healing, improve skin quality and address what we talked about, which is senescence biology in ways many topicals or injectables do not. In aesthetic practice write ups studies plated exosomes actually shorten downtime after procedures. So and that's by the way, like they also improve how your body responds to retinoids. So it's not that they replace those. When we compare them, we see that a lot obviously in our industry where brands are trying to juxtapose themselves with like an injection or a treatment. We don't think that this is going to replace any of them, but it's on its own. It does something that is significantly more fundamental from a longevity standpoint, from a cellular function standpoint, which would also make you or help you get better results from other treatments.
- [36:35]
C
Yeah. And that's why I think it's also like, is really the staple now in so many regenerative practices. And really that's like the pinnacle of regenerative medicine. And, and it also is really a great preventative measure too. Like you definitely will reap a lot of benefits from this ingredient like platelet derived exosomes, vampire exosomes. If you are more mature and you have mature skin, so you're in your 50s, 60s, 70. But even if you're in your late 20s, 30s, that's such a good preventative measure in my opinion. So maybe we could talk about biggest differences in results between PRP facial and PRP derived exosomes using a serum. I think, you know, vampire facial, vampire exosomes. Like, you know, people might get confused like you want to talk about it.
- [37:26]
A
So PRP is variable by patient preparation. The, you know, literature suggests exosomes are key paracrine effectors inside PRPs. In other words, they are the main drivers of results when you do PRPs. And isolating them enables standardized particle counts and dosing with fewer biologic variables. So anyone that has ever paid thousands, tens of thousands of dollars to get, whether it is like V cell or their own stem cells injected to them or doing, you know, a series of PRP facials or anything like that, they would know that the practitioner should or probably has told them that the results depends on, you know, their decades of health behavior. So you're basically reaping the reward or not of how you behave and the kind of the age, the functional age of your cells, the new strategy there, and that's something that the US is iffy about within stem cells discussions is okay, if your cells are not that great, what we're going to do is we're going to go to the lab and we're going to work on them and we're going to multiply them and they're still going to be yours, but they're going to be like cultured. So you're going to have more better things there when they're re injected. Right. That costs alone tens of thousands of dollars. What you can do if you pre isolate the exosomes from, from prp, you can cut all that process down. You can again know exactly what you're getting. If you know, we're going to get to quantification and micronized mRNA, micronized RNA count, you can actually dose, you can know what is the dose of what is the most important every time you apply the product. And I think that is the most important because some people have paid, you know, thousands and tens of thousands of dollars and actually, you know, de facto got very little.
- [39:40]
C
Yeah, yeah, I agree And I will just, you know, sum up the PRP can deliver volume of growth factors acutely, but PRP axisomes deliver a curated cell ready signal you can use daily without blood draws and with early human data for improved texture, pigment and redness at 6 weeks, plasinescent pathway changes by 12 weeks. I mean that is like convincing enough for me to do that. And that said, that they can be complimentary. Yes. Especially around procedures. Whether to skip PRP depends on goals, access and clinical guidance. And I think that also we should always do like, you know, psa, that everybody's bio individual and you should always kind of, you know, be the end of one experiment, always track your results from any given product and treatment and be in tune with your body.
- [40:40]
A
Yes, I would say we normally, for the most part, you know, we never say and we actually had the discussion about that on a podcast very recently. Shout out to Natalie Nidam that we said we are not a company that says hey, we're going to save you money because you can use our products and not use something else. Having said that, within the, if you, if you ask to me. And we did get a lot of questions from our peers when we were developing this product, you know, just like pit PRP facials with using vampire exosomes. I would say that if you had to choose between the two, I would do just normal micro needling without the added thousands of dollars of PRP and use the vampire facials, vampire exosomes at home. If you had to choose one and not the other. Yes, they are complementary, but you're going to get more standardized, stable, effective results by using something like that daily at home than doing it once in a while.
- [41:42]
C
In a. Yeah, I mean consistency is always better than anything. Once in a while goes for everything like exercise, nutrition, you know, you got to be consistent.
- [41:52]
A
Having said that, another question that I think we should, we should address, which is very different, is will that replace, you know, Botox or fillers in five years?
- [42:00]
C
I love this question. And I would say that it's unlikely to replace it. They work through regeneration and signaling, not volume or neuromuscular blockage. So the realistic expectation is fewer units of Botox. Right. Or longer intervals for some users as the skin quality improves and faster recovery after procedures. So I think again, going back to what you said, like we're not gonna be, this is not gonna be our, the way we, we promote this product where we're like doing a clickbait, where it was like this is a new Botox or this is A new retinol or this is a new filler on the market. Use exosomes and replace. But you very well might find that you can space out the treatments more and, yeah, I mean, achieve your. Your desired outcome faster and be able to maintain it easier.
- [42:54]
A
Yeah, I love that's. That's 100% true.
- [43:00]
B
Let's take a quick break from this episode to discuss skincare that makes big promises but deliver small results.
- [43:08]
A
We know how tiring it can be.
- [43:10]
B
Yungoos isn't playing that game. This is longevity science for your skin, where breakthrough ingredients meet real results. For example, our bio barrier formula features LPC6, an antioxidant that's 20 times more powerful than vitamin C. We're talking triple action defense against every type of free radical that ages your skin. And our revolutionary spermidine serums, the first skincare products to harness this cellular powerhouse that literally triggers your skin's renewal process. Every Yungoos product targets aging at the molecular epigenetic level. NAD precursors that restore cellular energy, peptides that rebuild collagen, bioidentical compounds that reinforce your skin's natural defenses. This isn't surface level skincare. This is your skin's biological reset. Whether you're dealing with dryness, signs of.
- [44:14]
A
Aging, or just want skin that actually.
- [44:17]
B
Looks as good as you feel, Yungoos has cracked the code on what your skin really needs.
- [44:25]
A
If you're ready to experience what happens.
- [44:27]
B
When science meets skincare, check out the Yungoos link in the show notes or go to yungoos.com because your skin deserves the future, not just another cream.
- [44:45]
C
Okay, so in this particular product, we kind of pivoted a little bit. We didn't use the whole nad apex that we use in our other products. We added rejuve nad.
- [44:57]
A
I think it's important to understand that even though we kind of. This podcast is mainly about, like, the technology of Vampire Exosomes. Of prp. Exosomes. We are talking about Vampire Exosomes, our new product. Yeah, we didn't really say that. So we have a product. We. We have a new product. I mean, I'll let you continue, but.
- [45:16]
C
No, no, you go ahead. I. I didn't even realize. We didn't say that. Yeah.
- [45:20]
A
So we have a new product. It's called Vampire exosomes. It has 3 trillion exosomes per 30 milliliters, which is 3 to 20 times more than any other product in the market. And the crazy thing about this product is that it's the first product in the world that we're going to have quantification of excellence. We're going to tell you how many, how much, you know, what's the percentage of, and the composition of micrornas in every batch that we make. Third party testing.
- [45:54]
C
And we do that through third party testing. Yeah, A lot of the times, and I'm sorry to interrupt but a lot of the times the data about the product from some of the other stem cell, sorry, exosome products comes from their own labs, their own facilities and you know, I think third party testing is the golden standard and I think that really helps provide the transparency that is lacking right now in the field.
- [46:21]
A
Yeah. And I would say no one, no one publishes results on micro, micro, microrna that's non existent. There are maybe a couple of companies that say, hey, we have, you know, a proprietary way to know that you really get, you know, 500 billion exosomes or a, or a trillion exosomes.
- [46:39]
C
I mean a lot of companies just can, can say we have small things. They don't even, they can't even say it's exosomes. And then they have like another test to deduce that those are indeed exosomes. But they don't really show how viable those exosomes are. But again there is a lot of like gray area.
- [46:57]
A
I'll tell you why they, they don't do it because there is a company that has like, I'm not going to name the name, but I'll tell you off air because you know the company, they have like a 400 and something, 400 something dollar serum with exosomes. But they have four types of vitamin C in the same formula. And we're going to get to it when we talk about, you know, kind of ingredients that we've combined it with. But most ingredients are actually going to destroy the exosome layer and then the material inside is going to be rendered useless. It can't absorb into the skin without the exosomes. Exosomes are extremely delicate.
- [47:33]
C
They're very delicate ladies.
- [47:34]
A
Yes, they're very delicate ladies.
- [47:36]
C
And actually a lot of what also went into our R D is how to make them shelves stable.
- [47:41]
A
Yes.
- [47:42]
C
Because you know, and you want to talk about that a little bit.
- [47:47]
A
I mean there's not much to talk about. We're going to talk about it in a second. However, I'm just saying that many companies are going to create a product, they're going to have a certain amount of exosomes. Nine out of ten times there. You're not going to actually know the amount that they have, it's not going to be third party tested, but it's not going to be also third party tested within the final formulation. So you're not going to know that they're stable, you're not going to know they survive within that formula. And I can tell you that ingredient, that product specifically is a no, no, because vitamin C does not play well with exosomes. So this is one example to our, and I think to kind of advance this discussion, we could not introduce any NAD precursor building block together with the exosomes. It was, it, it was not, they didn't play nice with each other. But we know that a lot of those, you know, microrna transcriptions, whether it is reducing senescent cells, activating autophagy, any type of renewal that it's encoding, a lot of it relies on nad. So obviously the more NAD that cell has, the better it's going to do its job. So we really were looking for a way to find how to introduce higher NAD levels to that cocktail. And we are using a fraction of our complex which is called NAD Apex. That fraction is called Rejuvenad, which is a patent that we don't own. So just a patent that what it does and we can talk about it a little bit like how it works. Yeah, go ahead.
- [49:28]
C
So the Radiofinity is a sunflower sprout derived cosmetic active designed to increase cellular NAD plus by activating nampt, which is the rate limiting enzymes enzyme in the NAD salvage pathway. It targets several hallmarks of aging relevant to skin longevity. And I think as, as AMIT I mentioned that's such a like important part of the puzzle. Okay, we've got the exosomes, we got them shelf stable. Is that enough or do we want to add something to improve their function? So as you mentioned, we added Rejuvenated, you know, for, for cellular energy.
- [50:09]
A
I, I, I just want to say where people can see it in the market is it's a very foreign concept. The idea of like activating an ampt, so NAMPT is a target of it basically is another way to increase NAD without actually providing the building blocks which are precursors to the skin. This is actually pretty popular right now within supplements. Anyone that would see like the Trade, the brand NAD3 which brands like Biostax are using as an NAD, that's kind of their NAD supplement. It uses NAD3, that's an oral version of an NAMPT upregulator. So it's just an example. Right. So Rejuvenate D is a, is a topical Version of an nampt. It's something that interacts with nampt. It's really good at boosting NAD levels. And we talked about the hallmarks of aging. So it actually they claim to target or they've shown to target five hallmarks of aging. So let's talk about. Maybe you can talk about which once. Then why do. Why does it matter if, you know.
- [51:16]
C
I could, I could, but I just remembered that Chelsea, our podcast producer, asked us to record the bonus episode on Rejuvenated. So I think we'll save that for that discussion. Shout out to Chelsea. I think for this discussion where we really wanted to focus on exosomes and the science behind exosomes. And you know, it just, it. I think it's worth mentioning that when it comes to our formulation, it doesn't have just exosomes. We have some other cool ingredients that play nicely together, like really support each other, work as a team.
- [51:49]
A
Yeah, it improves NAD economy.
- [51:53]
C
Yes. Rejuvenating. Yes, for sure. And again, guys, don't worry, we'll do a deep dive on Rejuvenate D. Stay tuned for a bonus episode. Anything else you want to talk about when it comes to exosomes? Vampire exosomes serum.
- [52:09]
A
I think that was a cool, like, obviously we can do many, many more episodes, whether on like exosomes specifically or, you know, what do you do around them to reap the most benefits out of them? I think that's a really good way to start. What we talked about today is, you know, what exosomes are, why they are that, you know, that super hyped up molecule. Everyone's talking about differences between where you are deriving exosomes and why that matters. We talked about micrornas, different proteins. Then we talked about, you know, we've identified as far as skin rejuvenation is concerned, that platelet derived or PRP derived exosomes are the most coveted, the most beneficial. And then we looked at what do they do as far as whether it is collagen production. So how we look right now, whether it is again, different types of longevity processes. And we really looked at and again what studies says. We talked about five different studies, published studies today. And then we talked a little bit about what's inside the formula that interacts with exosomes. Both doesn't destroy the exosomes, which is very difficult. For example, we have vitamin B5 there. That's one of the only things that can kind of interact with it. But there are many things that cannot.
- [53:38]
C
Yeah, I think the fact that this Cocktail of like exosomes, platelet derived exosomes and rejuvenation together, they get fewer zombie cells plus more repair capacity. I think if we were to sum it up fantastic.
- [53:55]
A
Yeah. We also did one last thing we did is for stability and for reaping the most benefit is that what we have there are glycol penetration enhancers. So we actually allow the skin to be a more stable and calm environment for the exosomes to actually absorb into the deeper layers of the skin without getting destroyed on the way. Which I think is extremely important because we really kind of arrived to the point of oh, you know, we got them stable, we got them to the skin. Studies say this, but how do we know that specific person that is going to use the exosome, the vampire exosomes product, how do, how do they know that they're the best candidate to absorb it? Well, so we've created a product that also makes their skin at time of application to be the best canvas or the best like receptor of those exosomes. So we've, we've done. Obviously this is years of work condensed into one podcast, but we're going to do some more podcasts around that.
- [54:57]
C
Yeah. So yeah, if you, if you're curious about the products. So vampire Exosome Serum. And by the time this product, this podcast is out, it would have been one day after our launch if everything goes to plan.
- [55:12]
A
If you are hearing this.
- [55:13]
C
Yeah. So really it's, it's a daily longevity serum that pairs standardized PRP derived exosomes with rejuvenate D and barrier first base.
- [55:23]
A
Oh, we have, you have fermented aspects there. We didn't even. Okay.
- [55:27]
C
Anyway, the rationale is simple. Deliver target repair instructions while raising the cellular energy ceiling. The skin needs to execute them all inside a soothing vehicle. The breakthrough is not just the ingredients, but the system level design across senescence, mitochondria and matrix remodeling.
- [55:46]
A
Nice. Okay, Anastasia, I think it was a really cool podcast. I can't wait to talk more about exosomes.
- [55:52]
C
Yeah. Stay tuned for, for the bonus episodes. Again, if everything goes to plan, we'll have just a few days. We'll have a bonus episode about Rejuvenate D and then really any other thing you want to learn more about, you can always leave a review on the Apple podcast. And that's where we also kind of derive a lot of inspiration for our subjects and topics. And we have been addressing questions and reviews one by one. You can see the track record. You can compare and contrast to the reviews that you can see on Apple podcasts to the episodes, so you could really help guide the conversation here.
- [56:28]
A
Yes. All right. Thank you very much. Thank you for listening, everyone, and we'll see you here next time.
- [56:34]
C
Thank you. Bye.