B (3:25)

I'm here. I hear. I have it. I have it.

A (3:28)

Huh.

B (3:29)

Okay, it goes. So, first of all, it's Fire Barbie 27.

A (3:34)

Really cool name. Shout out to Fire Barbie.

B (3:36)

Yes. There was one puppy Kittens like a month ago, and I couldn't. Couldn't read that because I couldn't stop laughing. But FireBarbie27 says new favorite. It's rare. I take time out of my busy working mom's schedule to write a review. I'm pretty sure this is only the second time I've reviewed a podcast. I believe it's warranted to give a shout out to Young Goose. I listened to the better podcast by Dr. Stephanie Esteema and through her shout.

A (4:07)

Out to Dr. Stephanie Estima.

B (4:09)

Yes, huge shout out. Through her I discovered the podcast by you guys and young Gus. It's very timely for me as I'm 48 and have been deep in the optimal health world for at least the last 10 years, and my skin is definitely aging. Amita is very down to earth, yet speaks quite intell intelligently and is very current on the science around optimal health. I'm excited to listen and I'm loving my new products. Normally, the price point would be out of my range to maintain. However, if you skip the expensive spa treatments, one can make room to spend more. I'm very holistic and I only tried Botox and a filler once 10 years ago. I also invested over $3,000 in this last year on RF treatments and other lasers. The information I've learned since split picking up this podcast is so paramount. Thank you.

A (5:04)

So what about the shout out to Anastasia? Where's Anastasia?

B (5:08)

Maybe she only listened to your interview.

A (5:10)

With Stephanie, wasn't there that she's in for a treat.

B (5:16)

But nonetheless, this is a really sweet review. And yes, Amitai is very down to earth and does speak, very intelligent and firebird.

A (5:26)

You're only getting half of a product. Since you didn't mention.

B (5:29)

No, you don't.

A (5:29)

No, you don't. No. But anyway, let's. Thank you very much. Obviously, write to us and we will send you the product asap. But all right, let's talk Elastin, because honestly, this stuff is like the hidden force behind youthful skin and almost no one is talking about it.

B (5:52)

Right? Everyone's focused on collagen, which is important, but elastin is what Actually lets your skin stretch and return to shape. It's the reason your cheeks bounce back after your smile and why you don't.

A (6:03)

Or when your aunt pinches you. Yes.

B (6:08)

And that's. This is why you don't wake up or go all day with those sleep wrinkles. Yeah. That's all Elastin's job.

A (6:15)

Yeah.

B (6:16)

Collagen is of elasticity.

A (6:19)

Collagen. Collagen is the song hero. It's the structural, the structure, the scaffolding. Elastin. This is your skin's ability to recover shape after movement. Think of it like the elastic part of a trampoline. Collagen is the. You know, think of everything as a trampoline. Collagen is your mental metal frame.

B (6:48)

But we're going mental here with the trampoline.

A (6:51)

Batelastin is the spring action. No springs. You are now a YouTube. YouTube blooper video. Right.

B (7:02)

You just fall flat.

A (7:03)

You just fall flat. Or get through the thing anyway.

B (7:06)

Exactly. And here is the crazy part. If it wasn't crazy. Elastin only makes up about 2 to 4% of your dermis by.

A (7:18)

By dry weight.

B (7:20)

Dry weight.

A (7:21)

Yeah.

B (7:22)

It's a small amount, but it's biomechanically critical. It can stretch up to eight times its original length and still recoil. That's what keeps your skin from going slack and crepey. So if your skin is slack and crepey, that's the sign that you are running long and lasting.

A (7:42)

Yeah. That bounce, that snap back, is what gives skin its vitality. And when it starts to go, people usually blame it on collagen loss or dehydration. But the truth is, elastin degradation is a huge driver of that saggy, tired look.

B (8:01)

And here's where it gets even more interesting from a longevity perspective. Elastin is one of the longest living proteins in the body. In fact, it has a half life of about 70 years.

A (8:13)

77.

B (8:15)

Zero. Yeah.

A (8:16)

Years. Yeah, I know. So the Elastin.

B (8:18)

I thought you corrected me the way.

A (8:19)

I pronounced 70 years. So the Elastin you've built when you were, say, 16 is still the same Elastin your skin's relying on in your.

B (8:31)

50S and when you are 140.

A (8:35)

Well, that.

B (8:36)

Yes, technically, half life of 70 years.

A (8:38)

Yes.

B (8:39)

Yeah. And we're all gonna live to 140, right, guys?

A (8:42)

Yes. So, again, so what does that mean, Anastasia?

B (8:44)

Okay, that also means once it's damaged, it doesn't regenerate easily. Adult skin has very limited elastin turnover. That's why UV damage glycation or chronic inflammation can be so permanent because the elastic fibers just don't get replaced the way collagen does. You know, like a lot of things in your body replace every seven years. Like you kind of like whole new every seven years. That not your last thing.

A (9:12)

Yeah. You know what I wanted to have as a reference when we were. When we were studying for this episode, which we did, we have 30 pages of science that we went through for this podcast. I was thinking of Death becomes her the movie. When they. When they. When you know, they can live forever, but their body, whatever. Whatever is getting damaged. That's it.

B (9:34)

Actually, we got recommended this movie at an opening of the new location. And I know ladies from VRY listen to this podcast. So if you're listening to us, shout out to you. We watched this movie. It was a fun movie night. And now we're referencing it here.

A (9:52)

Yes. So basically, once you mess up elastin, your skin pays the price for decades.

B (9:59)

That's right. And this is also why people in their 30s and 40s start noticing those subtle but stubborn changes. Like skin is not snapping back, as we mentioned a few times, or those fine accordion lines that stick around after you laugh. It's not just about volume loss. It's architectural.

A (10:19)

And as I always say, prevention is way sexier than correction.

B (10:24)

First time I hear you say this.

A (10:28)

Who?

B (10:28)

You've been saying this.

A (10:29)

No, I've been saying it. Not maybe like that. I think elastin, though, is the perfect example. If you protect it, you know, if you. If you protect elastin fibers now, you can preserve skin function for decades, but if you ignore it, that's way harder to reserve. Reserve and reverse.

B (10:49)

Yeah. And the good news is, while we keep. We can't fully regenerate elastin the way we can with collagen. We can protect the fibers we have, improve the matrix they live in and even support some, to some degree, the functional remodeling.

A (11:06)

Yeah. You know, in the words of Cameron Chestnut, within the. In the. In the. When we talk about the Elastin, quantitative is very hard to affect the quantity, but the quality is something that you can affect.

B (11:16)

Yeah.

A (11:17)

And what we'll do today is we will talk through exactly how to do that in this episode. But first, let's talk about the five main reasons elastin starts to break down in the first place. Because if you understand the why, the strategies make a lot more sense.

B (11:36)

So here's something that most people have no clue about. Your body makes most of its Elastin before you are even a teenager after that, it pretty much stops. Elastin biosynthesis actually peaks around birth, slows down during childhood, and then almost completely halts at puberty. So by the time you're, say, 15, your body has already made the majority of elastin you have for life.

A (12:04)

Which is pretty insane when you, you know, you're walking around, if you think about it at 40, maybe 50 years old, relying on elastin you made in middle school. Oh, at birth or at birth or in your mom's belly.

B (12:25)

Yeah, it's pretty crazy. And the scary part is that elastin has one of the longest half lives, as we mentioned, up to 70 years. Around 70 years. But also means it's very slow to rebuild it, if at all.

A (12:40)

Yeah. So when again, when it is damaged, we are not replacing it very well. We're just stacking damage on top of damage. Especially with things like UV pollution or chronic inflammation.

B (12:53)

Yes. That's why once elastin gets fragmented or degraded, the damage tends to accumulate. You'll see it as deeper lines that stay etched after facial expressions, early creepiness in the neck and general loss of bounds in the cheeks and jawline.

A (13:12)

And it hits earlier than people expect. You don't need to be in your 60s. Most people start noticing, you know, elastin change what they don't know it is, but that those are elastic changes in their 30s, especially if they've been exposed to a lot of, you know, a lot of UV radiation Or chronic skin inflammation.

B (13:33)

Yeah, exactly. Especially for people with inflammatory skin conditions, smokers, or those with high oxidative stress, they are going to see elastin breakdown much earlier.

A (13:45)

Okay, so that's challenge one. We barely produce elastin after puberty, and the little we have has to last us decades, AKA death becomes her. Let's talk about centuries. Yes, let's talk about challenge number two. And that's what UV exposure, you know, is. You know, we're going to talk about what UV exposure does to elastin.

B (14:10)

Chronic UV exposure actually creates a condition called solar elastosis. What happens is that the elastic fibers in the skin become thick, clamped and disorganized. Instead of a nice smooth network that allows the skin to stretch and bounce back, it becomes chaotic and dysfunctional.

A (14:30)

So instead of springy and smooth, you get a leathery, saggy, and almost rubbery skin.

B (14:39)

Exactly. You see this especially on areas that get long term sun exposure, like the forehead temples, lateral cheeks, the skin become yellowish, thicker and wrinkled in a way that doesn't match someone's actual age.

A (14:54)

And we're talking less even about just superficial damage. Right. UV is very special because it also triggers enzymes that actually destroy elastin. Actually gobble elastin up.

B (15:09)

UV radiation upregulates matrix metalloproteinases or MMPs, and other proteases like lstases. So proteases are the enzymes that break things up proteins. So these enzymes literally degrade both collagen and elastin in the dermis. So we do not want to upregulate or turn on this metalloproteases.

A (15:35)

Yeah. So even if you're doing all the fancy skincare treatments that we make, or if you're not protecting but like. But if you're not protecting your skin from UV sickly going two steps forward and one steps back. One step back.

B (15:51)

Absolutely. This is why consistent sun protection is one of the most high leverage things you can do to preserve your elastin.

A (15:59)

Yeah. All right, let's move to challenge number three. And this was the sneaky one, which is intrinsic aging. This is what, you know what happens even if you've been good with your sunscreen, right?

B (16:14)

Yes. Even if you. You've been using sun protection, you can still experience natural loss of elastin fiber content as we age. Studies show about a 30% loss by age 50 and nearly 50% loss of Elastin by age 80.

A (16:31)

And that's not just quantity of fibers. Right. It's also the structure that changes.

B (16:39)

Correct. The fibers become thinner, fewer in number and less connected. And it's not just that there is less elastin. The network itself becomes disorganized, as I mentioned before, and loses ability to function properly.

A (16:53)

Which by the way, explains that subtle sagging or slippage people notice as they get older, especially in the mid face, the jawline, or even the upper eyelids.

B (17:08)

Yes. You also get slower recovery from pressure like sleep lines or mask marks that stick around for hours instead of disappearing in minutes.

A (17:18)

Yeah. There's something else there that we're not going to get go over today. The science is pretty early on that. And maybe we're going to cover it with my. With that, you know, very in depth, esoteric type of red light therapy thing I'm planning on. But there's also the coating of elastin also changes its polarity where elastin fibers have a hard time gliding over each other. But that's just an honorable mention. Maybe we'll mention it later in episodes when science, obviously when science becomes more robust, but also when there is more when we can really dive Deep into what's going on there. But let's talk about challenge number four, which everything leads to it. This one really hits close to for anyone who's ever lived on sugar or had blood sugar issues, which is glycation.

B (18:15)

Yeah, Glycation is a huge factor. What happens is that sugar molecules bind to proteins like elastin and form cross links. We call this advanced glycation and proteins.

A (18:28)

Or age, the best synonym of all times when it comes to aging.

B (18:33)

Yes. Once elastin is glycated, it becomes stiff and brittle and loses its ability to recoil.

A (18:41)

Yeah. One thing to think about cross linkage is if you guys see hyaluronic acid that we use, for example, in products, this is non cross linked hyaluronic acid. If you see, if you remember like old fillers, hyaluronic acid fillers that are almost solid, that's because of very pronounced or very strong cross linkage. And everything is between. Is the difference between that runny substance to that stiff substance is the amount of cross linkage. So think of that also within the context of elastin. So it's kind of like turning your elastin band into a dried out rubber band. It might still be there, but it snaps, you know, snaps completely instead of stretching.

B (19:32)

Exactly. And inflammation makes this worse by increasing the activity of enzymes that degrade elastin even further.

A (19:39)

Yeah. So in which we've talked about before. So high sugar diet, blood sugar dysregulation, chronic inflammation, Honorable mention or dishonorable mention here to drinking alcohol. These are all just like. It's like throwing accelerants on the elastin breakdown fire.

B (20:00)

Yeah. And what you will see in the mirror is stiff, dull looking skin.

A (20:08)

It stinks too.

B (20:11)

Again, the way you can kind of like diagnose yourself with issues with elastin is that you, your faults will be deeper around the mouth and eyes, even when there is still enough volume in the face.

A (20:26)

Yeah. All right, fifth and final challenge, and this is the. The part where the myth busting really begins is rebuilding elastin or let's be honest, the illusion of rebuilding elastin.

B (20:40)

Yeah. Unfortunately, rebuilding elastin is extremely difficult because the synthesis is so limited in adulthood and the existing fibers are so long lived that once they've been damaged, there is no reliable way to regenerate them at scale.

A (20:54)

So all of those elastin boosting creams that claim to rebuild the elastic network, they're just marketing, right?

B (21:02)

Pretty much. Elastin as a topical ingredient is too large to penetrate the skin barrier. And while some peptides or antioxidants might support the environment around elastin thick, they don't actually replace it.

A (21:17)

Yeah. And even vitamin C. Okay. Which people think of as this gold standard of anti aging skincare. And I'm talking about ascorbic acid specifically. So simple form vitamin C can actually suppress elastin gene expression if you go too high with the dosages of it, which, you know, if you go over like 5 or 10%.

B (21:42)

Yeah. And a lot of concentrations of ascorbic acid can be like 30%.

A (21:46)

Yeah.

B (21:46)

Yeah. Every time it gets all riled up and red and steamy.

A (21:50)

When he talks about I lose elastin fibers because mmps, by the way, also stress, also cortisol increases mmps.

B (21:57)

Okay. Yes.

A (21:58)

So you don't want to get me. You don't want to get me started on.

B (22:02)

Yeah. Okay. So when it comes to skincare, a lot of it is about concentrations, like the right concentrations and delivery systems. So yeah. In general, percentage more is not always better.

A (22:14)

And then there's the issue or the whole issue of aggressive energy based devices. I mean, people are frying their faces thinking they're tightening, when in reality they might be breaking down their matrix even more.

B (22:33)

Exactly. So we've spoken about this before, but, um, a lot of times we have new listeners. So just so you guys know where we stand on it. Devices like radio frequency microneedling or hifu might produce short term tightening. But the long term remodeling is often fibrotic, meaning it's more scar tissue than functional elastin. So if you've been collagen.

A (22:59)

Yeah. So if you're someone who's been chasing results from, you know, lasers, topicals, procedures, and you are still wondering why your skin still feels thin, saggy or deflated, this probably is why.

B (23:17)

But it's not all doom and gloom. There are strategies we can use that respect the biology of elastin, that preserve it, protect it and even enhance its function.

A (23:27)

So to some degree, and that's exactly what we're getting into next. The four pillars that give your skin and you real leverage when it comes to elasticity.

B (23:39)

Yeah. We will talk. We talking about daily protocols, topical ingredients, devices that actually support skin architecture, all backed by science.

A (23:49)

All right, so let's show people what elastin optimization really looks like.

B (23:55)

If you take one thing from this entire episode, let it be this. Protecting your existing elastin is the single highest return move you can make for your skin's longevity.

A (24:05)

Yeah. Because let's be honest, if your Elastin has a 70 year half life and barely regenerates then whatever you've got now, this is what your skin is depending on for the next. For. For the rest of your life. Or for the next few decades at least.

B (24:25)

Yeah, hopefully.

A (24:26)

Yeah, for the rest of your life.

B (24:29)

Yeah. Okay. So the question becomes, how do we keep that elastin from getting damaged in the first place? And it starts with controlling the four biggest enemies. UV radiation, oxidative stress glycation, and chronic inflammation.

A (24:46)

This is what I call layered defense. And most people only address the one layer, like spf and think they're covered. But that's like locking the front door and leaving the windows wide open. Let's take a quick break from this episode to discuss skincare that makes big promises but delivers small results. We know how tiring it can be. Yungus isn't playing the that game. This is longevity science for your skin, where breakthrough ingredients meet real results. For example, our bio barrier formula features LPC6, an antioxidant that's 20 times more powerful than vitamin C. We're talking triple action defense against every type of free radical that ages your skin. And our revolutionary spermidine serums, the first skincare products to harness this cellular powerhouse that literally triggers your skin's renewal process. Every Yungoos product targets aging at the molecular epigenetic level. NAD precursors that restore cellular energy. Peptides that rebuild collagen, bioidentical compounds that reinforce your skin's natural defenses. This isn't surface level skincare. This is your skin's biological reset. Whether you're dealing with dryness, signs of aging, or just want skin that actually looks as good as you feel, Yungoos has cracked the code on what your skin really needs. If you're ready to experience what happens when science meets skincare, check out the Yungoos link in the show notes or go to yungoos.com because your skin deserves the future, not just another cream.

B (26:47)

Okay. UV protection. So broad spectrum mineral sunscreen is non negotiable. Every single day, rain clouds indoors. Doesn't matter. UVA penetrates windows and breaks down elastic fibers silently without a burn. So you guys, UVB rains rays are the ones that you feel. So you're like, oh, I'm getting a sunburn. Oh. With uva, you don't know that you don't feel.

A (27:14)

May help to understand that what comes after UVA is blue light. So it makes a lot of sense to people that they don't feel blue light. But maybe because you. You'll. You'll understand that this is the next door neighbor to uv, uva. It would make sense to you that you also don't feel.

B (27:28)

On that note, the 2022 published study showed that blue light also breaks down collagen and elastin fibers. So actually blue light also breaks down your elastin. That's why you should wear your bioshield in the house if you are working in a computer or looking at any kind of screens.

A (27:50)

Yes. And we're going to talk a little bit more about the kind of the relationship between oxidative stress and UV damage in a second. But it's not, it's, it's, it's important to understand it's not just any SPF that will do the best job here. Mineral zinc based SPF with antioxidant support. This is the real magic formula here, for example. And again, we're not necessarily pushing our products to push our products. We're explaining the decision making around why we create a product. And yeah, so BioShield SPF 40, for example, uses 17% zinc oxide, a special form of zinc oxide which is smushed zinc oxide. Yeah. Plus LPC6 and ectoin and a few other antioxidants which help reduce oxidative stress and improve barrier resilience alongside protecting from oxidation, alongside protecting from UV damage. Uvb, uva.

B (28:56)

Yeah. So second will be antioxidants, free radicals. Upregulate the enzymes that chew through your elastin. Things like elastasis or MMPs, topical antioxidants help keep that in check. And the internally, your diet and lifestyle play a huge role.

A (29:14)

Yeah. And again, mindfulness, because also stress also increases mmps. Yeah. Which again, this is why we love stacking things like NAD boosters, polyphenols, which you could think of as antioxidants, and copper peptides in the same formula. As an example, as I said before, U3 set, for example, has NMN, resveratrol, spermidine and GHKCU, which is an entire elastin preservation protocol in one serum. Same with basically all youth products there. One of their big goals is preserving elastin.

B (29:53)

Yeah. And copper peptides have actual evidence showing they can stimulate elastin and collagen synthesis in fibroblasts. So there was like stem cells of your skin cells. So you're not just defending, you're supporting the matrix.

A (30:09)

Then you've got lifestyle drivers. You know, you want to keep blood sugar stable, minimize blood sugar spikes spikes and avoid high glycemic foods because glycation is what stiffens elastin and makes it brittle. And you can use if you want a real biohacky whatever self tailored understanding. You could use a glucose monitor a CGM for a while and understand what spikes your specific biology. Your specific biology's glucose.

B (30:47)

Love that advice. Also, don't underestimate pollution and smoking. Both increase oxidative stress and and elevate elastase activity. Remember that enzyme that chews through your elastin fibers. Even secondhand smoke can damage a large.

A (31:03)

And also this is has less robust studies behind it but it also has some studies but also follows the same logic EMF non native EMF exposure. That's why again when we made the sunblock that was one of the things we addressed. So here's the bottom line. Protecting your elastin is less about fancy treatments and more about consistency. A smart morning routine, a clean lifestyle and a few bioactive topicals can go a long way.

B (31:36)

And that morning routine doesn't need to be complicated. Gentle cleanse. And again in the morning you can actually skip like any kind of soap, any kind of facial wash like a just cleanse with the lukewarm water or cold water. Then you can spray antioxidant mist such as blue peptide spray. If you use Young Goose products. Then you can layer NAD precursors and copper peptides. So you have both in our U3 set serum. Then you can apply instead of that serum you could also use vampire exosomes. And then you will go in with your eye care for moisturizing around your eyes. Then with facial moisturizer. In our case we recommend you daily. Then you have your neck and chest support if you want to bring it down your neck. And then don't forget to use your mineral SPF.

A (32:30)

You're in and out in five minutes.

B (32:32)

With VampireX it takes a little bit.

A (32:34)

Longer because you get in and out in seven minutes.

B (32:37)

No, with. Well, I was going to say it will be actually about five minutes if you use vampire exosomes. If you were to keep that for the evening routine and in the morning just use youth reset. You're in in a minute.

A (32:49)

Yeah, you're out. And you're basically shielding a seven year structure that your future face depends on. That's some solid roi.

B (33:00)

Oh, wake up. That's true. Okay. And by protecting what you have now, you also make any future remodeling attempts like microneedling or exosomes far more effective because the baseline tissue is still functional.

A (33:16)

And I always say, you know, prevention is way sexier than whatever else I Always say there. Anyway, so pillar one is about preservation. Next we'll get into how to nudge the skin towards remodeling. Doing it safely, using ingredients and protocols that actually work with your biology.

B (33:39)

And spoiler alert, we're not talking about blasting your face with lasers or pills. This is about smart signal based remodeling that supports elasticity without overdoing inflammation.

A (33:50)

Yeah. So here's the thing. You can't brute force elastin back into your skin, but what you can do is stimulate your fibroblasts to behave more like the, you know, the younger form of themselves or like they did when you were younger. And that's where remodeling comes in.

B (34:09)

I wish you used that motto to the kitchen appliances. You can't just brute force things in a place in our home anyway.

A (34:15)

Apparently you can do it with pots and pans. You cannot do it. Yeah, go ahead.

B (34:20)

And with my Matcha machine.

A (34:21)

Yes, it's true. Let's give it a little brute force. How did the guy that played double O7? I gave it a little schlap this morning.

B (34:32)

Okay, back to elastin. So no brute force. The goal here isn't to force elastin production because that doesn't work. But what we want to do is create the right signals and environment so your skin naturally recognizes the matrix. That means supporting fibroblast function, ecm, structure.

A (34:52)

And balance, turnover, ecm, AKA extracellular matrix. And when we say stimulates, we don't mean going full blast with laser or high concentration acids. We're talking about topicals that nudge the biology forward without triggering chronic inflammation or barrier breakdown.

B (35:12)

Exactly. So let's start with retinoids. These are probably the most well researched compounds for extracellular matrix remodeling. They increase collagen, and in some studies, they've also been shown to upregulate elastin gene expression in fibroblasts. Again, remember we talked about the fact that naturally this natural upregulation of fibroblast happens, you know, up until your early adulthood, but with some modalities like retinoids and other things we'll be talking about, like GHKC that we mentioned.

A (35:46)

Yeah.

B (35:46)

We can actually affect our biology and physiology, which is pretty exciting.

A (35:51)

Yeah. And the key is using them feeds at physiological strength. That's something that is not talked a lot about. But for example, 0.5% retinol. That's really the sweet spot where you get results without irritation or extra inflammation. Which is exactly what we chose to use when we designed bioretinol, which is a buffered biomimetic lipid structure that supports barrier integrity with introducing the retinol into the skin.

B (36:24)

Then we have copper peptides, particularly ghkcu. These are fascinating because they don't just stimulate collagen. They've been shown to increase elastin, glycosaminoglycans. Glucosaminoglycans. Sorry guys. And overall, I can't talk fibroblast repair activity.

A (36:43)

And they're in a lot of our formulas. Surprise, surprise, surprise, surprise. For exactly the reason of that kind of all encompassing function. So blue peptide spray you3 set youth daily eye care, Youth firming neck and chest. Yeah, a lot. I'm probably forgetting some ladder light activated DNA repair serum. It's really one of the most versatile elastin friendly actives you can work with.

B (37:16)

Another category worth highlighting is vitamin C derivatives. The trick is using stabilized lower dose forms like thd, ascorbate or magnesium ascorbyl phosphate. These support collagen, normalize the matrix and help with pigmentation without pushing fibroblasts too hard.

A (37:35)

Because remember, higher dosages, especially of ascorbic acid or L ascorbic acid actually turn off and damage elastin. And again, all of these or all of that's built into for example Youth Daily or Youth Reset or any youth product. So you're getting NAD support copper peptides and balanced vitamin C and ergothioneine, which kind of goes hand in hand there. All in one step. Or you know, two steps for that matter. And that's what we mean when we say smart formulation.

B (38:07)

One more advanced layer here is senolytics. Senescent fibroblasts secrete inflammatory cytokines and matrix degrading, degrading enzymes. So clearing or calming those cells is key for healthy remodeling. And I think in today's day everybody heard about senescence.

A (38:27)

Yeah, and that's why we love using platelet derived or PRP derived exosomes like the vampire exosomes formula. The reason is that specifically platelet derived exosomes have been shown in Mayo Clinic studies to reduce senescence by up to 40% in skin tissue.

B (38:45)

So think of it this way. You're not trying to bulldoze the skin into changing, you're creating the conditions for younger behavior. That means leaner cell populations, smarter signals and gentle consistency resistant nudging. So remember, we don't want to create any inflammation.

A (39:03)

Yeah, and timing matters. That's why we often recommend using these actives at night. That's because that's when the skin is already in kind of repair mode. You could definitely use them during the day, but if you had to choose, night is the best. Because what you're doing is you're syncing with biology instead of trying to conform biology to what you're trying to do.

B (39:28)

Exactly. So the ideal evening routine might look like this. Cleanse, apply vampire exosomes, layer on top of vampire exosomes. When it's fully absorbed, you could layer bioretinol later. I personally would space it by like, 15 to 20 minutes. I'm just on the cautious side. And then seal with. You know, you could use Youth Daily. If you're extremely dry, you could consider another serum like Bio Barrier. But honestly, Youth Daily should be great. And then last but not least, you could consider also occlusive, something like Hyperbaric Mask. And this is a really good stock.

A (40:09)

Yeah. And for people with sensitive skin, you can alternate nights or use, you know, barrier primers like Bio Barrier to buffer irritation before using B retinol. So it's called the sandwich method.

B (40:24)

Yes. And then with the Hyperbaric Mask, some people use it nightly, some people like to cycle it in like once or twice a week. It's really great for any areas that show creepiness or early laxity. The Happy Birth mask has pro collagen peptides. It has marine algae, it has the yeast extract that really helps support firmness and matrix reorganization. You know, speaking of elastin, so this.

A (40:53)

Is pillar number two. And by the way, you can download the protocols for elastin support specifically, it's going to be in the show notes. So if you're driving, you know, look at your phone while driving. I am kidding. Don't do that.

B (41:10)

Yes.

A (41:10)

Okay. You can always go back to the show notes. So this was filler two again, remodeling the skin from the inside out slowly, smartly, and in a way that actually respects the biology of aging. Right. Rather than trying to force something. Brute force, if you would.

B (41:31)

Yes. And when you do that consistently over 3, 6, 12 months, you start to see those subtle but powerful changes in the skin. Texture, elasticity, and bounce.

A (41:46)

Let's take a quick break from this episode to tell you about our new Youth Firming Body Cream. If you're tired of body lotions that just sit on the surface, it's time to upgrade to something that actually works from the inside out on an epigenetic level. Yungoos Youth Body Cream isn't just your typical moisturizer. We've powered it with nad apex Selviospermidine, longevity mushrooms, and ergothioneine and lemongrass extract with lipopeptides. This is a formula that literally reprograms how your skin ages. It restores cellular energy, boosts collagen production, and clears out cellular waste like senescent cells. Cells targeting those problem areas like your arms, legs, neck, and decollete, where aging shows up first. Think of it as a biological reset for your entire body skin. Because when your skin gets the science it deserves, the results speak for themselves. Ready for your full body upgrade? Visit younggoose.com today and discover what happens when longevity science meets skincare. You can grab the link in the show notes below. Okay, coming up next, let's talk about how to use light and exosomes together to regenerate skin in a way that feels almost. I would say we're paving the way for future concepts of regeneration here.

B (43:31)

Okay. All right. And what I love is that it's totally doable at home.

A (43:34)

Yeah.

B (43:35)

You just need the right strategy and the right products. Okay, so you want to talk about.

A (43:39)

Yes. And again, I've been teasing a lot. Spoiler alert. That we're going to do a bigger dive into this. But one of my favorite combinations for skin regeneration, which is light and exosomes. This is where we really start layering in some of the most exciting, more advanced, novel tools in the biohacking world.

B (44:02)

Yes. And what I like also about it, that we're not doing it in a way that involves trauma or inflammation. So when you think about red and infrared light, what you're really doing is changing. Charging up. Sorry, not changing, but charging up your mitochondria. And over time, you're changing the. You can have more mitochondrial mitochondria. You can have better function in mitochondria. So. Yes. And that happens specifically by stimulating cytochrome C oxidase, which then increases ATP production.

A (44:32)

Yeah. And then when fibroblasts have more energy, they can do more. More what?

B (44:39)

More elastin production, more efficient repair. What's interesting is that even though we don't have tons of human data on elastin specific light effects, we do have evidence of increased ecm. So extracellular matrix production and skin thickness. But this is a good skin thickness. That's not a scar tissue one. Actually, like. Yeah.

A (45:04)

And that's where I love stacking modalities in that kind of area. Red light therapy plus exosomes. You're giving your skin both the fuel and the blueprint for repair.

B (45:16)

And exosomes are fascinating. They're like tiny biological messengers carrying proteins. Rna, but micro rna, not mRNA. If anyone is worried, don't worry. There's absolutely no, no MRNA ever in any exosomes and growth signals from one cell to another. In the context of skin, they can nudge fibroblasts into a more youthful state and even reduce cellular senescence.

A (45:44)

Right. That's what we really designed or built into vampire exosomes, which is platelet derived exosomes rejuvenate or rejuvenate D beta glucan bifida, ferment, hyaluronic acid. It's a full post light regenerative treatment or just like a full stack regenerative treatment.

B (46:06)

Yeah. And timing is everything. You want to apply your light activated topicals before red light therapy.

A (46:12)

Like lad.

B (46:14)

Yes. Such as lather. Also really good to stack it with the spray, the blue peptide spray and your exosomes after. That way the skin is primed to respond and the recovery signals go deep.

A (46:27)

So. Yeah, so here's how it might look like in practice. You do a red light or near infrared light session maybe three to five times per week. Before the session, you apply something like again, blue peptide spray, like ladder serum that is designed to sync with red light therapy because it has the most advanced form of NAD apex that we make, photolase, which are DNA repair enzymes and pro collagen peptides.

B (46:53)

Yes. So that's before. And then after the red light therapy sessions, when the skin has. Once the skin has absorbed the light energy, you apply the vampire exosomes. That's when the skin is most receptive to extracellular messaging and you get synergistic effects between the mitochondria and the matrix signals.

A (47:12)

And if you want to dial it even more, dial it up even more. You can use again, I did mention blue peptide spray, but the combination is really good. So you use both blue peptide spray and ladder because the methylene blue plus copper peptides, it creates a mitochondrial CO factor environment that makes the entire light process even more effective.

B (47:38)

Yep, yep. So just because we're running short on time, I want to emphasize then again, I love this modality and this regenerative medicine. Basically treatment translated to aesthetics such as exosomes. Also because again, there is no trauma. There is a lot of. There's a lot of results, long term and short term and zero trauma.

A (48:02)

All right. And shout out again to Nick Engerer the micro trial that we. We've done.

B (48:09)

Yeah, actually I think we shouted out him in a different episode.

A (48:13)

Exactly. So micro trial that we've done. With ladder and red light therapy. And in eight weeks, he reduced 20% of his UV induced photo damage.

B (48:22)

Yeah.

A (48:23)

Unheard of. Yeah. All right, We've powered up the mitochondria, layered in the cellular messengers, and next we're getting mechanical microneedling, but done in a way that actually respects elastin.

B (48:39)

So the skin you see in the mirror right now is only part of the picture. What you're doing here is programming how your skin will behave 6 months, 12 months from now.

A (48:49)

Yes. So basically, you know, part of the. Part of the issue that we see with. With kind of treatments that people are doing to try to avoid plastic surgery, they're using a lot of heat, they're using a lot of ablation, they're using a lot of stress. That actually damages elastin fiber. So in the long run, it damages both elastin fiber density and function. Okay. What I love is that the remodeling in microneedling happens without damaging the epidermis. That means your barrier stays intact, Pigmentation risk is low, and you're not triggering that kind of inflammatory cascade that actually ages your skin and your elastin, your elastic fibers over time. When done right, microneedling supports regeneration while minimizing collateral damage. The key is precision, Using the right depth, the right frequency, and pairing it with topicals that support repair. And I wish we had more time. We were maybe. I mean, go to the episode that we recorded with Joel. I forget his last name now, but Joel Marshall. Great episode about microneedling. And we're really talking about all of those things.

B (50:10)

Yeah.

A (50:10)

There. And kind of how to stack them together with different protocols. And what I would like to say is that these are the protocols that we have, including for microneedling. Is actually going to be in our show notes.

B (50:24)

Yes. And just. Just small note, you said the right depth of microneedling in the right frequency. Just for anyone that maybe thought Amita is talking about radio frequency, God forbid. No, no, no. Yep. And I will just say that the.

A (50:40)

Frequency of times that you do it, not frequency.

B (50:42)

Yeah, no, I. Yeah, that's why I wanted to clarify it for people. And the science backs that up. Studies show that microneedling increases both collagen elastin fiber density, Especially in the papillary dermis. That's the zone responsible for skin bounce and tightness. And yeah, you guys check the show notes for the protocols for elastic remodeling and protection, ECM remodeling that we put for you together.

A (51:11)

Yeah, we'll catch you next time. Until then, Stay optimized and stay radiant. I'm trying to find a catchphrase. Thank you for biohacking your beauty with us.

B (51:21)

Thank you. Thank you for listening to this episode and for going back and watching our older episodes. Fun fact, we just looked at the 90 past 90 days analysis and the top performing episodes, some of the older ones, which actually shows us that a lot of people go back and discover some of the older episodes and the love in those. So it's fun. It's fun.

A (51:44)

Thank you for recommending us to all of your friends and even random people on the street. We really appreciate that each and every one of you, hint hint. Is doing that.

B (51:53)

And we've also been getting a lot of really sweet mentions on stories. Like when you put our podcast episode on a story and you say, oh, I really love this one. I really love that one. That really helps us to also know what do you guys respond to? And this, this past year, 2025, I don't know when this podcast will be aired. I think in 2026 already. We've had tremendous growth of our podcast. You guys see we put out a lot of episodes. I hope you enjoy them. I hope they are helpful to you guys. We are putting together lots of topics, lots of deep dives that Amita already alluded to. But we are also really very eager to hear any of your suggestions. So feel free to DM those, share on stories and suggest other topics. Yeah, really guys, you are at the heart of this podcast. It's all for you. We do it with all of our hearts.

A (52:46)

And thank you very much.

B (52:47)

Thank you.

A (52:49)

Bye everyone.

B (52:49)

Bye. Sam.