Podcast Summary:

Biohacking Beauty: The Anti-Aging Skincare Podcast
Episode: Dr. Doris Day: Reverse Skin Aging By Fixing Inflammation
Date: November 26, 2025
Host: Young Goose
Guest: Dr. Doris Day

Episode Overview

This episode dives deep into the intersection of dermatology, internal health, and cutting-edge biohacking for skin longevity. Dr. Doris Day, a renowned dermatologist known for integrating holistic approaches with evidence-based skincare, joins host Young Goose to discuss reversing skin aging by addressing underlying inflammation. The episode covers the impact of lifestyle, hormones, stress management, novel technologies (like Softwave and rapamycin analogs), the role of fillers and devices, and practical advice for radiant, youthful skin at any age.

Key Discussion Points & Insights

1. Dr. Day’s Holistic Dermatology Philosophy

• Influence of Family: Dr. Day credits her father, the "OG holistic doctor," for influencing her holistic and integrative view of medicine (00:59).
  • “He used to say, ‘We should all die young at an old age.’” – Dr. Doris Day (01:23)
• Skin as a Reflection of Health: Early career insight: Patients are more responsive to health recommendations when linked to appearance (03:29):
  • “If you say, ‘Don’t smoke because your skin will look better, less lines,’ they all quit smoking.”
• True Holistic Care: Advises that improving skin health improves overall health:
  • “When I help somebody have healthier skin, I’m also helping them have a healthier… entire body, a longer lifespan.” (04:36)

2. The Skin-Body Connection: Scientific Updates

• Senescent ‘Zombie’ Cells & Systemic Aging:
  • Host references research (Lisbon University) showing that senescent skin cells can hijack the skin-brain axis, inducing brain and systemic inflammation (05:06).
• Breaking the Dogma: Food & Inflammation
  • Dr. Day recounts that decades ago, dermatologists denied any food-skin connection—now she’s completely reversed this stance (06:40).
    • “It’s exactly backwards. What you put in your mouth … all of that affects your skin and your breakouts.”

3. Modern Anti-Aging Myths

• Persistent Sunscreen Misconceptions (09:43):
  • “People think if I put it on in the morning, I’m done.”
• Sun Damage Is Reparable:
  • “After a certain age, it doesn’t matter… That’s not true. You can still repair.” (09:55)
• Misunderstood Hormone Replacement (HRT):
  • “Menopause hormone therapy… is actually not just safe, but life-saving and skin saving.” (10:13)
  • Earlier HRT (especially for women) is more beneficial (11:26).

4. Integrated Approach: Combining Procedures & Skincare

• Surgical vs. Nonsurgical Divide:
  • Dr. Day insists the best outcomes combine both, tailored to patient needs:
    • “Even if you do a surgical approach, you still need the non-surgical benefits.” (11:53)
  • Importance of patient participation:
    • “You are responsible for your results in many cases.” – Host (13:05)

5. Prejuvenation & Responsible Device Use

• Caution Against Preventative Overtreatment:
  • Prejuvenation means different things across ages (13:10). For younger adults, proper care is often adequate.
• Softwave & Device Safety (16:03):
  • Softwave uses ultrasound to build collagen “without fibrosis, without fat melting.”
    • “What it’s doing in the skin to build collagen without fibrosis—it’s pure collagen building…” – Dr. Day (16:53)
  • Dr. Day stresses careful, evidence-based device adoption and matching procedures to real patient needs.

6. Biohacking Molecules: Rapalogics & Topical Rapamycin Analogs

• Selective mTORC1 Inhibitors (18:38):
  • RLX201, a molecule from the Rapalogics line, selectively inhibits mTORC1, promoting skin cell turnover and repair without unwanted side effects (21:00).
  • “Those 56-year-old fibroblasts reverted to 23-year-old fibroblasts.” – Dr. Day (21:37)
• Improving Healing & Collagen with Topicals:
  • RLX201 outperformed standard retinoids in supporting youthful fibroblast function.
  • “It just makes everything else you do work better, but without the safety issues.” (26:10)
  • Rapid improvement noted especially on the arms in studies (28:44).

7. Role of Inflammation in Skin Aging

• Acute vs. Chronic Inflammation:
  • “We need some inflammation…The problem is chronic and extended inflammation.” (34:43)
• Unresolved Inflammation = Silent Ager:
  • “Unresolved inflammation is the issue.” – Host (35:24)
• Contextual Approach:
  • Dr. Day warns against oversimplified “all or none” thinking (36:50), and stresses the need for nuance in interpreting research and making treatment/supplement choices.

8. Fillers, Perception Drift & Responsible Aesthetics

• Dr. Day’s Cautious, Anatomical Approach:
  • Patient assessment is key: “The single most important thing you do is an assessment…” (46:41)
  • Fillers are “not line erasers. Lines and wrinkles don’t make people look old. I never do it to fill a line. I do it to create balance.” (49:01)
  • Properly used, fillers restore balance and youthful structure—not artificiality.
• Criticisms from Surgeons:
  • Addresses claims about encapsulation and migration:
    • “If you have fillers underneath and even if there is some fibrosis…but the skin looks great…who cares?” (52:22)
  • Emphasizes that bad outcomes are more often about misuse, not the filler itself.

9. Practical Anti-Aging & Biohacking Tips

• Top Internal Health Habits (58:33):
  • Sleep: “Try to go to bed at the same time every night, wake up at the same time every morning… I would be a competitive sleeper.”
  • Hydration and protein intake for healthy skin
  • Resistance training: builds collagen within the skin (59:13)
  • Supplements: Vitamin D + K, non-rancid omega-3, NMN, N-acetylcysteine, glutathione
  • Low sugar diet, intermittent fasting: “A 13-hour fast basic is a good thing.” (60:28)
• Skincare Routine (60:49):
  • “Cleansing is the most important step in your routine.”
  • Night: RLX/REQ, retinoid, moisturizer
  • Morning: Moisturizer, sunscreen, possibly serum; retinoid body care as well
  • Advocates for consistency over complexity.
• Never Too Late:
  • “It is healing and recovering and it’s never too late to help your skin look its best.” (62:26)

Notable Quotes & Memorable Moments

• “We should all die young at an old age.” – Dr. Doris Day (01:23)
• “When I help somebody have healthier skin, I’m also helping them have a … longer lifespan.” – Dr. Doris Day (04:36)
• “You are responsible for your results in many cases.” – Host (13:05)
• “What it’s doing in the skin to build collagen without fibrosis—it’s pure collagen building…” – Dr. Doris Day (16:53)
• “Those 56-year-old fibroblasts reverted to 23-year-old fibroblasts.” – Dr. Doris Day (21:37)
• “We need some inflammation…The problem is chronic and extended inflammation.” – Dr. Doris Day (34:43)
• “Unresolved inflammation is the issue.” – Host (35:24)
• “Fillers are not line erasers. Lines and wrinkles don’t make people look old. I never do it to fill a line. I do it to create balance.” – Dr. Doris Day (49:01)
• “It is healing and recovering and it’s never too late to help your skin look its best.” – Dr. Doris Day (62:26)

Timestamps for Important Segments

• Dr. Day’s holistic approach and family influence: 00:59–04:36
• Skin as reflection/driver of health: 04:36
• Senescent Cells & Skin-Brain Axis: 05:06
• Food impacts & inflammation: 06:40
• Debunking anti-aging myths & HRT: 09:43–11:26
• Prejuvenation, devices, and Softwave: 13:10–16:53
• Rapalogics RLX201: science and promise: 18:38–28:44
• Role of unresolved inflammation: 34:43–36:22
• Responsible use of fillers: 46:41–55:58
• Top anti-aging tips & routines: 58:33–61:49
• Final advice: never too late: 62:26

Final Takeaways

• Effective anti-aging is both an art and a science: holistic appreciation, novel breakthroughs, responsible use of technology, and keen clinical observation are all key.
• Chronic, unresolved inflammation is a central silent ager—resolving it unlocks unprecedented skin and systemic benefits.
• It's never too early or late to begin optimizing your skin and health, and the best results depend on personalization—not one-size-fits-all solutions.

Follow Dr. Doris Day:

• Socials: @drdorisday
• Website: drdorisday.com
• RLX product: rapalogix.com

For further details on products, studies, and Dr. Day’s upcoming innovations, visit her sites or check the full episode show notes.