Biohacking Beauty: The Anti-Aging Skincare Podcast

Episode: Dylan Gemelli: Injectable Peptides, PRP Exosomes and Skin Repair
Host: Amitay Eshel
Guest: Dylan Gemelli
Release Date: January 14, 2026

Overview

In this episode, host Amitay Eshel sits down with biohacking educator and YouTube personality Dylan Gemelli for a deep dive into the world of peptides, PRP exosomes, and skin regeneration. The discussion bridges the gap between performance biohacking and skin health, exploring how peptides, hormones, and lifestyle choices intersect for both longevity and youthful appearance. Together, they deliver actionable advice, address myths in the peptide industry, dissect the science behind topical and injectable therapies, and offer transparency about product sourcing and safety.

Key Discussion Points & Insights

1. Authenticity & Education in Biohacking

[04:30–08:00]

• Dylan attributes his popularity to authenticity: “I don't play a role, I don't play a cartoon or a person. It's just straightforward.” (Dylan, 05:09)
• He emphasizes the importance of simple, actionable steps for health beginners—focusing on sleep, sunlight, walking, mindset, and accountability.
• Both agree that fundamental health habits (sleep, nutrition, mindset) are irreplaceable, no matter the biohack or supplement.

2. The Dangers & Realities of Peptide Sourcing

[13:00–20:50]

• Both speakers urge listeners not to cut corners with peptides, warning about rampant fake products and inconsistent quality:

  “I discovered peptides in 2011… I have probably some of the most intricate knowledge of any human that you will ever find in terms of the underground research SARMs, peptides, nootropic world.” (Dylan, 13:51)

• Dylan explains the prevalence of fake COAs (certificates of authenticity) and shady practices among peptide sellers and even some testing labs.
• The financial and ethical risks for companies offering quality-verified peptides are high; genuine testing is expensive, and regulatory oversight is inconsistent.

3. Peptide Mechanisms, Benefits, and Use

[28:26–44:44]

• GH-releasing peptides (Ipamorelin and CJC-1295):
  • Commonly prescribed for longevity, these stimulate natural growth hormone release, improving sleep, skin, and overall health.
• BPC-157:
  • “Body Protective Compound” originally evolved for gut repair, this peptide also offers systemic anti-inflammatory and healing benefits when injected.
  • Oral forms are less effective due to low bioavailability; Dylan prefers the cream version for convenience and efficacy.
• Combination Peptides (GLOW, CLO):
  • Emerging blends feature BPC-157, GHK-Cu (copper peptide), TB-500, and KPV for synergistic effects on skin and healing.

  “The hero ingredient in there is GHK-Cu copper peptide… It’s going to stimulate collagen and elastin production and that’s going to really help improve your firmness, your skin firmness. It’s going to help reduce wrinkles.” (Dylan, 41:04)

• KPV:
  • Particularly beneficial for inflammation and skin conditions like rosacea, eczema, and dermatitis.

  “I have seen crazy results with KPV—even topical KPV—people reconstituting it into just sprayers and spraying it on their face.” (Amitai, 45:37)

4. Injectable vs. Topical Peptides & Misleading Practices

[35:08–54:21]

• Consistent, prolonged use is crucial for results; single IV or facial injections do not align with how these peptides function.

  “Peptides don’t work… you can’t just do it once a month and expect anything to happen. Using it daily, building it up in your system, is the way to go.” (Amitai, 37:00)

• Some peptides in topical form are limited in concentration to avoid unwanted hair growth, but injectables can offer broader benefits (e.g., skin and scalp health).
• The importance of product sourcing, transparency, and proper application is repeatedly stressed.

5. Innovation in Skin Rejuvenation: PRP Exosomes & Future Biohacks

[54:21–58:54]

• Upcoming PRP-derived exosome products (like Young Goose’s “Vampire Ex”) mimic the in-clinic effects of vampire facials, potentially offering convenient home skin rejuvenation.

  “About six studies show that PRP-derived or platelet-derived exosomes are comparable to having a PRP facial just by applying it.” (Amitai, 55:57)

• Advances in peptide research (including those selecting from thousands of peptides for senescence or collagen induction) are shaping the next generation of skincare products.

6. Consistency, Routine, and Holistic Health

[62:20–64:59] Rapid-Fire Q&A

• Biggest mistake in skincare and fitness: lack of consistency.
• Top underrated longevity factor: sleep (and avoiding alcohol).
• Hormone optimization is foundational; imbalances quickly manifest in skin and health.
• Modeling days anecdote: adherence to a personal care routine trumps all.

7. The Future of Biohacking

• Both anticipate mainstream adoption of peptides and improved delivery methods (pens, topicals) in the next five years.

  “Peptides are going to become more mainstream, widely used, widely implemented, widely prescribed and widely accepted. I think when that happens, you’re going to see a drastic change in healthcare…” (Dylan, 64:59)

Notable Quotes & Memorable Moments

• “There is no steroid you can take that beats bad sleep, basically.”
  — Amitai, 08:35
• “People look at biohacking… and they think, oh, you got to spend 20 grand on technology... That’s just not it. It comes down to your health and taking care of yourself and doing it on your own.”
  — Dylan, 08:43
• “When you have your hormones messed up, it causes everything to be off. It’ll show in your face and your skin.”
  — Dylan, 63:32
• "[KPV]…is going to be sooner than later one of the most widely used and popular peptides out there."
  — Dylan, 46:12
• “Consistency is key… You can get away with things when you’re young to a point, but you can still see that lack of consistency and account, man, it, it shows and it shows fast.”
  — Dylan, 64:50

Important Timestamps

• [04:30] – Dylan’s path to biohacking and community-building
• [13:00] – Peptide sourcing, regulation, and dangers
• [28:26] – Core peptides for longevity, healing (Ipamorelin, CJC-1295, BPC-157)
• [35:08] – Injectable vs oral/topical peptides; pitfalls of IVs and facial injections
• [41:01] – GHK-Cu and combination peptide therapy for skin and hair
• [45:37] – KPV for inflammation and tough skin conditions
• [54:21] – PRP exosomes, “Vampire Ex,” and next-gen topical science
• [62:38] – Rapid-fire: Consistency, sleep, alcohol, hormones, biohacking future

Closing Thoughts

Dylan and Amitai demonstrate a shared commitment to evidence-driven, ethical biohacking—placing foundational health above gadgets and quick fixes. Their dialogue uncovers both the enormous potential and the hazards of peptide therapies in anti-aging and skin health. Crucially, they stress that new science only goes as far as the user’s consistency, priorities, and trust in reputable products and suppliers.

For more from Dylan Gemelli, visit dylangemelli.com, the Dylan Gemelli Podcast (Apple), or @dylangemelli on Instagram.