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In this essay, Anthropic CEO Dario Amodei examines the growing friction between the exponential advancement of AI and the comparatively slow pace of government policy. He argues that the emergence of "Powerful AI" presents immediate, significant risks to national security, global biology, and labor stability, necessitating a transition from voluntary transparency to binding regulation. Amodei proposes a five-pillar framework that includes mandatory safety testing, pro-employment economic incentives, and the modernization of regulatory bodies like the FDA to handle AI-driven scientific breakthroughs. He further advocates for protecting civil liberties against automated surveillance and forming a democratic coalition to secure the global AI supply chain. Ultimately, the text serves as a call to action for leaders to proactively manage a technology that could soon match the transformative impact of the Industrial Revolution.