Derek Barris (32:48)
But that's not natural because, for example, in ayahuasca, the combination of the natural ingredients is still chemical based. So it's only certain chemicals in there that are having the effect that it's having. And yes, the, the side effects do exist. I never threw up in ayahuasca, but the next day when I had to, it was not pretty every time. So it does something to your digestion that, that you can't process. Regardless, and you're going to most likely have some sort of effect from so Milltown again, where I grew up, the drug, it was a huge hit in 1956. One in 20Americans were using was huge in the mainstream. Comedian Merton Berle promoted it on his show, he Cool Miltown. Salvador Dali was paid to create an exhibit that captured the feeling of being on this tranquilizer. As with many early drugs, though, side effects started to take off the more people use them. And within a few years it was rescheduled. It was eventually taken off the market. But tranquilizers open the door for antidepressants. In the 60s, experiments revealed that serotonin plays a vital role in mood regulation, inspiring interest in serotonin reuptake as a therapeutic target. Scientists believe that increasing serotonin in certain brain regions could relieve symptoms of depression. This is known as the serotonin hypothesis, and it is completely contested. It was contested in the early 70s, it's still contested today. But it caused drug developers to focus on this neurotransmitter pathway. And so SSRIs, or selective serotonin reuptake inhibitors, became the first class of antidepressants designed with this particular strategy in mind. Chemists began searching for molecules that could modulate the serotonin transporter without negatively impacting norepinephrine or dopamine. Again, this research originated from modifications to phenothiazines. The first SSRI, zine, was withdrawn in 1983 due to rare cases of Guillain Barre syndrome syndrome. Then you get Fluoxetine, or Prozac. This was developed at Eli Lilly, and it was approved by the FDA in 1987. Known as a miracle drug, it has helped millions of people and was initially thought to have fewer adverse effects. And so SSRIs quickly became the standard for depression treatment. And didn't just treat depression, but also anxiety disorders, ocd, ptsd, and panic disorder. And yes, they definitely have side effects. You have gastrointestinal disturbances, sexual dysfunction, insomnia, irritability, and in rare cases, increased suicidality, particularly in adolescence. This created a growing amount of public distrust, which led to more people questioning the chemical basis for depression. If Miltown was requested by name, which was really happening a lot in the 50s, so was Proac. Due to the flood of advertising on television and in magazine magazines. Peter Kramer wrote a bestseller in 1993 called Listening to Prozac. And he introduced the idea of cosmetic psychopharmacology. And this is the notion that you can feel better than well, which, as we Know is pretty common in wellness influencer speak and biohacking spaces. Now optimization comes straight line right from there. You have the tech people in the early 80s who are playing with all sorts of pharmacology and you have have this basically it's in the water, it's in the air. The idea that you can optimize in particular targeted ways. Prozac was also being called out for suicidal ideation at the time. However, the Citizens Commission on Human Rights petitioned the FDA for its withdrawal. A high profile FDA review found no causal link between Prozac and suicide or violence, but anecdotes from some patients and Doctors continued. Still, SSRIs remain first line therapy for depression and anxiety disorders. While research continues on creating better therapeutics that treat a wide variety of people, don't have as many side effects, and fit into our evolving understanding of mood disorders. We should just know it's really no different than what is happening with autism. There are better diagnostic criteria, we have a better understanding of how different individuals react. And so we are, are trying to create better therapeutics for it. There's benzodiazepines which were introduced in 1960 and many people take Xanax today. That's what I was prescribed when I was diagnosed with generalized anxiety disorder. And for a short period it was quite useful for me. Should also note that a lot of these drugs are only recommended for short periods. So a lot of the systemic effects that happen over time are probably because there's really no recommended tapering processes for people who want to get off them. And that is a real issue. You also have the first SNRI or serotonin or epinephrine reuptake inhibitor, which hit the market in 93. And more recently you have interventions like ketamine that have come onto the market. Kramer's better than well thesis triggered ethical debates over medical enhancement versus treatment. And I feel like Kennedy has tapped into this lineage of criticism. We know that SSRIs like Prozac have helped millions of people deal with mood disorders. And we know there are side effects in some people. Research consistently shows that interventions like talk therapy in conjunction with pharmaceuticals work better than pharmaceuticals alone. Yet in America, that's cost prohibitive to many people who can only for afford a prescription. And you hear that kind of nuance come from Kennedy, who has repeatedly opposed socialized medicine. Yet as with many things that he says, there's a grain of truth, all chemicals have side effects. But as is his nature, his myopic focus on antidepressants, which have helped many people with crippling depression or anxiety navigate their lives. It obscures more than it reveals. Could their use have aided in some shootings? It is certainly possible. But to suggest that they're a root cause of gun violence is a convenient way to avoid conversations about gun control or as I just mentioned, socialized medicine. Two factors that certainly affect gun violence more than pharmaceuticals.