Podcast
Core Memory
Hosted by Ashlee Vance · EN
Core Memory is a podcast about science and technology hosted by best-selling author and filmmaker Ashlee Vance.
Vance has spent the past two decades chronicling advances in science and tech for publications like The Economist, The New York Times and Bloomberg Businessweek. Along with the stories, he's written best-selling books like Elon Musk’s biography, made an Emmy-nominated tech TV show watched by millions and produced films for HBO and Netflix. The goal has always been to bring the tales of complex technology and compelling people to the public and give them a path into exceptional and unusual worlds they would not normally have a chance to experience.
www.corememory.com
www.corememory.com
22episodes
Episodes
Newest firstAll episodes
Can You Reverse Decades of Drinking Damage? Perhaps. - EP 75 Jacob Kimmel Is Back
5d ago02:00:29Tap to summarizeJacob Kimmel returns to the show. And he might have cured the hangover and liver disease. NBD.Kimmel is the co-founder and president of NewLimit and one of the deepest thinkers in the longevity field. His company has been working to reverse the aging process in the body and has seen some stunning results with a new therapy that undoes liver damage in mice. We’re talking old mice that shrug off the effects of too much booze as if they were teenagers and that exhibit recoveries from long-term alcohol abuse.The results have been good enough to help NewLimit raise another $435 million from the likes of Founders Fund and Thrive Capital. They’re also good enough to have NewLimit kick off a human trial of the therapy next year. And I’ll drink to that.We discuss all of this on the podcast and then go much deeper on the longevity field, bio-tech and the collision of AI and biology.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you like the show, please leave a review and tell your friends.OUR SPONSORSSendCutSendDo you make stuff? Do you need metal parts fast and believe in truth and justice? Then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.BrexThe Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.We run on Brex and so should you. Learn more about Brex right here.Timestamps0:0) Intro3:50 What Is Epigenetic Reprogramming?7:16 Growing a Whole Animal From One Old Cell13:06 Meet Ambrosia, the AI Hunting for Youth22:44 $435 Million and the Race to Human Trials29:26 The Drunk Mice That Skip the Hangover36:48 Inside the First Human Trial43:14 Will There Ever Be a Hangover Pen?49:39 Beyond the Liver: The Delivery Problem1:03:27 Answering the Skeptics1:12:42 Will OpenAI Become a Drug Company?1:23:53 The Health Story Bigger Than AI?1:35:00 How Far Behind Is the US vs China?1:53:10 Can We Build Computers From Neurons? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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The Startup Trying to Save Us From AI Bioweapons- EP 74 Hannu Rajaniemi
2w ago01:48:17Tap to summarizeOur guest this week is the renowned science fiction author Hannu Rajaniemi. And he has come to terrify and then perhaps comfort you.Rajaniemi made an immediate name for himself in literary circles with his debut novel The Quantum Thief. He’s since written a string of novels that explore the directions technology might take in the future, and his work always stands out for its creativity and imagination.These days, Rajaniemi is putting those skills to very practical use at Red Queen Bio. The company appeared near the end of last year with a focus on AI biosecurity. Red Queen’s main objective is to try and outthink and outflank bad actors and/or AI systems run amok that might unleash bioweapons onto the world. As such, Red Queen must concoct all sorts of dark scenarios and then come up with ways to undercut and defeat them.Rajaniemi has a background in mathematics, physics and bio-tech and possesses one of those fast-twitch minds that makes the rest of us envious. We talked about his life and career and, obviously, the wild reality we now inhabit.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you like the show, please leave a review and tell your friends.OUR SPONSORSSendCutSendDo you make stuff? Do you need metal parts fast and believe in truth and justice? Then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.BrexThe Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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Schmidt Out of Luck — EP 73 Ashlee Vance And Kylie Robison
2w ago00:54:30Tap to summarizeWe are back with another episode of Ashlee and Kylie gossiping about the latest in Silicon Valley.First, a re-cap of our Alexandr Wang interview — his first real sit-down in eleven months — and what it actually revealed about Meta’s AI play. Wang seemed nervous hashing out the strategy in the studio, and we both keep circling the same puzzle: Meta has endless compute and top talent in Nat Friedman and Daniel Gross, so why does the model still feel underwhelming?We get into Eric Schmidt getting booed off a commencement stage at the University of Arizona, which becomes a longer conversation about the generational fury aimed at AI. Everyone Kylie’s age seems to hate it, but is it due to misinformation or legitimate anger about jobs and data centers? Ashlee admits he’s more confused by this moment than anything he’s covered in tech: the predicted Wall Street collapse hasn’t come, the models keep getting better, and the valuations still make no sense.Then, the news that broke minutes before we hit record: OpenAI won the Musk lawsuit on statute-of-limitations grounds. We dig into whether OpenAI’s shift from open-source nonprofit to for-profit was an original sin or just the only way to pay for the compute. Also, Ashlee’s texts with Sam Altman being part of discovery?!In more Musk news, Bloomberg reported that Musk’s xAI stiffed staff on the $420 they were promised for feeding their tax returns into Grok. One host would decidedly not trust a chatbot with their financials, and the other already has. We also get into the strange new bedfellows: SpaceX selling compute to Anthropic, a company Musk has long been philosophically against.We even take you behind the scenes at Core Memory — so study up and watch our latest videos on Phantom Neuro and Starfront Observatories. Consider this your homework on mind-controlled arms and galaxy photography. Essay due on our desk by morning.Don’t forget you could win tickets to the Weezer tour by leaving an amazing review for our podcast wherever you listen.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you like the show, please leave a review and tell your friends.OUR SPONSORSSendCutSendDo you make stuff? Do you need metal parts fast and believe in truth and justice? Then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.BrexThe Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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The Freshman Who Took Down Stanford's President And Its Perfect Image - EP 72 Theo Baker
3w ago01:27:25Tap to summarizeAs a freshman, Theo Baker signed up to write for The Stanford Daily on a lark. He thought it might be a fun way to spend some time when he wasn’t busy studying and coding. But then, he turned out to be quite good at reporting and tips started coming his way. One of these tips included information suggesting that there were inconsistencies and perhaps massive errors in past scientific papers tied to Stanford’s then-president Marc Tessier-Lavigne.Despite warnings to stay away from the story, Baker pursued it and produced a string of pieces that did, in fact, show a long history of shoddy research publications linked to Tessier-Lavigne. The mighty Stanford president, who had been a towering force in the scientific community, resigned by the end of Baker’s freshman year.Baker has now written a book about his experience and joined the podcast to discuss it.How to Rule the World: An Education in Power at Stanford University is three things: a rollicking account of Baker’s takedown of Tessier-Lavigne, an indictment of the start-up-obsessed culture Stanford has fostered, and something of a memoir, describing what it’s like to endure one of the more unusual freshman years any student will ever have.The bulk of the book focuses on Stanford and what it has become, which is a meat market of young, brilliant minds being wooed by the venture capitalists seeking to acquire their talents. There are investors paying students tens of thousands of dollars for connections to other students and inviting the kids to their mansions and sex parties. All very wholesome stuff.The book is fantastic. Baker is a rare talent. We had a wonderful conversation. You will enjoy it.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you like the show, please leave a review and tell your friends.OUR SPONSORSSendCutSendDo you make stuff? Do you need metal parts fast and believe in truth and justice? Then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.BrexThe Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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Meta's AI Chief On AI Beef, New Models And Life With Zuck - EP 71 Alex Wang
4w ago01:23:00Tap to summarizeLast June, Meta pried Alex Wang away from Scale AI, the company he co-founded and ran, in a deal valued at $14 billion. Zuck could feel Meta fading in the AI race and decided that Wang was the rescue plan. He would work full-time at Meta, assemble a super team and hopefully make the company more competitive against the likes of OpenAI, Anthropic and Alphabet.Wang has basically been in hiding ever since. He moved from San Francisco to the South Bay to be closer to Meta’s headquarters and has been working non-stop. Last month, the world saw the first fruits of the revitalized AI effort in the form of Meta’s new Muse Spark model. And now Wang is speaking for the first time about the model, Meta’s grand AI ambitions and all the happenings over the last year in an exclusive interview here on the Core Memory podcast.Wang arrived at our studio sporting a mullet and a powerful whitetail deer camouflage shirt. He was in good spirits and tried his best to convince us that Meta can catch up to its rivals.We hit on his personal beef with Sam Altman, Zuck delivering soup to AI recruits, the incredible pay packages Meta has been handing out, the vast amount of work Meta still has to do and the Meta AI hierarchy that includes all-stars like Nat Friedman, Daniel Gross and Shengjia Zhao, who seems to have blocked me on X for reasons I know nothing about.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you like the show, please leave a review and tell your friends.Enjoy!Do you make stuff? Do you need metal parts fast and believe in truth and justice? Then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did. We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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Everything You Need To Know About The Nuclear Energy Boom - EP 70 James Krellenstein
May 602:34:55Tap to summarizeWe’re in the midst of a new nuclear energy boom. Start-ups – both fusion and fission – abound, and the U.S. government has cleared the way to build again. Meanwhile, China is racing ahead with nuclear plans that dwarf those of the rest of the world combined.As with any boom cycle, there is a lot of hype and a lot to understand if you want to get a handle on what’s real and what’s not. And so, we brought James Krellenstein onto the podcast. He’s the co-founder and CEO of Alva Energy and he’s sort of frightening in how much he knows about the nuclear industry. Like, really. You’ll see.This episode runs long because we wanted to use it as a chance to go through the past few decades of history and really explain why the U.S. nuclear industry slowed and how the U.S. might fix the situation. We also wanted to explain how all these new technologies work and, of course, explore where China is heading.Krellenstein is something of a contrarian and thinks many of the U.S. nuclear start-ups are misguided in their approach.He’s also incredible to listen to. You will enjoy this one. I think it’s one of the best episodes we’ve ever done.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.We run on Brex and so should you. Learn more about Brex right here.We’ve also brought on a new sponsor. Welcome, SendCutSend!! They are an American manufacturing powerhouse and will help you make your metal parts with speed and skill. Core Memory subscribers can get a 15 percent discount on their next parts right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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The Cyborgs Commeth - EP 69 Connor Glass
May 101:19:52Tap to summarizeIt is time to talk about robotic body parts.Connor Glass, this week’s guest, has a company called Phantom Neuro, and it makes a human machine interface. By this, we mean a computing device that gets implanted in your body and lets you control a robotic limb with your mind.The first people using this technology are amputees. If, for example, you’ve lost your arm, you can get outfitted with a robotic prosthetic coupled with Phantom’s implant and then make your prosthetic move by thinking about what you’d like to do with it.Phantom’s technology competes in places with implants from the likes of Neuralink and Synchron. The big difference is that nothing needs to be implanted in the patient’s brain. Phantom’s implant goes near the site of the amputation and links the robotic prosthetic with motor neurons to convey signals back and forth from the brain. It’s a simpler, faster surgery.Where this technology is heading in the future is another story. Glass can see a day when humans have elective amputations to become, well, cyborgs.We get into this weird and possibly wonderful future on the episode, along with Glass’s backstory and much more detail on how Phantom’s implant works.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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Is America Cooked? — EP 68 Ashlee Vance And Kylie Robison
Apr 2801:13:27Tap to summarizeWe’re trying something new. Ashlee and Kylie dishing on Tech Land and dishing hard. The Core Memory podcast you didn’t know you needed but now can’t live without.We dove into our recent sit-down with Sam Altman and Greg Brockman: why Greg seems to have stepped back into a real leadership role at OpenAI, our biggest takeaways from the episode, and why the startup has become its own telenovela.We had to unpack the state of American manufacturing. Ashlee makes the case that we’re screwed on actuators — the motors that move every humanoid robot — and walks through who’s actually trying to fix it. LA as the secret manufacturing capital, Texas as the emerging center of gravity, SendCutSend (our newest sponsor!) as the closest thing America has to China for fast parts, and the hardware cult in central Texas that you should probably watch our video about.We get into SpaceX’s $10B partnership with Cursor that may or may not be a Hail Mary for xAI. Whether space data centers are real or window dressing. Why Apple under Tim Cook feels creatively bankrupt and who actually builds the next computer for the AI era. Also, Anthropic quietly becoming a trillion-dollar company while Google somehow escapes scrutiny.Plus: organs grown in mouse wombs (yes, really — go read the KindBio piece), merch is finally live, and a very special listener contest. Leave the most creative review on Apple, Spotify, or YouTube and we’ll send you two tickets to The Shins/Weezer tour. Do it!!! Er, please!!!!The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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The Great Reset At OpenAI — EP 67 Sam Altman And Greg Brockman
Apr 2101:22:40Tap to summarizeSam Altman and Greg Brockman came on Core Memory together for a ten-year look back at OpenAI. It’s also the first time they’ve done a media podcast together.We juiced every second of our 90 minutes with the cofounders of OpenAI. We got into the company restructuring. Why Sora got cut. Why the social network is dead. The “personal AGI” that knows your calendar and your taste and books the concert ticket without asking. Sam said he’s worried Elon Musk will drop the lawsuit before it gets to court. Read that however you want.There’s new OpenAI tech on the horizon too — a model that “makes ridiculously great images,” another that’s allegedly better at writing.Ashlee pressed them on American manufacturing and whether we’re cooked. Sam says OpenAI will go so far as producing their own actuators for robots. We discussed the possibility of a real permanent underclass, the two futures Sam sees, and the third one Greg wants instead. Safety. Anthropic. The Mythos thing. Sam also talked, briefly, about the days after the attacks on his home.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.We run on Brex and so should you. Learn more about Brex right here.The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.Core Memory is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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The $50,000 Underwater Drone - EP 66 Ulysses
Apr 1601:10:56Tap to summarizeGuinness. Sharks. American manufacturing. These are a few of the interests I share with the founders of Ulysses, a San Francisco startup building autonomous underwater drones.The idea for Ulysses started when one of the four co-founders was on a surf trip and learned how much of humanity depends on a single marine plant: the humble seagrass. He spent a weekend designing a robot to plant it. Two years later, the group of Irishmen — and for diversity, a Scot — have moved well beyond ecological restoration. They’re providing services for the Great Barrier Reef Foundation and selling their drones to the U.S. Navy.The robots are called Mako. They’re two meters long, weigh about 400 pounds, and can dive 5,000 feet for up to 72 hours at a time. They’re also modular — payloads swap in and out like Legos, so the same vehicle that plants seagrass in Australia one week can inspect a submarine cable in the Baltic the next. A base Mako costs $50,000. Most legacy underwater drones built by big defense contractors can run between $1 million and $20 million each.On this episode of the Core Memory podcast, we’re joined by Will O’Brien and Akhil Voorakkara, co-founders of Ulysses. They build these drones out of an office in San Francisco — for conservation, for academia, for national defense. They just raised a $38 million Series A led by Andreessen Horowitz through its American Dynamism fund. We discuss what it actually takes to make robots for the most hostile environment on Earth, why the ocean is about to have its SpaceX moment, and the surprisingly thin line between planting seagrass and defending NATO.The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.We run on Brex and so should you. Learn more about Brex right here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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