Crime House Daily: Night Watch – The Ketamine Queen who Killed Matthew Perry

Host: Katie Ring
Date: September 30, 2025

Overview

This Night Watch episode of Crime House Daily dives deep into the circumstances, investigation, and legal fallout following the overdose death of beloved actor Matthew Perry in 2023. Host Katie Ring methodically unpacks the web of enablers, dealers, medical professionals, and personal assistants that enabled Perry’s final relapse—and the case against the so-called “Ketamine Queen,” Jasveen Singa, the central figure accused of supplying Perry with the fatal drug.

Key Discussion Points & Insights

1. Matthew Perry's Career and Battle with Addiction

• [04:34] Katie recounts Perry’s rise to fame on Friends and his long, public struggle with addiction.
  • Perry’s opioid dependence began with a Vicodin prescription following a jet ski accident in 1997.
  • His substance use led to severe health consequences: repeated hospitalizations, depression, and memory blackouts.
  • Despite opening a Malibu recovery center in 2013 and periods of improvement, Perry continued battling addiction until his death.

Quote:
"In his memoir, Friends, Lovers and the Big Terrible Thing, Perry wrote, 'it is very odd to live in a world where if you died it would shock people. But surprise no one.' Almost a year to the day after that quote... Matthew Perry sadly lost his battle with addiction."
—Katie Ring, [04:52]

2. The Introduction of Ketamine and Perry’s Downward Spiral

• [07:44] By 2022, Perry tried medically supervised ketamine infusions—an emergent treatment for depression and addiction—with initial success.
• When medical treatment ended, Perry turned to illicit sources for ketamine, catalyzing his fatal relapse.

Notable Insight:
Katie explains the dual nature of ketamine:

• In controlled, clinical doses: a potential antidepressant.
• In large, unsupervised amounts: dangerous dissociative, risk of overdose.

3. The Drug Network: Jasveen Singa and Complicit Enablers

• [09:13] Jasveen Singa, dubbed the “Ketamine Queen,” becomes Perry’s supplier through a chain of connections:
  • Eric Fleming: A former producer working at a shady Bel Air rehab, The Red Door, with previous patient deaths.
  • Kenneth Iwamasa: Perry’s assistant, who personally injected Perry with ketamine from Singa (and others), bought via Fleming.

Quote:
"They masked their greed behind labels like addiction specialists... who would drive people to buy drugs, doctors who would prescribe anything, and enablers who would stay silent as long as they were paid."
—Ex-wife of Red Door patient, [10:48]

Key Point:

• Multiple doctors (Salvador Plascencia and Mark Chavez) were also involved, writing fake prescriptions.

4. Events of Perry’s Final Day

• [14:43] On October 28, 2023, Iwamasa gave Perry four separate injections of ketamine. After getting Perry settled in his hot tub, Iwamasa left to run errands.
• Upon returning around 4pm, Iwamasa found Perry unresponsive and called 911. Perry was declared dead at the scene.

Medical Examiner’s Report:

• Cause: Acute effects of ketamine, with contributing factors including drowning and heart issues.
• Importantly, Ketamine did not come from Perry’s previous medical treatments, but from illicit sources.

5. The Investigation and Break in the Case

• [16:35] LAPD and DEA launch a joint inquiry, focusing on Perry’s associates and internal Hollywood circles.

• Interview with Brooke Mueller (Charlie Sheen’s ex-wife) points investigators to Fleming and Singa’s operation.

• [20:29] Key evidence includes:

  • Texts and Signal app messages (some deleted, but recoverable via subpoena).
  • Previous raid on Singa’s home revealing large stashes of ketamine, methamphetamines, mushrooms, and cocaine.

Quote (from a doctor):
"I wonder how much this moron will pay."
— Text message from Dr. involved in the scheme, [20:49]

Prosecutor Statement:
"These defendants cared more about profiting off of Mr. Perry than caring for his well-being… Drug dealers selling dangerous substances are gambling with other people's lives over greed."
— US Attorney Martin Estrada, [21:15]

6. Legal Outcomes and Sentencing

• [21:15] Jasveen Singa pleaded guilty on September 3, 2025, to modified federal charges (including distribution resulting in death or serious injury).
• Faces up to 65 years in prison; sentencing is scheduled for December 10, 2025.
• Perry’s assistant (Iwamasa), Eric Fleming, Dr. Plascencia, and Dr. Chavez also pleaded guilty and await sentencing.

Defense Argument:
Singa’s lawyer insists she has, “accepted responsibility and deserves a lesser sentence.” [21:50]

Notable Quotes & Memorable Moments

• “Matthew Perry was fighting a battle that never let him go… investigators uncovered a dark web of greed, disposal, deceit and betrayal that preyed on his pain.”
  — Katie Ring, [01:44]

• "After that, Fleming buys 50 more vials from Singa and sells them to Iwamasa… Over the course of a few weeks, Iwamasa makes about four $55,000 worth of ketamine purchases on his boss’s behalf."
  — Katie Ring, [12:11]

• "It sounds like this was Eric Fleming's real job—not to help people recover, but to feed off of them."
  — Katie Ring, [10:37]

Timestamps for Key Segments

| Timestamp | Topic | |------------|--------------------------------------------| | 00:59 | Breaking news: Five suspects charged | | 04:34 | Matthew Perry’s career & addiction history | | 07:44 | Ketamine therapy: hopes & risks | | 09:13 | Introduction of Jasveen Singa | | 10:37 | The Red Door rehab and enabling culture | | 12:11 | The drug-buying network grows | | 14:43 | The day of Perry’s death | | 16:35 | Investigation widens | | 20:29 | Electronic evidence; the criminal case | | 21:15 | Singa’s plea deal and legal fallout |

Episode Tone

Katie Ring’s narration balances methodical reporting with genuine empathy for Perry’s struggles. Her tone is respectful and clear, refraining from sensationalism, and directly addressing listeners who may be affected by addiction.

For Listeners:

• Singa and others await sentencing—Crime House Daily promises to cover further developments.
• Listeners are invited to share their thoughts on the case via Crime House’s social channels.

This episode provides a comprehensive overview of Matthew Perry’s tragic final chapter while exposing the systemic exploitation faced by vulnerable individuals battling addiction. It highlights not just personal failures, but gaps and abuses in addiction treatment and celebrity culture.