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Last year I had surgery on my nose so I could breathe again. Oh yes. My nose was broken in two spots. It's been broken since like high school. So I finally got it fixed and it's been nice breathing. Oh man. Incredible. I was like missing out on it, you know? But when I was in the hospital, the doctors gave me some really strong pain medication. You know, I had woken up and they were like, we're gonna give you some pain medication. And I was like, what is it? And the doctor told me it was fentanyl. And at first I was like, fentanyl? Doesn't that kill everyone? Fentanyl? But after a few seconds I was like, wow, this is great. It worked really well. Turns out fentanyl has been used in hospitals for a long time. It's used in epidurals, it's prescribed for cancer patients, and there was a time when doctors were even putting it in lollipops. I don't know about you, but for me it feels like fentanyl came out over like the last few years, just out of nowhere. So I was like, dude, what is up with fentanyl? And surprise, surprise, it actually has a long and crazy history. So how did America, big pharma, and a well meaning scientist create the most powerful and deadly drug in history? I mean, where is this stuff even coming from? And how did the fentanyl epidemic become a problem too big to stop? Well, let's find out. Now join me for the dark history of fentanyl. Hi friends. I hope you're having a wonderful day today. My name is Bailey Sarian and I'd like to welcome you to my podcast, Dark History. Hi. Here we believe history does not have to be boring. It might be tragic. Sometimes it's happy, A lot of times it's sad. But either way, it's our dark history. Now, before we get into it, don't forget to like and subscribe because I'm always posting new content. And let me know what you think down below in the comment section. Cause I'd love to hear from you. Now let's get into it. Fentanyl. I know it's kind of like a heavy, heavy topic, but look, I had a lot of questions. I don't know about you guys, but for me Personally, since like 2020, I've known about seven people who have died from fentanyl. Seven. And that's just me. And it feels like everyone is. Has been touched by it in some kind of way. And I personally just want to know, like, dude, where does this thing come from because it truly felt like out of nowhere, it just was like, here. And a lot of people were dying, right? Or maybe not to you, but for me. And I wanted to know how, when, where, what? Whoa. How, what is this? What is this? So let's start from the beginning. What we do know is that fentanyl is what's known as a synthetic opioid. Now, synthetic means it is manufactured rather than, like, found in nature. Like, think of like poppies in the wizard of Oz. That's, like, found in nature, you know? So who made it and why has been my question. Now, it all started with a man from Belgium named Paul. I know. What are the odds of that, Paul, huh? I know his name was Paul Jansen. Now, Paul was born In September of 1926 in the city of Turnout in Belgium. Now, when Paul was a kid, his younger sister, she was like four, she sadly died of tuberculosis. That's a hard one for me. But, you know, that was like a death sentence. And this tragedy made Paul passionate about going into medicine. Maybe he thought, like, with the right medication or the medicine, like, he could have helped or saved his sister or he wanted to, like, make sure no other children would go through what his sister did. But despite, like, not having much money, Paul worked hard to start his own research lab. By the time he was 27, he called it Janssen Pharmaceutica. Paul was specifically interested in pain management. Now, at this time, there were two main pain relief drugs being used by doctors. There was morphine and meperidine. Now, these two were fine. They did the job. People would have to take high doses and eventually they would be in less pain. Like, it worked. But Paul wanted to find a stronger and quicker solution for pain. So Paul's lab made an important discovery about pain relief drugs. Not to get all chemistry on you, you know, keep it simple. But they realized that both morphine and the paridine had a chemical structure called a piperidine ring. Just go with me. Look, they had this, like, same thing to it. They had the same feature, okay? And like, this piperine ding ring, whatever it's called, was the magical ingredient that was making the pain go away. So Paul's like, okay, let's take that little magic and put it in a pill that will work faster and better. But of course, you know, this would be easier said than done. So between 1953 and 1957, Paul's lab was getting closer and closer to a pain reliever like morphine, but in smaller and faster acting doses. Finally, Paul's lab created something called phenylperidine. This was about 50 times stronger than meperidine and 25 times stronger than morphine. So this was strong, okay? So Paul and his team introduced this new drug called phenoperidine to a few European markets. Now, people liked it. It was working, you know, But Paul wasn't satisfied. He was sure that he could make a painkiller even better. And then, in 1960, he finally did it. Paul Jansen's team created the strongest pain reliever that had ever existed. They called it fentanyl.
