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Eric Prime
Foreign.
Dr. Brett Weinstein
Hey, folks, welcome to the 331 episode of the Dark Horse podcast live stream.
Eric Prime
I'm Eric Prime. Just gonna, I'm just gonna start with that. Yep.
Dr. Brett Weinstein
Obviously. Yep. I'm Dr. Brett Weinstein, you're Dr. Heather Hyeing. It is summer. Finally. Finally summer.
Eric Prime
This year it is summer. And. And so we are going to talk about the sun.
Dr. Brett Weinstein
Yes.
Eric Prime
Yeah.
Dr. Brett Weinstein
Which we get more hours of. Well, every day. We get just a tiny bit less now. But anyway, we are approximately at the maximum as of two days ago.
Eric Prime
And it is glorious. Three days ago. But yes, it is absolutely glorious. This far north, you know, there's already the faintest hit, hit, hit of light in the sky by like 4:15, 4:00am even. And at 10:00pm there's, there's still light as well. So it's, it's really an extraordinary place and time to be alive, actually.
Dr. Brett Weinstein
Yeah, it's great. It's great. It's worth all that, that winter in order to get the benefit of the glorious long summer days, maybe.
Eric Prime
As someone who has long experienced cheating photo periods, I'm. I'm not sure of that, but I do, I do love this time of year here in the Pacific Northwest. So, yeah, we're going to talk about, let's see, vegans and sunscreen and sun. Oh, my.
Dr. Brett Weinstein
Yeah.
Eric Prime
Today.
Dr. Brett Weinstein
Yeah, it, it's, you know, it's a lot. Or maybe it's going to be less, but we'll see.
Eric Prime
I'm not sure that it's a lot, but we are going to talk about the sun and sunscreen and some of the apparently conflicting evidence as to whether or not sunscreen is good for you. Go check us out on locals. There's no Q A today, but all of our past Q and A's are on locals and we always have the watch party going on there and a reminder that if you're watching us on YouTub, they have in theory, remonetized us. But, but things are, things are weird over there. So if you are watching there, please consider subscribing, liking, sharing, so we can try to figure out.
Dr. Brett Weinstein
Clicking. We'll watch watchership clicking the notification bell in addition. Apparently that has magical implications.
Eric Prime
Is watchership a word?
Dr. Brett Weinstein
Watchership. Viewership.
Eric Prime
Viewership. That's the one.
Dr. Brett Weinstein
That's the one. That's. That's the ship in question.
Eric Prime
Viewership. Y. Yeah, I kind of like watchership.
Dr. Brett Weinstein
I like it. It's going to become a thing.
Eric Prime
Yeah. All right. But before we get into the meat of the show or the, or the Tofu of the show pending. We have three sponsors right at the top of the hour. As always, carefully chosen. If you hear us reading ads here, you know that we truly do believe in these products or services. In this case, three products.
Dr. Brett Weinstein
Our first sponsor for this episode, Heather, is Mud Water. Mud spelled correctly. Water spelled very efficiently. If you like your routine.
Eric Prime
I mean, if you're gonna say you gotta, you gotta give them a hint.
Dr. Brett Weinstein
M u d WTR Yep. All right. If you like the routine of making and drinking a cup of something warm in the morning, but don't drink coffee if you're thinking or if you're trying to cut down on coffee intake, try Mud Water. If you're looking for a different way to kick off your day with a delicious warming enhancing drink, try Mud. Mud Water makes fantastic products. Their original super functional coffee alternative has a beautiful list of ingredients that can be read right off this can. They include cacao and chai for just a hint of caffeine. Lion's mane mushrooms to support focus, cordyceps to help you support physical performance, Chaga and reishi to support your immune system and cinnamon, which is a potent antioxidant. That's what's in their original coffee alternative. But Mud Water makes a whole suite of other drinks too. They've got a matcha coffee alternative and a mushroom coffee and a turmeric forward drink that is caffeine free and has the same mushrooms plus ginger, cinnamon and baobab. What? And Mud Water has a drink they call rest, which has rooibos tea and valerian root, turkey tail and ashwagandha. A place I've always wanted to go.
Eric Prime
Yes, you have. You're never going though.
Dr. Brett Weinstein
Chamomile and passion flower, there's still time. There are more products than that too. So you should go to mudwtr and find exactly what you're looking for. Every single ingredient in their products is a hundred percent USDA organic, non gmo, gluten free and vegan. That means it does not eat meat. Mud Water's original flavor is warm and spicy with a hint of chocolate. Plus masala chai, which includes ginger and cardamom, nutmeg and cloves. It is also delicious blended into a smoothie. True. Ready to make the switch to cleaner Energy? Head to mudwater.com m u d wtr.com and grab your starter kit today. Right now, our listeners get an exclusive deal. Up to 43% off starter kits plus free shipping and free rechargeable frother when you use the code darkhorse that's right up to 43% off with the code Darkhorse at M U d w t r.com after your purchase, they'll ask you how you found them. Please show your support and let them know that Dark Horse sent you.
Eric Prime
All right, Our second sponsor this week is Caraway, which makes high quality non toxic cookware and bakeware. Whether you're looking to make easy summer meals as things heat up outside, or planning some big shareable dishes to take to picnics and potlucks, Caraway has the right solution for you. Having beautiful, simple, functional cookware, bakeware and other kitchen essentials in your kitchen helps maintain visual calm, which is awesome no matter the season. Caraway has everything from mixing bowl sets to cutting boards, muffin tins to big pots on which to braise a piece of meat or make a long stimmered stew. A long simmered, long simmered stew stammered Whether you're spending time at the grill, the stove or the oven, Caraway has the gear for you. Roast chicken and Caraway's cookware Mix a summery cocktail with their bar set or bake a seasonal berry crisp in their bakeware. Caraway Kitchenware is crafted with FSC certified Birchwood Premium Premium Stainless steel enamel cast iron and naturally slick ceramic. They make several lines of cookware and bakeware are favorites of their stainless steel line and their enameled cast iron which is offered in six stylish and beautiful colors. These pots are strong and highly scratch resistant. They'll last generation. We're cooking with Caraway and this past year Zach, our elder son, was too in his first college apartment. He says it's amazing, which we know to be true and we know that he will be cooking with it for a long time to come. Right now you can save up to $230 on the 12 piece cookware set as opposed to buying the products individually. Plus, if you want to include their fan favorite Minis duo, you can save up to $350. Visit carawayhome.com darkhorse to take an additional 10% off using code Darkhorse on your next purchase. This deal is exclusive for our listeners, so visit caraway.com darkhorse or use code Darkhorse at checkout.
Dr. Brett Weinstein
Hell yeah.
Eric Prime
Our final sponsor this week is Puri. Puri makes a wide array of supplements and powders, from vitamin C and magnesium to creatine and protein powders. What makes Puree different is how clean and pure all of their products are. All of them. Puri was founded in 2009 by two men who set out to create the cleanest and purest products to support their own active lifestyles. Since then, their product portfolio has grown to address common nutritional deficiencies in the developed world. Knowing that health requires a good diet, physical activity, recovery and balance, the founders of Puri have rejected quick fixes from the very beginning and insist on the most stringent purity testing on all of their products. Let's focus on Puri's grass fed whey protein powder which was named best Overall by Vogue US and Cleanest Protein by Wired. Our 20 year old son Toby agrees. He's been making protein enriched smoothies for a few years now, but had a hard time finding a protein powder that he liked. Of Puree's protein powder, he says, this is the best of all the ones I've tried. It's smooth going down and full of great whey protein. Toby loves the bourbon vanilla flavor, but they've also got a dark chocolate flavor made from organic cocoa powder. Puri's grass fed whey protein powder is not just nutritious, it's clean. A significant fraction of protein powders on the market contain lead in amounts that are known to be dangerous in comparison. Puri consistently meets California Prop 65 standards and is Clean Label project certified. Puree's protein powder also delivers a whopping 21 grams of whey protein in each serving and is free of GMOs, pesticides and exogenous hormones. Whether you're looking for magnesium or a multivitamin, collagen or protein powder, you can't go wrong with puree. Use code darkhorseuri.com that's P U O R I puri.com darkhorse to get 32% off your first puri grass fed whey protein order when you start a subscription subscription. In addition, you get a free premium shaker bottle on your first subscription order. Subscription is going to be the word that I cannot say today. Go to puri.com that's P U-O-R-I.com darkhorse and use the code darkhorse at checkout for this amazing lim offer.
Dr. Brett Weinstein
Can you say conscription? Conscription, yeah, no problem. All right, so it's just subscription.
Eric Prime
Just subscription?
Dr. Brett Weinstein
Yeah.
Eric Prime
There must be other scriptions.
Dr. Brett Weinstein
There's a scripts institute, but that's. No, I don't think there are spelled differently.
Eric Prime
Yeah. All right. Should we talk about the sun?
Dr. Brett Weinstein
Yeah.
Eric Prime
Or. Yeah, the sun. I guess a bit. I'm gonna finish my sort of setup of this with a short reading from our book, the medicine chapter of our book in which we talk about sunscreen and sunlight and vitamin D, and I think I've shared that on air before. But so this is, this is not a new topic for us. But it being the summer, there is of course a lot of opportunity to get out in the sun and many have gotten into the habit because they were advised to by health professionals, by their doctors, by their mothers, by, you know, any number of people that what you need to do if you're going to spend time in the sun is slather yourself with sunscreen. And so the question is, does this make sense? And I was prompted to think about this in part because it's summer now and we've been having a remarkably warm late spring and early summer here in the San Juan Islands where usually it stays cool for a while, but it's been quite sunny, quite hot. And when I ran into this. I'm going to start with this sort of summary of a newish piece of research and then go to the research itself. Here we have Nicholas Hoelscher, Master of Public Health, writing on his substack Focal points Courageous discourse, the headline of which is Study finds sunscreen use linked to higher risk of multiple skin cancers. A 470,000 plus person study found sunscreen users face dramatically higher risk of melanoma, basal cell carcinoma and squamous cell carcinoma, even after accounting for major skin cancer risk factors. A UK Biobank study involving over 470k people found that individuals who reported using sunscreen more frequently had substantially higher risk of multiple skin cancers, even after researchers accounted for major confounding factors like age, sex, skin type, tanning ability, sunburn history, sun lamp use and time spent outdoors. The findings are worrisome and this is just the very quick summary of the relevant to the part of the story that he's reporting on part of this large study, melanoma, they found an increase, according to his summary here, of 292% higher risk of melanoma with sunscreen use. And he's, he's alighting some of the details people were reporting. So this is observational, this is after the fact people were reporting either, you know, variation in sunscreen use and he, I believe is just summarizing basically sunscreen use versus no sunscreen use. So he's, he's lumping some categories. For basal cell carcinoma, you had 140% higher risk in users with sun of users of sunscreen than in those without. And for squamous cell carcinoma, 120 higher risk. And again in what this study attempted to do was control for like it was not looking specifically at sunscreen risk. That was one of very many variables that it was assessing based on a pre existing data set that it went in and looked at. It was actually interested in. And here's the title. Gene Environment analysis in a UK Biobank skin cancer cohort identifies important SNPs and DNA repair genes that may help prognosticate disease risk. Now you know, but I have to tell the audience that as soon as I saw that headline that now this, this title title of a research paper, unlike a headline, the authors do get to decide what the title of their own research paper is. That's already a very long title. It's pretty informative. But no one in their right mind should have used the word prognosticate in a scientific paper when obviously what they meant was predict. Same meaning, sure, but prognosticate. So I'm sort of, I'm a little bit leery of these authors to begin with because I don't, I don't trust their editorial. Common sense.
Dr. Brett Weinstein
Yeah, it's doubly bad because not only does it overcomplicate, everybody knows what predict means. Prognosticate is going to throw people. So it's jargon that is exclusionary with no benefit. But because prognosis is also a real thing, it sort of makes it sound more medical rather than just straightforward. Predict would be perfectly clear what it meant. So yeah, I agree with you that that was poor judgment on somebody's part.
Eric Prime
Yeah. Okay. So this guy, again, Nicholas Hulcher, doesn't do much beyond, beyond this. He's. It's a short piece and at this point I basically want to go to the paper itself and just show a couple of, a couple of individual bits.
Dr. Brett Weinstein
So let me just get what I got so far.
Eric Prime
Yeah.
Dr. Brett Weinstein
The study was looking for many different factors, trying to figure out what factors were predictive.
Eric Prime
It was actually really looking heritable for genetic genetics.
Dr. Brett Weinstein
Right.
Eric Prime
And it, and it attempted to control
Dr. Brett Weinstein
for all these by measuring them.
Eric Prime
And sunscreen use is one of the things it was trying to control for along with age and sex and history of burning and childhood burns and winter exposure to the sun. You know, just a number of things that were their attempts to control so that they could then know if they were finding any real variation in genetic risk in this mass at 470,000 thousand people data set.
Dr. Brett Weinstein
So that does a couple things. One, it's really good, it's encouraging that this is a real result because it wasn't that they went looking for it and then found it, which opens the possibility that they fooled themselves or something by some other mechanism. So finding something you didn't expect is interesting, but arguably it makes this an observation now needs a test.
Eric Prime
Yes.
Dr. Brett Weinstein
So philosophically speaking, that's important.
Eric Prime
It absolutely is. And they do not like, to the extent that they found this and they did, they don't want to put any attention on it at all. And in fact they want to basically explain it away. So this is not, this is the message of this paper in either the abstract or the discussion is not, whoa, look at what we found. It's like, oh yes, there was this, but. But here's why it's probably not real. So. And that's what I'm.
Dr. Brett Weinstein
And the effects, the effects were huge. It sounds like, you know, 100% increase would be double and this is above that for at least two of the types of cancer. So that's. That's amazing.
Eric Prime
Yes. Okay, that's the wrong paper. Here we go. Here's. Oops. Here is the paper in question. That is. Nope, that came out in 2023. So it's not brand new, but this is the paper that we were just seeing a summary of in Holscher substack this month. Again, Jeremiah Nadal, 2023 Gene environment analyses in a UK Biobank skin cancer cohort identifies important SNPs in DNA repair genes that may help prognosticate disease risk okay, I'm going to read the abstract and then just scroll down and show you a couple couple of things that they do. Background despite well established relationships between sun exposure and skin cancer pathogenesis and progression, specific gene environment interactions in at risk individuals remain poorly understood. Methods we leveraged which means they went into an existing data set. We leveraged a UK Biobank cohort of basal cell carcinoma, cutaneous squamous cell carcinoma, melanoma in situ, invasive melanoma and health controls to quantify the synergistic involvement of genetic and environmental factors influencing disease risks There. They do say they weren't just after the genetic stuff, but my sense, reading the papers that they were trying to control for the environmental stuff so that they could figure out if there are predictive factors in individuals genes. We surveyed little under 9,000 single nucleotide polymorphisms. That's the SNPs from the title from 190 DNA repair genes and 11 demographic behavioral risk factors. Results Clinical analysis identified darker skin and hair colors as protective factors. That is something we all know, right? Dark Skin and dark hair are predictive of being less likely to burn and less likely to get skin cancer. Where was I? We identified. There we go. I'm sorry, I can't even figure out where I just was. Oh. Clinical analysis identified yes, 11 SNPs were significantly associated with BCC. This is not the important part in the results. The only thing they say with regard to environmental factors or non genetic factors is darker skin, darker hair. And then they talk about the various genetic things that they found. Conclusions. We identified novel risk factors for keratinocyte carcinomas and melanoma, highlighted the prognostic value of several Fanca alleles among individuals with a history of sun lamp use and childhood sunburns, and demonstrated the importance in combining genetic and clinical data and disease risk stratification impact. The study revealed genome wide associations with important implications for understanding skin cancer risk in the context of the rapidly evolving field of precision medicine. I read the entire abstract so that you can see that there's no mental mention of what Tolscher in his substack is leading with is saying that this is the surprising finding in this paper. There's no mention of it at all. And it ends with this term of art jargon, if you will. Precision medicine. Precision medicine is basically a stand in for how can we know your genetics so finely and generate a therapeutic that is targeted for your genes, the particular alleles that you have such that we can fix you. That is precision medicine in the modern era.
Dr. Brett Weinstein
All right, I want to ask you a question before you go for it. Yeah,
Eric Prime
I'm sorry. And I thought I might have gotten this wrong. There's one more sentence in the abstract and they do actually, they do actually mention. Well, they do actually mention other things. Major individual factors including sex, hair and skin color and sun protection use were significant mediators for all skin cancers interacting with over 200 SNPs across four skin cancer types. So again, they don't, they sort of circle around it, but they don't, they don't indicate anything about what Alsher has suggested they find.
Dr. Brett Weinstein
Okay, so I don't want to drag us too deep into the weeds, but I see one potential confound in the sunscreen result based on how they dealt with race. Did they deal with it other than to say skin color?
Eric Prime
I'm not sure what you mean.
Dr. Brett Weinstein
So let's take African Americans. African Americans do not typically burn. They do not typically get skin cancer. They do not typically use sunscreen. So you might find a correlation with sunscreen. Your tendency to put on sunscreen is correlated to your fear of getting a skin cancer. So the fact that people who fear getting them might get them.
Eric Prime
So this, this is one of the complications of all of the work, all of the decent work, which is inherently complicated in part because it's inherently about complex systems.
Dr. Brett Weinstein
Yep.
Eric Prime
And I don't have any way to look into the models, the statistical models that they used, nor if I did, because those aren't in, in the public domain, nor if they, nor if I did, would I be able to interpret them. And this is of course part of, you know, part of my long standing objection to these very complicated statistical models. Do they provide more power? Yes, but at the cost of confidence. And I'm not talking about statistical confidence, but like human confidence that you actually know what it is that the model did and could and can trust that it did the right thing. Should they have done exactly what you're talking about? Yes, I don't know if they did
Dr. Brett Weinstein
or not, but they do address skin color and they try to control for it. Right. So it's possible that it gets subsumed in that.
Eric Prime
I don't know.
Dr. Brett Weinstein
Okay.
Eric Prime
Yeah. I just, I, I don't, I don't remember enough about what is in this long, long, ornate study to, to say, okay, so they, they go through their work here and in the results. Actually in the discussion section we have usually the first sentence of the discussion section is what the authors think is going to be the biggest takeaway. So I'll just start there before going to what I've highlighted. Discussion. By leveraging robust data sets from the ukb, we performed disease environment, Disease gene and gene environment investigations and identified key variables underlying the complex interplay between 190 DNA repair genes and 11 environmental and demographic factors in the pathophysiology of melanoma and keratinocyte carcinomas. That's just a repeat of what it is they did and doesn't say anything about what they found. First sentence of the second paragraph of the discussion. We first conducted disease environment analyses and showed that sex, skin and hair color, skin tanning behavior and use of sun protection show the greatest associations with risk of all four cancers. This is consistent with previous findings as skin associated DNA damage upon exposure to UV light is a major driver of both skin cancers, while hair color is a weak proxy for skin tone and genetic makeup and is not directly related to this effect. Moreover, male sex was positively associated with BCC, basal cell carcinomas and particularly cscc, consistent with previous findings and negatively associated with minv and mis. In contrast to literature. So. So that's. I didn't actually know that there was a sex. Sex axis along which skin cancers were predicted. Surprisingly, at first, frequent use of sunscreen was greatly associated with all cancers. This surprising association was reported in prior studies. Let me take a step away from what I'm reading of this study for the moment. The study, which was published in 2023, I went and looked at the references, a couple of them from the late 90s, if I remember correctly, and one of them is from 2019. The 2019 one is the really big one. It's called Challenges in Assessing the Sunscreen Melanoma association, which had been found before. It attempts to go in and look at all of the existing work. It's basically inconclusive, but it does find some support for sunscreen actually being protective against melanomas. These authors in the 2023 paper are citing three previous pieces of work, the recent of which tries to go in and make sense of it says, we're not really sure. It's messy. All of the results seem to go in different directions. But there's one pretty decent study they find that seems to suggest that sunscreen is protective against melanoma. Okay, so that's who these people are citing. They say, surprisingly, at first, frequent use of sunscreen was greatly associated with all cancers. This surprising association was reported in prior studies. This paradoxical finding was the increasing risk of skin cancers with increased sunscreen use, which we posit can be explained by greater exposure to UV light and or lack of reapplication of sunscreen throughout the day or due to increased use of sun protection following a skin cancer diagnosis. Collectively, however, these findings demonstrate the importance of adequate and frequent sunscreen use and minimization of exposure to UV light, particularly in individuals with fair skin. Skin what? Those last two sentences of this highlighted section of the discussion are extraordinary. This is some of the most egregious pseudo science I have actually seen. Given that they. They. I'm just like, let's just walk. Walk through it one more time and then you can have your what? Reaction again. Right? Surprisingly, at first, frequent use of sunscreen was greatly associated with all cancers. That's their result. Surprisingly, actually also doesn't belong in that sentence. But maybe for readers who are like, wait, did I read that wrong? No, even the authors. They're telling you were surprised by this. Again, frequent use of sunscreen was greatly associated with all cancers. That is their result. Okay. It's not their only result. They've got a lot of other Things that they found. But then they say this paradoxical finding was the increasing risk of skin cancer with increased sunscreen sunscreen use. That's what they found, which we posit can be explained by greater exposure to UV light. Except they're also looking at sun exposure and. Or lack of reapplication of sunscreen throughout the day. User error in sunscreen use insufficient like they were. What? What? Or due to increased use of sun production following skin cancer diagnosis. The idea being that sunscreen use is itself indicative that you're more prone to skin cancer because you've already had a diagnosis, which isn't a terrible hypothesis. But the idea that they're putting. They've got three explanations to whisk away their result and then ignore that result for the rest of their discussion. The rest of their paper is extraordinarily bad for. For.
Dr. Brett Weinstein
Well, it is absolutely par for the course for modern science where there is dogma in each of the fields. You can validate the dogma. The more extreme your validation, the faster you're going to rise. And if you say anything that goes against the dogma, you have to explain it away. And you have to deliver the paragraph that says, we found X, but we still believe Y. Yes, right. So the point is, this is. Hey, this isn't science you're looking at. It's something that uses the. The language of science. It has some of the methods of science, but it is not scientific because somebody's got their thumb on the scales. Now, the right way to say what they found is we do not know what to make of this result. Yes, it is possible that this result does not mean what it appears to mean. Because, for example, people with a diagnosis go on to use more sunscreen.
Eric Prime
Yes, but it's their job actually to pause it. Yeah, but you don't pause it as a. To. To.
Dr. Brett Weinstein
You don't.
Eric Prime
Your results.
Dr. Brett Weinstein
You say that's a possibility. It's also possible that this result means something and that sunscreen is not having the intended effect. This is a place where further study is urgent. Yes, right.
Eric Prime
Precisely. Precisely. So that's. And we see evidence that these authors are at least being dishonest with themselves and their intended audience. And again, I went back and looked at the research that they cited which suggests that there is a relationship between melanoma and sunscreen use in some surprising directions. And that too is inconclusive. Okay, But I actually think that this conversation so far is missing two of the bigger points, one of which is that sunscreen itself is a category error. Sunscreen isn't one thing. Right. And most sunscreen. For instance, I didn't know this until this week. Most sunscreen has aluminum in it.
Dr. Brett Weinstein
Aluminum oxide.
Eric Prime
Lots of. Lots of forms of aluminum here. I'm actually going to read. It's a. It's a most of, if not all of this one page. Not that one. Here we go. Letter to the editor, published in 2007 in the journal Free Radical Biology and Medicine Medicine. Aluminum a potential pro oxidant in sunscreens and sunblocks. Question mark okay, so it's a letter to the editor. This is not a test of hypothesis. It is basically a hypothesis to the editor. We have measured. And this is written by. Sorry, let's just go to the bottom so I can. Where are the authors? The authors, since somehow they're not on here, are Nicholson and Exley. This is again published in 2007. Oops. Oh, there they are. We've measured the aluminum content of sunscreens and sunblocks which either include or do not include an aluminum salt, for example, aluminum hydroxide, aluminum oxide, aluminum silicate, aluminum stearate, aluminum starch, acetynol, succinate as an ingredient. All those aluminums. Aluminum was present in all products, and its content was of particular significance in three products, each of which listed it as an ingredient. That sentence is doing a lot of work, too, because that sentence strongly implies that they were looking at several sunscreens, many of which did not have aluminum on the ingredient list, but all of the products that they tested had aluminum in them.
Dr. Brett Weinstein
Yeah.
Eric Prime
Okay. So after numerous inquiries, the manufacturers were not forthcoming as to the role of aluminum in their product, except the manufacturer of Simple Sun Protection Cream, who confirmed that aluminum hydroxide was added to their product to cause to coat the surface and thereby prevent the agglomeration of another ingredient, titanium dioxide particles. WHO guidelines for the application of sunscreens and sunblocks recommend a single application of at least 35ml of product to achieve the stated sun protection factor. For three of the sunscreens and sunblocks investigated in this study, a single application of product would result in about 200 milligrams of aluminum being applied to the skin surface. In addition, WHO guidelines suggest reapplication of product every two hours, which, for example, for an average day on the beach, would result in up to a gram of aluminum being applied to the skin surface. Skin is permeable to aluminum salts. When, for example, they are topically applied as antiperspirant formulations, it will accumulate in the skin and it will Be transferred from the skin to systemic sites. It is highly likely that the everyday use of sunscreens and sunblocks is a hitherto unrecognized contributor of aluminum to the human body burden of this non essential metal. Perhaps of immediate significance is the potential for aluminum in the skin to act as a pro oxidant. Recent research in free radical biology and medicine, the journal where they're publishing this letter, has shown that UV filters and sunscreens promote the formation of reactive oxygen species in the nucleated epidermis of the skin. The authors speculated upon the role which might be played by antioxidants either already in the skin or included in sunscreen formulations in counteracting the pro oxidant activities of UV filters, Though they did not consider how the presence of additional pro oxidants might exacerbate such effects. Aluminum is one such pro oxidant and could significantly increase the potential for oxidative damage in the skin. Whereas the relationship between the burgeoning use of sunscreens and sunblocks and the increased incidence of skin cancers and a particular melanoma is highly controversial, it has not hitherto been considered that aluminum in these products could be an extremely significant contributing factor. Of course, aluminum is already in the skin surface and may not need to be a component of sunscreen screens and sunblocks to exacerbate oxidative damage attributed to the application of such products.
Dr. Brett Weinstein
Wow.
Eric Prime
Wow. And also just that is how it's done. Like, put aside the content for the moment. They have built a careful argument in which they actually collected observations. They have not tested a hypothesis, but they have collected several observations which will look like lab tests to many people. Right. They, they solicited information from manufacturers. They did chemical analyses of several sunscreens. They found aluminum at various levels in every single one of the products that they found. They did a literature review. They posited a mechanism by which aluminum in sunscreens being absorbed by the skin might have a toxic effect on health. And they have not made any claims that are beyond what they know.
Dr. Brett Weinstein
Yeah, that's amazing. For multiple reasons. One, when you put on sunscreen, you tend to be putting on a lot. I mean, sometimes I guess you just put it on your face. But if you're out in the sun, you're likely have a lot of stuff exposed. You're putting on a lot. So you're talking about a large amount of this potentially pro oxidant.
Eric Prime
Yes.
Dr. Brett Weinstein
And if I'm remembering, you know, chemistry was probably my weakest Science. But. But if I think about what I think I know about chemistry, you've got oxidants, which are actual molecules in a state that's reactive. An antioxidant is going to neutralize it. If you put a bunch of stuff all over your surface, it's going to occupy all of the antioxidants that you have available. So one mechanism here as to where cancer might come from is that you're leaving a lot of reactive oxygen species now free to basically attach to and disrupt the various systems that are keeping cancer at bay. Normally your normal metabolism, right, it's like throwing a bunch of stuff at your immune system. So that immune system is preoccupied dealing with garbage, and it misses the pathogen that sneaks through because, you know, all of your cells are busy. So. Okay, that's interesting. Did I also. Maybe I just misunderstood something, but did they say that the aluminum was in there to tint the titanium?
Eric Prime
I don't think tint. Let's see.
Dr. Brett Weinstein
They say because the titanium will tend to be white, which might be off putting.
Eric Prime
So they, they inquired after all the manufacturers of the products that they were looking at, and they only heard from one and from that one manufacturer who really. I feel bad for them that they actually responded. And they're, of course, being singled out here. They confirmed, quote, that aluminum hydroxide was added to their product to coat the surface and thereby prevent the agglomeration of another ingredient, titanium dioxide particles. So not tint, but keep it aggregated.
Dr. Brett Weinstein
It. It's basically emulsifying it. If it were a fat, it would be.
Eric Prime
It's. Yep.
Dr. Brett Weinstein
Yeah. Keeping it separate rather than in emulsifier
Eric Prime
is one of the great evils of the modern era, as it turns out.
Dr. Brett Weinstein
Yeah.
Eric Prime
Yeah.
Dr. Brett Weinstein
All right, well, that's interesting.
Eric Prime
So, you know, I bring, I bring that up. This is, this is one of my two main critiques of the really fairly pseudoscientific work that is being done on whether or not sunscreen help, you know, protects against or against or tends to make you more likely to get skin cancer. One of, one of my main issues is sunscreen isn't sunscreen. Right. Sunscreen is wildly variable. According to this 2007 letter. In all of the sunscreen products that they looked at, every single one of them contained aluminum. I, you know, I happen to know that there's at least one out there in the market, and I hope more than one at this point that doesn't contain any aluminum at all. And that's Van man sunscreen, which is telephone and zinc and, you know, a Few other things. But I went and looked, you know, and they, they are a sponsor of the show, but they're not a sponsor today. They're not paying me to say this, but they, you know, they, they have a, you know, rather than a chemical, a mechanical sunscreen. Meaning that the zinc actually tints your skin.
Dr. Brett Weinstein
Yeah, it's a physical block.
Eric Prime
It's a physical block and it's in a base of, of tallow and maybe beeswax. I don't remember everything else else, but that is actually, you know, it's. Otherwise it's all the same good stuff that's in their regular tallow bomb, which is, is fantastic. And there, you know, there are, there are moments, there are situations when even people who don't want to use sunscreen in general, for lots of reasons, some of which we haven't even gotten to yet, may end up needing sunscreen. But I would say given, given what we've heard so far, you can't trust the labels on the mainstream sunscreens. Apparently even the ones that don't list aluminum often have aluminum in them. Aluminum is a known pro oxidant. Many people by now have heard about the potential risks of wearing aluminum based antiperspirant. Why would it be any better to coat your entire skin and then bake it into your skin in the form of sunscreen screen? I feel like it's got to be worse.
Dr. Brett Weinstein
Yeah, well, and even worse, the. I consider them insane. But the spray on sunscreens that people use, you're also potentially breathing this stuff or the person sitting next to you on the beach is going to be breathing it. Yeah, right. Which is like the worst possible case in terms of, you know, short of injecting it. Having it come into your lungs is very dangerous. I mean, it's dangerous almost no matter what it is.
Eric Prime
Yeah, exactly. Okay, so there's that not all sunscreen is created equally. And my, my message still not medical advice is avoid sunscreen whenever you can. But if you're going to use it, find sunscreen that is as pure and clean as possible, that uses a physical barrier rather than a chemical change in your skin. And man, man, sunscreen is the example that I know to fit that, that category. But there's also the question of whether or not sunscreen use has an effect on all cause mortality that is separate from skin cancer. And so much as we were talking about during COVID if all you're looking at is okay, we've got this product and the reason we're telling you to use it is to deal with. With we got product X and we were using it to deal with Y. And the only thing you look at is when you use X, do you see a reduction in Y, Then you are potentially going to miss all of the other possibly positive, but often negative effects of X that will not be found when all you're looking at is Y. This is true for statins, it's true for Covid vaccines. It's true across many, many pharmaceutical products.
Dr. Brett Weinstein
Another way to put it is because you're dealing with a complex system and your purpose is to live a long time and live well. You care about the integrative measure. You don't care that it does something positive to one metric if it does a bunch of negative things to a bunch of other, you know, factors. So the thing you really care about is, hey, doc, if I take this thing, do I live longer?
Eric Prime
Right. Exactly.
Dr. Brett Weinstein
Before we get there, though, I wanted. I came up with five. And then you have added a sixth hypothesis that I think could account for the correlation they see. And interesting.
Eric Prime
The correlation in the diamond, the 2023 paper that finds that positive association with cancer. Yeah. Skin cancer.
Dr. Brett Weinstein
With skin cancer. Right. Okay. And so I think this is interesting because that, that result is suggestive that something is going on. Whether the something is straightforwardly, hey, this stuff causes skin cancer or not is something that needs to be understood. Okay, so here are what I think are the six hypotheses that would account for this as far as I can tell. Great. First is that you might paradoxically have a greater risk of sunburns, which are known to be causal to skin cancer by virtue of the fact that sunscreen prevents you from developing the resistance to the sun that occurs over the course of a season.
Eric Prime
So a prediction of that would be that people who visit the sun and spend a couple days outside and otherwise don't have seasonal exposure to the sun. This isn't going to apply to. This is going to be about establishing your baseline over a season and becoming. Becoming behaviorally accultured to the idea that you're actually protected.
Dr. Brett Weinstein
Right. And just to make that clear, I find I'm somebody who is prone to burns, but if I expose myself to the sun rather than hide from the sun, I develop the capacity to be in the sun for a longer and longer period of time. When I get in trouble is if I, at the beginning of the season, go out and have a very long exposure. But if I build up my tolerance, I actually have a tolerance, which is because I have endogenous sunscreen that Darkens me and protects me.
Eric Prime
And it may be so. If, if there are people around you, if you live in a place where summer is a season where you spend time outside and there are other people around you who are generating their. Their skin resilience over time in, you know, without relying on sunscreen, then your social events over the summer are likely to involve more and more time spent outside because the people with whom you are with are going to have greater capacity to end up in the sun. You may not, but you may not be thinking about that.
Dr. Brett Weinstein
Right. And so the way to test this hypothesis is to control for burns. That's one way to test it. You could also control for skin darkening. But the basic point is, if you controlled for burns, does the correlation go away. Away with sunscreen? That is, the sunscreen is interfering with your protection against burns. Okay. The second hypothesis is chemical toxicity. Yeah. So chemical toxicity. There might be a carcinogen in many sunscreens which would have the effect directly. You could test for that by comparing between chemical sunscreens and physical sunscreens.
Eric Prime
The. And so that's. That's a. That's in the category error.
Dr. Brett Weinstein
Yes.
Eric Prime
Part of the. Part of the story.
Dr. Brett Weinstein
Right. The third hypothesis is that it blocks. And this is related to the first hypothesis, but separate. If we take away the question of burns, that it blocks the production of endogenous melanin, and by blocking that production, exposes your tissues, even if they don't burn to UV radiation, they wouldn't otherwise be exposed to. So the point is you end up lighter because you're using an extrinsic sunscreen. And it may be that being lighter exposes you to UV, so that. That could cause it.
Eric Prime
4 is interesting, talking about, like, subdermal tissues.
Dr. Brett Weinstein
Yeah, yeah. That your skin has a reaction that's there. It's built in sunscreen that's not there all the time. It responds, you know, the darker you are, the more that's there all the time. But for that's.
Eric Prime
That's your endogenous sunscreen.
Dr. Brett Weinstein
Yeah, yeah. But, you know, the fact that we tan, it happens for a reason. And there's a reason that people who are tan look good. Right. That's the paradox of this whole thing. Don't tan has always been like, huh, why does that look healthy to us?
Eric Prime
Yeah.
Dr. Brett Weinstein
Okay. The fourth one goes back to something that longtime listeners will remember, which is that there are paradoxical results. Dermatologists have been surprised, for example, that people who have sun weathered skin who they would have thought had a very high Risk of skin cancer have essentially none.
Eric Prime
Now, the paper that I was talking about in the beginning, the I'm sorry, Jeremiah paper, actually does mention looking older than the having sun weathered face being protective against some or showing a correlation as if it is protective against some skin cancers.
Dr. Brett Weinstein
Right. And so I will remind you that's
Eric Prime
one of their environmental parameters.
Dr. Brett Weinstein
I will remind people that. The explanation for that, I believe, coming from my grad work on telomeres, is that when you get a mutation that causes cells to divide and head towards being a tumor, the number of cells in the patch of unregulated tissue is smaller the more damaged your skin has been ahead of time. So the older you are, the more damage you've lived through, the shorter your telomeres, the fewer cells result from that mutation. And so the point is, your risk of a future cancer depends on a second mutation, which is proportional to the number of cells in which you are are running that risk. So the smaller that patch of cells when you get your second mutation, the less likely it is to be in one of those cells. So residual. The basic point is the more you protect something early, the greater your cancer risk later. So it could be a weird paradoxical telomere result.
Eric Prime
Yeah, but. But don't burn, right? Right.
Dr. Brett Weinstein
But don't burn, right, Right.
Eric Prime
Like, no, no, burns are protective.
Dr. Brett Weinstein
Burns are never good. Burns are the thing that causes cancer. Sun. And that's, that's kind of the division that I think is straightforward and obvious at this point from the evidence, incomplete as it is, that we have now is do expose yourself to the sun, but don't burn. Right. At all costs, avoid burning. Even sunscreen might be a better alternative to a burn, but figuring out how to behaviorally prevent it or use a physical sunscreen rather than a chemical sunscreen.
Eric Prime
And sometimes physical sunscreens are called hats.
Dr. Brett Weinstein
Totally. Yes. Get yourself a thick hat.
Eric Prime
It doesn't even need to be thick as long as it's opaque.
Dr. Brett Weinstein
It has to be thick enough to cast a good shadow. That's pretty much all it has.
Eric Prime
That's wide
Dr. Brett Weinstein
little joke. All right. The fifth hypothesis is the one we mentioned earlier, that there's some reason that is not causal about the sunscreen, but something like people use sunscreen in proportion to their concern about cancer and therefore cancer prone people are wearing more sunscreen and it's really their endogenous risk which they are correctly predicting.
Eric Prime
Yeah. Which is, which is one of the ones that the authors that Jeremiah and et al say as they're trying to get their result.
Dr. Brett Weinstein
Well they strangely narrow it and they say if you've had a diagnosis of cancer, maybe you're using more sunscreen. And really the point is no, people who are pale or people who've had a history of, well, they can't say
Eric Prime
pale because they've like, they've separately assessed skin color, skin tone in, in their work. So they, they think that, that, that paleness is not what explains this result away because they have already effectively controlled for those, for that.
Dr. Brett Weinstein
Yeah. All right, well, in some way, maybe, maybe race then falls out as a non explanation if they've dealt with it through, through skin color. And then the last One is the O2 mechanism or at least the, the oxidative species. And that aluminum in sunscreens might be binding up all of the antioxidants that you endogenously produce to protect yourself, making yourself vulnerable. I think that that's kind of an interesting one. So anyway, yeah, that's five and possibly six different hypotheses that could account for this result. If they, the, if the result is real, and I think the result looks like it's real. The analysis is weird, but there's some reason there's a correlation there. Whether it's causal or not remains to be seen.
Eric Prime
Yeah, I mean I, it, it's hard, it's. It's very hard to assess because there's so much behind the scenes invisible to the reader. Complex statistical models that are complicated statistical models that are being used. And again, I keep on saying it, but it really feels critical to me. Sunscreen is not actually a good category. You know, I feel very strongly about the hypothesis that this result would look different if you, if you compared all these aluminum based sunscreens. Aluminum based meaning just that they have aluminum containing sunscreens that the Authors of the 2007 letter to the editor we're looking at, to a, to a sunscreen like Van Mans, which has no aluminum in it at all and uses a physical barrier as opposed to a chemical. A chemical element.
Dr. Brett Weinstein
Yep. Or even zinc oxide, which is, you know, rarely used anymore. But it's just that white stuff that people.
Eric Prime
Yeah, I just don't know what else is in those.
Dr. Brett Weinstein
Yeah, that's a good question.
Eric Prime
So that I don't, I don't. I assume that many of those also had other things in them that it wasn't just pure zinc oxide. Yeah, I doubt they were. But I wanted to say too that I guess I already did this before you went through your hypotheses that my, my objections to the conversation as it seems to be happening is one. Sunscreen isn't one thing. The use of sunscreen in this research is a category error. And there's multiple types of sunscreen, some of which I don't expect would end up being toxic in and of themselves. But also there's the question of all cultures cause, all cause mortality, and what else are you keeping your body from getting by applying sunscreen? Even if we accept, as you and I did in our book here, that sunscreen itself is going to reduce skin cancer incidence. Which interesting to find that here we have in the medicine chapter of Hunter Gatherer's Guide to the 21st Century, which was published in 2021. Related to the reductionist thinking around vitamin D is the fact that for decades now, we have received a nearly universal recommendation to slather ourselves with sunscreen whenever we're in the sun. Reduce your exposure to the sun, the larger it goes, and skin cancer rates fall. True enough, that's where, I don't know, guess what goes up when sun exposure goes down though? Blood pressure. And as blood pressure climbs, so do rates of heart disease and stroke. People who avoid the sun have higher overall mortality rates than do people who seek it. A research study on Swedish women reported this remarkable result. Quote, non smokers who avoided sun exposure had a life expectancy similar to to smokers in the highest sun exposure group, indicating that avoidance of sun exposure is a risk factor for death of a similar magnitude as smoking. So reductionist scientism has misled us yet again and likely caused many deaths. Should we stay out of the sun and take vitamin D or seek moderate sun exposure and get the nutrients we need by seeking something closer to an ancestral diet? An evolutionary analysis suggests the latter, at least on this topic. The medical literature is catching up to that conclusion as well. So that Swedish cohort study is excellent. And that's my nod to it with the bit from Hunter Gatherer's Guide. The idea that the only thing you should be thinking about with regard to sunscreen, should I use it or not, is your risk of skin cancer, is patently wrong. So again, be thinking about the effects on your overall health and whether or not being exposed to the sun might be good for you. And the answer is. Answer has to be yes. The answer has to be yes, because we evolved outdoors under the sun.
Dr. Brett Weinstein
All right, I want to add something, a more general consideration. I'm toying with the idea. I haven't 100% convinced myself of it yet, but I'm increasingly convinced of the following thing. All actual solutions in a Complex system are simple, that if you apply a complex solution in a complex system, the likelihood of unintended consequences is so high that it can't possibly work. So at the very least there's a strong bias towards. We tend to think, oh, that system is complicated, we're going to need a complicated answer. And the answer is no. If it's truly complex, then you're looking for a simple answer that's the most elegant.
Eric Prime
And it's possible, yes. Not guarantee, but it's possible.
Dr. Brett Weinstein
It's possible. And you might have some chance of understanding the impact of what you've done enough to track whether or not it was actually a win. I wanted to go back to your point about hats. Okay, a hat. Sometimes I look at people wearing hats, like hats with brims.
Eric Prime
Which you do yourself.
Dr. Brett Weinstein
Which I do myself. And you know, like glasses, like that's a weird technology you're wearing on your face. But we have taken it as part of what it is to be human. And we don't look at somebody wearing glasses, you know, they're not wearing toasters. Right, right. I mean sometimes on Halloween, perhaps, but. But my point is this. A hat is kind of a strange object, right. It's like a shadow caster that you, you know, ring your head with so that the shadow follows you around like a cloud. You know, you could imagine that, you know, instead if you wanted, you know, to, to raise the humidity, you could have a mister around your head and it would make equally as much sense as a shadow cast.
Eric Prime
I can basically guarantee you that probably product exists.
Dr. Brett Weinstein
It probably does. But, but here's my point. How elegant is a hat actually? Pretty elegant. Because if you think about, you've got a complex system that is your skin that has a built in mechanism. Like you have your endogenous level of melatonin based on the latitude that your ancestors lived in. That does a pretty good job of fending off your regular level of incidence of sun exposure. Then you have your capacity to ratchet up your UV protection. Your skin does it automatically upon exposure to sun. If you're exposed in a, you know, in a reasonable way, your skin will darken and that will give you just enough protection that you don't burn, which is really the thing you're trying to fear. Okay, but what if it's not enough? Well, you could slather stuff on. Sure. Or you could wear a shadow caster around your head. What does the shadow caster around your head do that none of the others do? Well, because it's at a Distance. And because you're walking around and looking at things and walking there and then turning around and walking back, it casts a shadow some percentage of the time. Right. If you want to go full sombrero, it's a lot of the time because it's casting a very big shadow. Right. A small brim cast a little bit of a shadow. But the point is, what it's doing is it's breaking up your sun exposure. Sometimes the shadow is over your face, and you are not in the sun. Your face isn't. Sometimes you turn your head and you're directly in the sun. And as you're walking around, as you're looking at different things, you're getting little bits of sun exposure. It does exactly the right thing to. Basically, it's like, what are those, like, meshy jersey kind of things that people sometimes wear? I think.
Eric Prime
Yeah. Or I mean, a straw hat, I think, does also the job that you're talking about.
Dr. Brett Weinstein
Right. So the point is you can. That has little block some percentage of the sun by making a mini pergola. Right. And, you know, I think the jerseys people do it because they're trying to not trap heat. They have to wear a jersey to have their number or whatever and their team affiliation, but they're trying not to trap heat. So it's like, you know, 50% more space than fabric. Yeah, yeah. But the point is, it's an elegant solution to the problem. Why? Because it's simple.
Eric Prime
It's. It's simple. A parasol is similarly simple. Sunglasses, as opposed to myopia or presbyopia. Correcting glasses also seems simple. But I think a hat will not trick your body into imagining that it's in a different. Different sun situation than it is, especially because you do move around and you do end up experiencing these different. These different sun exposures. Whereas sunglasses, I believe, actually trick your brain and therefore your skin into responding to a darker moment than is going on and put you at greater risk of burning.
Dr. Brett Weinstein
I would love. I mean, I don't know, but I would love to know.
Eric Prime
That's the hypothesis.
Dr. Brett Weinstein
And so I love it.
Eric Prime
Yeah. And, you know, so, you know, this. This will sound crazy to many people. Don't use sunscreen. Don't wear sunglasses. Like, what do you want me to do? You want me to stay inside? Like, no, go outside. Don't use sunscreen. Don't wear sunglasses. It's summer. That sounds risky to a lot of people. And it may be impossible for more than a few minutes at a time, at least at first. And Certainly there are a lot of people living in climates where their ancestors, ancestors did not evolve. And if you, you know, if you're, if you're pale skinned and red haired out of Ireland and living in Southern California, you're gonna need to be using some protection. Better to make it physical protection in the form of fabric or, you know, or zinc based sunscreen than anything chemical. But also you came up with advice when our kids were young where, you know, they, they were, I, I was lucky just never to have had burning skin. And so I didn't see coming that children would burn. And you generated advice for them that almost 100% worked. And I think it did 100% work. It was just sort of user error when it didn't.
Dr. Brett Weinstein
So it doesn't work if you don't do it. And there are times when you can't pull it off.
Eric Prime
Yes. Okay, so what is the advice?
Dr. Brett Weinstein
The advice is you're out in the sun for a half hour, you begin to think, think, maybe I'm going to burn. You spend a few minutes in the shade. Sometimes you can do it by turning so that the side of you that's been in the shade because you're, you know, lying on the beach or something is not the side being exposed. But the point is.
Eric Prime
But my experience, because, you know, we all do become more susceptible to feeling the heat of the sauna potentially burning as we age, my experience is that getting your entire body out of the sun for call it five minutes every 30 actually almost entirely resets the clock.
Dr. Brett Weinstein
Yes. And I will tell you, I don't know if this is actually right in any physical way, but the experience matches the idea that there is some capacity to absorb the insult of the sun and that it gets exhausted. Right. Like you were, you know, like a sponge soaking up a liquid. And the point is if you can empty it and it empties fast, then you can soak up that same amount again. So it's not proportional, it's not 30 minutes on, 30 minutes off, it's 30 minutes on 5 or 10 off. And the place where this fails is if you screw it up and you forget. Forget, for example, you're snorkeling so you're cool and you're not thinking about the heat that'll do it. Or you're in a frickin kayak crossing between A and B. And there is no shade aid. Right? Yeah. So there are cases in which you can't pull it off, but when you can pull it off, I think it's near perfect. And I will say on the sunglasses thing, you did this first, but I now do not wear them except in circumstances where I have to like driving into the sun. It's not worth the risk. Boat in the sun, even worse.
Eric Prime
Yep. You know, and so I, I do have a pair of sunglasses that I very much like and I do use sometimes, but they're very pale. They're like they. So. So they do less to confuse my eyes when I'm outside wearing them than would very dark sunglasses.
Dr. Brett Weinstein
Yeah. And I, I almost wonder if. I'm sure there's some research, but I would be interested in a set of sunglasses that disrupted as few things as possible. I personally hate sunglasses that, that change the color profile of the world. I find that awful. But you know something? For cameras, if you're shooting outdoors, there's a thing called a neutral density filter. Neutral density filter changes nothing about the photons coming through except how many of them. So. And there are variable ones that you put on the lens and you can rotate them and it gets darker and darker.
Eric Prime
And is it polarizing? No. That sounds like a polarizing filter. Maybe, maybe not.
Dr. Brett Weinstein
I do not think it is inherently polarizing. Certainly polarizing does some of this, except that polarizing cuts literally the angle of the light. But in any case, something glasses wise that disrupted as few of the channels as possible, especially something. I mean, the problem is fashion wise, nobody's going to want, you know, like a variable thing tried on the tech
Eric Prime
bros see if they can start a thing.
Dr. Brett Weinstein
But anyway, from the point of view, they'll eat anything. They will. From the point of view of you're trying to live your life and disrupt your health as little as possible. A sunglasses that reduce the light as little as necessary to do whatever it is you're trying to do and distort the light as little as possible is likely to be at least disruptive.
Eric Prime
I wonder, actually. So I said this thing about sunglasses and astute viewers may realize that that doesn't make sense given that I always show up here in glasses. I, I'm actually, you know, quite myopic. I require corrective lenses to move around the world, but I normally wear contacts when, when I'm not on camera, I wear contacts and so I can wear sunglasses. I have never ever worn tinted contacts. But I wonder if tinted contacts don't have exactly the same problem. And like, like just being in the habit of wearing sunscreen. It may be even worse than having sunglasses on because you don't even realize that you're sending your body the wrong the wrong signals. And I hope that regular contacts don't have this problem. But of course, you know, wearing a form fitting piece of plastic on your eyes can't be 100 safe.
Dr. Brett Weinstein
Yeah. It's not, it's not going to be good.
Eric Prime
Yeah.
Dr. Brett Weinstein
A question for. I didn't know that tinted contacts were a thing. I'm sure that contacts that change your eye color for fashion reasons exist. Is that, is that the extent of them?
Eric Prime
I think so, yeah. I mean I don't, I've never looked into it but. And I have no idea how widespread in use they are, but they're widely available. I'm, I'm always, it's, it's always an option when, when I get my contacts,
Dr. Brett Weinstein
it raises all kinds of concerns. Right. Imagine, imagine you're single and you fall for somebody who's been wearing the wrong eye color would result in tinted love. I just think that's.
Eric Prime
It's terrible.
Dr. Brett Weinstein
It is terrible.
Eric Prime
Or maybe that's the joke. I can't tell.
Dr. Brett Weinstein
Yeah. I don't know.
Eric Prime
Yeah.
Dr. Brett Weinstein
But it can't be good.
Eric Prime
No. No. All right, one more story for today.
Dr. Brett Weinstein
Yep.
Eric Prime
Yep. I think I should just, I think I should just read, read the article. But my, my lead up to it. Is that the New York Times. Yeah, that's right. I still occasionally read the New York Times. Cannot figure out what team it needs to be on. Like, and that's, I just, you know, you gotta feel for them. They're, they've been so, they've been trying so hard to just have one position and one position only and, but the
Dr. Brett Weinstein
evil is on two sides and they're trying to guess.
Eric Prime
It's so hard for them. Just like feel for the New York Times. Let me see, does this have. Okay, here we go. Can you see my screen at this point? Good. Protect every animal from Cruelty. Not in 2026. Oregon. Democrats say a possible referendum in Oregon on animal rights would end fishing, hunting, even pest control. Just when Democrats are trying really hard not to be seen as quite quote, weirdos again. I just. The headline and sub headline alone are worth the price of admission here. Like, yes, I'm still sending some of our hard earned money to the New York Times so that I can see stories, stories like this. And so before I am going to read part of this, I will say that we've been talking a lot about California and Washington and how completely off the rails they are. So I thought it was time to spend a little time talking about Oregon and how it too, as a western state sandwiched between California and Washington has gone off the rails. Okay.
Dr. Brett Weinstein
Completely nuts.
Eric Prime
Completely nuts. Okay, so this is published a couple days ago, January 21st. This is David Michelson, the organizer of the People for the Elimination of Animal Cruelty Exemptions, wants, quote, a system where we're not killing or hurting animals anymore. Oh, and he says it that way. It sounds totally reasonable, does it not?
Dr. Brett Weinstein
Okay.
Eric Prime
Since the 2024 elections, Democrats in or seeking office have tried hard to stick to the new playbook. Focus on pocketbook worries. Criticize President Trump if you must, but for the love of all that is sacred, avoid the social issues that Republicans have used to paint the party as out of touch and maybe even a little weird. A little weird. A new animal rights measure in Oregon has Democratic leaders like Governor Tina Kotak going out on a limb. They want voters to know they're just as committed to killing animals as Republicans. I had to read that several times to establish that Governor Kotak, who is a piece of work, like she is seriously woke and very left wing and not doing good things for Oregon. The New York Times is making sure that we know that Governor Kotak is, quote, just as committed to killing animals as Republicans.
Dr. Brett Weinstein
Wow.
Eric Prime
Quite a framing. The measure, known for now AS Initiative Petition 28, is the stuff of political nightmares for Democratic leaders in Washington. That's Washington, D.C. not state. It would give all animals the same protections from cruelty that Oregon grants dogs and cats, and in the process, remake the state's economy and dinner plates. Hunting, trapping and fishing would be outlawed, along with scientific research on animals, lethal pest control, and conventional livestock production. It's incredible. The goal, said David Michelson, a substitute teacher, vegan, and the petitions organizer, quote, is to have a system where we're not killing or hurting animals anymore, end quote. Democrats in Oregon are fleeing Mr. Michaelson faster than Bambi's mother tried to escape the hunter. Or perhaps faster than James Talarika, the Democratic nominee for Senate in Texas reached for a barbecued hunk of meat to prove he's not vegetarian. No establishment Democrat in Oregon would ever support this, said John Horvik, senior vice president with the polling firm dhm. Recent research. Still, he added, republicans see this as an opportunity to say, look at those crazy Democrats being weirdos again. Ms. Kotak, up for reelection in November, said in a social media video last month that she wanted, quote, to be very clear she's against something she sees as attacking the people who feed our communities. Okay, I'm going to go down. I just want to tell you a little bit about the guy who's behind this. I've gotten a few emails telling me it's not the right time for this, Mr. Michelson said. By that logic, it never will be. Mr. Michelson is an unlikely candidate to upend Oregon politics. Originally from Southern California, he moved to Oregon from Denver in 2020 because he figured his chances of meeting another gay vegan were better. In Portland, he did part time work gathering signatures for several liberal ballot measures and realized he could use Oregon system for his own passion, convincing people to stop hurting animals. Most people really like their companions, their pets, Mr. Michelson said. We're just trying to say these other animals have Those needs too. IP28 is his third attempt to qualify for the ballot. His initial effort collected just 2,000 signatures. This time he gave himself the full two years allowed under Oregon law to gather signatures and put more energy into fundraising for paid canvassers. He and other supporters have collected more than 135,000 signatures, etc. Etc. One more thing about him he's collected more than $305,000 to fund the campaign with help from PETA, the Craigslist charitable fund, and his own pockets, where he found $35,000. I live very cheaply, he said. No car, no children or roommates. So this gay vegan who wants to sup all hunting, fishing, trapping, livestock production and animal research in Oregon is the the male equivalent of the middle aged white woman who is looking to the state to fix all of her problems for her. Or also actually the the younger, the the young, the young childless white women who don't have a place to direct their energies that historically would have been there. So here we have a guy who who is a substitute teacher and yet found $35,000 in his own pockets. As the article reads, because he has no car, no children, no roommates. I don't know why roommates would make his life more expensive. But he basically has no affiliations. And so he's focused entirely on a social campaign. He focused entirely like his entire life on this social campaign. As you know, later in the piece you see Oregonians complaining he's an outsider. It's like, well okay, he's from Southern California and then from Denver. Like, you know, can we stop being scared of outsiders in all of their forms? That's become an easy boogeyman for people on the right. However, he's moved in. He has no affiliations. Apparently he hasn't been lucky in finding his gay vegan love of his life in Portland, although I'm sure there are others who fit that description in Portland and so he's putting it all into a petition, which I don't think could possibly have a chance of passing even in Oregon. Even. Even given that Oregon's population is largely centered in Portland and Eugene, which some proportion of the people might even vote for such a thing. But. But it can't possibly pass yet. The idea that anyone is taking this seriously is extraordinary. And the idea that the New York Times can't quite figure out which side they're on is just hilarious. Hilarious.
Dr. Brett Weinstein
Oh, that's great.
Eric Prime
Yeah.
Dr. Brett Weinstein
Somebody finally got far enough out to the left that the New York Times is like. Seems like a bridge too far. All right. I got a number of things to say, one, to your point, about childless white women looking to the state to solve their problems. Yeah, that's part of it. It's also using the state to bully others.
Eric Prime
Oh, yes, yes.
Dr. Brett Weinstein
And those are two.
Eric Prime
Those are different.
Dr. Brett Weinstein
Two aspects of the same syndrome. But they are different. But I wanted to just point out a couple things. Animals. All animals.
Eric Prime
Yeah. I have not gone and looked at the. At the petition. I don't know, you know, what. What all is written in. But it does say in this article something about pest control. Now, my guess is they're talking about, like, road vertebrates. I bet the. I bet that he's only concerned about vertebrates. Vertebrates. What kind of bigotry is that, dude?
Dr. Brett Weinstein
In which case, the New York Times, of course, has, you know, tripped over its own shoelaces. Because to say all animals is so unthinkably extreme, even for a vegan. I mean, you know, can you drive if, you know, insects are gonna get killed on your windshield, like, you wash
Eric Prime
your face and kill some of the mites that were living in your eyelashes.
Dr. Brett Weinstein
Can you slap a mosquito? Right. I mean, the point is, insects are animals.
Eric Prime
You can clap along with a mosquito. Mosquito.
Dr. Brett Weinstein
Not something I'd be likely to do, But. But anyway, all animals is a question mark. If it really says all animals, then that tells you this is just next level in terms of.
Eric Prime
My guess is. My guess is it's vertebrates. Even if he doesn't know what a vertebrate is.
Dr. Brett Weinstein
Right. Here's another thing. And I think it's just time that we do this logic cleanly. Okay. There is something counterintuitive about animal husbandry. The desire. First of all, I should just say, I believe I speak for you. If I say something that doesn't sound like I speak for you, feel free to correct it, but.
Eric Prime
Oh, I will.
Dr. Brett Weinstein
I know you will. There's a lot that we do to mammals especially, but also some birds. That is unthinkably terrible and should be ended absolutely immediately. The factory farming of these creatures is completely inhumane. The use of them in testing. There is an argument, in fact, a quite compelling argument that there are some things for which you need to test on animals because they're the only complex systems that will allow you to predict impacts on humans. But, but what we do to animals in product testing is insane. And if you saw would make you cry. So this is no defense of that at all.
Eric Prime
And, and some unnecessary cruelty still remains a huge amount.
Dr. Brett Weinstein
Just unthinkably much.
Eric Prime
Yes. But even like, even in, in research, certainly in like livestock and chicken. Yes, Husbandry.
Dr. Brett Weinstein
And if you were to understand the massive fishing fleets, I don't mean to blame China specifically, but they seem to be a major culprit in the Pacific at the moment. These giant fleets that are just thrashing the oceans, just absolutely liquidating the wildlife there. There's a lot of unthinkably terrible stuff. And yes, animals need much better protection than they have, including insects need protection from the insane pesticides that were destroyed.
Eric Prime
Beating. Yes.
Dr. Brett Weinstein
With all that said, however, the idea that you are raising those animals to kill them and eat them, and that's mean, is wrongheaded. And the way to think of it is this. Let's take a domestic chicken. Domestic chickens outnumber jungle fowl, their closest living relative, by. By who knows how many orders of magnitude in terms of the number of individuals alive on earth today. Jungle fowl could go extinct. The chicken can't go extinct. Right?
Eric Prime
Right.
Dr. Brett Weinstein
Let's say that we decide not only that raising of chickens in cages and even free range chickens are just technically free range. Let's suppose that we decided that all raising of chickens is wrong because it either involves exploiting them for their eggs or, or killing them for meat. Or very often exploiting for their eggs and then killing them for meat. And killing is mean. Okay, so we stopped doing it. Chicken goes extinct. Did you do it a favor? No.
Eric Prime
The fact is the future chicken whom you saved from being killed never came into existence in the first place.
Dr. Brett Weinstein
Right? And if you think about whether or not, you know, you would be spared all of the suffering that you will have in your life by never having been been, most people would prefer to have been even knowing that they will ultimately die and that they may die horribly, most people would rather have lived a life. Doesn't make any sense. So the point is the chicken or the goat or the sheep or the cow have arranged. They have evolved into a mutualism with people, and the mutualism involves them living. I would have them all live under natural circumstances where they actually have joy and pleasure and, and all of that. I don't want them to live intolerably, but they would rather, if they could speak for themselves, exist and then cease to exist as a result of the deal that they've worked out with humanity, rather than break that deal and banish them to extinction. Nobody wants to go extinct. The whole point of your evolutionary drive is to not go extra extinct. So you are not doing them a favor by not eating them. You are doing them a favor by eating them and recognizing that they should be raised in a way that actually matches our values rather than hidden away so that we can't see the suffering that we are causing. We should raise them honorably, but we should raise them and we should eat them and we should not feel bad about it. We would not be doing them a favor by not doing it. And frankly, there are a lot of issues that work this way. If you think about, about what is actually in that creature's interest. It's not always what you think. And evolutionary analysis actually is very clarifying in this regard. What would the animal want? All these people who want to end suffering, that would be an insane thing to do. Actually, even human suffering, which is not good when it happens, is part of the system that allows you to have meaning in life.
Eric Prime
To motivational.
Dr. Brett Weinstein
It is motivational. It gets you to solve your problems. If you were to try. Like medicine sees pain as a disease. Should we get rid of pain? Hey, we can anesthetize that. Don't people who have the malady of not being able to feel pain die early? All of them, they can't figure out how to live because pain is a teacher. So the point is these things, it's
Eric Prime
an evolved signal and it's a useful one. Some things that evolved are no longer useful. But before you get rid of it, go Chesterton's fence on it and figure out what you're getting rid of.
Dr. Brett Weinstein
Right.
Eric Prime
Why is it there in the first place?
Dr. Brett Weinstein
Which is not to say that there aren't instances where it's useless. Right. If you have lost a limb and you have pain in a phantom limb, that pain isn't helping you. Right. So we should try to figure out how to anesthetize that one. But that's the exception. In general, pain is telling you something. Either you're doing damage or you're taking a risk. That is unacceptable and will cause damage. It's telling you something. So anyway, the point is. Enough. I don't want to be told by some vegan that I can't eat ethically raised meat. Who the hell appointed this guy? I evolved as a meat eater. I am entitled to eat meat and I am not doing the animals any favor by not eating them. You just don't understand what you're talking about, sir, at all. So go educate yourself and stop trying to boss other people around. And if you wanted to, if you wanted to make your efforts to useful, you could point them at the inhumane treatment of animals in laboratories, in factory farms. If you want to talk about that, you'll find a much larger audience of us ready to listen. But you're not in a position to tell us what to eat and whether or not we can go fishing. I'm sorry, it's just not your business.
Eric Prime
Amen. All right, all right, here it is. I hope he sees that.
Dr. Brett Weinstein
Yeah, I hope so too.
Eric Prime
Yeah, well, maybe. Maybe that's it, man.
Dr. Brett Weinstein
All right.
Eric Prime
Should we go out in the sun without sunscreen or sunglasses and just enjoy the rays on our skin?
Dr. Brett Weinstein
Yeah. I mean, and if it's really intense, we could put on our circular shadow casters.
Eric Prime
Or maybe I'll carry a parasol.
Dr. Brett Weinstein
It's not done so much here, but yeah, yeah. Oh, that does remind me. I got a lovely parasol from Rupert Lowe. Oh, what's really an umbrella. It's a. It's a Restore Britain umbrella, which I managed to get home in one piece and I'm very proud to own it. But anyway, if you haven't watched the Rupert Lowe episode of Dark Horse, check it out. Rupert. Somebody you should know about, he is a fellow traveler. I think you'll really dig it. And I think Restore Britain and Rescue the Republic are the right ideas. And this is how we we fix the West.
Eric Prime
Excellent. Excellent. Beautiful. So check out our sponsors this week again, they were Mud, Water, Caraway and Puri. Join us on Locals to check out previous Q&As and such. And until you see us next time, we'll be back on Wednesday. Next week on our usual time and place. Be good to the ones you love, eat real food and get outside.
Dr. Brett Weinstein
Be well, everyone.
Hosts: Bret Weinstein & Heather Heying
Date: June 23, 2026
This episode explores the science, controversy, and evolutionary implications of sunscreen use, sun exposure, and skin health. Bret and Heather critically analyze recent research linking sunscreen to increased skin cancer risk, question the reliability and category of “sunscreen,” and discuss the broader health consequences of sun avoidance. The conversation also touches on practical sun protection, evolutionary logic regarding animal husbandry, and contemporary cultural/political debates.
Content skipped as per guidelines.
[09:25–34:35]
Heather introduces new research summarized by Nicholas Hoelscher, citing a massive UK Biobank study (>470,000 participants) showing sunscreen users had substantially higher risk of melanoma, basal cell carcinoma, and squamous cell carcinoma, even when correcting for confounders.
“A UK Biobank study involving over 470k people found that individuals who reported using sunscreen more frequently had substantially higher risk of multiple skin cancers, even after researchers accounted for major confounding factors...”
—Heather [09:29]
Risks found:
The study looked at genetic and behavioral predictors—not sunscreen in isolation.
Bret points out the paper's title is needlessly obtuse (“prognosticate” instead of “predict”). Both hosts reflect on the risk of jargon being exclusionary. [13:37]
Authors explain away the surprising findings, listing possible confounding reasons for their results (e.g., people at higher risk using more sunscreen, user error in re-application).
“This paradoxical finding was the increasing risk of skin cancers with increased sunscreen use, which we posit can be explained by greater exposure to UV light and/or lack of reapplication… or due to increased use of sun protection following a skin cancer diagnosis…”
—Heather reading the authors [26:54]
Bret highlights the dogmatism common in modern scientific publishing:
“This isn’t science you’re looking at. It’s something that uses the language of science...but it is not scientific because someone’s got their thumb on the scales.”
—Bret [27:39]
Not all sunscreens are equal; chemical composition differs (e.g., many contain aluminum compounds or titanium dioxide).
Most studies treat ‘sunscreen’ as a homogenous category; however, toxicity and effectiveness varies by ingredients.
“Sunscreen itself is a category error. Sunscreen isn’t one thing...most sunscreen, for instance, I didn’t know this until this week, most sunscreen has aluminum in it.”
—Heather [28:35]
[29:40–34:08]
Heather cites a 2007 letter in Free Radical Biology and Medicine revealing all tested sunscreens contained aluminum, sometimes at high doses.
Aluminum is a potential pro-oxidant, may be absorbed into the body, and could increase risk of oxidative skin damage.
“It is highly likely that the everyday use of sunscreens and sunblocks is a hitherto unrecognized contributor of aluminum to the human body burden of this non-essential metal...aluminum is one such pro-oxidant and could significantly increase the potential for oxidative damage in the skin.”
—Heather, quoting Nicholson & Exley [32:18]
Authors sometimes add aluminum to coat titanium dioxide and prevent clumping.
Physical “barrier” sunscreens (e.g., zinc-based) may avoid these issues.
[34:35–63:00]
[39:06]
Focusing solely on skin cancer risk ignores other health consequences. Sun avoidance is linked to higher all-cause mortality (e.g., heart disease, hypertension). Swedish cohort study: sun avoidance as risky as smoking.
“Non-smokers who avoided sun exposure had a life expectancy similar to smokers in the highest sun exposure group...”
—Heather, quoting study [50:55]
Bret and Heather propose multiple explanations for the observed correlation:
Physical barriers (hats, clothing, parasols) are recommended over chemical sunscreens.
“A hat is kind of a strange object, right. It’s like a shadow caster that you, you know, ring your head with so that the shadow follows you around like a cloud… But how elegant is a hat actually? Pretty elegant.”
—Bret [54:17]
The most important advice: Do not burn. Gradual sun exposure builds tolerance.
Take breaks in shade—“30 minutes on, five off” can prevent burns [60:02]. Sunglasses may send incorrect signals to the body regarding UV exposure; caution advised, especially with dark or tinted lenses.
“Don’t use sunscreen. Don’t wear sunglasses...go outside. Don’t use sunscreen. Don’t wear sunglasses. It’s summer. That sounds risky to a lot of people. And it may be impossible for more than a few minutes at a time...”
—Heather [58:29]
[65:16–81:21]
Factory farming is denounced as cruel and unacceptable.
However, ending all animal husbandry would drive domestic species extinct and is not in their evolutionary interest.
“The chicken or the goat or the sheep or the cow have arranged...a mutualism with people, and the mutualism involves them living. I would have them all live under natural circumstances where they actually have joy and pleasure...But they would rather...exist and then cease to exist as a result of the deal...rather than break that deal and banish them to extinction.”
—Bret [76:53]
Pain and suffering are evolutionary signals, and attempts to abolish them without understanding their adaptive purpose can be disastrous.
“Pain is a teacher...these things, it’s an evolved signal and it’s a useful one. Some things that evolved are no longer useful. But before you get rid of it, go Chesterton’s Fence on it and figure out what you’re getting rid of.”
—Heather [79:50]
Animal advocacy is important—but moral absolutism and blanket bans risk backfiring.
On the sunscreen study’s authors:
“This is some of the most egregious pseudoscience I have actually seen...”
—Heather [26:54]
On evolutionary solutions to complex systems:
“All actual solutions in a complex system are simple, that if you apply a complex solution in a complex system, the likelihood of unintended consequences is so high that it can’t possibly work.”
—Bret [53:34]
On the advice to avoid sunscreen:
“My message, still not medical advice, is avoid sunscreen whenever you can. But if you’re going to use it, find sunscreen that is as pure and clean as possible, that uses a physical barrier rather than a chemical change in your skin.”
—Heather [39:06]
Next episode: DarkHorse returns next week; get outside, eat real food, and question mainstream consensus!