
Your gut microbiome may be one of the most powerful forces controlling your health—and most people are destroying it without realizing it. In this episode of The Digital Social Hour, Dr. Sabine Hazan breaks down the shocking science behind gut bacteria, fecal transplants, probiotics, and how modern lifestyles are wiping out essential microbes. From autism and Alzheimer’s to COVID and immune health, Dr. Hazan explains why bifidobacteria may be one of the most important microbes in the human body. She also reveals how antibiotics, processed foods, sterilized environments, and stress are damaging our microbiome—and what this means for the future of human health. You’ll also hear the surprising role of stool transplants, why most probiotics may not actually work, and how the microbiome could reshape medicine in the coming decades. Chapters 0:00 The Microbes You’re Born With 0:39 Why America Is Losing Its Microbiome 1:20 The Science of Stool & Microbiome Research 2:23 The Business a...
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Dr. Sabine Haz
You're born with certain microbes. You go through life eating a bunch of junk. You alter that microbiome that you were given. You came from India, Japan, the Amazon jungle. You came with certain microbes. You adapt to this environment of America, which is sterile community, you know, where you're sterilizing with alcohol. You're basically losing a lot of microbes that you had. You know, you look at a person that comes from India and then they come to America, they've lost like how of their microbes, if not more because of this sterilization that we do in America. We give antibiotics for everything.
Interviewer/Host
Okay, guys, Dr. Sabine Haz here. Today we are at a 4M and we're going to talk poop today.
Dr. Sabine Haz
Yes.
Interviewer/Host
Fun topic, right?
Narrator/Advertiser 3
Yes.
Interviewer/Host
Think a lot of shame around it, but you fully embraced it. You've actually figured out a way to make money off it. So let's talk about it.
Dr. Sabine Haz
Well, I don't know that I made money because we're research lab and we're nonprofit research center. So I'm not sure this money in. There's definitely money in poop. The right for the person that's donating because they're actually the donors can make a lot of money if they have really good poop.
Interviewer/Host
How do you qualify for really good poop? Like, what determines that?
Dr. Sabine Haz
I, you know, I've kind of stepped into this world and somehow I ended being the buyer, the seller and the appraiser. So I'm not quite sure how I got here. But we're here. And so, you know, it's kind of like I look at stool samples all day long because people test of our lab. So our lab is a genetic research lab that's basically trying to figure out the microbiome, understanding the microbiome in diseases, different, you know, sequences of signature microbiome for the disease. And so stepping into this, I, you know, just realized, hey, this donor is really diversified. This donor really has the good microbe that this patient is lacking. And therefore, you know, let me see if I can make a match. Right. So it kind of like just kind of became like that. Yeah. And so what I'll do is I'll say, hey, there's a patient that may need your services for your poop. And I'm going to connect you to because I don't want to be part of the interchange between money. So, so I connect patients with the recipient, we test the stools, and then essentially that's how it happens. So we have a Kid with neuroblastoma, right now that we found a kid that could be a perfect match for him. And so we got the FDA involved, and so the family pays the kid. That's the donor.
Interviewer/Host
Got it.
Dr. Sabine Haz
And that's how it works, essentially. Yeah. But the future is probably going to be some kind of, you know, I'm sure there's going to be a business out there for that kind of stuff. Right now we're not at the business level. We're just trying to. I'm trying to swim upshore to like not sink and figure it out, this poop business. So.
Interviewer/Host
So poop is powerful, huh?
Dr. Sabine Haz
Poop. You know, this is why I stepped into it, because I said, wow. Colleen Kelly at Brown University did two cases of alopecia areata and the patients grew hair.
Interviewer/Host
What, just from eating poop?
Dr. Sabine Haz
No, from transplanting. Taking stools from the healthy donor and putting it into the colon of a patient with two patients with C that had alopecia areata. So when she saw that, I was really intrigued because I said, wow, I have a lot of hair. I wonder if there's a microbe that's linked with hair. Right? And so I started getting interested. And in my own case of Alzheimer's that improved after doing fecal transplant, I kind of said, there's gotta be something more to poop than just poop. Because the problem is the same two cases that developed that improved hair, there's two other cases that developed alopecia areata from poop. Oh, so the same thing that can heal, can kill.
Interviewer/Host
Interesting.
Dr. Sabine Haz
So I stepped into it. Not as, hey, I'm gonna start a poop business, but I stepped into it. Hey, I wanna understand poop, right? And I wanted to understand what causes Alzheimer's, what causes autism, what causes Parkinson's, and figuring out markers, signature microbes that could cause the disease. And here we are, still taking your
Interviewer/Host
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Dr. Sabine Haz
It's all part of the environment. So you're born with certain microbes. You grow through life. You go through life eating a bunch of junk. You alter that microbiome that you were given. You came from India, Japan, the Amazon jungle. You came with certain microbes. You adapt to this environment of America, which is sterile community where you're sterilizing with alcohol. You're basically losing a lot of microbes that you had. You know, like where, you know, you look at a person that comes from India and then they come to America, they've lost like half of their microbes.
Interviewer/Host
Wow.
Dr. Sabine Haz
Because if not more, because of this sterilization that we do in America, you know, we, we give antibiotics for everything. You have a virus, we give you antibiotics. You have a headache, we give you antibiotics, you know, so it's like it. And we give pills. We're constant pill pushers.
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Dr. Sabine Haz
You know, and it's not just the, the, the, the antibiotics. It's all the stuff out there, you know, the vitamins that are not necessarily so great. You know, it's the herbs that are not necessarily processed so well. It's the poor quality of products. It's every time you see some data on some product, for example, a probiotic, right? For every probiotic that writes the data for the lab that does the research and comes out with the research, there's 20 copycats that become, you know, fake probiotics. So the consumer doesn't know which one's a real from a fake. You know, it's like a Gucci purse with imitation Gucci that breaks down, right? So it's the same thing. There's people doing the right research and then there's all these copycats that are not even putting the right probiotic in there or don't even know how to process it properly. So, you know, this is what it's all about.
Interviewer/Host
How do you verify if you're taking, I guess, good probiotics is. It just says probiotic on the label.
Dr. Sabine Haz
Yes. So you don't. You kind of like, you know, like
Interviewer/Host
if you buy yogurt. If you buy.
Dr. Sabine Haz
Yeah. So we test it because we have a lab, but not every consumer tests it. So if you look at the label and it says, for example, Bifidobacteria 3, we did a study in Malibu looking at the local yogurts and we looked at every yogurt that said bifidobacteria in the back. So we tested 26 yogurts. Out of those, only three of them had bifidobacteria. And here's the problem. The consumer I can't even come out and say, well, these are the three yogurts that had it. Because first of all, huge liability. Second of all, how do I know this is not just a fluke? I didn't test all the yogurt of that brand around the country. Maybe for that yogurt, they forgot to put the bifidobacteria or it didn't grow or whatever, right? So maybe in Malibu it didn't have it, but maybe in South Carolina it does, right? So rule of thumb, if a yogurt. If you tolerate a yogurt that makes you feel good, then keep doing it, right? If you don't tolerate it and you're getting problems and you're starting to have acne, losing hair, indigestion, then there's something with this probiotic yogurt, then you probably don't want it.
Interviewer/Host
Well, I can name this one because it's public now. But he's in a lawsuit.
Dr. Sabine Haz
Yes, yes.
Interviewer/Host
Over something similar to this.
Dr. Sabine Haz
Exactly. And by the way, didn't have bifidobacteria.
Interviewer/Host
Oh, they didn't. Come on, step it up. That's crazy, though.
Dr. Sabine Haz
But here's the thing, right? It's sort of like, you know, it's sort of like these companies have a duty to do quality, okay? And at the end of the day, you gotta make sure that there's quality on the product, otherwise it's misleading the consumer. If you're putting a certain yogurt has this and it doesn't have it. And here's the other thing. What about the stuff that is not in there, right? Like, what about the stuff that's added, like the arsenic? Do you know that 90% of chocolates have arsenic in them?
Interviewer/Host
That's why I stopped eating dark chocolate.
Dr. Sabine Haz
Yeah. So you're thinking, oh, this is good for my gut. And then next thing you know, you find out you have arsenic in there. So, you know, we have to have better system to have quality for our produce. And so when people ask me, well, what do I do? I get to know my farmer. I get to know what my food is. I get to. I plant, I garden. I have, you know, I'm very big into, you know, I have my chickens, I have fresh eggs, you know, so I'm very big in all that. So it's time to take back our health. It's time to be more vigilant. It's time to demand quality from these products and not just buy in massive quantities.
Interviewer/Host
Agreed. Do you think everyone should take a stool test at some point, at some
Dr. Sabine Haz
point, we're not there yet. You know, the. All these stool tests, unfortunately, are not validated. You know, when you look at a stool sample and you test your same stool sample, if you don't have the same result, it's not really a test you can trust. And the other thing is, what are you looking at in the stool test? Right. So let's say I give you a consumer product of a stool test and I tell you, you bacteria, is that a good microbe or is that a bad microbe? And are you going to freak out that you have that microbe? And therefore, are you going to start trying to kill that microbe? What if that microbe is your microbe? That makes you who you are? Right. Then I wouldn't necessarily kill it. So the problem is that we're. All these tests are out there and it's very confusing for the consumer. That's why when I started doing the research, I really felt like, yes, I could have developed a stool test, a consumer product for everybody. But the problem is the consumer pro. Then what do I tell my consumer? What if I'm wrong? What if I guided them in the wrong way? I would feel horrible about it. Right? So I really feel that we need to advance medicine with the art of medicine. Discovering ways to heal people and then go back and see what did we do to heal those people. Right? And so I think that's the direction that I'd rather take rather than saying,
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Dr. Sabine Haz
There's a stool test and good luck. Go figure out what's wrong with you and try this, this and that and then nothing works. And then, you know, you're back to saying, hey, I spent thousands of dollars. And then so I would hate to do that. When people do a stool test with us, they do, they're part of a research, they sign an informed consent, they pay a portion of the test. The other, the other portion is paid, you know, by, by people that donate. And so essentially we try to, you know, see the data. We try to see the data with the best eyes possible. The microbiome is complex. It's trillions of microbes. And every day I'm learning something, you know, every day it's like Christmas. Wow. I didn't even know this microbe. Like, you know, we were talking about dogs before I came in, right? And I met a scientist who actually does fecal transplant with her dogs. Really? She actually raised a bunch of, you know, pure, not pure, but like really well fed dogs. And she, they're, they're blooming, they're amazing. And, and she uses dirt poop to help other dogs that have Lyme disease or that have, you know, inflammatory bowel disease. And she basically helps these dogs by giving them the poop from other, from her dogs. So we partnered and she's one of those people that you can buy, she's One of those people that's like, wants to do it for the goodness of helping these dogs. And so we partnered for free, like, you know, voluntary. And she said to me, why don't I send you my dog poop so that you can have a normal microbiome of the dog, what a normal microbiome looks like. Because she didn't want to give it to people and then they would sell it or just, you know, put it under the ground so we could protect the data. And so I'm excited because I work with a lot of people that, you know, save and rescue dogs.
Interviewer/Host
That's incredible.
Dr. Sabine Haz
So this is going to be amazing because so many rescue dogs have a lot of problems. You know, they're agitated, et cetera. So if we can help them with this, this is the best way to do it. Yeah. So. And this is an animal study, right? I mean, in a way, because it's kind of like telling us what we're doing on the dogs. We can apply to the humans safely.
Interviewer/Host
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Dr. Sabine Haz
100 I see. You know, it's amazing because I see a couple celebrities that have stepped up. You know, Rob Lowe talking about his dogs, Paris Hilton. And I love that. I love that Rob Lowe is giving his dogs honey, local honey. Because that's what I do with my patients.
Interviewer/Host
I'm like, go to a low for allergies, right?
Dr. Sabine Haz
For allergies. I go, go to get some local honey in your area. Yogurt with local honey. That's the best. Jason Strauss, who's like, a big, you know, restaurant business. He's in the restaurant business, and he's. He has a restaurant in Beverly Hills called Avra, and he has local honey on the yogurt, which is an amazing food for your gut. So, you know. Yeah, so a lot of restaurant owners and everything are kind of like, learning all about the microbiome, and they're trying to do the right thing for, you know, patience and to see, you know, like, sour. Now you're seeing sourdough bread more in the restaurants, which I think is not coincidental. It's really because of the push of, hey, sourdough bread is better for your gut. Right? Yogurt in the dessert menu. Dessert, you know, it's better for your gut than, you know, a cheesecake, you know, full of sugar. So I think there's. The world is changing. I think this path of the microbiome is really opening up the world to. And I think Covid in itself, you know, kind of, you know, made the consumer more aware, less trusting, less trusting of the healthcare, less trusting of the guidelines, less trusting of the pharmaceutical products, more, you know, taking health into their own hands. You know, I think that's the key.
Interviewer/Host
Yeah. And I saw during COVID you were examining people's stool, and so in severe cases of COVID they were missing the bifidobacteria, Right?
Dr. Sabine Haz
Yes, yes. And I. I stepped in. I'm. I'm a Malibu physician, and so my clientele, you know, I had to figure out how to save them. And so I stepped in to figure out, well, how. And also how to save me and my family. You know, my whole family is our doctors. Right. So we have nine doctors in the family between my husband, my sister's husband, or his siblings. My parents did well. Yeah. So, you know, we were all on the front line, so I needed to see another way.
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Dr. Sabine Haz
way that was presented to me, right? Because I When we discovered Covid in the stools, we were the first lab to ice, to basically see Covid in the stools by whole genome sequencing.
Interviewer/Host
Oh, you could see it in the poop.
Dr. Sabine Haz
Yeah, you take the poop and then basically you sequence it, you take away the bacteria and you just focus directly zoom in on the virus and you enlarge the sequence and you see a sequence, right? Like a bunch of numbers and you see the spike protein, right? Like 1a, 1b, 3a, the regions of the virus and then you see spike proteins, right? So the first samples that we collected from Beverly Hills and then Atlanta, because we were the first ones to start, hey, it's probably in the stools because everything goes in your stools. You know, you put a lotion that has some bacteria in it, it's going into your blood vessels. The blood vessels travel and then it goes into your colon, right? So everything ends up in your poop. So I, I really, at the beginning I kind of said this gotta be in the stools. And so we started Testing the microbiome, we started testing the stools and discovered that 100% of people that had nasal PCR positive or positive whole genome sequencing in the stools. When we saw the whole sequence of the virus, we discovered that the person in Beverly Hills that lived on Wilshire and the person in Beverly Hills that lived on Rodeo Drive had a different virus. So when we started a different mutation in the virus and add the spike protein. So in other words, some had, let's say you had four spikes. One had a mutation on the first spike, another one had a mutation on the third spike. So if I'm vaccinating you, for example, and I'm giving you spike B, but you're getting spike C, well, you're not vaccinated against spike C. And if the virus keeps on mutating, so in other words, now it's 32 spike mutations, right? You're never catching the virus. You're constantly going, and this is why we're still having Covid right now, because this virus is constantly mutating, it's adapting, it's changing. People are, are basically tolerating it, are surviving better, but it's still mutating, right? So it's still with us. It's kind of like influenza. Anything that's viral mutates bacteria. If, if it mutates, you can vaccinate against a bacteria better than a virus. Because if a bacteria mutates, it has a property that it can clean up its mutation. And so when it reproduces to the second bacteria, it now removed its mutation, a virus. When it reproduces, it'll reproduce with a mutation and it'll keep reproducing with a mutation. It doesn't have that property to clean up the mutation. So when we discovered Covid in the stools, we started looking at the microbiome and we said, well, what's different from people that have severe Covid, from people that are exposed to Covid? Never got Covid. And bifidobacteria was the key bacteria that kind of popped up and it made sense because it's your trillion dollar industry of probiotics. And the other thing that we discovered is we started looking at, well, who else is lacking bifidobacteria? Autistic children, people with Alzheimer's, people with Lyme disease, talking about Lyme disease, people with Crohn's disease, people with invasive cancer. And then from there we started looking at what kills the bifidobacteria and what helps the bifidobacteria. And then from there different treatments and here we are with autism because we discovered loss of bifidobacteria and autism. We restored the bifidobacteria, killed the microbes that were the possible problem for those two twins, two identical twins. And now the two twins are verb are speaking and reading. Wow. So it's a, it won a research award at the American College of Gastro because the judge said this is a proof of concept. Right. We showed loss of bifidobacteria and autism. We showed that if you restore bifidobacteria, these kids are speaking. And so this is kind of, you know, the way moving forward.
Interviewer/Host
Huge.
Dr. Sabine Haz
Yeah. So it's huge. So I'm very excited.
Interviewer/Host
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Dr. Sabine Haz
1 in 12 boys in California. Yeah. 1 in 12 boys. Yeah. And so you have to ask, what has killed the orbifidobacteria that we have? 1 in 12. Is it the food? Is it the antibiotic we're putting on these newborns? Is it whatever, everything? I think it's an accumulation of everything. I think it's, I think you, the mom is stressed. You know, even the mom being pregnant right now, you know, she's not giving as much good bacteria to her kid because she's stressed. She's working, doing two jobs, you know, trying to pay all the bills and everything. So she delivers a baby that has less bifidobacteria than in the olden days when mom was just calm at home, relaxed. And so now you're thinking, this baby is born, he's getting some topical antibiotic on his eyes right away. On day one, he gets a vaccine of hepatitis B, right? Which is a virus which is mutating, right? And then on top of that, the stress of the mom or the baby, and then you have all these formulas that are probably just like the yogurt. Half of them are garbage. And so you're feeding garbage to the kids. And so this kid goes from like probably what should be, you know, 90% good bacteria to zero. And now he's in flatline, right? That's what I like to call flatline. So now that baby doesn't have the microbes to absorb sugar. So now I'm giving him breast milk or I'm giving him sugar. He's not able to put that sugar into the cell. So he either develops autoimmune processes, inflammatory bowel disease down the road. And of course, this is all research that I'm telling you, but also diabetes, possibly, and then autism. Right? So as we follow, there's a study that just came out on Nature that showed that 75% of newborns lack bifidobacteria. Only 25% have adequate levels of bifidobacteria.
Interviewer/Host
That's a lot.
Dr. Sabine Haz
Is that why are we killing the bifidobacteria so much that these kids are not growing normally like they should be? What do. And not only that, but bifidobacteria decomposes plastic. Do we have a plastic problem because. And do we have a climate problem because of climate, or do we have it because we've killed so much the planet, the soil, the environment, that now we can't even. Our guts can't even decompose plastic. You know, so something is happening to humanity. When you see increased rate of cancer, increased rate of Parkinson's, increased rate of autism, and this is the time to stop and say, okay, let's stop panicking about viruses and let's start seeing what is happening to our children. Because this is a look into the future. Because if 1 in 12 boys right now have autism, in about 50 years from now, it's going to be 1 and 1.
Interviewer/Host
Geez.
Dr. Sabine Haz
And that's goodbye humanity. When one on one kid is born with the inability to speak. I'm not talking about the autism. The people that are. The kids that are on the spectrum that are geniuses. I mean, like the Mozarts of the. I'm talking about the kids that are banging their heads on the wall and cannot think, speak, or tell you what's wrong with them. That's what I'm talking about. So this is why I kind of stepped up. And during COVID I was seeing something. You know, I'm a gastroenterologist that does fecal transplant process, taking stools and implanting it into Golan. And I'm the doctor that basically has done clinical trials for pharma. I brought, you know, trials to market. I brought vaccines to market. When fecal material became a capsule, one could say I went rogue because I said, wait a minute, we're pushing Poop and we have no idea what the hell we're doing, right? This is an idea. So I'm not here to push poop, but I'm here to kind of do the research properly to say, maybe the right poop, maybe the poop of a dog, for example, when we talk about dogs and transplant, maybe the poop of a dog that's healthy, that's eating good food, that's in an amazing environment is good enough for a dog that's living in the city, that's eating junk food and could maybe fix that dog, right? Same thing with a kid, you know, So I think we need to be better. We need to do better for humanity. And so instead of rushing to just sell consumer lab test probiotics, we should just stop for a minute and say, what are we doing and how do we do better research for our kids and for humanity?
Interviewer/Host
How can people watching this take action, support you and keep up with your journey?
Dr. Sabine Haz
Microbiome Research Foundation.org is how we raise funds to do, you know, to, to take stool samples to analyze, especially of kids that cannot afford, you know, a lot of parents can afford these expensive testing, but there's a lot of kids that cannot afford. So microbiomeresearchfoundation.org Progenobiome is the research lab where all the data is written. You know, support us. I'm on X. I'm easily, you know, reachable through Instagram or X. I always answer all my messages personally and email. So if people go to Projana Biome, they can contact me directly.
Interviewer/Host
Beautiful. Check her out. Guys, thanks for coming on.
Dr. Sabine Haz
Thank you so much.
Interviewer/Host
Yeah, see you guys. All right, Sean, thanks for watching all the way to the end. Guys, please hit like and subscribe. It helps us grow the show and helps us get bigger guests. Thank you so much.
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Episode #1860 | March 15, 2026
In this episode, Sean Kelly is joined by Dr. Sabine Hazan, a pioneering gastroenterologist and microbiome researcher, for a candid and illuminating conversation about the science and significance of human (and animal) poop. Dr. Hazan demystifies the “ick” around stool, revealing its power in shaping health, driving innovation in medicine, and, yes, sometimes even creating business opportunities.
The conversation touches on the use of fecal transplants to treat disease, the wild world of probiotics and supplement fads, COVID’s surprising link to gut health, and what the latest research is exposing about the collapse of beneficial microbes in modern living. Dr. Hazan is passionate, straight-talking, and committed to raising standards and awareness about the microbiome’s crucial role in human health.
Lack of Regulation & Quality Control:
Advice to Consumers:
Contaminants in Foods:
Dog Microbiome Collaboration:
Celebrity Attention & New Food Trends:
COVID & Gut Health:
Proof of Concept in Autism:
Dramatic Trends:
Need for Better Research & Standards:
How Listeners Can Help:
| Timestamp | Topic / Key Insight | |-----------|--------------------| | 03:35 | Poop as a business (donor matching, not profit-driven for the lab) | | 05:39 | Why Dr. Hazan started studying poop – link to surprising cures and risks | | 07:53 | Environment and lifestyle dramatically shift microbes; “losing” original flora | | 11:01 | Supplement fads, fake probiotics, and food industry deception | | 12:07 | Consumer advice: judge by your own body’s response to foods/supplements | | 13:28 | Hidden food contaminants (e.g., arsenic in chocolate) | | 14:51 | Problems with commercial stool testing | | 20:42 | Fecal transplant research in dogs; mapping the healthy canine microbiome | | 23:57 | COVID-19, the microbiome, and bifidobacteria’s role | | 26:51 | Groundbreaking COVID sequencing in stool samples—as early marker and for tracking mutations | | 29:54 | Restoring bifidobacteria improves autism symptoms in case study | | 34:16 | Discussion of autism rates and modern microbiome collapse | | 38:09 | Dr. Hazan’s plea for better research, not consumer fads | | 39:01 | How to support and connect with Dr. Hazan’s work |
This episode dissolves stigma around “poop science,” making a compelling case for why your gut may be the biggest uncharted frontier in health. Dr. Sabine Hazan’s message is clear: the microbiome is foundational to wellness, yet modern living is eroding it at alarming rates. Her research and advocacy are pushing for more rigorous, ethical study—and warn against easy answers or commercial shortcuts.
Listeners are encouraged to reclaim agency over their health by demanding quality, being vigilant about products, and supporting the kind of microbiome research Dr. Hazan champions.
Find Dr. Sabine Hazan and support the cause: