
Loading summary
A
There's no such thing as a single healthy microbiome. There's many different ways of being healthy.
B
Yeah.
A
And I would say that, you know, people with very few pathways that are out of whack would be in the generally healthy category, and that's definitely less than about 5%. All bacteria are not bad guys. Yeah, most of the time bacteria tend to be good guys, but sometimes they express the bad genes, depending on the environment they're found in. So environmental factors are the majority of the contributors to chronic disease at the end of the day, and those are in your control. The people who have the lowest biological age relative to their chronological age are vegetarians. There's no such thing as a universally healthy food.
B
Yeah. No superfoods or anything.
A
Nothing. Nothing.
B
Okay, guys, founding CTO of Viome at the AI4 conference here with Guru. He's speaking in a couple hours. Thanks for coming on, man.
A
Thank you so much. Sean.
B
Yeah. What do you plan on speaking about today?
A
Well, I'm going to be speaking about rna, microbiome and AI, how those three things come together to support prevention of chronic disease and also maintaining and improving your health span.
B
Right. So the microbiome is really important.
A
Rna, microbiome and AI are all important.
B
Rna.
A
Yeah, rna. And that's really, really important.
B
Interesting.
A
Yeah.
B
Tell us more about rna. I don't know much about it.
A
So everybody knows about DNA, right? And DNA is sort of the basic blueprint for your biology. But DNA is a very static molecule. You know, you're born with it, you die with it.
B
Yeah.
A
RNA is changing all the time. RNA is the expression of your DNA. Right. So if you have. As a human, you have approximately 22,000 genes. So now you think about approximately 5% of those 22,000 genes being expressed at any given point in time, depending on what you're doing right now. You know, what you ate, how you slept, whether you're stressed or not. So that 5%, which 5% of your entire human genome is being expressed at a given point in time. That is super important. And if the wrong things are expressed, then you end up having chronic disease of different types. So RNA is basically the dynamics of your biology. DNA is kind of like the static blueprint from which the RNA is derived. And. And it's the same thing for your microbiome. So when I think about microbiome, like, think about a bacteria, right? A bacteria Approximately has about 3,000 genes. Again, 5% or less of the 3,000 genes are expressed. And you know what? All bacteria are not bad guys. Most of the time. Bacteria tend to be good guys, but sometimes they express the bad genes, depending on the environment they're found in. So it's much more important for us to measure and analyze rna.
B
Got it.
A
Than DNA.
B
Okay.
A
So when we realized this in Biome and we made the bet that RNA is going to be more important, that was back in 2016, 2017, we were way ahead of everybody else. There's really nobody in the industry who measures RNA right now. It's definitely not in our industry. Still, right now, even now, even now, we are the only company that measures rna and everybody does DNA or they do something called metagenomics, which is to look at the DNA of microbes. Right. So that will only give you a very static view of what is going on. It doesn't say what is actually active.
B
Wow.
A
It only tells you who's there. Doesn't say what they're doing. They may be doing something great, they may be doing something really terrible. You don't know the difference if you're just looking at DNA. That's why RNA is super important. And then you look at not just the human rna, but you also look at the microbial RNA and you combine the two.
B
Interesting.
A
And the way you do that is through AI. AI is so important here because the amount of data that you can get from any sample, like in Biome, we get three samples, typically for our full body intelligence, which is your stool sample, your blood sample, and your saliva sample. Right. With those three samples, you can get a tremendous amount of the RNA molecules.
C
Meaning the express genes in your gut.
A
In your mouth, in your blood. So in your gut and your mouth, it's a majority of your microbiome RNA molecules that we get. But in your blood, it's your human RNA that we get.
C
So we connect all those dots, and.
A
The amount of data we get from a given individual is like millions and millions. It's like literally tens of millions of data points for a given individual.
C
And then we select a few of them and combine the dots and create these pathways. And we measure something like 10,000 very important data points for a given individual.
A
Right.
C
I mean, you talk about companies that are out there who say they have 100 biomarkers, 150 biomarkers, whatever. They're fighting in the hundreds.
A
Right.
C
We have 10,000 biomarkers that are critical for a given individual from your stool, from your blood, from your saliva. We combine all of those things, and the only way you can do that is through AI.
B
Wow.
C
So that's what I've been doing. For the last eight years, building up the basic infrastructure, the bioinformatics, the pathway analysis, the biomarker discovery, the recommendation engines, all of those things that are required to understand the RNA and the microbiome through AI. So I'm going to put all that stuff together and talk about it in.
A
A couple of hours.
B
That is fascinating. I can't believe there's that many biomarkers. 10,000.
C
10,000 keywords. I'm talking about measuring literally tens of millions of biomarkers in your raw sample.
A
Right.
C
So we measure all of those things, then we connect the dots and we build pathways. And those pathways are based on the 10,000 key biomarkers.
B
Nice. Have you seen. So let's say someone takes a test, they get the results back. What's the next step from there? Have you seen people improve over time?
A
Oh, yes. Yeah. We've done randomized placebo control clinical trials where you have two arms, one arm gets a placebo intervention. Right. They get little supplements that have, you know, just, just inert material like water, by the way. I just, just want to say that the pathways that we measure, the 10,000 biomarkers eventually leads to recommendations.
B
Okay.
A
And the recommendations are food recommendations. There are also supplement recommendations. Right. So those are the interventions that we recommend for you as a specific individual with a specific dynamic biology where we say, okay, these pathways are looking good, these pathways are not looking good. So you can do the following changes in your, in your dietary, in your nutritional lifestyle, and you will see an improvement in those, in those pathways. Right, so now your question is, have we seen improvements? Absolutely, yes. We've seen people retesting after, you know, our recommended timeframe is about six months because it takes about six months for the microbiome to settle into a new state.
B
Got it.
A
So after six months, we see that people have changed pretty dramatically just from food and supplements. With food and supplements.
B
Wow.
A
With food and supplements. And then we do a randomized clinical trial so that we can get sort of gold standard methodology and science that we can publish. So in the last three randomized placebo controlled trials that we have done, we have an arm that is looking at just placebo supplements. Like, you know, get the same shape supplements and they just have inert substance in them. And the other group has an intervention which is coming from our algorithms, the AI algorithms. And we see that there's a significant difference in the improvement of the intervention arm compared to the control arm when it's placebo controlled. So that's the kind of, the, the call it, the Gold standard science with which we prove that our recommendations and our science at the end of the day works in a positive way for people.
B
That's exciting because with diseases, it's very important to discover them as early as possible, Right?
A
Yep.
B
So this sounds like it could be preventative.
A
This is, this is exactly the key for us, right? The earlier that you detect, the better, right. Chronic disease. Let's just talk about chronic disease for a minute. Right? So when we talk about metabolic diseases like, like diabetes and non alcoholic fatty liver disease and other things, right? These develop many years, maybe decades before it actually shows up. Cardiovascular disease, right. Before a person has a heart attack, there is probably like five years before there are markers in your blood, in your microbiome, in your oral cavity and so forth. So what we do in biome is to try to detect those very, very early markers. So we can give you the advanced warning, we can give you the early warning and say, hey, look, your pathway for, you know, TMA production is not doing great in your gut, right? TMA production can get stunned. It gets converted into TMAO when it translocates into your bloodstream and that can create plaque, it can create atherosclerosis, it can create cardiovascular disease, heart attack at the end, right? So we can detect when your TMA pathways are not optimal or suboptimal. And we can tell you up front, hey, look, there's something going on with your TMA pathways. You need to do something differently. And here are recommendations of what you can do differently. And it's all boiling down to your nutritional regimen, your regular foods that you eat. You know, some people can eat a lot of red meat and their TMA pathways are great. Some people eat red meat and their TMA pathways go haywire, right? So we can detect where your TMA pathways are and then we can say, hey, look, do more of this, do less of this, and then you're going to change the pathways and that will give you an early warning for all the chronic disease that, that we care about.
B
That's interesting because a lot of people recommend certain diets, but it could be more complicated than that.
A
Oh, you know, the critical thing that we've discovered is that there's no such thing as a universally healthy food.
B
Yeah. No superfoods or anything.
A
Nothing. Nothing. You know, I'll give you an example, right? I take this test every year or so. Sometimes I do it every nine months. But the last time I did the test, which was in May of this year, it came back and said I should not eat turmeric. Wow. Turmeric, which everybody thinks is a superfood, right? Curcumin, it's anti inflammatory. They say, hey, have turmeric, you get it in, you know, in all the coffee shops and all the smoothie shops that you go to and so on. Guess what? For me, it's not a good food. And the reason is, given my Indian heritage, right. I use a lot of turmeric in my cooking. I probably overdone it.
B
Wow.
A
And my bile acids and my secondary bile acids, right, they're all haywire. So now I need to slow down on that. I need to say, hey, listen, I don't. I should not be eating too much turmeric. And I've actually started doing that the last couple of months. I've been slowing it down. On the other end of the spectrum, my biome test came back and said I need to eat a lot more mushrooms. You know, it's a good thing for me to eat mushrooms because it's going to improve my bile acid metabolism. And so, you know, I'm not a big fan of mushrooms, but I have, I have been looking for mushrooms now. I go to restaurants, I look for mushroom dishes, I go to a grocery store, I look to buy mushrooms. And I'm eating a lot more mushrooms now. So, yeah, I mean, I change my lifestyle based on my viome results. And in many cases over the last few years, I've seen results. Like example is, you know, my oral health has been not very good, especially during COVID I did not go to the dentist for a year and a half, two years. Didn't want to, you know, you know, take the risk. But, you know, when I, when I saw my dentist in 2023, they said it was in not very good shape. I had, you know, gum inflammation. I had like the early signs of periodontitis. For the last two years now, I've been taking viome's toothpaste and oral lozenges very seriously. And I've been having that every single day as much as I can. And in the last one year, my dentist like, what did you do? It's like, how did you change your, you know, your, your whole oral environment so dramatically in the last one year? So everything has changed now. And, and I have a really good, you know, oral, dental, gum health and everything else. So that's. Those are the kinds of examples where I've literally changed my lifestyle and it makes a difference.
B
Wow. Yeah. I think we're now realizing how important oral health is recently, right?
A
Yeah.
C
Oral Health.
A
You know, people have, you know, ignored it. And it turns out there's a lot of connection between your oral health and your cardiovascular health, your brain health and so forth. So there's this bug, you know, bacteria called Porphorminus gingivalis, which is in most people's mouths. Okay. It just lives there, just, you know, normal. But for some people, the porphormis gingivalis starts to express a particular toxin called ginger pain. And if that ginger pain translocates from your oral cavity into your blood because you have bleeding gums or something like that, that can actually create a lot of havoc. It can create cardiovascular problems, it can create brain problems. There was a recent paper that showed that ginger pains are even found in your brain. Wow. And if it translocates from your oral cavity into your blood, it goes throughout your whole system, and it causes all of these other issues.
B
Jeez.
A
And also, you see, the thing is, every day we swallow our saliva, right? And we basically, in our gut, health gets transformed by whatever we are eating, whatever we are swallowing. Your digestion actually begins in your mouth, Right. So you better take care of your mouth. If you take care of your mouth.
C
A lot of other things also get taken care of.
A
So that's the lesson that I've learned in the last few years.
B
Eastern medicine says that each tooth is connected to an organization.
A
Well, you know what? I cannot tell you that. Our science says that yet. Okay.
C
It's possible.
A
You know, there's a lot of things that we're discovering every single day. But I will tell you for sure that there is a lot of connection.
C
Between your gut health, your oral health.
A
Your cardiovascular health, your brain health. Right.
C
So those connections are definitely there.
A
Whether it's a single tooth or whether it's your whole cavity, it's difficult to tell with our science.
C
But what our science says is that when you get saliva from an individual, we can measure the activity of these pathways, and we can see whether that's impacting your oral, I mean, your heart health, your brain health, and so forth. And we see that you can improve your heart health and brain health once you detect what's going on in your mouth.
B
What's your science saying about microplastics?
A
Well, microplastics are still a new area, and we haven't dug that deep into it, to be honest with you. But, you know, there's. So the first thing we do in our science is to measure all the express genes. Right. So what we would have to do soon is to measure the Impact of microplastics on the express genes, which we plan to do in a short while and we'll publish that data as well.
B
That's needed. A lot of concern with it.
A
I would agree with you. Yes, we need to do that.
B
They're finding it in every organ right now.
A
You bet.
B
The heart, the brain to stop in the particular region.
A
Yeah. Toxins from the environment. Right. Microplastics are one of the biggest things. But also pesticides. Right, Right. Also fungi in your. In your house.
B
Right.
A
There can be lots of things in your, in your. In your. Yeah. Mold. Exactly. In your household. And all of these toxins, environmental toxins, are impacting your microbiome and your microbiome is impacting your overall health, which impacts your chronic disease status. Right. That's the science that we're building step by step. Hey, this might be a good time to say that we have in viome collected more than a million samples now.
B
Wow.
A
And that is from about a half a million individuals from more than 100 countries around the world. So we are getting data from everywhere, from all different demographics, all different geographies, all different disease types and so forth. So the phenotype data, meaning the, you know, the disease symptoms, the lifestyle, the medications that people take, all of that.
D
Information is shout out to today's sponsor, Quince. As the weather cools, I'm swapping in the pieces that actually gets the job done that are warm, durable and built to last. Quince delivers every time with wardrobe staples. They'll carry you through the season. They have fall staples that you'll actually want to wear like the 100 Mongolian cashmere for just $60. They also got classic fit denim and real leather and wool outerwear that looks sharp and holds up. By partnering directly with ethical factories and top artis, Quince cuts out the middleman to deliver premium quality at half the.
B
Cost of similar brands.
D
They've really become a go to across the board. You guys know how I love linen and how I've talked about it on previous episodes. I picked up some linen pants and they feel incredible. The quality is definitely noticeable compared to other brands. Layer up this fall with pieces that feel as good as they look. Go to quince.comdsh for free shipping on your order and 365 day returns. They're also available in Canada too.
A
There along with the molecular data. So what we are able to do is now correlate what kinds of phenotypes are a result of what kind of molecular activity.
B
Interesting.
A
And we are starting to publish that data, little by little now, you bring up microplastics, you bring up other kinds of toxins. We're going to be publishing all that data from the phenotype and from the molecular activities that we already have in our data set. So our data set is, you know, on the one hand, it's providing a service to individuals so people can take advantage of it and get the right nutritional habits in place. But at the same time, it's also helping every person that comes after you because it goes back into an R and D sort of flywheel, if you will. And we are able to turn that into new insights that we can tell the next person who comes by and asks for the same question.
B
So out of the 500,000 people that have taken a viome test, what percentage of them would you say were pretty healthy, pretty good results?
A
You know, that's a, that's a very difficult question because there's no such thing as a single healthy microbiome. There's many different ways of being healthy.
B
Yeah.
A
And I would say that, you know, people with very few pathways that are out of whack would be in the generally healthy category. And that's definitely less than about 5% of the population.
B
5%.
A
Yeah. You know, that's where I would put it. Just knowing the pathways that we measure and knowing the data of our individuals. Right.
C
That's.
A
I'm talking about people who have very few pathways that are out of whack.
B
Yeah.
A
Now, there's a lot of different ways in which people's pathways can be out of whack. Okay? That means there's many, many ways in which people can be unhealthy. And we find that all the time. And we look at every individual and we say, hey, look, you are not.
C
Doing great with your sulfite production pathways.
A
Or your.
C
Methane production pathways or your short chain fatty acid pathways. So to me, the more important question is to understand what specific pathways are not doing great for any given individual and give them recommendations and insights based on that.
A
So that's what we focus on. Right. The people who are healthy, the small percentage of them for whom very few pathways are out of whack.
C
Those guys are doing pretty great for them. What we say is, hey, in order.
A
For you to maintain it, make sure.
C
That you eat the following things, make sure that you avoid the following things, because then you can maintain your great health.
B
Yeah.
C
But for the vast majority, we are.
A
Telling them, how can you bring yourself.
C
Back into some kind of a good.
B
State when it comes to out of Whack pathways. Have you seen any trends with it being genetic versus environment?
A
Well, first of all, remember, RNA is gene expression, so some people would say that is genetic in some sense. Right. But it's not genes as in your DNA, what you were born with, but it's more about what have you done with everything that you were given from nature. Right.
B
Yeah.
A
By the way, your microbiome also comes from your mom more than anyone else.
B
So the mother's health is really important.
A
The mother's health is really important because your, your micro gets transferred, you know, when you have a vaginal birth.
B
Wow.
A
Your mother's microbiome gets transferred to you. And then it's up to you how you maintain it. Right. Depends on how you, you know, build your lifestyle and what have you. Right. So the question is what. What fraction of the people have bad pathways and what do they do about it?
B
Yeah, I guess.
A
Yeah. So what we end up seeing is, you know, the work that you did to maintain your pathways may be good for a small population, but it's generally speaking, a lot of pathways are out of whack. So what we see is the out of whack pathways comes from what you've been eating.
B
Got it.
A
Right. Because whatever you eat has the substrates for basically feeding the bacteria. Right. Your bacteria are eating what you eat and then producing the outputs which are then absorbed by your intestinal lining.
B
Yep.
A
So your question is, you know, how much of it is genetic, how much of it is toxins? I would say it's. It's a majority of it is coming from your environment. Right. Your environment, to me means it is your. What you eat, what you breathe, how you manage your stress, your sleep and your activity. All of that is the majority of what we see in our pathways, because that's what determines what gets expressed and therefore what pathways are doing well and what not doing well. So the thing about chronic disease is that you go to blue zones, right?
B
Yep.
A
Their environments are so good that they generally tend to have very few chronic diseases. They tend to live very long. But you go to the developed world, you tend to have a huge prevalence of chronic diseases. Metabolic disease, neurological disease, cardiovascular disease, all these diseases, and they also tend to have out of whack pathways. So overall, my answer to your question is it's mostly your environment, not so much your genetics.
B
That's exciting, right, for a lot of people.
A
Absolutely. Absolutely. You know, the really interesting point to me is that you can change your environment. Right. You can do the things that will help you first improve your Nutrition. And maybe you can do things to change your toxins in the environment as well. You can get rid of mold, for example. You can move to places where there's fewer microtoxins in the environment. Microplastics, for example. Interesting point. People who play golf. You go to a golf course and guess what? There's a lot of pesticides, right? These are all toxins that go into your body, Right. You can decide that you want to do something different than playing golf that may help you actually manage your toxins. Right. So those are the choices that you have in your hand. So environmental factors are the majority of the contributors to chronic disease at the end of the day, and those are in your control.
B
Did you see that recent study on people that live on a golf course?
A
People? What?
B
People that live on a golf course.
A
Tell me, tell me more about it. I did see something.
B
People that live within, I think a mile of a golf course. Their lifespan was a couple years shorter.
A
Wow.
B
Just from living in that area, not surprised. Crazy, right?
A
At all. Crazy. Crazy.
B
Don't be golfing.
A
Well, that is that, you know, I, I, I love hiking. You know, hiking is another way to, you know, go out into the nature and all of that stuff. So I would definitely go h hiking instead of going golfing. But, you know, the other thing that we noticed in our VIOME data is we do something called biological age.
B
Right.
A
We kind of look at your entire top to bottom, your molecular profile and we say, how close is your molecular profile to your age? You know, you can come in and let's say you're 32 years old. Right. But if your molecular profile is close to a 38 year old, we tell you that your biological age is 38 years old years. Instead, it could be 28 year old, right. You could, you could biologically look very similar to a 28 year old. Right. We tell people all of that stuff right? Now, we did a study in VIOME where we said, hey, let's look at the biological age of all of the people with certain dietary habits.
B
Yeah.
A
We said as a group, are people who do ketogenic diets younger or older than their actual age? All the people who do vegan diets, are they younger or older than their chronological age? Right. And these are not small groups. Because biome has such a big population. We have thousands of people who are in any one of these subgroups that we measured. Right. Here's the interesting thing we found. The people who have the lowest biological age relative to their chronological age are vegetarians.
B
No way.
A
Vegetarians, which is a combination of plant based foods, but a little bit of animal foods as well. Right. You can have yogurt, for example, you can have, some people have eggs and so on and so forth. Vegans have a little bit less in terms of the difference between their chronological and biological age. On the other side of the spectrum, people who come in with very heavy meat based diets like Paleo, Paleo or keto or something, they had biological age that is greater than their chronological age. And we published this data in one of the papers that we've recently picked up. So it tells you, right. Your lifestyle matters. And when you look at all of the AI techniques that we've used to build these biological aging models, the AI is looking for generic patterns. It's not being biased. It's given all the data that we already have from a very large population. We're just asking the question, hey, tell me more about what is the difference between people with certain diets and people with certain other diets. And you can see a very stark difference between, you know, these categories of.
B
People that is shocking to me. Wow, I'm really shocked with that. I thought carnivore diet was healthier than vegetarian.
A
Yeah, you know, it's, it's actually very now well established that plant based, you know, fibers, which are prebiotics. Right. Are a very good input to your, your microbiome.
B
Yeah.
A
Right. So many short chain fatty acid producing bacteria. Look for these, you know, hard fibers to break down and convert that into butyrate and propionate and acetate and so forth. Right. So those are the short chain fatty acids which are very good for you for many things. Energy, for anti inflammatory effects and so on and so forth. So it's pretty well known that roughage makes a difference, but a lot of people take that to the extreme and they make it, hey, you know, let me go vegan. Right. Turns out that, you know, vegetarian, meaning there's a slight amount of, you know, balance between the plant based and animal based food that's actually, you know, the best, according to our data. Right. I mean, you know, there could be other studies that show other things, but in our, you can go look at our iScience paper where we publish all these numbers. We're talking about 2, 3, 4,000 people in each of these dietary categories.
B
Yeah, yeah. And was it a significant age jump from biological to chronological?
A
Yeah. For, for vegetarians it was something like two to two and a half years difference.
B
Wow.
A
Between their chronological age and biological age being lower.
B
Yeah.
A
And for People with heavy ketogenic and paleo kinds of diets. It was in the opposite direction. Two and a half years older. So than their chronological age.
B
Five year difference. Wow. Five year difference. Yeah, yeah. Do most people have a higher biological age than their real age out of all your results?
A
Well, you know, the distribution of the differences between chronological and biological age is like a bell curve.
B
Yeah.
A
So a lot of people are pretty close to their chronological age, but there's a few people who are further away in one direction, further away in the other direction. So it's like that bell curve.
B
Right, got it.
A
And it's approximately about five years as a standard deviation from the mean.
B
Yeah. Because Brian Johnson is 18.
A
Okay. All right.
B
You know what that is?
A
Yes, yes. I've heard the name before and I've seen the kind of biohacking and everything that he does.
B
That's incredible. To be. I think he's almost 50. Chronological age, but to be 18, biological, that's pretty amazing.
A
I need to go look him up a little bit more and see what exactly he does. He's vegetarian. Yeah. And you know, there's a lot of people who take a ton of different types of supplements.
B
Yeah.
A
And there are some people I know who take dozens. Right. Like, you know, 50 different supplements every single day. And you know, that's, that's quite a lot. It's like, you know, eating breakfast full of, you know, full of supplements. Right. So, yeah, I mean, there's many things that are known to improve your, your, your lifespan and your biological age and so forth. So I'm sure Brad Johnson is doing a lot of those things.
B
Shout out to him what's next for viome? Where could people find you guys and buy, buy the test kit and everything.
A
Yeah, yeah. I want to leave you all with a few pointers here. So any consumer in the world can buy Vaiome by going to viome.com so get our premier test. It's called Full Body Intelligence. It will take three samples from you.
C
Stool, blood and saliva.
A
And it gives you a ton of.
C
Insights, it gives you a ton of recommendations.
A
And based on that, you can either.
C
Follow the food recommendations or you can take supplements and you can take biotics.
A
You can take toothpaste, you can take.
C
You know, all kinds of lozenges, everything.
A
That'S made for you specifically.
C
So it's customized for you based on what we discover from your samples.
A
Right. So that's for consumers. Now people can go to, let's say.
C
An entire wellness program in a company.
A
Right.
C
You can, you can have people take biome tests as a way to prevent chronic disease.
A
That can improve. We just did a pilot where we.
C
Saw that people improved their productivity, people improved their happiness, people improved their gut symptoms, people lost weight. They lost an average of about 10 to 12 pounds in a six month period.
B
Wow.
C
Taking, taking the VIOME supplements.
A
Right. So the whole VIOME program. So it's super, super cool.
C
And most recently, what we've done is we've created, created a pro version of the VIOME full body intelligence test.
A
It's called Precision Health Pro, which can.
C
Only be ordered by doctors.
A
So if you prefer that you don't want to do it yourself at home.
C
You want to get it through a doctor to go talk to your doctor and your doctor can implement it and.
A
They can order it for you.
C
And once they order it for you, they get a result on their side as well. They can interpret all the results. In fact, they get a lot more depth of data because they're trained. They can get better interpretation of things. You also get, as an individual patient or an individual who is looking to prevent chronic disease, you also get a lot of information on an app, but your doctor gets a ton more information. So they can interpret that for you and give you some suggestions for what you can do and what you need to do.
B
Right.
C
So that's called Precision Health Pro. So that's a new product that we've just launched and that is for healthcare providers to provide to their patients as well. So that is a clinical grade tool, whereas the other one is a consumer grade tool that we can give to anyone and everybody in the world. And as I said before, people from more than 100 countries have taken it. You can take advantage of it. Everybody who's listening to this can take advantage of it. Go look@biome.com, look for full body intelligence.
A
And you'll get it.
B
I can't wait to try it. Thanks for your time today, man.
C
Thank you so much.
B
Check them out, guys. See you next time.
D
I hope you guys are enjoying the show. Please don't forget to like and subscribe. It helps the show a lot with the algorithm.
B
Thank you.
Guest: Guruduth Banavar (Founding CTO of Viome)
Host: Sean Kelly
Episode Title: "Why Your DNA Doesn’t Decide Your Health"
Release Date: December 23, 2025
This episode dives deep into the science of the microbiome, gene expression (RNA), and artificial intelligence (AI) as pivotal factors in health and longevity, challenging the conventional wisdom that DNA is the primary determinant of health. Guruduth Banavar discusses how environmental factors, lifestyle, and personalized nutrition—rather than genetic inheritance—shape our health outcomes and risk for chronic disease. He shares groundbreaking insights from his work at Viome, including their innovative, AI-driven approach to analyzing the dynamic microbiome and RNA markers for early detection and prevention of chronic disease.
[00:00–01:32]
[01:19–05:41]
[05:41–07:41]
[07:41–09:26]
[09:31–11:58]
[12:03–13:51]
[17:35–22:45]
[23:22–27:07]
[28:42–31:07]
| Timestamp | Segment Topic | |-----------|-------------------------------------------------------| | 00:00 | No universal healthy microbiome, dynamic individuality | | 01:19 | RNA vs. DNA and why expression matters | | 03:23 | Limitations of DNA (static) vs. RNA (dynamic) in tests| | 04:41 | Power of AI in analyzing vast health data | | 05:47 | Clinical trials: food and supplement interventions | | 07:47 | Early detection of chronic diseases and pathway focus | | 09:35 | Debunking superfoods and personalized recommendations | | 12:04 | Oral health’s systemic connections | | 17:35 | Viome data on health in global sample | | 19:23 | Microbiome inheritance, maternal importance | | 21:47 | Environmental factors dominate over genetics | | 23:22 | Measuring and understanding biological age | | 24:35 | Vegetarians lowest biological age; dietary study | | 28:42 | Viome consumer and professional offerings |
This episode reframes the conversation about health away from genetic determinism and towards actionable, individualized interventions based on real-time gene expression and lifestyle factors. Listeners are encouraged to take charge of their health through precise, science-based insights made possible by innovations in microbiome analysis, RNA data, and artificial intelligence.
For more, visit viome.com and explore both consumer and clinician pathways to personalized preventative care.