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A
People with bleeding gums, poor oral hygiene, had higher heart attacks and strokes. So the solution back then, well, let's kill all the bacteria. But now, fast forward 100 years, we know that there's a microbiome. There's bacteria that live in the mouth, on the skin, in the gut. And if we kill these good bacteria, it causes systemic disease. So we know better, and we got to do better. But yet two out of three Americans still use mouthwash. Probably 99 out of 100 people are using fluoride in their toothpaste, and it's causing complete dysbiosis. Fluoride's a neurotoxin. Decreases IQ in kids by as much as 7 points. There's no benefits. It's all risk. So get rid of it.
B
All right, guys, here at A4M, we got Dr. Nathan. Brian. It's been almost two years since you came on, I think.
A
Is that right?
B
Crazy, right?
A
Time flies.
B
Time flies. You got a book now, man.
C
You're an author.
B
Congrats.
A
That's like my fifth book, I think, but that's the latest.
B
Wow. What was inspiration for this one?
A
You know, really to bring people up to date on the science of nitric oxide. So this book, it tells the story of nitric oxide, what it is, how it's produced, why people should be concerned with it. But it's not just a scientific book, but it kind of interlays my personal journey, who I am, my personal journey of discovery, and then how we've been able to take the science of nitric oxide and translate that into clinical medicine, product technology that actually restores the body's ability to make it.
B
Yeah. When I think of nitric oxide, I literally picture your face now. That's how, like.
A
Well, my. My p. My PR and media and agents done a good job then.
B
That's how I feel like you've positioned yourself when. When people think of nitric oxide, though.
A
Well, Look, I spent 25 years in academia. I mean, I spent my entire adult career studying this single molecule. And, you know, I've always believed that to be successful, do one thing, and do it better than anybody else in the world. And so that's what we've done.
B
Yeah. Any new studies or things since the last time you came on in regards to nitric oxide?
A
Well, we're moving the field forward. We've got drugs now for heart disease that we're developing through the fda. We've got a drug for Alzheimer's which I'm convinced will completely eradicate Alzheimer's. Really, Nick Oxide Drug therapy.
B
Wow.
A
Because Alzheimer's is a vascular, metabolic disease that leads to protein misfolding. So it's. It's hypoperfusion of the brain, it's insulin resistance in the brain, which we call diabetes type 3. And what does nitric oxide do? It dilates the blood vessels, it improves glucose uptake, it improves mitochondrial function. When you get the cells of the brain, the oxygen, the nutrients, and activate their mitochondria, then you don't get misfolding of proteins and you don't lose cognition.
B
That's very interesting.
A
That's what nitric oxide does.
B
Because they say Alzheimer's starts when you're very young. Right. Like you start building it up in your 20s and your 30s.
A
Well, it's. I mean, there's. There's risk factors. So everything that we know, risk factors that are associated or lead to a loss of nitric oxide production increase your risk for developing dementia and Alzheimer's. So what is that? High blood pressure, erectile dysfunction, smoking, poor diet, sedentary lifestyle. All those decrease nitric oxide production. The end result is lack of blood flow, gluc, insulin resistance, and then eventually Alzheimer's.
B
Yeah, you're seeing a lot of Alzheimer's and a lot of erectile dysfunction too, these days.
A
Yeah. So all erectile dysfunction precedes dementia and Alzheimer's?
B
Oh, it does.
A
So it's like a. Yeah, it's what we call the canary in the coal mine. Because think about it. Erectile dysfunction is the lack of the ability to dilate the blood vessels of the sex organs. So when we need to recall memory or have some executive function, we've got to dilate, we've got to perfuse certain regions of the brain. So if you can't dilate the blood vessels, the sex organs, when you're going to have sex, then you can't. That same dysfunction occurs in the brain, cerebral. So now you've lost the ability to dilate blood vessels, increase blood flow on demand, and that's what nitric oxide does. So ED is a risk factor for development of heart disease, Alzheimer's, diabetes, and it's all related to those two. Lack of nitric oxide.
B
Yeah, that makes a lot of sense. So it's like a precursor for.
A
Sure.
B
And there's guys in their 20s with it now.
A
No, look, and here's the. The therapeutic solution is drugs like Viagra and Cialis, the PD5 inhibitors. But we know that those drugs only work in 50% of the men in which they're prescribed. So 50% of the people that have ED. Men who have ED don't even get a therapeutic benefit from drugs like Vagrant. But yeah, and what we've discovered is that drugs like Vagra are dependent upon the body's ability to make nitric oxide. So in these people who don't respond to Viagra, their body doesn't make any nitric oxide to activate that second messenger system which Viagra can, can enhance or potentiate. So that told us, you know, 20 years ago, erectile dysfunction is a symptom of nitric oxide deficiency and we have to treat it as such.
B
I don't personally ever want to take Viagra. Did you see Dan Bazarian talk about his experience with it?
A
No, I missed that. Oh, you missed that. Look, these are, I mean, the goal of medicine should be to never prescribe drugs, understand the root cause of disease, and, and implement what we call restorative physiology. Give the body what it needs, remove the body from it, what, what it doesn't need, and then the body heals itself.
B
Right.
A
And in that paradigm, there is no need for drug therapy. And that should be our goal.
B
That should be the goal. Yeah. But instead we got average elderly person on what, over 10 medications?
A
Yeah, at least. I mean, we did a Covid drug study during COVID from 2020 to 2023. And some of these patients that we enrolled in our clinical trial were on 24 different medications.
B
Oh my God.
A
50 to 80 year old people on 15, 20, 24, 2. I mean, and they wonder why they're sick. When your body's exposed to 24, 25 different synthetic compounds that inhibit normal biochemical reactions the body can't perform because there's
B
a side effect for each one they take, Right?
A
That's right.
B
So then they got to take another one.
A
It's a vicious cycle.
B
Crazy. 24 is insane, though. Like, why would you wake up and rely on 24?
A
These people are zombie like, and they wonder why they're kids, susceptible to viral disease and have all these other comorbidities. I mean, we got to do better. We understand the mechanism, disease to the extent that we can eliminate drug therapy and fix it, address root cause. You know, that's one of the benefits of the A4M because we're, we're addressing root cause and really getting to longevity medicine.
B
Yeah, Part of me feels for them because they're, I feel like that generation really trusts doctors. Like, they really value their opinions, you know, and they'll just as soon as they say, like, you need to take this, they're like, yeah, let's Start taking that.
A
Well now, that's been the problem. We've been conditioned to trust doctors, never question doctors, and we have to question everything now. I mean, the goal of medicine should be to understand what's causing the symptoms, not treat the symptoms with drug therapy, but then correct, take corrective measures. Because we know diet and lifestyle is key. Yeah, but you know, we've been conditioned to, you know, just take a pill. You don't have to change your diet, you don't change your lifestyle. We're just going to give you this pill and that's easy. But health is not easy. I think it's simple, but it's not easy.
B
Respect for saying that, first of all, because you are literally a doctor and
A
we have to do better. I taught in Medical School for 15 years teaching future physicians. And you know, we understand the biochemistry and the physiology to the extent that we have to address what's causing people to get sick. And all you have to do is look at the numbers. We have the most advanced civilization in the history of the world and yet we have the sickest people on the planet. Americans are the sickest people. And why is that? It's because most of getting people get sick, get symptoms and we take drugs. But we never address the root cause of. Wow. We get sick or don't optimize our human physiology.
B
Valid point because I think during the pandemic, didn't we lose either the most or the second most out of any country?
A
You know, I don't even know what numbers to believe. Yeah, I don't believe anything that happened during COVID You know, the so called experts, you know, I think we were
B
duped because they were labeling a lot of deaths as Covid. So it's hard to know.
A
Yeah. Seasonal flu. During those three years of COVID there was not a single death due to influenza.
C
Right.
A
And every year we know 20 to 60,000 people die of influenza. But the same people who got sick and died from COVID were the same people sick and died from flu for the past 100 years.
B
Right.
A
There's known risk factors and what we found is that the people who are nitric oxide deficient were the people who get sick and die from flu. People got sick and died from COVID So let's address restoring nitric oxide production, mitigate those risk factors and make you resistant to viral infections. I've never had Covid.
B
Wow.
A
I didn't get the shot, I didn't wear a mask. I was exposed to Covid and I've never had Covid.
B
Were you on. Can I ask if you were on nicotine?
A
I never took nicotine.
B
Okay. Because I know there was some studies on people that were taking nicotine were a little more immune.
A
Well, I think for us, what we'd recognize is that the Spike protein binds to the ACE2 receptor. And so in people who are nitric oxide deficient, there's an upregulation of the ACE2 receptor. So there's more binding sites for the spike protein. People who take nitric oxide like me, or who are nitric oxide replete. The ACE2 receptor is downregulated, so we may be exposed to Covid or the Spike protein, but there's no, there's no receptor for it to bind to. So we become resistant to viral infections. Wow.
B
Just by having proper nitric oxide.
A
That's right. And understanding the, the signaling aspects and downregulation of adhesion molecules, decreasing inflammation, oxidative stress and immune dysfunction and allowing the immune system to go. Because we, We've known since 2005 that nitric oxide prevents coronavirus replication. That was SARS CoV1, SARS CoV2 or COVID19 is basically the same mechanism. So it prevents viral replication. And it's how our innate immune system works. Similar to bacterial infections. If we get a bacterial infection, our immune system is mobilizing. We generate nitric oxide, it binds to the iron sulfur centers of the bacteria, shuts down the respiration and kills it. But if you can't make nitric oxide, if you don't have a good immune system, a good cardiovascular system, the, the bacteria or the viruses become immune to the cardiovascular system because poorly vascularized tissues are more prone to infections. So for me it's been all about blood flow and circulation.
B
And that's what happened to their pandemic. Everyone's immune system was weakened.
A
Staying inside all the, and everything that the so called experts were recommending made us more susceptible. Yeah, you know, social isolation, wearing masks, rebreathing carbon dioxide, using antiseptic, you know, antibacterial wipes, sterilizing our environment.
C
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A
Quantumupgradeio Using mouthwash, everything made us more susceptible. And it was a vicious cycle that made no sense from a biochemical physiological standpoint.
B
You got me off mouthwash the first time you came on, by the way. I never drank.
A
It's always, you know, for 30 something years. I published over 100 peer reviewed papers and you know, we made this observation that, you know, there's oral bacteria that are responsible for the production of nitric oxide that are regulating blood pressure. So anything that kills oral bacteria will decrease nitric oxide production and cause an increase in blood pressure. But that's the, that's the headline grabber. Yeah, this causes high blood pressure.
B
Yeah, because it's something that just everyone did growing up, you know, no one questioned it. No one questioned brushing with fluoride, growing up or using mouthwash.
A
I know, but you get, look, I always look back and say, why were we doing this? Why was this ever introduced? And I think it was with good reason, because a hundred years ago was first this oral systemic link. People with bleeding gums, poor oral hygiene, had higher heart attacks and strokes, incidents of heart attack and stroke. So the solution back then, well, let's kill all the bacteria, let's use chlorhexidine, let's use fluoride, and let's sterilize the oral environment. But now, fast forward 100 years, we know that there's a microbiome. There's bacteria that live in the mouth, on the skin, in the gut. And if we kill these good bacteria causes systemic disease. So we know better and we got to do better. So we have to support the microbiome today. We know that we can't destroy it, but yet 2 out of 3Americans still use mouthwash. Probably 99 out of 100 people are using fluoride in their toothpaste and it's causing complete dysbiosis. Fluoride's a neurotoxin. Decreases IQ in kids by as much as seven points down. There's no benefits, it's all risk. So get rid of it. We have to get rid of it.
B
That's terrible. Seven points.
A
Yeah. No, that study was published last year in September.
B
Dude, that could like ruin your life in certain situations. That's a lot. That's a lot of intelligence.
A
Go and kids early on.
B
Yeah.
A
If the. I don't think you recover from that.
B
It's hard. It's really hard, they say to gain IQ back or gain IQ at all, you know? Jesus, seven points is terrible. But even if they remove from the top water, it'll still be everywhere, right?
A
I don't think so. You know, when you look at risk, benefit, because everything we do in terms of medicine, a public policy. It's public policy. It's what is the benefit this can provide and at what risk? And now the data are very clear. There's no benefit to fluoride. It doesn't improve teeth mineralization, it doesn't prevent cavities. So if there's no benefit and there's risk, what's the risk? It's a neurotoxin. It shuts down your thyroid function, it's antiseptic and it lowers iq. So eliminate it from this. Any source of exposure, dentists got to get rid of it in their practices. The municipalities. 73% of municipalities in the US have fluoride in their drinking water. You must remove it and get rid of fluoride and toothpaste and then people will get better.
B
We got uranium in our top water here.
A
Okay. Yeah, yeah. No, look, I think that's why it's so important for people to have home filtration systems.
B
For sure.
A
Filter the water. Because look, the water, it's not just the water we're drinking, it's the water we're bathing in. The water we cook in. And so water is extremely important.
B
It's everywhere.
A
Yeah.
B
When you shower, you absorb a pint.
A
When you come, that's even worse because you're heating it up to 104, 110 degrees. Now you're volatilizing it.
B
The chloride, the fluoride, you're inhaling it, Right?
A
Yeah.
B
That's why steam rooms anymore.
A
Yeah.
B
I used to love them, but they're using tablets.
A
The water supply. Yeah.
B
Yeah. So hell no. What's the biggest thing to look out for other than fluoride, do you think?
A
I think the big culprit are antacids. Antacids? Antacids. That what we call proton pump inhibitors. These are the prescriptions are omeprazole and pentoprazole. And then the over the counter proton pump inhibitors are things like Prevacid, Nexium, Prilosec These drugs are causing a 40 increase in heart attack, stroke and Alzheimer's.
B
Holy.
A
And it's because they're completely inhibiting nitric oxide production. And yet there's 200 million prescriptions written for antacids every year. Two out of three Americans using these over the counter. You don't even have to have prescription for these drugs. And they're causing death and destruction.
B
Oh my God. That's crazy. 200 million a year.
A
You saw 200 million prescriptions just in
B
the U.S. that's like 2/3 of the population.
A
No, that's right.
B
That's insane.
A
And people, people have been on these antacids for years. Decades. And the data show that if you've been on them for at least three years, 40% greater incidence of heart attack, stroke and Alzheimer's. And people take these just like candy. They're popping candy every day.
B
How reversible is that damage if they're
C
on it for years?
A
Well, here's the problem with those drugs is you can't just quit them cold turkey. You have to wean off of them because you're going to get a hyper secretion of stomach acid and it's going to make your life very miserable. So we have to start implementing protocols to slowly wean off. Because you need stomach acid to break down proteins into amino acids. You need stomach acid to absorb B vitamins, calcium, zinc, iodine, selenium, chromium. And so you become nutrient deficient if you're on antacids and then you're inhibiting nitric oxide production. So it's, it's the perfect recipe for chronic disease. If I wanted to completely destroy one's life and physiology, the first thing I'd do, put them on a proton pump inhibitor. Second thing I would do is get their cholesterol below 200. Get give them a cholesterol lowering medication. Third thing I do is put fluoride in the drinking water. And that's our healthcare system.
B
Yeah, the statins are crazy.
A
Statins.
B
Yeah, that's the whole debate.
A
It makes you completely dependent upon pharmaceuticals for the rest of your life. And it's a great business model, it's a great financial model, but it's at the expense of our own health.
B
It's a great model because they always
C
talk about the heart and everyone worries about their heart.
B
So as soon as they're like, you got heart issues, take a stand. They're like, yeah, let me get that. You know.
A
Yeah. But if you look at the data, if someone who's knows how to Read clinical trial data and look at the absolute risk, the number of patients to treat, to see an effect, versus the relative risk, what they report. There's no benefit to cholesterol, cholesterol lowering medication either. In primary prevention of heart attack, secondary tertiary prevention, there's zero benefit. So again, it goes back to the question, if it's no benefit, then okay, what's the risk?
B
Right.
A
The risk is muscle cramps and pains, myalgia, diabetes. These statins are mitochondrial toxicants because they're causing certain cancers. So if there's no benefit and it's all risk, that's a very easy quotient. You don't give it to anybody. The data are very clear. So cholesterol doesn't cause heart disease. Why would you target it if it's not the causal agent? And it doesn't. So, you know, that's, that's early on, in the 80s, that was the prevailing hypothesis. But again, science prevails. Data are the data. And it's clearly shown that lowering cholesterol does not prevent heart disease. So why treat it?
B
So many people think the two are linked, cholesterol and heart disease.
A
Yeah, because that's what the American Heart association and all the American Medical association and Big Pharma has ingrained in our mind for the past 30, 40 years.
B
Cheerios.
A
Cheerios.
B
I always associate cherries.
A
There's a reason. Look, I'm trained as a biochemist and physiologist. There's a reason our body makes cholesterol because we need it. If you can't make cholesterol, you can't make testosterone. Women can't make estrogen, you can't make vitamin D, you become immunocompromised. And we have an epidemic of men with low testosterone, women with hormone disorders, an epidemic of immunocompromised people because they have vitamin d in their 30s, you know, below 50, which makes them immunocompromised.
B
I think my high LDL or LDL cholesterol is out of thing. I think mine was like 111. They said that was high.
A
Yeah, but look, the standard lipid panel looking at cholesterol, LDL and HDL, has zero prognostic or diagnostic value. Zero. It's not predictive, it's not diagnostic. What you have to look at are the different kind of advanced lipid panel. What's the amount of oxidation that's occurring to the lipoprotein particles, the particle size, number and density.
B
Got it? Yeah, I don't think they measured that.
A
No, they don't all they do is give you total cholesterol, ldl, hdl, and then try to treat you to normal.
B
Yep. They tell you to stop eating eggs.
A
Stop eating eggs. Yeah. I don't want. If, if normal is the general population. I don't want to be normal.
B
I hate how they always compare your blood results to the normal range.
A
But that's. But what is normal? It's a bell curve. It's 95 confidence intervals within 95% of the population.
B
I don't want to be that.
A
No. All you got to do is walk around and look. Do you want to be like 95% of the people that walking around? 95% of people walk around are metabolically unfit. 93% of Americans are metabolically unfit. 2 out of 3Americans have high blood pressure. 2 out of 3Americans are obese or overweight. I mean, count me. I don't want to be normal.
B
Base.
A
Yeah. I don't want to be normal if that's normal. I want to be optimal.
B
Crazy. I wonder what the healthiest country is. It's got to be like that.
A
Data is out there. I don't know what it is.
B
Mediterranean diet. Somewhere in Europe, I'd imagine.
A
Maybe.
B
Maybe Japan or Asia.
A
I think Japan certainly. I mean they have the, I think the highest number of centurions. People live greater than 100. I don't know what their overall kind of health span is.
B
Country would be tough because there's so many different cities and, and.
A
Yeah. And now the whole world is a melting pot. Right. We've got convergence of cultures and different ethnicities.
B
Yeah.
D
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C
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D
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B
So when you started speaking out against all this because you said you were teaching for 15 years, did you lose your job? Like what happened there?
A
So the discoveries we made over the past 25 years have starting to be fundamental truths. Right. These are truths based on normal physiology. And I like this quote by Schopenhauer from 1600s. Truths go through three stages. They're opposed.
B
Yeah.
A
Or they're, they're, they're ridiculed, they're violently opposed and it's accepted as being self evident. So obviously I was ridiculed early on. My academic colleagues. I left academia because I knew that I didn't want to put my technology in the hands of other companies to see it forward. So I left academia to become an entrepreneur, started companies and then I productized, commercialized my discoveries. But I kept a, you know, kind of a presence in academia for probably five or six years. But then it's very difficult to do two jobs, be a full time professor of medicine, be an entrepreneur running companies. So I made a decision to step aside from academia and run these companies. But you know, as we've progressed the technology competitors have entered the market and you know, it's, they've come after me. I've been sued personally, my company's been sued.
B
For what?
A
For telling the truth and identifying products that don't work. Because when companies that do not understand the science of nitric oxide really have no business commercial or selling a nitric oxide product because they don't understand the science. It's not like a vitamin C or vitamin D. We can put in a capsule and give it to you and treat a number. If your vitamin D is 30, we'll give you a vitamins D and get to 80 or optimum. Nitric oxide is a gas. It's gone in less than a second when it's produced. So unless you understand how the body makes nitric oxide and how to what leads to a loss of its production, then these companies out there have no business selling a nitric oxide product. Because it's a complex science.
B
Yeah.
A
So when I started I started testing products, nitric oxide products and revealing that they didn't work. They didn't like, they didn't like that. No, because these, there's, you know, this is a big industry.
B
I can't believe you could sue for that though because you're literally factually testing it and showing the results. It's not like you're defaming them.
A
No. Well, that there's Luck. Anybody can sue anybody. Right. Whether there's merit to it or not. So look, we defend, we stand on truth, we defend our science. And you know, it's a very, it's, it's a business strategy. Big companies sue little guys all the time to deplete them of the resources. It's the art of war and it's a business strategy.
B
Yeah.
A
You know, we stand on truth and we've survived it and we're, we're moving forward.
B
I love it. Where can people watching this get some product? I think we have a discount code that we set up.
A
Yeah. So the product technology can be found@n101.com my company is called Brian Therapeutics and we're developing drug therapy. But we have a consumer line of products with an in101 brand. We make a lozenge, we make a fermented be powder for pre workout and energy. We make a complete skincare line of products. I developed a nitric oxide friendly toothpaste, fluoride free, targeting the microbiome, improving the diversity, improving nitric oxide production. Yeah. So N101.com that's the letter N number one, letter O. Number one code DSH.
B
I believe we said.
A
Yeah, coupon code DSH.
B
Perfect.
A
And then. Yeah. I've got a new book I just published in February. We launched it on Fox and Friends in New York and nice Brick Tower Press and my agent Alan Morrell made that happen. But yeah, it tells the story of nitric oxide. Kind of my personal journey of discovery. So I think it's a must read. People need to know what nitric oxide is and understand its importance.
B
Beautiful. Check out the books, guys. Check out the products. I use the toothpaste and I love it. So thank you, man. Good to see you again.
A
Yeah, good to see you.
B
See you soon. Yeah, see you guys.
D
I hope you guys are enjoying the show. Please don't forget to like and subscribe. It helps the show a lot with the algorithm.
A
Thank you.
Episode: Is Toothpaste Hurting Your Child’s Brain? | Dr. Nathan Bryan | DSH #1840
Host: Sean Kelly
Guest: Dr. Nathan Bryan
Date: February 27, 2026
In this compelling episode of Digital Social Hour, Sean Kelly welcomes back Dr. Nathan Bryan, a leading expert in biochemistry, physiology, and nitric oxide research, to discuss the dangers lurking in everyday oral health products and the broader implications for health. Dr. Bryan passionately reveals how mouthwash, fluoride, antacids, and statin drugs may be contributing to systemic disease, decreasing IQ in children, and perpetuating chronic illnesses. The conversation spotlights the critical role of nitric oxide in health, flaws in mainstream medicine, and why challenging conventional wisdom is essential for longevity.
Oral Microbiome Misconceptions (00:00, 11:41)
“If we kill these good bacteria, it causes systemic disease. So we know better, and we got to do better.” — Dr. Bryan [00:05, 11:41]
The Dangers of Fluoride (00:13, 12:42)
“Fluoride's a neurotoxin. Decreases IQ in kids by as much as 7 points. There’s no benefits. It’s all risk. So get rid of it.” — Dr. Bryan [00:21, 11:41]
“That study was published last year in September.” — Dr. Bryan [12:44]
“Dentists gotta get rid of it in their practices. The municipalities. 73% of municipalities in the US have fluoride in their drinking water. You must remove it…” — Dr. Bryan [13:06]
Sean’s Reaction (12:42-12:56)
“Dude, that could like ruin your life in certain situations. That’s a lot. That’s a lot of intelligence.” — Sean Kelly [12:44]
What is Nitric Oxide? (00:49, 01:21)
Nitric Oxide and Disease Prevention (02:00, 02:25)
“Alzheimer’s is a vascular, metabolic disease…What does nitric oxide do? It dilates the blood vessels, it improves glucose uptake, it improves mitochondrial function.” — Dr. Bryan [02:01]
“All erectile dysfunction precedes dementia and Alzheimer’s.” — Dr. Bryan [03:00]
Root Cause Medicine (04:34, 06:03)
“The goal of medicine should be to never prescribe drugs, understand the root cause of disease, and… implement what we call restorative physiology.” — Dr. Bryan [04:34]
Prescription Overload (04:59, 05:24)
COVID-19 Reflections (07:12–08:46)
Dysfunctional Pandemic Advice (09:40–10:57)
Antacids (Proton Pump Inhibitors) (14:29–15:07)
“They’re causing a 40% increase in heart attack, stroke, and Alzheimer’s…[and] completely inhibiting nitric oxide production.” — Dr. Bryan [14:50, 15:13]
Statins and Cholesterol (16:17–17:10)
“Statins are mitochondrial toxicants because they’re causing certain cancers. So if there’s no benefit and it’s all risk, that’s a very easy quotient. You don’t give it to anybody.” — Dr. Bryan [16:58]
Standard Health Markers (18:20–19:27)
Lifestyle and Optimal Health (19:39–19:59)
From Academia to Entrepreneurship (21:01–21:59)
“We defend, we stand on truth, we defend our science… Big companies sue little guys all the time to deplete them of the resources. It’s the art of war and it’s a business strategy.” — Dr. Bryan [23:03]
Consumer Solutions (23:26–24:02)
On Fluoride as a Neurotoxin:
“Fluoride’s a neurotoxin. Decreases IQ in kids by as much as 7 points. There’s no benefits. It’s all risk.” — Dr. Bryan [00:21, 11:41]
On Modern Medicine:
“The goal of medicine should be to never prescribe drugs, understand the root cause of disease... in that paradigm, there is no need for drug therapy.” — Dr. Bryan [04:34]
On Nitric Oxide’s Importance:
“When you get the cells of the brain, the oxygen, the nutrients, and activate their mitochondria, then you don’t get misfolding of proteins and you don’t lose cognition.” — Dr. Bryan [02:10]
On the Pharmaceutical Model:
“If I wanted to completely destroy one’s life and physiology, the first thing I’d do, put them on a proton pump inhibitor. Second thing I would do is get their cholesterol below 200. Get give them a cholesterol lowering medication. Third thing I do is put fluoride in the drinking water. And that’s our healthcare system.” — Dr. Bryan [16:03]
On Rejecting “Normal” Lab Values:
“If normal is the general population, I don’t want to be normal.” — Dr. Bryan [18:55]
Dr. Bryan’s urgent message—question established health advice, protect the oral microbiome, reject fluoride and unnecessary medications, and prioritize the body’s natural regulatory molecules—is both provocative and empowering. The episode challenges listeners to revisit the fundamentals of health, advocating for informed skepticism, self-advocacy, and science-based personal choices. For those who want practical takeaway, Dr. Bryan offers alternative oral care and supplement solutions at N101.com and details his research and journey in his latest book.
To learn more, check out Dr. Bryan’s new book and microbiome-friendly products at N101.com (code: DSH).