
What if one of the most promising discoveries in health is also one of the most misunderstood? Molecular hydrogen has been studied for years, yet most people have never heard of it. While some call it the future of wellness, others say the research isn't there yet. So what's the truth? In this episode of Digital Social Hour, Sean Kelly sits down with Tyler W. LeBaron, molecular biologist, researcher, and founder of the Molecular Hydrogen Institute, to discuss the science behind molecular hydrogen, how it works inside the body, and what current research actually says about its potential benefits. Tyler explains why molecular hydrogen is different from hydrogen water myths, alkaline water, and many of the exaggerated claims circulating online. He breaks down how hydrogen interacts with the body's cells, why it's able to reach the mitochondria so efficiently, and why researchers are studying its role in inflammation, exercise recovery, metabolic health, cardiovascular function, and...
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Science is all about being self correcting and changing its position to be in line with the evidence and being improving by friction, by people being curious and asking questions like explain this, how do you explain that? What about this? That's how science works. And that's the nice thing about molecular hydrogen is it is the smallest molecule and so it can easily penetrate hydrogen gas. Because it's a neutral and non polar molecule, it's easily able to diffuse right through the cell membrane and directly into say the mitochondria, which we have shown has really important effect.
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Foreign
A
guys here at Dave Asprey's biohacking Beyond conference. We got Tyler here, we're going to talk molecular hydrogen. I've never had someone talk about this on the show. So thanks for coming.
E
Yeah, my pleasure. Absolutely.
A
Yeah. Fill everyone in because there's probably a lot of people watching this that don't even know what that is, what it does, not all that stuff.
E
Yeah, so, so hydrogen, if you think about the periodic table of elements, hydrogen is number one. Right. And that hydrogen is just a proton and an electron and but with just a single electron is actually reactive. It's a free radical. So it's going to react with other atoms, other elements, very easily. So for example, it can react with oxygen and can form water. That's why you have H2O, you have oxygen and two hydrogens combined to that. Right. Or it can react with carbon to form hydrocarbons. Right. So you have like glucose, which is C6, H12O6. In other words, you have 12 hydrogens in that glucose molecule. That hydrogen atom could react with, you know, nitrogen to form, you know, amino acids, ammonia, or it could react with another hydrogen atom to form a molecule of hydrogen. We call that molecular hydrogen, hydrogen gas. And that is the therapeutic molecule that I've been researching and I'm excited about. And I've been, you know, involved in this area basically since 2009. So, you know, around 16 years and
A
you're finally starting to see some success.
E
Yeah, it's starting to take off, which is exciting. So I, I've always been involved in health and wellness. Just my whole, like since elementary school. Right. Just really loving this area. And I learned about hydrogen gas around 2009 and started reading the papers. And then in 2013, for my biochemistry degree, I went to Japan and I researched some of the molecular mechanisms of hydrogen on various cell signaling pathways. And we found, you know, it's, it's actual effects in cell culture systems and of course, animal studies and so on. But it was really neat for me to see that with my own eyes and to meet other researchers and just to have that overall experience. And so then when I came back to America, I was passionate about this. Like, wow, this is something that's really neat. It's really picking up here in Japan. Nobody seems to know about it here in America. And also I realized that in Japan there's also a lot of misunderstanding about hydrogen. People would conflate it with atomic hydrogen, right. Just that hydrogen atom or alkaline water or something. That's totally not what hydrogen gas is about. And so I decided to start a website so I could educate people and bring the awareness about the potential of hydrogen gas, the therapeutic molecule, and increase that research and so on. And I called that website the Molecular Hydrogen Institute. And that is now has been as a 501c3 science based nonprofit which I've been, you know, basically doing since 2013, is focused on just that, education and formed collaborations, a lot of research groups around the world. And now later did my Master's and later PhD. My PhD was in animal physiology.
A
Okay.
E
And I did my dissertation on cardiovascular and cerebrovascular diseases. And we used hydrogen gas therapeutic and we could see some, you know, pretty interesting effects in animals. In animals, we actually did a couple ones, but we did like in rats, radio protective effects like on the heart. And as well as in adult pigs, we did heart, simulated heart transplants. Really. And we also find that hygiene gas had some benefits in the entire transplantation situation. Because this is a really difficult thing. We talk about the heart being exposed to free radicals, inflammation makes it. The heart doesn't work as well. So being able to improve that process, increase survivability is really important. And hydrogen gas, being the smallest molecule in the universe is, has that potential to really help with that.
B
Interesting.
E
And so those are some of the studies that I was involved in with my PhD. But there's, you know, now there's a lot of research all over the world that's been researching this. And there's, you know, the research is still growing, right? There's, there's not, it's not FDA approved. There's still a lot of questions about how clinically effective it truly is, like when we really look at the hardcore science. But the therapeutic effects of hydrogen has been shown across 200 different human and animal disease models with over 3,000 publications, 200 different human studies.
A
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E
Right. And again, a lot of these are, you know, small, maybe only a year long. There are maybe less than 100 subjects or so. But again, this is good noise, right? Or good. Sorry, good signal that's coming from. From the noise. And the preliminary evidence is important. And I think it behooves us as researchers to investigate that signal more and determine how clinically relevant it really is. And that's really what I'm passionate about.
A
Nice. So are hospitals using hydrogen yet or
E
not at this point? Because it's not FDA approved. But, you know, in, in Japan, for example, hydrogen gas was. Was given initial approval as a. As an Advanced Medicine, Class 2B medicine for the purpose of doing clinical research. And they did a major study in post cardiac arrest syndrome. And there was a 15 different hospitals that were set up doing this study. And they found that those inhaling the hydrogen gas, basically they. They, they applied 2% hydrogen gas. So it was an inhalation of hydrogen gas. It was that compared to standard treatment alone. And those inhaling the hydrogen gas after three months, they looked at their survivability, like how people survived after three months. And it was like a 39% increase
A
just from inhaling it once?
E
Yeah, it was. Yeah, it was actually just a one session.
A
Holy crap.
E
It was 18 hours. They came in comatose patients and there was like 39% increased survivability with. That's insane. And there was also improved neurological scores as well. Um, I don't know. I don't think that one reached statistical significance yet. But that's largely because it was the sample size only 73. This happened during the COVID pandemic. And so they actually had a truncate the study a little bit. But, but even the neurological scores, I mean, it's the. The trend was extremely strong. Cause it was like, it's like, I don't know, 30% or something. Improved neurological function as well. That's Impala.
A
And so I might start taking it just for that reason alone, because I make a living off my brain.
E
So yeah, we do. And that's the nice thing about molecular hydrogen is it is the smallest molecule and so it can easily penetrate the blood brain barrier. No, when talking about improving the cellular function or whatever it is, we first have to get that molecule inside of us. And that's difficult for a lot of molecules because, for example, we have we can use a vitamin C as an example. Vitamin C, of course, can go everywhere, but it takes time. It has to go through certain transporters. Vitamin C is water soluble and so it doesn't easily pass through the cell membrane. And so you actually have these protein channels that are required like transporters.
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E
that are able to transport vitamin C from the extracellular space to the intracellular space. And this, this takes time and everything. So pretty much every drug and supplement the hydrophilic ones anyways they require these transporters, secondary or active transporters. Even water. Water is just a small simple molecule, right? It's neutral, but it is a polar molecule. Water does not just pass through the cell membrane. It has to go through these protein channels called an aquaporin. But hydrogen gas, because it's a neutral and non polar molecule, it's easily able to diffuse right through the cell membrane and or the blood bone barrier or the testis barrier anywhere and directly into say the mitochondria which we have shown has really important effects.
B
Nice.
A
So you, you're put the tablets right, you're putting it in water and then
E
drinking it or there's a couple ways to administer hydrogen gas. You can take the gas and dissolve it into water such as with the hydrogen producing tablets. Those are on the market. We've done clinical research on that and other groups as well. But there's lots of ways to get hydrogen water. There's even like water bottles and there's you know, ionized water. The problem lot of these methods is that a lot of times the hydrogen gas is not a very high concentration or not even therapeutically relevant or maybe the concentration decreases over time depending on how it's being used. So I, I, I know a lot of people prefer to use a tablets at least, at least in research just because we, we know we're giving a high consistent dose of molecular hydrogen. Right. But, but the hydrogen water, that's one way is through hydrogen water but the other way is through inhalation of hydrogen gas. Those, those are two primary ways and both of them have their own benefits because they have unique profile, pharmacokinetic profile to get the molecular hydrogen. I've recently now involved with inhale H2. It's a hydrogen gas inhalation machine we developed. We can talk about that a little bit later. But that's for providing inhalation of hydrogen gas. And this is going to be really important for, for those who want to try hydrogen therapy through inhalation because it's, it's like I said, it's a different method to get it and we can regulate the dose and make sure it's at a therapeutic level.
A
Right. Can you get that hydrogen gas not naturally in certain areas of the world or you can Only get it through concentrated. Let me ask you something. When was the last time you truly relaxed? Not scrolling, not sleeping with your phone in your hand. I mean real mental recovery. That's why I've been using Braintap. It combines guided visualization, immersive sound and light based brainwave entertainment technology to help your mind shift from stress mode to a more balanced state. Research in the Braintap literature review highlights growing evidence of brainwave entertainment and relaxation focused outcomes. I use it to reset, refocus or unwind after long days. Thousands of sessions are available for sleep, stress support, focus and mental fitness. If your brain feels overloaded, maybe it's to time time to train it rather than push through. Check out tribraintap.com and experience it for yourself.
E
You know it is interesting there are some natural places around the world where hydrogen gas is naturally present. Whether it's from like basalt catalyzed reactions and you know, iron for example. In fact it's believed that life started deep down in like the deep sea hydrothermal vents. Yeah. Where hydrogen gas was being produced. And hydrogen gas could act as an energy source. And that's when your archaea, your bacteria basically first started as using hydrogen gas as an energy source and then throughout time, which is another cool thing. So if we consider that hydrogen gas was basically the first substrate of life that got life to start and it's also involved even in the evolution of life. Like our mitochondria are really similar to bacteria themselves. But there's this whole research on hydrogens and hydrogenases and their similarities to mitochondria. And that hydrogen gas seem to be really key in forging this separation between your prokaryotes and your eukaryotes or like your bacteria and your plant and animal cells. But there's a lot of similar proteins that are also involved. And so hydrogen gas actually been involved this entire time. And so going to your question, there are even these, there are still some places today where there's hydrogen gas like in these waters. And so it's been propose that maybe some of these waters that have had beneficial effects, if those are true, potentially is because of the dissolved gas on there. But, but even more, we, we have evolved to develop a symbiotic relationship with hydrogen producing bacteria in our gut. And it's very interesting that if you have a healthy microbiome and you have a healthy diet, then you naturally produce lots of hydrogen gas.
B
Interesting.
E
And, and in fact there's this, there's a pretty interesting correlation between the more hydrogen gas you're producing you, you tend to have lower risks of metabolic syndrome or diabetes or dementia, Alzheimer's. In fact, Japanese centenarians that are centenarians, they have higher breath hydrogen gas production. And so there's something important about the microbiome. Of course this is different than say people with SIBO or something with small intestinal bacterial overgrowth because that's overgrowth in the small intestines. But just that hydrogen gas is a commonly produced molecule, like I said, from the bacteria. And almost everybody produces a hydrogen gas, but not as much as maybe our ancestors did just because they don't have as much of that hydrogen producing bacteria and they're not getting near as much fiber as they used to back in the day. But we see again from these studies, like even if we look at the Parkinson's patients and their studies published, showing that they tend to have less hydrogen producing bacteria in their bodies and in their gut than those who don't have Parkinson's disease. So again, this is just a correlation. A correlation does not equal causation, of course, but it's an important correlation because it suggests that a signal could be there because it's all in the right direction. So then we do these RTC studies and we can see administration of molecular hydrogen and see therapeutic benefits. Right. It starts to make sense, that controlled study.
A
Yeah. When you were in Japan, did you meet any centenarians out there?
E
I don't know that I meant a centenarian, but I mean there's a lot of very older active individuals and it's amazing how, how they are in, in Japan that everyone, they sort of have a purpose. Right. And really old people, elderly people that are, you know, working at the store, there's just sweeping or they're picking up trash or something and it's really, they're, they're slow, it's difficult for them, but they're happy to do it. And I think that's really a big reason why they live so long.
A
Community.
E
Right. A community and active lifestyle. Just felt a purpose. Right.
A
How good was the food? There have never been.
E
I liked it. Yeah. I like Japanese food.
A
Yeah, I want to go there. It's on my list.
E
How long were you there in that case? I was not very, very long because it was just for my biochemistry degree, my bachelor's degree, but it was just a few months, but it was enough to, you know, have fun in the laboratory, explore a little bit.
A
Yeah. They seem to be on the forefront of hydrogen over there because I've heard from a few people now that they went there to look into it.
E
Yeah. So what happened was in 2007, there was an article that was published by Japanese researchers. And this is really what ignited, no pun intended, the hygiene research. And maybe I'll just describe this study a little bit. This study was in 2007 is Nature Medicine. And they looked at the effects of hydrogen inhalation in a rat model of a stroke. So it was a middle cerebral artery occlusion, which is basically just cut the blood supply to the brain. And that's going to cause a lot of damage like a stroke would. And you have no oxygen going to the brain, so that can be problematic. And then you have this, and that's this called ischemia. And then you let the oxygen rich blood go back to the brain. That's called reperfusion. And this is the IR ischemia, perfusion injury. And it caused lots of damage. But what the researchers found, Osal and his team, was that when you administered hydrogen gas and they actually did different concentration, they used 1%, 2% and 4% hydrogen gas. And they found that 1% had some therapeutic effects at decreasing the amount of damage done to the brain. 2% was very effective. I mean, remarkably effective, actually. And it seemed to actually be more effective than maybe even 4%.
A
Interesting.
E
Now this is also really cool because hydrogen gas at above 4% is explosive.
A
Oh, wow.
E
So we need to be really careful. We need to respect this molecule. Okay. That's crazy. Yeah, it's like. Yeah. Like if you think of the Hindenburg. Right. Or you think about maybe in high school chemistry, a lot of people remember chemistry professors might have made a balloon full of hydrogen oxygen gas and you ignite that. Yeah. It's a spectacular explosion. Well, it's because hydrogen gas is explosive. Right. It's three times more energy dense than gasoline. And that's why it's being used as an alternative energy source. And now it's being researched as an alternative medicine. And so this study is powerful for several reasons. Number one, it showed that hydrogen gas, even below the flammability or explosive threshold, is therapeutic. And then number two is the fact that it is therapeutic or had these therapeutic effects. And Nature Medicine is a major publication, so that paper's been cited now several thousand times. Just because it's such a landmark paper. We consider. There was actually a study earlier, back in 1975, where they also showed that hydrogen gas was therapeutic for cancer. And it was actually just. It was remarkable. It just totally regressed the tumors in 75. Yeah. In 1975.
A
I think they would have looked into that.
E
And they, they did a little bit. But see, this was, this was published also in Science, which is also another, like, top journal. Like, I mean, science is the, like, kind of the gold standard of, like, college. Anyway, this is its top publication. Right. This is really phenomenal. But the thing is, is 1995 publication that was on this hyperbaric hydrogen chamber, so very high pressures and concentrations. And, and because hydrogen gas is explosive, well, it's. It's not really feasible for clinical use. And so that's probably the reason why it didn't get followed up. Even though it was such a good cure in this animal study, it didn't really catch on a lot because how is that clinically relevant? That's different with his Nature Medicine publication because in that case, they found that hydrogen gas, even at levels below the therapeutic level, were therapeutic. And in fact, 2% tended to be more effective than even 4%, which is important when we come and we talk later about hydrogen gas inhalation. If people wanted to try that, how do you ensure you're getting a therapeutic dose? And what do we know what that is? And it comes back to some of these, some of these earlier studies showing that, you know, 2% is actually very effective and 4% effective, but you don't necessarily need to be higher than that.
A
Right. So that's where Inhale H2 comes into play. So what percentage is that using?
E
Yeah, so this is a fun story, but we use between 1 to 4% hydrogen gas. Okay, so maybe I'll just take some of the background on this. So as I mentioned, I started in 2013 the molecular hydrogen Institute, and I've just been really focused on the research, education, awareness of hydrogen as a medical gas. Do my PhD and doing all these things and do research. I teach at the university as an adjunct, and I really love that side of things and doing the research. And Alex Tonava, my partner, but he came to me maybe eight, eight years ago, probably by now, and he was like, hey, Dr. Tyler. Well, it's just Tyler. Actually, I don't think I was any doctor at that time, so just, you know, Tyler. But anyway, he said, hey, we had the hygiene water figured out with these tablets. What do we do with hydrogen inhalation? Can you recommend a device for us? Like, I want to, like, let people know, because hydrogen water has these benefits
B
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At Venture Global, we think about what can be done, not what's usually done through innovation. Venture Global is not only building some of the largest energy facilities in the world right here in the United States, but delivering American energy at a fraction of the cost in a fraction of the time. So while others are busy talking, we're busy building. That's Venture Global. That's unstoppable energy.
D
If you walk into a room and can't remember why, it could be nothing or something more. If you confuse a familiar recipe, it could be a slip up or it could be associated with amyloid plaque buildup in the brain. Amyloid is a protein that your body produces naturally, but a buildup in the brain could lead to memory and thinking issues. To see what what may be behind your memory and thinking issues, talk to your doctor about getting a full assessment. It's never too early to start the conversation. Visit amyloid.com to learn more.
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E
other really good benefits and I of course I I agreed with him that yes, inhalation does have different benefits you cannot get from drinking hydrant.
A
Oh really?
E
And we'll talk about that in just a minute because I think it's important to talk about differences.
A
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E
So he wanted to do that, but he was like, but how do you. Like, everyone right now is using these nasal canulas. And how are you supposed to ensure you're getting the right amount of hydrogen gas? Like, how do you do it in the clinical studies? And I was like, wow, you're exactly right. You. You can't do that with the clinical. With. With the nasal canulas that you just put into your nose, like we. With oxygen. And we don't do that in the major clinical studies either. We use a face mask. We use a face mask with a ventilator. And then the gas we're administering comes from purified gases that are, like, in these compressed tanks. So even my colleagues at Harvard doing hydrogen gas research, like in pediatrics, they will have these tanks of premixed gas that are exactly, say, 2% hydrogen gas, again, below the explosive level, because you're administering hydrogen gas, which is explosive, and it's therapeutic. So 2%, because we've already established that with both animal and human studies. And so I explained this to Alex, like, so this is how we do it. He's like, well, how. How can we make a machine like that? And I'm like, well, there just isn't one like that. Because, I mean, when we breathe, like, we may only breathe between, you know, 5 to 12 liters per minute. As we're sitting here, like, you and I are talking, we're probably around, you know, 10 to 12 liters per minute. But what. That will work. When we take an inhalation, we're not inhaling the entire minute. We're inhaling for only about 15 to 20 seconds, because most of the time we're exhaling, right? We only inhale for about one third of the time. That means that our inspiratory flow, that inspiratory flow can be upwards of 30 to even 100 liters per minute. That means you have to have a flow rate with a nasal cannula that's very high in order to ensure that the amount of hydrogen gas you're breathing remains at that therapeutic level. And that becomes impractical. In fact, just as a quick example, you've seen people who are on oxygen therapy. They have oxygen concentrators and they use oxygen in the hospitals. What flow rate do they use in the hospitals or at home? What is the flow rate? How many milliliters or liters per minute do oxygen, people on oxygen use? It depends on every individual. They have the same target. They target. They just measure the pulse oximeter and they, and they target for say around 90% saturation of the hemoglobin. So same target, but yet the flow rate based on somebody's lungs, how well the gas diffuses into the lungs, their nasal passage. Like if they have a stuffy nose or a deviated septum with their mouth breathers, like all these things matter. They just titrate the flow until you increase the concentration. The concentration. Right. The saturation to that 90%. So that means that the flow with oxygen goes from a couple liters per minute all the way to maybe even a hundred liters per minute. Such a wide flow rate. So you can't simply use a hydrogen gas inhalation machine with one set flow rate and there it is. It's going to be exactly this for everybody. And in fact, studies have shown with using nasal cannulas that a certain percent of people, if you have like say, you know, a liter, 2 liters per minute of hydrogen gas, very high flow rates. So it can be therapeutic for sure. So in fact, a certain percent, though, they'll be hap therapeutic per amount of hydro gas they're inhaling. But another percent, because maybe they are mouth breathers or they have a DVD acceptum or whatever it is, they're not even reaching 1%.
A
Wow.
E
So therefore they're not going to get therapeutic amount. So they may have spent 10, $20,000 on a unit and they're, or they're maybe they're doctored in, they're going in to get a patient or a therapy. They're not even getting a therapeutic level of hydrogen because of their nose, because they're sick, because. Or maybe the way their lungs are. Right. They're just not breathing. Right. They're anxious breathers or something. Right?
A
Yeah.
E
So that's on one extreme. Not even extreme, actually. It's, it's, it's. A lot of people aren't going to get as much hydrogen as we use in the clinical studies. The other group though, maybe they have a really good nasal airway and they're just taking these long inhalation inspirations, which, the longer your inspiration, the more you activate your sympathetic nervous system. So it's not Even necessarily recommended to do long inspiration. Normally it's the other way around. Right. Slower, shorter inspirations and longer extended. Right. Exhalations. That's going to be put you more parasympathetic anyway. But you can have this other group of people that are getting it, that are getting hydrogen gas above 4%. And now you have two problems. One, it may not actually be as therapeutic. And number two, the biggest one is it's explosive. Anything above 4% is explosive. And there are documented cases where people have been inhaling the hydrogen gas like for some therapy. They believe it's going to help them. And their nasal passages filled with this hydrogen gas. And an ignition, a spontaneous ignition occurs.
A
Holy crap.
E
Ignites inside, inside their nose. And then you get an internal detonation in the airway and they get rushed to the icu. Vomiting of blood. I mean it's crazy. This is documented in the literature. So it's not just hypothetical. But I've talked to a lot of people and they're like, well, I've had this unit for three years and nothing's ever happened. But it's like the same idea with hyperbaric oxygen chambers. Right. Like people bring in their cell phone all the time and nothing ever happens.
A
Yeah.
E
But just that one time it does. And so we, we really.
A
Are you not supposed to bring your phone in there? Because I've done that.
E
Yeah. Does that. You're not a good, it's not a good idea. It's against protocol.
A
So it could explode.
B
Yeah.
E
Because oxygen gas is a very strong oxidizer. So if there's static or something build up or whatever it could.
A
They didn't even tell me that. I've rent out one out of one. They never told me that.
E
Yeah. Maybe they have other protocols and maybe it's not as, you know. I don't know.
A
I want to. That's not a, you know how there's hard shell ones.
E
It's a soft shell one.
A
So maybe that could be why. I, I, I don't know.
E
I, I better not comment. I just, I, I, I just know that there are. You can look it up in the news reports. There's a number of major explosions that happened where people have died in these chambers. Oh my God. Because they have been doing something violating protocol over and over again until one day it catches up with them. That's not. And the same thing is true with hydrogen gas. You know, it's. Hydrogen gas, like I said, is not FDA approved. We don't know with certainty it's going to cure your cancer or cure your dementia or something. Again, there's some really fun evidence that's coming out, emerging. But since we don't really know that, we have to really weigh the serious real risk with the possible potential benefit. So the algorithm just doesn't make sense, in my opinion, to comfortably recommend this for anybody to use hydrogen gas inhalation if they're putting themselves at risk. And plus, as I said, there's no reason to go above 4%. 2 to 4% is where the therapeutic magic we've already seen in clinical studies.
A
Yeah, why risk the chance?
E
And then it gets even worse because people who are inhaling this high concentration, right. 100% hydrogen gas or 66% hydrogen gas, it's possible that every time they take that inspiration, they're diluting the gas down. So it's not even therapeutic. So it's, it's just going back and forth, cycling between non therapeutic inspiration to explosive levels during the transition period. And it could explain why we've had a number of doctors, clinicians reach out to us to say, wow, we are about ready to like, not even try hygiene therapy anymore. Because we've had these other machines in there. We've never had any real benefits. Some people have, but a lot of people haven't. We got your machine. And I'm like, we've seen a lot of really good effects. And that could be because they're actually getting a therapeutic dose of hydrogen consistently. And that's what makes our machine different than any other machine in the market. We filed patents, global patents on this concept where we can ensure that the fraction of hydrogen being inspired, the FIH2, that's the dosing metric. We, we ensure the fraction inspired hydrogen is always therapeutic and remains below the explosive level. That, and that's really anybody who's interested in trying hydrogen therapies or hydrogen inhalation, those are the three. There are three questions you should ask them. You should always ask, number one, am I sure that I'll always get a therapeutic dose regardless of my breathing pattern or whoever is inhaling from the machine? Right. Can I ensure that I'm always getting the right amount? And number two is, am I sure it will always be below 4% so I don't put myself at risk? Right. And number three is, can you precisely control the concentration? So I can choose 2% for this time and say 4% for this time? Those are really important questions. So you can assure that you are optimizing the therapy that you want to, if you want to try it. Right. And our Machine does precisely that. And it's the only one that does it because again, the clinical research, we use these tanks of Primus gas at, you know, very high flow rates in order to ensure that we're matching the individual's inspiratory flow.
A
Makes sense. Did inhaling hydrogen improve your mile time because you've got a 4:38 mile. I don't know if you disclose your age publicly, but it's, it's impressive regardless of what age you are. Right.
E
Yeah, I'm just, I'm just, I'm turning 39 and just, you know, this month, basically next month, July, July 4th is my birthday. Nice.
A
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E
But yeah, I, you know, I, I do use hydrogen gas inhalation and hydrogen water as well, both of them. And yeah, I, I don't, I don't know, I mean, I guess I can joke that yes, all I do is use hydrogen therapy and, and I train a couple hours every day for the past 20 years. But I do believe that hydrogen gas does have the potential to improve athletic performance, especially over time. And this is actually a really big point because when it comes to improving exercise recovery and just overall performance, different interventions that are out there, sometimes they actually have the opposite effect. They can actually impair physical performance or exercise performance and impair adaptations. And we've seen this over and over again in a number of clinical studies. Some good examples would be like with antioxidants, it makes sense on the surface that if you're training really hard, heat
B
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C
Venture Global, we think about what can be done, not what's usually done through innovation. Venture Global is not only building some of the largest energy facilities in the world right here in the United States, but delivering American energy at a fraction of the cost in a fraction of the time. So while others are busy talking, we're busy building. That's Venture Global. That's unstoppable energy.
D
If you walk into a room and can't remember why, it could be nothing or something more. If you confuse a familiar recipe, it could be a slip up or it could be associated with amyloid plaque buildup in the brain. Amyloid is a protein that your body produces naturally. But a buildup in the brain could lead to memory and thinking issues. To see what may be behind your memory and thinking issues, talk to your doctor about getting a full assessment. It's never too early to start the conversation. Visit amyloid.com to learn more.
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Celebrate America's 250th with Dish for a limited time. Get an extra $250 off when you sign up. Call 888-add-dish or visit dish.com today and use code DISH250 to claim your $250 savings. That's 888 add Dish offer ends August 12th. Terms apply. Suffering from dry, tired, irritated eyes? Don't let dry eyes win. Use Sustain Pro. It hydrates, restores and protects dry eyes for up to 12 hours. Sustain Pro Triple Action Dry eye Relief.
E
You're producing a lot of free radicals and that that those free radicals lead to oxidative stress. And then oxidative stress can impair your recovery and make you fatigued and so you can't do your exercise as well and so on. Right? Yeah. So the conclusion is take lots of antioxidants and now you can fight off that oxidative stress and you can adapt faster and train. But it turns out when you, when you do the actual studies, what happens if you take the antioxidants, mainly high doses, you typically find that you blunt exercise training adaptations. Really, you blunt the performance benefits.
A
So if you eat too many blueberries.
E
No, not food.
A
Oh God.
E
Yeah. There's no evidence that taking too much food, antioxidants.
A
Got it. Got it.
E
That's going to be a problem. Like I'm talking about when you take the extracts from the blueberries and pack it into a little pill, make a very high concentration. Right. High dose vitamin C, vitamin E. These are the types of studies that have been done that can actually blunt mitochondrial biogenesis. You can see they it prevents the increase in PGC1 alpha. PGC1 alpha is a marker of mitochondrial biogenesis. A peroxone proliferator activated receptor, coactive gamma 1 alpha.
A
What a long word.
D
Choices.
E
He's long. Right. But it's a transcription factor or an act. It's a CO transcription factor, P1alpha. Anyway, but this is blocked with a high levels of antioxidants. So you can imagine you're trying to be a healthy individual and like, all right, I'm going to start my exercise program, I'm going to get in there and do my training and I'm going to take my antioxidants. And after, you know, six weeks of intensive training, you don't actually have the improvements that you were looking for.
A
Yeah. And you would never attribute that to too much antioxidants.
E
I feel like. Yeah. You want to maintain homeostasis in your body. Right. So that's the key with hydrogen gas is it doesn't do that. Hydrogen gas is, is. Yes, it has antioxidant effects, but it's a unique type of antioxidant in the sense that it's selective and regulates your body's own antioxidant system. So when you do these studies with hydrogen gas, in fact, one study in particular, they compared, they took exercise and then they looked at with used vitamin C and they used hydrogen gas. And what they find exercise. Yes. Increased PGC1 alpha with vitamin C. It blunted the rise in PGC1 alpha. Wow. But hydrogen gas actually increased, enhanced the rise of exercise, induced PGC1 alpha increase. So hydrogen gas showing to be kind of like an exercise mimetic is therapeutically helping improve more mitochondria. This is really important when it comes to exercise performance. And so I guess to your point. Yeah. Does hydrogen gas improve my exercise performance? Right. With my running or weight training, other sports and things that I do, maybe, but I do it. I believe that hydrogen gas is safe. And that's really what makes me comfortable even being on this podcast, sharing the passion with you about my research because I've been researching this for a long time and I think that, well, obviously a lot of people, especially in this biohacking space, they read my papers like, I want to try This, I want to get on this. And I'm thinking, you know, we don't really know how effective this is. We don't. It's not FDA approved yet and all these things. But people have the money and they're willing to just buy it and they want to try it. And so unfortunately, sometimes my papers or another people's can be misrepresented to like, you know, it's the end all, cure all or something. And we don't want to have that, but we also want to make sure that people do want to try it, such as even myself. Like I remember in the laboratory when I was doing my PhD and then looking at the results and thinking, man, I want to try hydrogen gas, more like for my longevity. And so I had the tank, it was premixed gas, you know, and I, you know, take some inhales that, you know. But it's really nice now that we have a machine for those who want to try it. They can, and they can assure that it's going to be safe. It's not going to impair their performance. And it pairs really well with all other modalities.
A
I want to try it later today.
E
Yeah, come.
A
Is it at the booth?
E
Yeah, it's at the booth. Yeah, come try it.
A
How many minutes do you need to inhale it for?
E
You know, we typically recommend a minimum of 20 to 30 minutes, just based upon how long it takes the pharmacokinetics for the gas to dissolve into the blood, diffuse reach and target the mitochondria. That's the big thing. We published a major paper in Redox biology showing that hygiene gas directly targets complexity of the mitochondria and in turn improves the function of the mitochondria. Basically leads to its regeneration and rejuvenation.
A
Nice. Yeah, I want to try because whenever I fly, I want to make sure my body's in good shape because people get sick when they fly. The guy next to me is always sick on flights.
E
Terrible.
A
Yeah. On the way here, the guy was coughing nonstop. I'm like, really, dude?
E
Well, yeah, we, we need more research, of course, but yeah, I mean, hydrogen gas being able to help just improve the resilience to stress, improving the mitochondrial function. You know, this could have some benefits for your immune system and things. I, I think all of these are very plausible. We need more research with it. But I'm happy that now that now there is a machine available. Yeah, that's great. If people want to try it, they can do it safely and they can at least ensure they're getting a dose similar to what we use in clinical studies.
A
I love how objective you stay because in this space, it's easy to tie your emotion to your product and your brand and want to sell as many as possible. But you're like, I don't know if this works yet.
E
You know, yeah, it's important. I really believe in informed consent. Right. And so I. There are people in this world who believe unless something has been studied for 50 years, 50 or whatever, I'm maybe being hyperbolic, but maybe not. Let's just consider there are. There are drugs that have been approved by the FDA who have big studies, and in the end, when those studies are followed up, it turns out those drugs didn't actually move the needle. It didn't really help. Right. Okay. So that, that's just a simple fact of science that sometimes we do studies and they. And in the end, the big, big studies don't really pan out. And that's why I'm trying to be conservative, saying, yes, we have some really fun data. It's really cool. I'm excited about it. I want to try it. But we need to temper our excitement with our ignorance. I don't have a crystal ball. I don't really know. And so I believe in informed consent, which is that people should be aware that this research exists. They should be aware of products that work well so you can try it. They should be aware of what the limitations of this research are, and they can make their own decision about whether or not they should try it, if they want to try it. Right. If they have the discretionary means to do it. I do not think it's appropriate for people to make false claims and misleading claims and try to hype people up too much about the potential or the. Or, you know, claiming cures or treatments or something where we don't have that evidence.
A
Agreed.
E
And I also don't think it's appropriate for people to say, because it's not FDA approved, and because this and that, we shouldn't even talk about it. I think that undermines our. Our individual choice. We should be able to make the choice for ourselves. We just need to have that knowledge. And so here I am today to provide that knowledge so people can make their own informed decision if it's something that they want to try.
A
Right. I want to talk about arm wrestling, too, because being a distance runner and also winning arm wrestling championships, that's like, never. I feel like that's never been done. Honestly, I feel like you're the first person to pull that off because like a distance runner, usually pretty skinny, right? You're not muscle, muscular. So let's dive into that. How are you doing that too?
E
Well, I, I guess I like the hybrid athlete, but it makes me kind of mediocre and everything. You know, I, I thought about training for the Olympics, for the marathon. I'm like, you know, I don't know, 10 minutes away from the Olympic qualifying.
A
Wow.
E
And so I think, hey, you know, if I lost, you know, you know, 10 kilos, you know, 20 pounds or something, maybe I could, you know, if you do the math, it's like, maybe I could do that, right? But then, but then I'll go to an arm wrestling competition or something. I'm like, dang, you know, if I could just like, just focus on like really building some more muscle or whatever, increase my weight a little bit more, like I could really perform even better, right? It's like I always on this battle back and forth and I realize, you know, I, I kind of like where I'm at. I'm just kind of hybrid athlete. We know that longevity, there are two very important things for longevity is your VO2 max and your muscle mass in strength. Right. And, and so I think those are really important. And I really am into longevity and just overall, you know, healthy living. And so I try to focus on both of those. And it is important and I hope that I can maybe be even inspiration to people to train both of them. Because you get too many of these, you know, powerlifting bodybuilder type people who are like, I don't want to do cardio, gonna kill my gains in the gym or whatever, you know, and then, well, I can arm wrestle them and all. I beat them. And you could be a power lifter.
D
Yeah.
E
Yeah, that's cool. I mean, when you're, when you're a serious arm wrestler, you know, if you listen, it's, it's, there's technique and there's different strengths, all right. And you can check out my Instagram, I have a couple videos on me being some big guys or something there. It's, it's fun. Maybe I just have a big ego. So it's fun to.
A
I've seen that one nerdy guy that wins a lot. I forgot his name. Chime is changing the way people bank. They offer the most rewarding fee free banking. This is fee free banking built for you. They're not like traditional old banks that charge you overdraft and monthly fees. They have thousands, thousands of fee free ATMs. Why would you pay to get your own money. This is built for you, not the 1%. Chime members can benefit from up to 1150 in annual rewards. Fee free real humans 24. 7. You're not just switching banks. You're upgrading to America's number one choice for banking. With a Chime checking account, you can even get up to 500 of your pay. When you pay with my pay, they also have Spot me which lets you overdraft up to 200 fee free. Chime is not just smarter banking. It is the most rewarding way to bank. Join the millions who are already banking fee free today. Head to chime.comDSH that is chime.comDSH it only takes a few minutes to sign up. Optional products and services may have fees or charges. Stated annual percentage yield and cash back for Chime pay only. No minimum balance required. Checking account ranking based on a J.D. power survey published October 30, 2025. Chime is of fintech, not a bank. Banking services for MyPay and Chime Card provided by Chimes bank partners. Head to chime.comDSH that is chime.comDSH it only takes a few minutes to sign up. He won like a school boy. Yes. He looks like a normal dude.
E
He does. He is super. He's, he's actually, he's, he's he's like six something. He's like two and something pounds. He's, he's, he's big. But, but there's guys who are bigger than him and he'll still beat him. But, but, but point is like with me it is, it is fun. You know, I'll go, I'll go gone against you know, 250300 pound dudes and, and I'll beat them. Holy crap.
A
That's double your weight.
E
Oh yeah it is. Double my weight. Yeah. I beat guys that are easily double double my double my weight. But again, there's technique and there's specific strength exercise like certain strength exercises like on the wrist or whatever. I typically can do three to four times more than most people can do.
A
Wow.
E
But I've been training that specifically and most guys don't go out and train this really weird like finger, wrist, you know, degree of freedom or something.
A
Well, isn't grip strength really important too for longevity?
E
Well, it is, but it's more of a correlation. Right. So you can't just train your grip strength and then live longer. It's really if you have a strong grip strength and that suggests that you probably have overall pretty good muscle spiking Maybe you're doing deadlifts so you have a good quad strength, right? So it's more of the total amount of muscle and then also strength because you actually have two performance metrics when it comes to muscle. You have your muscle mass and you have your strength, and both of those are independent. There's a correlation. Of course. The more muscle mass you have then the stronger you should be. But that is also not always a tight correlation. And that's why you can have guys who are really strong but don't have a lot of muscle.
B
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C
At Venture Global, we think about what can be done, not what's usually done through innovation. Venture Global is not only building some of the largest energy facilities in the world right here in the United States, but delivering American energy at a fraction of the cost in a fraction of the time. So while others are busy talking, we're busy building. That's Venture Global. That's unstoppable energy.
D
If you walk into a room and can't remember why, it could be nothing or something more. If you confuse a familiar recipe, it could be a slip up or it could be associated with amyloid plaque buildup in the brain. Amyloid is a protein that your body produces naturally, but a buildup in the brain could lead to memory and thinking issues. To see what may be behind your memory and thinking issues, talk to your doctor about getting a full assessment. It's never too early to start the conversation. Visit Amy to learn more.
B
Celebrate America's 250th with Dish. For a limited time, get an extra $250 off when you sign up. Call 888-add-dish or visit dish.com today and use code DISH250 to claim your $250 savings. That's 888Add Dish offer ends August August 12th terms apply. Suffering from dry, tired, irritated Eyes don't
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E
and then vice versa.
A
Interesting.
E
And that correlation, especially as you get older, people can have a lot more muscle, but their strength is a lot lower.
A
Right.
E
And so you want to be able to have, you know, the right balance basically on all of those things.
B
Yeah.
E
And so I. So going back to my point with longevity, I want to have high strength, I want to have a decent amount of muscle and I want to have a high VO2 max. That's just having a high VO2 max alone is important. And then just training consistently for overall healthy lifestyle. And so those are the things that I do and I feel like I don't actually train incredibly like crazy wise. Right. Like the serious athletes are like professional ones. I mean they'll train for four or six hours a day.
A
Yeah, I think that's over training.
E
Sometimes it can be and it depends on what you're equivalent including in training. Right. Because sometimes you're just doing some really, some like easy type stretching, pyometrics and like body work or whatever. Right. So just there's, there's, it depends but a lot of times you can over train and actually when it comes to being an elite athlete, that's typically how things have to go is basically muscles and your performance is largely volume dependent and you have to just keep on getting more reps in more sets in or like with running, you get more and more miles per week. So like for me for example, I've done 120 miles a week when I was like training but I get injured maybe, maybe because I'm just heavier joy. And, and so I just can't handle that higher volume. And so it probably means I'll never be at a high, high level athlete if I wanted to because I just tend to get in and maybe if I lost, you know, like I said 20 pounds, I could do that.
A
Yeah.
E
But the idea though is that if you can keep on training and recover faster, then you can continue making improvements. And that comes back to molecular hydrogen is maybe that's helped me to recover. I've never had any major injuries or setback. Luckily I'm as old as I am. I've been trained pretty hard my entire life.
A
That's almost unheard of. I feel like that's like LeBron James.
E
Yeah, yeah. Well, yeah, I mean there's some pretty impressive athletes out there and I'm not near to their level but, but I But I feel happy with where I'm at because, you know, I do about, you know, 30 to 60 minutes of cardio in the morning, and then I'm lifting weights. No, from one to two hours a day. And it's not hard lifting weight. Like, I'm a strength athlete, and so, you know, I'll rest, you know, quite a lot of time between myself and I'm doing this and that. So I'm doing a lot of things. I'm even working while I'm lifting weights. I'm just trying to.
A
I do that, too.
E
Yeah, I'm listening to a podcast. Yeah, I always listen to podcasts, for example. I love doing that. And so. But yeah, so. So I guess to your point, being the hybrid athlete and things, it's something I love. I love to compete. I love pushing myself. It's the best that I can. And I think hydrogen, you know, might be. It's just part of my story, really.
A
I got to see you arm wrestle now, man.
E
Yeah, we can. We'll have to do it for after.
A
I mean, you can destroy.
E
Oh, yeah. But I'll teach you how to do it. I'll send you some cool techniques. It's amazing just knowing a few techniques, especially if you're. If you're similar in strength to somebody. It's all about technique. Okay. Right. But. But if you. Obviously, if you're just a lot stronger than the other person is, it doesn't matter what their technique is. Like, they're gonna. They're gonna beat you. Right?
A
Right.
E
So technique really matters when you start getting closer to the same strength, and that's why weight classes matter. So, like, for me, I typically compete at 150 pounds. Okay. I weigh 160.
A
So you. You cut 10 pounds right before?
E
Yeah, I like. Yeah. 150. 154 pounds. So I'll do, like, just a little water cut.
A
Okay.
E
And it just depends, like, where it's at. I've. I've gone as low as £139. Watercut. I did. I was £158, and I went down £139 for the world. The IFA. World Championship arm Wrestling.
A
Wow. So you literally won the national title.
E
Well, I win. I took. I was like, fourth place or fifth or still insane. Yeah. And they have different federations. Like, I'm like. It's just. There's a lot. Actually a lot of federations. And I'm. I'm. I'm not near as good as. There's. There's guys that are. You know, 125 pounds. That can beat me.
A
Really? So is that technique or what is that?
E
Oh, it's strength and technique. They're much better than I am.
A
Okay. But.
E
But there, but there are certain muscles and just certain like even your body mechanics. Right. Like where your insertion points are at and just how long your lever is. Right.
A
Because I have long arms, so that's probably weakness in arm wrestling.
E
It's both, actually. So if you have longer arms, then you. You actually can be on top of somebody and you're able to. You have better leverage over. Right. If you have shorter arms, then yeah, you can do like more. We call like a hook or inside arm wrestling is better. So you could be better at outside arm wrestling. So it's just learning how to work with your body in general. Longer arms are an advantage when it's arm wrestling. Oh, yeah.
A
Okay. I would have assumed the opposite because when I lift, it's harder. I feel like it's harder.
E
It is because your insertion for. It's just the lever the out further. Right. But that. It'll lever that further. But. But at the same time you can gain more muscle. So a shorter individual, they're. They're going to hit a genetic potential earlier.
A
Yeah.
E
And. And then they're going to max out on their strength. And so they may not need as much muscle to lift as a certain amount of weight, but they're going to hit that and then plateau out versus you could continue getting stronger and stronger. And because you have. There's more. You can add more sarcomeres in series and then. Then add more in parallel and so on. You can actually get stronger.
A
Yeah. Yeah. Marathon runners, are they tall or they're kind of your height usually?
E
You know, I'm. I think they're about my height. They're not super tall, you know, and they're going to be, you know, the weight around 130, 540 pounds, I think so.
A
Yeah. I always wondered the optimal build for a marathon runner. Is it like a tall person or kind of average height?
E
Yeah, I think just long legs. And I'm actually my. My anatomy is not. Is not terrible for a good marathon runner. I do have very long legs and a shorter torso. Right. So that helped me a lot.
A
Okay.
E
But yeah, if you're too tall, then you're also going to weigh a lot more and then your running economy is challenging.
A
Yeah.
E
But then you have like Usain Bolt, for example. He's very tall, strong. Right. And he's super fast. But I mean, his mile time is Nowhere near to what. What you even did back in high school.
A
Yeah, my event was the half mile.
E
Okay, what Was your total?
A
159.
E
Ah, nice. Under two minutes. Yes. That's a really.
A
Once I broke that, I was like, all right, I can die happily like 10 minutes. Did you get under two?
E
I. You know, I never actually gone all out to try it. I'm not sure that I could. My 400 is really slow.
A
What's your 400?
E
Like 56 seconds.
A
Okay, that was my 400. So you might be able to.
E
Yeah, yeah.
C
So I might.
A
Yeah.
E
Because our mile times from. Maybe I'll give that a try sometime. I. I'd like to. I just haven't. I gotta find another race to go out and do it, you know, I know if I run just for me, like I can hit like 205, 206 on a mile. No, no, sorry.
A
Oh, just in practice.
E
Just in me. If I just went out.
A
Oh, you could definitely break it.
E
So I, I think I could. But you know, still, as you know, when you're going that fast, taking 5, 6 seconds.
A
Oh my God. I mean, I tore my glute the last 800. I did.
E
Is that right?
A
That's why I quit track. I tore it in the last 50 meters.
E
Oh my goodness.
A
That's the toughest part of the race. Yeah, those last 50, Hunter. Oh my gosh. You're just praying.
E
Yeah, yeah. It's all mental. Tough race. Yeah. You. You have to go all out. That's what it takes.
A
Yeah. Well, anything else, man? Where do you sell the machines? Online too? Can people learn more?
E
Yeah. So go. So if you want to check. So just a couple of things for you guys. All right? Number one, if you want just education on molecular hydrogen, check out molecularhydrogeninstitute.org okay? This is just. It's a non profit focus on education, research and awareness of hydrogen as a medical gas. You can even be certified and learn more about molecular hydrogen. And with that. So it's a non profit. With that, we're also doing the Wellness Science initiative. And this is a sector basically from this nonprofit where we're trying to help bring critical thinking to everybody. You've heard me on this podcast talking about the limitations of the studies, some. Some of the potential benefits, how we evaluate things. We want to educate everybody in the wellness space how to evaluate claims. And you don't have to be a PhD to determine whether or not something is good. But how do you even look at a research study? What is a study? What's the purpose of this. So we're doing some really cool things with this wellness science initiative. So really I encourage you to check that out. We're going to actually be having some really fun competitions at Eudaimonia and I'm just grateful actually for eudaimonia. I'll just take a minute to say that for them hosting our inaugural event where we're going to have this, this wellness Science challenge where we're going to come actually compete and take our quiz questions and they're going to see how, how, how good they are evaluating things and critical thinking. It's for everybody. It's not just like, you know, your, your top like smart people or whatever but it's just, it's really there to help make it community, make it fun and help us to learn and grow the industry in, in a powerful science minded way. There is too many people who unfortunately have made a bad rap for science because we get this thing called scientism. Basically it becomes like a religion, like the authority has spoken, science has said this and science has been wrong. That's not what science is about. Science is all about being self correcting and changing its position to be in line with the evidence and being improving by friction by people being curious and asking questions like well then how do you explain this? How do you explain that? What about this? That's how science works. And so by doing this we're going to improve where we're at today with our critical thinking as well as hold the scientists to the same standards they claim that they adhere to. Because we're going to say well listen, here's the evidence then can you change your mind? Right. And it's a really cool initiative so please check that out. So that's right now that's Molecular Height Institute and the Wellness Science Initiative. Nice. So check those ones out and then you can follow me of course on just Tyler LeBaron. Tyler W. LeBaron. On all socials you can find me. TylerLebaron.com is my website. I actually have some university lectures so actually some exercise physiology stuff. I have some of those things I've covered with my advanced class that are on there. People can enjoy that. And then of course if you're interested in our inhalation machine, if you want to try this therapy. Yes, check it out. Inhale h2.com Again we are the only machine on the market that delivers hydrogen gas. The way we do it in major control clinical studies where we can ensure the amount of hydrogen gas you're getting is therapeutic and it's not explosive. So you want to exploit too. Exactly.
A
All right man, it's been fun. Let's do some arm wrestling.
E
Awesome. Cool.
A
Check them out guys. Peace. If you learned anything from this episode or got any value at all, please share the subscribe episode with a friend. It helps us grow the channel, it helps us grow the podcast, and it means a lot to us. Thank you so much.
B
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Date: June 28, 2026
Host: Sean Kelly
Guest: Tyler W. LeBaron, PhD – Founder, Molecular Hydrogen Institute
This episode dives deep into the emerging science and therapeutic promise of molecular hydrogen (H₂)—the smallest and simplest molecule in the universe. Host Sean Kelly sits down with molecular hydrogen researcher Dr. Tyler W. LeBaron at Dave Asprey’s Biohacking Beyond Conference for an eye-opening conversation that spans hard science, practical applications, and personal stories. Beyond the basics, they discuss everything from clinical trials and proper dosing to the intersection of athletic performance, muscle strength, and healthy longevity.
Quote:
“So that hydrogen atom could react with, you know, nitrogen to form, you know, amino acids, ammonia, or it could react with another hydrogen atom to form a molecule of hydrogen. We call that molecular hydrogen, hydrogen gas. And that is the therapeutic molecule that I’ve been researching and I’m excited about.”
— Tyler (04:07)
Quote:
“In Japan, there’s also a lot of misunderstanding about hydrogen. People would conflate it with atomic hydrogen, or alkaline water, but that’s totally not what hydrogen gas is about.”
— Tyler (05:24)
Quote:
“There was like a 39% increased survivability with—that’s insane. And there was also improved neurological scores as well...The trend was extremely strong...”
— Tyler (09:47)
Quote:
“Hydrogen gas, because it’s a neutral and non-polar molecule, it’s easily able to diffuse right through the cell membrane...directly into, say, the mitochondria, which we have shown has really important effects.”
— Tyler (13:41)
Quote:
“There’s a pretty interesting correlation—the more hydrogen gas you’re producing, you tend to have lower risks of metabolic syndrome, diabetes, dementia, Alzheimer’s. Japanese centenarians...have higher breath hydrogen gas production.”
— Tyler (18:11)
Quote:
“This study [2007] is powerful for several reasons. Number one, it showed that hydrogen gas, even below the flammability or explosive threshold, is therapeutic.”
— Tyler (22:03)
Memorable Moment:
“There are documented cases where people have been inhaling the hydrogen gas...and an ignition, a spontaneous ignition occurs. Ignites inside their nose. And then you get an internal detonation in the airway and they get rushed to the ICU...This is documented in the literature.”
— Tyler (33:25)
Quote:
“Hydrogen gas is...a unique type of antioxidant in the sense that it’s selective and regulates your body’s own antioxidant system...hydrogen gas actually increased, enhanced the rise of exercise-induced PGC1 alpha increase.”
— Tyler (43:16)
Quote:
“I really believe in informed consent. People should be aware that this research exists...of what the limitations of this research are, and they can make their own decision about whether or not they should try it...”
— Tyler (46:52)
Quote:
“We need to temper our excitement with our ignorance. I don’t have a crystal ball. I don’t really know. And so I believe in informed consent, which is that people should be aware that this research exists...”
— Tyler (46:52)
Quote:
“I kind of like where I’m at. I’m just kind of a hybrid athlete. We know longevity, there are two very important things...VO₂ max and muscle mass and strength.”
— Tyler (49:11)
On Molecular Hydrogen’s Unique Biology:
“Hydrogen gas...because it’s a neutral and non-polar molecule, it’s easily able to diffuse right through the cell membrane...directly into, say, the mitochondria, which we have shown has really important effects.”
(Tyler, 13:41)
On Safety and Dosing:
“Anyone interested in trying hydrogen therapies or hydrogen inhalation...should always ask: [1] Am I sure that I’ll always get a therapeutic dose regardless of my breathing pattern? [2] Am I sure it will always be below 4% so I don’t put myself at risk? [3] Can you precisely control the concentration?...Our machine does precisely that.”
(Tyler, 35:21)
On Research & Caution:
“We need to temper our excitement with our ignorance. I don’t have a crystal ball...People should be aware what the limitations of this research are, and they can make their own decision.”
(Tyler, 46:52)
On Athletic Performance:
“Hydrogen gas actually increased, enhanced the rise of exercise-induced PGC1 alpha increase. So hydrogen gas, showing to be kind of like an exercise mimetic, is therapeutically helping improve more mitochondria.”
(Tyler, 43:16)
Tyler LeBaron delivers a nuanced, evidence-based, yet accessible guide to the evolving field of molecular hydrogen therapy—balanced with humility, caution, and real-world experience as both a scientist and athlete. Whether you’re a health researcher, a longevity enthusiast, or just curious about breakthrough wellness tech, this episode offers both practical info and an authentic, critical perspective you won’t find anywhere else.
For further info: