
Hosted by Patrick Leddin PhD · EN
Disruption isn’t coming—it’s already here. Whether you’re leading a team, raising a family, or chasing a dream, curveballs are part of life. Disruption Lab helps you turn them into breakthroughs.
Hosted by Patrick Leddin and inspired by his book Disrupt Everything and Win (with James Patterson), each episode brings bold ideas and real stories to help you thrive in a fast-changing world.
Disruption is powerful—but so are you.

In this episode of the Disruption Lab podcast, Patrick Leddin sits down with Serena Ainslie, founder of Girl Math Capital, to explore how she’s rewriting the rules of investing and entrepreneurship. Serena shares her unconventional path into the world of venture capital and the mission behind Girl Math Capital—empowering women to confidently step into the financial arena and build companies that disrupt the status quo.They discuss the unique challenges female founders face in raising capital, why redefining risk is key to innovation, and how data, intuition, and courage come together in the investment process.Whether you’re an entrepreneur, an investor, or someone curious about the future of finance, this conversation will challenge the way you think about disruption, opportunity, and leadership. Learn more at www.girlmath.capital

In this episode of the Disruption Lab podcast, Patrick Leddin sits down with Jim Murphy, author of Inner Excellence: Train Your Mind for Extraordinary Performance and the Best Possible Life. Jim shares his remarkable journey—from professional baseball and FedEx, to years of solitude in the desert, to coaching world-class athletes and leaders.They discuss what true success really means, why purpose must come before self-focus, and how to perform under pressure with clarity and courage. Jim also tells the incredible story of how his book went from selling just a couple copies a day to more than 200,000 nearly overnight—after Philadelphia Eagles wide receiver A.J. Brown was spotted reading it during a playoff game.Along the way, Jim even coaches Patrick through some of his own current challenges—reminding us all that opportunities, fears, and growth are part of every journey.Whether you’re an athlete, a leader, or simply someone navigating disruption in life, this conversation will challenge and inspire you to live with greater purpose. Learn more at www.innerexcellence.com

What would you do if every decision you made had to be right, and you had less than a second to make it?In this episode of The Disruption Lab, Patrick Leddin sits down with Professional Racing Driver & Entrepreneur Phiroze Bilimoria to explore what it takes to perform when the pace is relentless and the pressure is high. Phiroze shares how he manages split-second decisions, works seamlessly with his team, and turns disruption on the track into fuel for success. Whether you lead from the boardroom or the driver’s seat, you’ll walk away with practical lessons on staying calm under pressure, executing with precision, and using challenges as a catalyst for growth.To learn more about Phiroze you can visit www.phirozeracing.co.uk

What if lasting change was closer—and more possible—than you think?In this episode of Disruption Lab, host Patrick Leddin sits down with neuroscientist Dr. Josh Davis and entrepreneur Greg Prosmushkin, co-authors of The Difference That Makes the Difference: NLP and the Science of Positive Change.They explore how Neuro-Linguistic Programming (NLP)—once considered niche or esoteric—can be a powerful, science-backed tool for creating positive change in everyday life and leadership. From Josh’s background in psychology and neuroscience to Greg’s journey from the courtroom to building multimillion-dollar businesses, the two share how NLP shaped their paths and why they believe it can do the same for you.Whether you’ve never heard of NLP, are skeptical of it, or count yourself among its devoted followers, this conversation offers a chance to learn, reflect, and engage with ideas that just might shift the way you see growth and transformation.Together, Josh and Greg break down practical techniques, personal stories, and the surprising science behind NLP, offering listeners a roadmap to communicate with impact, shift perspectives, and accelerate meaningful growth.Tune in for a conversation that will challenge assumptions, spark curiosity, and equip you with tools to disrupt old patterns—and unlock new possibilities.To learn more about Josh and Greg’s book, visit: https://us.macmillan.com/books/9781250349088/thedifferencethatmakesthedifference/

What if you’ve been measuring the wrong things all along?In this episode of Disruption Lab, host Patrick Leddin sits down with Karen Dillon—former editor of Harvard Business Review and New York Times best-selling co-author of How Will You Measure Your Life? with Clayton ChristensenThey dig into the pivotal “disruptive conversation” that changed Karen’s direction, leading her to co-create a book that challenges how we define success, meaning, and happiness. From her editorial background to that life-altering moment, Karen shares how making deliberate choices in the wake of disruption led to a deeply fulfilling path—and how you can do the same in your own work and life.Tune in for a conversation full of insight, heart, and practical wisdom on measuring what truly matters—and how disruption might be the catalyst you didn’t know you needed.To learn more about Karen you can visit https://www.linkedin.com/in/karen-dillon-author

What if real leadership isn’t just about driving results—but also about protecting your energy, staying grounded, and living a life that matters?In this episode of Disruption Lab, host Patrick Leddin sits down with Klaus Kleinfeld—former CEO of Siemens and Alcoa, advisor to global leaders, and author of Leading to Thrive. Drawing on decades of experience across industries and continents, Klaus offers a powerful blueprint for winning both the Outer Game of business success and the Inner Game of personal fulfillment.They explore how to lead through disruption, build world-class teams, recover your energy, and create a life where performance and purpose go hand in hand.If you're ready to lead boldly without burning out—this conversation is for you.To learn more about Klaus, visit leading-to-thrive.com.

What can 100 strangers and 1,000 everyday objects teach us about ourselves—and each other?In this episode of Disruption Lab, artist and storyteller Imran Nuri joins us to talk about what happens when you slow down, ask good questions, and truly see the world around you.Imran is the creator of Advice from America, a powerful photojournalism project where he traveled to all of the 48 lower states in the U.S. and interviewed strangers about the advice they’d give their younger selves. Now, he’s turning his lens to objects—photographing 1,000 items like gummy bears, coins, and chips, and displaying them side by side to challenge how we perceive differences.We explore how Imran turns personal disruption into creative energy, what it means to build trust with strangers, and how art can shift our assumptions in unexpected ways. His work invites us to find beauty in the ordinary, wisdom in others, and connection in the simplest things.This conversation is a reminder that even in a divided world, we’re far more alike than we think.Learn more about Imran and his work at www.imrannuri.com.

Feeling stuck in your career? You’re not alone—and you’re not without options.In this episode of Disruption Lab, career coach and author Lori Béen shares her wisdom from over 25 years of helping people break out of ruts, shift careers, and pursue work that actually aligns with their purpose. From working with college students to coaching seasoned professionals through reinvention, Lori has seen it all—and she brings a fresh, practical, and inspiring take on what it means to find your path.We talk about how to listen to your inner voice, recognize your gifts, and make career moves with confidence—especially in a world where the old rules no longer apply.You can learn more about Lori and her work at www.yourpassioninlife.com

What does it take to be the first? To break through when no one like you has done it before?In this episode of Disruption Lab, NYT bestselling author and Vanderbilt’s Director of Special Projects Andrew Maraniss joins us to explore what it means to be a trailblazer. Known for his powerful books at the intersection of sports and social justice—including Strong Inside, Singled Out, and Inaugural Ballers—Andrew shares insights on resilience, risk-taking, and the critical importance of having people who believe in you.We dive into the stories behind the firsts, the fight to keep going when the odds are stacked against you, and how sports can illuminate deeper truths about society—and ourselves.You can learn more about Andrew and his work at www.andrewmaraniss.com