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- [00:01]
Meta Ray Ban Display Announcer
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- [00:31]
Marshall's Commercial Narrator
Marshall's buyers are hustling hard to get amazing new gifts into stores right up to the last minute. Like a designer perfume for that friend who never RSVP'd wishlist topping toys for her kids who came too.
- [00:43]
Dr. Chapa
Mm.
- [00:43]
Marshall's Commercial Narrator
Belgian chocolates for the neighbor, a cozy scarf for your boss and a wool jacket for your husband that you definitely did not almost forget. Marshalls, we get the deals, you give the good stuff even at the last minute. Find a Marshall's near you.
- [01:08]
Newspaper Seller / Announcer
X ray. X Ray. Read all about it.
- [01:11]
Dr. Chapa
Podcast Family. You all know that one of our missions here, in addition to reviewing brand new studies or publications or new guidances, is to let you know what is hot in press, even in the vein or in the avenue of new medications. And that's exactly what we're going to cover in this episode.
- [01:31]
Newspaper Seller / Announcer
Extra, extra. Read all about it.
- [01:33]
Dr. Chapa
Yep, we're doing this on December 15th, 2025. Woo hoo. Ten days until Christmas. And just over the last few days, there's been a lot of progress on the war against gonorrhea. I don't know, I don't know if there's a war in gonorrhea or not, but maybe there should be. But this is new weapons in that arsenal against something that we were really concerned about because of the rise in resistan in that bad bug. Okay. And so in that same vibe, two medications were recently FDA approved. I'm talking about one on December 13th and then the other one just prior to that on December 11th. Let's do the first one that was approved first. That was Jepotitizen. That was called Blue Jiba by its brand name. Now if you remember, if you follow the show, we covered Blue Jiba months ago. Months ago because it already has a separate indication and approval for uti. So you gotta go back into the archives because we talked about, even though we'll just briefly mention it again, the mechanism of action is pretty novel. For Blue Jipa, that was FDA approved first for UTI. Now for oral treatment for gonorrhea, that was on December 11th. Then two days after that, the FDA gave another stamp of approval for For Zoliflotison, Zola Flauticin's brand name is New Volvins. What? New Zolvens. Yeah. All right. N U, Z O, L V E N C E. Nuzolvents, you try to figure that out anyway, even though Blue Jeepa is pretty catchy. Blue Jeepa, but Nuzolvents, I'm not digging that too much, but nonetheless, these are two brand new oral treatments for gonorrhea which are desperately needed because for people who don't like shots or whatever or they say they're gonna get it and then they don't get the first line of medication which is still ceftriaxone and it is weight based. Remember that under 150 kilos, then the dose for ceftriaxone is 500 milligrams. And if you're above 150 kilos, not pounds, but kilos, then you move up the dose of ceftriaxone to 1 gram. Im so we're briefly gonna talk about these two FDA appro jepotitazin, which was on December 11, and then two days later on December 13, zolifloticin, which were both approved as oral treatments for gonorrhea. Gonococcus. All right, so briefly, just a quick word on what is up because once again our goal here is let you know what is hot hot in not just in press, but also in the approval process.
- [04:15]
Newspaper Seller / Announcer
X ray. X ray. Read all about it.
- [04:17]
Dr. Chapa
I think I set it up enough. We'll be right back. This is Dr. Chapa's obgyn no spin podcast.
- [05:13]
Strong Coffee Company Sponsor
This is, excuse me, a damn fine cup of coffee I've had. I can't tell you how many cups of coffee in my life.
- [05:20]
Dr. Chapa
And this, this is one of the best podcast family. We are thankful for our personal partnership with the Strong Coffee Company that stands for striving to reach our natural greatness. This is not your regular cup of coffee. This cup of coffee with adaptogens to boost mental and physical performance without a caffeine crash. There is a 20% discount for anything that you order through the Strong Coffee Company only with the link in our show notes. Again, thank you to the Strong Coffee Company for offering this 20% discount unique to our podcast community with a link in our show notes. Yeah, I guess if we were back in the old days, I guess old days, like old old days back in the streets of London, we would be in the early newspaper business.
- [06:07]
Newspaper Seller / Announcer
Newspapers for sale.
- [06:11]
Dr. Chapa
That is so stupid. I can't believe I did that. Well, it's hey, we're close to December, right? Christmas story, Charles Dickens, all the British stuff. Come on now. Are you feeling it?
- [06:21]
Newspaper Seller / Announcer
Newspapers for sale.
- [06:22]
Dr. Chapa
Oh, my gosh. Michael, leave that in. Don't edit that out. Leave that in. So just recently, a couple of days ago, two brand new FDA approved medications for gonorrhea, which is good because ceftriaxone is still legit, still first line. But this provides brand new options here where the bacteria hasn't figured out how to eat this medication. Because these are pretty novel, okay? Now, both of them share similar paths here on mechanism of action. So if somebody asks you, hey, tell me about zolifloticin or blue jipa, which is jepotidacin, you go, oh, please, man. So easy. They work by inhibiting a crucial bacterial enzyme called type 2 topoisomerase. Duh. All right, hold on. That was really weird, guys. I worked all night, I'm a little punch drunk, post call goofy, and I go back on call tonight. I don't know. Michael told me, let's not do it. You're acting kind of weird. I'm fine. I'm a little sleep deprived. I'm gonna take a nap and then I'm gonna go back and I'm gonna fill my body up with my typical level of caffeine. It's gonna be just fine. So zolifloticin. Zolifloticin, otherwise known as, again, first in class, single dose oral antibiotic. End quote. Now, I realize that this sounds very commercially. They are not a sponsor. I'm just reading you directly from the FDA approval because we don't have a lot of other, like, you know, clinical population data on this because these just came out within days. All right, so I'm just reading directly from the press release quote, zolifloxin is a first in class single dose oral antibiotic approved for adults and pediatric patients 12 years and older for the treatment oral treatment of gonococcal infection. Now here's the catch. This is not a pill. So remember that Zolifloticin. Zolifloticin is granules that dissolve in water. Almost like the old monorail. Remember, it's like a little powder pack and you mix it with water and then you drink it or the zithromath, 1 gram powder pack of azithromycin. These are granules. So zolifloticin, otherwise known as nusolvents. So I kind of remember Nuzolvents as a solvent. I don't know. It works for me. Okay. New solvents is a Solvent made of granules that dissolve in water. So single dose. And it does inhibit that crucial bacterial enzyme called type 2 toporisomerase. Remember, that's the one that the bacteria needs to replicate and make more of itself. So it basically kills it and it can't make any more of its own type. So that's great. That is the one. And again, this does have phase three clinical data that showed that this thing works. So that's good news. First in class, granules, new solvents, dissolves as a solvent for granules for the treatment, single dose of gonorrhea. Now, Blue Jipa is a tablet. Remember, we covered this, as I said in the intro back in the day several months ago when this was approved for a separate indication. This one is a tablet. Same deal, okay? Patients 12 years and older who have no other alternative treatment options. So again, I wanna be very clear, these are not first line. First line is still ceftriaxone based on weight. However. However, for patients who have a shot aversion or you don't stock that in your clinic or whatever, this is an alternative that hopefully will open up avenues of for those who say they'll get the injection and don't for whatever reason. Now remember, this was back in March of 2025 when Blue Jipa was first approved to treat urinary tract infections. So Blue Jipa Jepotitizen, back in March. So fast forward, we are now in December. So nine months later, this now has the approval for gonococcal infection. And if you remember in that episode that we covered, I said this is coming down the pipe, guys, I told you this nine months ago. And again, not being braggadocious, I'm telling you, we do our due diligence, we try to see what's coming up ahead of print, what's down on the horizon that we can see and forecast with good evidence. And sure enough, we said that this was going to happen before end of year. And here we are, end of year in December 2025. December 2025. Again, this is first in class. And it's an antibiotic that prohibits DNA replication also that hits the type 2 isomerase. But it kind of has a dual function, a dual modality here. So both of these seem to have no resistance based on the gonococcal bacteria. The gonococcal bacteria can't really figure out how to destroy this medication because it is so new as Blue Jeopa, when that first got approved in March to treat UTIs. As that press release back nine months ago stated quote, this is the first new antibiotic class approved in over three decades. Again, not a sponsor. So there is some good news here. I mean, we need as much medications available to treat these potentially dangerous infections. And it's scary, guys. I mean, syphilis, you know, was on the watch, especially in Texas and in the Southeast for resistance. Thankfully, penicillin is still the way to go, but gonorrhea for sure. And this is the thing that is driving these new medications. And it's good. Blue Jipa does have a specific warning. Blue Jeepa carries a warning that potentially can cause QT prolongation and some allergic reactions. So you just gotta, you know, be aware of that. So again, one is a tablet, the tablet is called Blue Jipa, and then one is dissolvable granules, that is zolifloxin. Two new oral medications for gonococcal infection that came out within the last four days in December of 2025. These are novel. These are not in the traditional line of cephalosporins. They have their own mechanism of action. And once again, we should be celebrating this because these new oral treatments help protect against this global rise in gonococcal drug resistance. And they are non injectable. So those are two big wins. Podcast Family, really, this is very fast. Just wanted to let you know what is out there. We don't have a lot of clinical data out there outside of the clinical trial that was used for the FDA's approval. But again, just letting you know, your free newspaper has arrived.
- [13:24]
Newspaper Seller / Announcer
Newspapers for sale.
- [13:27]
Dr. Chapa
All right, Podcast family, I think we've done what we're supposed to do. This was just a very quick episode highlighting the recent changes to medications for gonorrhea within the last four days, starting on December 11th, and then on December 13th, 2025, with our recording this on December 15th, 2025. Podcast family, as always, we thank you. We're glad you're part of our podcast community and our podcast family. And now that we've done all that, Michael, now let's take it home. This has been Dr. Chapa Zobichyn, no Spin Podcast Podcast family. Thank you for your support. Thank you for listening. And as always, we'll see you on another episode of the no Spin podcast.
- [14:53]
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- [15:09]
Dr. Chapa
Limu is that guy with the binoculars watching us.
- [15:11]
Liberty Mutual Insurance Narrator
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