Cow burps are a climate problem, and one startup wants to reprogram them.

Hoofprint Biome is using enzymes to rewire the cow’s microbiome from the inside out, cutting methane production and improving feed efficiency along the way. The company just raised a $15 million Series A round from investors including Amazon’s Climate Pledge Fund, and they’re just getting started.

Today on TechCrunch’s Equity podcast, Tim De Chant sat down with Kathryn Polkoff, co-founder and CEO of Hoofprint Biome, to talk through it all.

Listen to the full episode to hear about:

How enzymes and AI are helping fight climate change (seriously).
What it takes to raise money for biotech in a sea of SaaS.
Why thinking like a farmer, rather than a climate scientist, was Polkoff’s superpower. As she put it, “That’d be like if you were engineering a car but had never changed the engine — that’s where all the energy comes from.”
The future of methane reduction and feed efficiency at scale.

Equity will be back Friday with our weekly news roundup, so stay tuned.

Equity is TechCrunch’s flagship podcast, produced by Theresa Loconsolo, and posts every Wednesday and Friday.

Subscribe to us on Apple Podcasts, Overcast, Spotify and all the casts. You also can follow Equity on X and Threads, at @EquityPod. For the full episode transcript, for those who prefer reading over listening, check out our full archive of episodes here.

Credits: Equity is produced by Theresa Loconsolo with editing by Kell. We’d also like to thank TechCrunch’s audience development team. Thank you so much for listening, and we'll talk to you next time.

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