Dr. Sandra Kaufmann is back for round two. She's the creator of the Kaufmann Protocol, author of three books on the science of aging, and a longevity physician.

In addition to her clinics in Miami and Las Vegas, she also runs Club Exosome, a quarterly gathering of longevity fanatics she calls a modern French salon.

This is a conversation for anyone who wants to understand not just what to take, but also why and how to think about longevity at a level that actually moves the needle.

— Episode Chapter Big Ideas (timing may not be exact) —

0:00 — Intro

2:49 — Club Exosome: what it is and why she calls it a French salon

3:29 — What she still believes from round one and what she's added

4:30 — Heterochromatin distribution: her new DNA obsession

5:30 — Why circadian rhythms are strictly biochemical

6:32 — Mast cells: why they increase with age and why that matters

7:48 — Iron toxicity: the silent accumulator nobody talks about

9:05 — Clean bloodwork but still at risk: how iron hides in your tissues

10:06 — The plague theory: why your ancestors' iron storage may be killing you slowly

12:09 — How to actually test for tissue iron accumulation

12:57 — Why giving iron to older patients with low blood iron is often the wrong call

13:39 — Aspirin as an iron chelator: the colon cancer connection

15:06 — High intensity exercise and iron recycling

16:25 — Natural chelators: wheatgrass, quercetin, astaxanthin, aspirin

17:31 — Blood donation as a longevity tool, especially for men on testosterone

18:28 — Hematocrit and stroke risk

19:09 — Exosomes: what they are and how they work at the cellular level

20:57 — Where exosomes come from and why source matters

22:52 — When to start using exosomes and how they compare to PRP

25:26 — Exosomes vs. stem cells: the key differences and why she prefers exosomes

27:43 — Exosomes as an amplifier

28:52 — Mast cells beyond allergies: the aneurysm and heart attack connection

30:26 — What mast cell degranulation is actually doing to your collagen

31:29 — Being allergic to stress: the cortisol-mast cell receptor connection

32:01 — Natural mast cell stabilizers

38:48 — Estrogen for men: why trying to eliminate it is a bad idea

40:14 — The estrogen algorithm she's building and what it will cover

43:37 — Glycation vs. glycan age: what's the actual difference

44:36 — HbA1c and skin autofluorescence as glycation markers

45:43 — Epigenetic clocks: interesting data, limited decision-making value

47:26 — Her actual assessment framework: what labs she starts with

48:01 — Grail liquid biopsy vs. full body MRI: why she wants both

51:31 — Tests she wishes existed: sirtuin levels and intracellular NAD

51:56 — Sirtuin hierarchy: which ones matter most and what activates them

56:06 — Her current pharmaceutical stack and why

1:03:37 — The question she's trying to answer next

— Connect With Dr. Sandra Kaufmann —

Website: https://kaufmannlongevity.com

Instagram: https://www.instagram.com/kaufmannlongevity

Book1: The Kaufmann Protocol: Why We Age and How to Stop It — https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047/

Book 2: The Kaufmann Protocol: Aging Solutions — https://www.amazon.com/dp/B0B5MVFBVQ

Book: Kaufmann Longevity Treatise Series, Volume 1: Mastering the Mast Cell — https://www.amazon.com/Kaufmann-Longevity-Treatise-Mastering-Mast-ebook/dp/B0GSX7BXL1

— Connect with Julian and Executive Health —

LinkedIn — https://www.linkedin.com/in/julianhayesii/

X — https://x.com/thejulianhayes

Don’t let your biology become the bottleneck to the enterprise you’re building. Book a private call —https://www.executivehealth.io/contact

***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner. Consult your provider before making any decisions.