In this episode of Forward Thinking Founders, Mat Sherman talks with Nikhil Yadala, cofounder and CEO of Helome, a company building AI copilots to help people slow their aging. Nikhil shares how Helome uses advanced “aging clocks”, AI models trained on blood biomarkers, to measure biological age and guide people toward healthier, longer lives.

We explore his decade-long journey from mathematician to longevity founder, why he believes measuring aging is harder than curing it, and how he built an open-source AI assistant called Longevity GPT to make personalized health insights accessible to anyone, anywhere.

Nikhil also opens up about moving from India to San Francisco, what the Bay Area’s startup culture taught him, and his candid take on Brian Johnson’s Blueprint experiment.

Topics covered:

What biological age really means
The science behind AI-powered aging clocks
How Helome helps people test and track longevity markers
Lessons from building in the longevity space
Why SF accelerates founders faster than anywhere else

Learn more about Helome at helome.one and try Longevity GPT at asklongevitygpt.com.

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