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Nelk Host
All right, welcome back to the full send podcast. We have an interesting episode today. Brian Johnson. I really enjoyed this one. If you guys have not downloaded the Prize Picks app and tried it for firing on sports, you're missing out. It's NFL playoffs. Literally watching NFL playoffs and locking in a prize picks with your boys at the same time. There's no better feeling than sweating that. Also, you guys have seen me promoting it. I am running a hundred mile race. If you're watching this, I'm probably running it right now. And we're live on kick. What's crazy is Prize Picks you can actually fire on my 100 mile race. So if you go to the prize.
Brian Johnson
Picks app and you go to the.
Nelk Host
Culture section and then entertainment, you can literally fire on so many different things. How long the first mile is going to take, how long it's going to take me to finish. There's so many people actually firing on this. Now I know what it's like to be a fighter and people are like firing on you. It's crazy. Also, UFC this weekend, first fight of the year. Patty Gaethje, our boy Suga. Sean's fighting. It's a great card. We're going to be locking in some prize picks for that. Stay tuned for that. Also, if you guys are a first time user, use code nelk. Put in $5 with that code and you're gonna get $50 for free. Shout out to PR the best app in the game to fire on sports. I gotta go run 100 miles.
Co-host 1
Let's get in the pod.
Nelk Host
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Co-host 2
Ncpgambling.Org is the toilet paper in the bathroom brown or is it just lighting?
Brian Johnson
Yeah, bamboo.
Co-host 2
Oh, okay. We gotta talk about that.
Brian Johnson
Yeah. Yeah. Did you try it?
Co-host 2
I did a test wipe. I'm not gonna lie.
Brian Johnson
I know it's your house, but I.
Co-host 2
Had to try it out. I've never seen that before.
Brian Johnson
Yeah, we test it for.
Co-host 2
It's honestly kind of soft too. I was impressed by it. Yeah?
Brian Johnson
Yeah. Like out of five stars, how many would you give it?
Co-host 2
It's like, eco friendly.
Brian Johnson
Well, basically, you're trying to eliminate toxins.
Co-host 2
Yeah.
Brian Johnson
So, like, don't die is like, find everything that could kill you and don't do that.
Co-host 1
What's wrong with conventional toilet paper?
Brian Johnson
Thing is, everything has toxins. Foods, air, water, clothing. It's just everywhere. And so identifying where those toxins are and then trying to minimize those. What's that, Zen? Yeah. Are you doing it now?
Co-host 1
I just have one in. Yeah, I like doing it when. Just when I.
Brian Johnson
Okay.
Co-host 2
It's for your crib.
Co-host 1
Is that cool?
Brian Johnson
No, no, it's. It's actually cool. Yeah. The problem, though, it creates vasodilation, dilation.
Co-host 1
Dense.
Brian Johnson
Yeah.
Co-host 1
And that's bad.
Brian Johnson
So. Yeah, so it will make your. So basically you have less blood flow to your. Your face, which will make your face age.
Co-host 2
Ah.
Guest or Additional Participant
What about this thing, babes?
Co-host 2
That's way worse for sure.
Brian Johnson
Yeah. Not a good idea.
Guest or Additional Participant
What's something that we don't know as people about vapes that you could tell us?
Brian Johnson
I mean, it's just not good. It's like, it's not something that makes your lungs better or your body better. Yeah, yeah. And if you look at some of the biomarkers, you'll see that it could have some negative effects.
Co-host 1
How'd you go from being, like, a tech wizard and I want to talk about that, because that's an interesting story too, but to learning all about the biohacking stuff. Like, how did you learn all this stuff?
Brian Johnson
I love to read history, and when you go back hundreds of years, you see certain times where people saw certain things. They saw the future, and that they actually. If people were to stop and say, I see it too, they could have lived, you know, better lives. For example, like in 1870, there was a crazy idea that microscopic objects called bacteria are the source of infection. And so when that new idea came out, people were like, that's stupid. Half the people were. And so the reaction in the community was half the people were. Doctors were not called gentlemen. They couldn't practice. They didn't want to be in the community practicing the medicine because they didn't believe in this new idea. Turns out bacteria is real. It can cause infection. It can lead to death. And so if you hear that idea and you're like, that's stupid. You might die. And so the question is, what ideas are there in the world right now that are actually true? And if they are true, may actually be in your best interest to do those things? So that's. That was the goal. And so I think basically the Insight is I'm trying to achieve immortality by the year 2039.
Co-host 1
Wait, wait, wait, 2039, you're 47, 48, 4814 years from now.
Brian Johnson
That's right. Immortality basically longevity, escape velocity where one year of time passes and you can stay the same age age biologically.
Co-host 1
So wait, define immortality.
Brian Johnson
That. Yeah, basically it's just like once you arrest biological aging, you still have the risk of getting killed in some accident, but you're not going to die of cancer or of metabolic, of cardiovascular disease or something else. So you take away the biggest risk factor for death. And so that's, I think, where there's error bars around that. But I think it's reasonable as a target. But yeah, I mean we're, my team and I are currently targeting that as a date where a year will pass and I will stay the same age. And not only that, I'll be. So that's 14 years. So I'll be 62 chronologically. But if the technology is actually advances the way we think, my body would probably be closer to a 20 year old.
Co-host 2
Really when you say that too, you're talking about like your heart and your brain will stay the same age.
Brian Johnson
That's right.
Co-host 2
How do you control that?
Brian Johnson
I mean there's technology now it's like, think about like this where, when, when a man and a woman procreate, the man contributes a sperm, the woman contributes an egg. They combine. And so even though, you know, like the, the father may be 30 years old, the mother may be 30 years old, when those two things combine, it basically goes back to zero. Right? The baby starts at zero. And so our bodies already have the ability to take aged cells and make it zero. And there are new technologies that do that outside of procreation. So you can take an adult cell, like one of your cells and take it back to zero. It's not fully developed yet where you just can't do it today. But that you can basically reverse time in biology.
Co-host 2
So what are the ways you test that where your body is staying the same age? Like how do you, and what is it considered right now?
Brian Johnson
So it depends on the body part. So for example, like I've measured, I'm the most measured person in human history. And so we've measured the biological age of my brain. But you can measure like 20 or 50 different age markers of the brain. You can measure the age of your heart, your lungs, your pancreas, your liver. You can measure like hundreds of biological ages for the body. So for example, like my, one of my oldest Ages is my left ear. It's age 64 because I shot a lot of guns. What's that? 64, 64. What about the right.
Co-host 2
That's a good question.
Brian Johnson
Yeah, like 45.
Co-host 1
45.
Brian Johnson
Wow.
Co-host 2
So you have better hearing in your right ear.
Brian Johnson
Exactly. So I shot kids. I shot guns as a kid and I also listen to a lot of music. Shot kids. Yeah, scratch that one.
Co-host 1
Clip it.
Brian Johnson
Yeah. So yeah, I have hearing damage in my left ear. And so but then like in other ways, like if you look at my blood glucose control, my cardiovascular ability, my fertility, my DNA, they're all roughly age 18. So in many ways my body runs like an 18 year old, like a legit 18 year old. And in other ways my body is old, like my ear or the mark.
Co-host 2
So when you wake up, you feel like you're in an 18 year old body. You have like more energy.
Brian Johnson
I do.
Co-host 1
Walk us through your daily routine.
Brian Johnson
Yeah, yeah. It's about five hours long. So the morning begins. The night before I go to bed at 8:30. I try to be on time every night, like within like 15 minutes.
Co-host 1
So what time do you sneak into bed then if you're asleep by 8:30.
Brian Johnson
Like 8:20, I typically have a book in my hand and I'll read for ten minutes. Uh, so like try to be embedded and I'll fall asleep within one minute.
Co-host 1
But I saw recently you've got a girl now, right too. So does that switch up the bedtime a little bit?
Brian Johnson
Because we don't sleep in the same bed. Oh yeah.
Co-host 1
Ever.
Co-host 2
That's a good tactic for sleeping. Better for sure.
Brian Johnson
Exactly. Right? I mean, honestly, sleeping together is crazy.
Co-host 2
I agree.
Co-host 1
It gets annoying.
Co-host 2
Do what you got to do and then go to the other room. That's where I'm at.
Co-host 1
Especially when the girl wants to like cuddle all night. Yeah, like you got to like cuddle and then it's like turn over to your side so I could actually. You know what I'm saying?
Brian Johnson
It's crazy.
Co-host 1
Yeah, yeah.
Brian Johnson
So I go to bed at 30, I sleep for eight hours. I'll wake up like at 4:35 naturally. And then I do like a five hour routine. So I'll, I'll do 10 minutes of breath work. I'll then get a light into my eyes. 10,000 lux. This is like sunlight equivalent. I'll eat a breakfast with some protein, then I'll work out for an hour. I'll do sauna for 20 minutes and then I'll do hyperbaric oxygen therapy. And then my morning routine wraps what's.
Guest or Additional Participant
Something you do in your daily routine that you secretly like, don't, like?
Co-host 2
Go ahead.
Brian Johnson
I love it.
Guest or Additional Participant
You love everything.
Brian Johnson
I love it so much. It's like my daily ritual. It's like my daily prayer. And when I don't get to do it, I'm ornery.
Co-host 1
Do you cold plunge too?
Brian Johnson
I don't.
Co-host 1
Is that what you don't think it's good?
Brian Johnson
It's just not evidence. It doesn't pass the evidence bar as a longevity therapy. It may make you feel good, which is cool, but there's not evidence that it's actually a good longevity therapy.
Co-host 1
Really?
Brian Johnson
Yeah.
Co-host 1
Cuz that's like the new thing, right? Everyone's cold, plunging. I love doing it. I love the way it makes me feel. Like right when I get out.
Brian Johnson
Yeah.
Co-host 1
Yeah.
Brian Johnson
It's a great high.
Co-host 1
Yeah.
Co-host 2
You're saying there's no studies that prove that it benefits the human body?
Brian Johnson
There's benefits like you definitely. There's some, some feel good effects. You know, there's some other potential benefits. But as a longevity therapy, what we've tried to say is like, in the world of things you can do for your health, the list is endless. And so you have to narrow it down some way and say, what do I do and what don't I do? And so we, the filter we use is we said what things will slow down my speed of aging or extend or, or, or reverse age. But we're basically trying to get to that immortality point where we're trying to get to the point where my body stops aging.
Co-host 2
When did you become so focused on this?
Brian Johnson
42.
Co-host 2
So after you made your money, right?
Brian Johnson
Exactly.
Co-host 2
It seems like you have to be worth at least a hundred million to like have even this thought that this is possible.
Brian Johnson
If I had somebody in my life who could have coached me in my 20s to do this, I would do it. I just didn't know. I. I bought the story that when you are in your 20s and you're ambitious, the script is to grind. You don't sleep much, you don't eat well, you don't exercise, and you kind of just tolerate it because it's like, it's what you do and you want to kind of brag about. You're kind of cool with three and four hours of sleep and it's kind of a flex, but you're just kind of wearing yourself down. And so I think the other point.
Co-host 2
Though is like, when you're in your 20s, you're not worried about death as much as you are as you get whatever that's later in life. So if you changed in your 20s, how much would that change your position now?
Brian Johnson
Like, my son is 20 and he's been doing this with me for the past four years and I envy him. You know, like to imagine doing this when you're 16 years old, because even in your 20s, when you don't feel it that much, you're still accumulating the damage, your body still has the wear and tear. And then when the 30s hit and 40s, it all of a sudden manifests in these pretty brutal ways. But it just, basically it's a hidden cost. It's like you're spending money from a bank account and you can't see that bank account is going negative.
Co-host 1
So what's like the supplement regimen after you finish your morning routine?
Brian Johnson
I take about, I'm probably in the range of like 30ish pills right now.
Co-host 1
And is that based on like your blood work?
Brian Johnson
Maybe 15% of it. Most of it is generic like creatine, for example, vitamin D, vitamin E. So basic things that everyone gets on a daily basis going back to.
Co-host 2
And I'm sure this is like the most common question you get, but go. We're going to use your son as an example because he's 20.
Brian Johnson
Yeah.
Co-host 2
His life is going to change drastically. And people might say he's not even really living if he's only focused on living forever at an early age of cuz 20 is young. So do you think he's going to miss out on certain things that he can enjoy in life when he's so hyper focused on what you're doing as well?
Brian Johnson
It's a good question. And this is probably the most common question I get is people see what I do and they say, bro, so living so busy trying to not die, he ain't living right. It's like the most common thing. And what they're getting at is they're basically saying in 2025, humans have an understanding of life, that we do these death rituals as part of who we are. So for example, it's acceptable and normal to get three hours of sleep, sleep under your desk, drink on the weekends, do all your things. That's living. And the, the irony is it's actually slow, slow boil suicide, but our culture calls it living. And so it's really weird. So if you just fast forward in time to 2035, those that exist in 2035, like the podcast that takes place in 2035 here, will look back at 2025 and be like, those were killing Themselves and thinking it was cool. Like, that's so weird. So we're just in a moment in time where we just. We can't see it.
Co-host 1
It definitely is transitioning, though. Like, health is.
Brian Johnson
Yeah.
Co-host 1
Is in. Yeah.
Co-host 2
I mean, you can't be the only guy who's trying this out right now.
Co-host 1
Right. I've heard some crazy stories of, like, Saudi princes or like, middle. Sorry, Middle Eastern, like Elon. People in the UAE are like, creating labs and like, taking, like, cells from babies and like, trying to do the same thing.
Brian Johnson
Right? Yeah.
Co-host 1
Have you heard any of those stories?
Brian Johnson
Yeah, I know all these people. Yeah, people. People.
Co-host 2
You guys have a group chat.
Brian Johnson
I mean, yes, people are doing. People doing a variety of things for their health. And you're right, it is changing. It still weirdly hasn't crossed total zeitgeist, where there's. There's still like leftover ideas of that if you're not doing these, if you're not drinking, letting loose and having a, you know, having a fast food meal every once in a while, you're. You're not fully living life. So there's still some hangover on that.
Co-host 1
Did you ever eat fast food or like.
Brian Johnson
Yeah, yeah, I did.
Co-host 1
When was your last fast food meal?
Brian Johnson
I. I had chili cheese fries a couple years ago because my. My oldest son was like, dad, I don't know if I believe this. You know, you're really into this. And I was like, all right, let's give it a go. So I said, I'll eat whatever you want me to eat. So he got me some chili cheese fries.
Co-host 1
They're probably fire, though, right?
Brian Johnson
You know, I got so sick, I ate like, I don't know, maybe 10. And I thought, this is bad news. I already feel the situation and this is going to be bad.
Co-host 1
Did you keep it down or do you throw it?
Brian Johnson
No, I stopped and he let me stop. But I was sick for a while.
Co-host 1
How long drinking. Do you ever drink back in the ever?
Brian Johnson
Not much. I. I was raised Mormon, so we didn't drink. And then I left the Mormon Church. I had a couple years where I was kind of experimenting with alcohol, but never more than a few times.
Guest or Additional Participant
What do you think is the biggest thing people do that makes them age faster?
Brian Johnson
Sleep. Yeah. Yeah. Not alcohol, just sleep. Sleep's number one.
Co-host 1
Anything.
Brian Johnson
So the reason why I would identify sleep is when you don't sleep well, your prefrontal cortex goes offline and your. Your willpower plummets. So that means the next day, in the morning, when you can either eat the croissant or eat the bowl of berries. You're gonna eat the croissant because even though you. You don't want to, you know how it's gonna make you feel. And then when lunch arrives, you have the big cookie and whatever, you just can't hold yourself back. And so that's why sleep. Because sleep kills willpower. Willpower just pummeled you. Then when you. When you engage in those bad habits, you lose even more willpower. So when people feel out of control, it's usually because they have no willpower reserve left. They've. They've spent all of it, and they're just an animal, just, like, kind of succumb to their passions.
Co-host 2
You have the highest sleep score, right? I do think I saw that.
Brian Johnson
What is it? The marker of good sleep is you want to. When your head is a pillow, you want to be asleep within a few minutes. Time two is.
Dan Bongino (Ad Segment)
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Brian Johnson
Once you're asleep, you want to stay asleep. You don't want to be up several times. You want roughly two hours of REM and roughly two hours of deep. That's like restorative metrics you would see on a wearable whoop or a apple.
Co-host 1
Garmin, what do you wear?
Brian Johnson
I wear whoop, and I have a bed that tracks it as well. All of them are the wearable.
Co-host 1
Do you have, like, what kind of bed do you have?
Brian Johnson
Eight sleep.
Co-host 1
Eight sleep. Does that make a huge difference?
Brian Johnson
It does.
Co-host 2
How much are those?
Co-host 1
I think the, like, 3K, right, or something like that?
Brian Johnson
Thereabouts. And I think maybe the topper is a bit less.
Co-host 1
So what does that do? It does temperature control, and that's a huge thing.
Brian Johnson
The body's very sensitive to temperature.
Co-host 1
So when did you get that bed?
Brian Johnson
Years ago.
Co-host 1
And how, like, does it really change a lot?
Brian Johnson
It's. It's one of the reasons why I hate traveling so much.
Co-host 1
See, that's why I don't want to get one.
Brian Johnson
It does.
Co-host 1
It ruins it really because people have told me to get one but we travel so much that I'm like, I feel like I'm not going to be able to sleep. I already don't like sleeping in some hotels.
Co-host 2
Yeah, I'm going to get one for sure. I didn't know they were that cheap. What is the biggest effect that keeps you asleep or it makes you fall asleep faster?
Brian Johnson
It's the routines. So the body wants to be on a schedule, it wants to do things at a certain time and it's your circadian rhythm. So I build my entire life around my circadian rhythm. That's why when I go to bed at 8:30, it's precisely at 8:30 because the body says I want to go to bed right now. So spinning up all these biological processes, if you wait and go to bed at 11:30, which a lot of people do that and they think oh that's fine, I can just sleep in that much longer the next morning. It doesn't work that way. So for example, one reason why is at 8:30pm my body's kickstarting a process where a trash collector rolls through my body and it picks up garbage. And if I'm not asleep at 8:30, the trash collector doesn't come. So the garbage builds up in my body. So as an example, so you can't miss your bedtime and let those processes happen.
Co-host 1
What's three tips for like improving your sleep?
Brian Johnson
Number one is have your final meal of the day four hours before bed. So if your bedtime is 10pm, don't eat after six.
Co-host 1
And that just keeps you asleep longer or just deep.
Brian Johnson
It gives your body time to digest. And when your body has that distance, it will lower its body temperature. You'll have blood glucose will be down, your melatonin is produced so it gets the body in a more relaxed state. If you are have eaten like a half hour, an hour before your body's busy digesting, you have higher blood glucose, your body's hotter you so you have a longer sleep onset. So sleep or eight, four hours before bed. Number two is you need like an hour wind down routine. So if your bedtime's 10pm when 9pm comes you want to have screens off and spend that hour like doing things that relax you. Read a book, breath, work, meditation, hang out with a friend, call a family member, anything but be on your your screen.
Co-host 1
TV's not as bad as phone, right?
Brian Johnson
It depends.
Co-host 1
Phone is the worst before sleep. I know phone's so like when you're scrolling through but it's so hard not to sometimes. But that just makes your mind just.
Co-host 2
It keeps you awake. And especially if you wake up in the middle of the night and you grab your phone, you're screwed.
Co-host 1
Oh, I never do that.
Co-host 2
That's the worst thing ever. It's changed. That's me up. What was the third?
Brian Johnson
Probably something positive. Such as reading a book for 10 minutes. Is it just before you go to bed, a book in hand, and read it for 10 minutes. And that is as powerful as a sleep medication. But that helps wind your body down. You're.
Co-host 1
I don't know. But as powerful?
Co-host 2
Well, it depends on what you're taking. There's levels to it.
Brian Johnson
I think there's that. Yeah, I think actually on some metrics, it's more powerful than sleep meds. It's. It's really. I mean, look at the evidence. It's really good.
Co-host 2
Well, I actually saw something recently and someone sent me that, like melatonin studies are being done that it affects your heart. I don't know if you've seen that. What's up?
Co-host 1
Do you have melatonin?
Guest or Additional Participant
Every night you take 5 milligrams? Yeah, because I have trouble sleeping.
Co-host 1
You like melatonin?
Brian Johnson
I do 300 mcg. So a third of a milligram of melatonin? Yeah.
Guest or Additional Participant
You think it's too high right now? Like 10 milligrams?
Brian Johnson
The highest.
Co-host 1
I feel like every kid takes Salim Chow's melatonin.
Brian Johnson
Yeah, man.
Guest or Additional Participant
Cuz I mean, it's hard for me to sleep within like 20 minutes of being on my bed. Like, I. I stay on my phone too.
Brian Johnson
So I knock out melatonin, then 30.
Guest or Additional Participant
Minutes after I'll be done out to sleep.
Brian Johnson
So I. This would be my bet is you could actually stop taking melatonin if you eat four hours before bed, get off your phone 60 minutes before bed and read a book. And that will be 10x more powerful than melatonin.
Co-host 1
Yeah.
Brian Johnson
Yeah.
Co-host 2
Are you going to try it out?
Guest or Additional Participant
You know, reading's tough.
Brian Johnson
I'm not.
Guest or Additional Participant
I'll try reading.
Co-host 2
You can't do an audiobook. You have to actually read, too.
Brian Johnson
Let me try. Do the experiment. Do both.
Co-host 1
The phone's the worst.
Brian Johnson
It is.
Co-host 1
You know, it's the worst to phone right in the morning. Yeah, but it's so, like, I'll go through phases where, like, I won't touch my phone Right. In the morning and I'll try to, like, not. But it's so hard.
Co-host 2
Yeah. It's the toughest thing ever.
Guest or Additional Participant
I could, I could see the digesting Part like eating four hours before.
Brian Johnson
Yeah.
Guest or Additional Participant
I mean, not having so much in your stomach and then, you know, going to sleep right away, it's like. Yeah, you're having so much in your stomach. Yeah, I can agree with that.
Brian Johnson
I'll tell you guys this, that people who have been around me for several years now and they've heard me say these things and it's kind of landed, but they haven't done it for a variety of reasons. Then they finally do it, they come back to me and they say, this is the most significant life changing thing I have ever had. Because once you start sleeping, well, everything in your life changes everything.
Co-host 1
So do you not wake up at all?
Brian Johnson
No, I mean, occasionally I'll ever go.
Co-host 1
To the bathroom in the middle of the night occasionally. I always do.
Co-host 2
I've been trying to cut off my water by a certain time.
Brian Johnson
Yeah.
Co-host 1
I go to bed, I piss in the middle of the night probably twice. If I do once, that's like a good night.
Brian Johnson
What's your.
Co-host 1
But I drink a lot of water.
Brian Johnson
Yeah. On. At what time?
Co-host 1
I mean, yeah, I will drink it like before bed too.
Co-host 2
It's like you gotta cut off.
Co-host 1
But I'm also working out a lot and like running.
Brian Johnson
So.
Co-host 1
Yeah, I need to drink a lot of water too. Yeah, it's like.
Brian Johnson
Yeah. So one thing you can do on that is do you use electrolytes at all?
Co-host 1
Yeah.
Brian Johnson
Okay, how much?
Co-host 1
Like a thousand milligrams a day.
Brian Johnson
Okay. You, you could try to increase that.
Co-host 1
Increase it? Yeah, a little bit just to hold the water.
Guest or Additional Participant
You know what I hate is going to the bathroom right before you gotta, gotta sleep. Like, are you getting up? And I know, Should I just play this real quick? Yeah, why not?
Co-host 2
And then.
Brian Johnson
Yeah, exactly, you have to do that. You guys could try this for the, the liquid thing. I try to stop drinking fluids around 4pm So I hydrate very heavily in the morning. So I've. Lately I've been consuming around 4 to 5,000 milligrams of sodium per day. What? Because I, I work out really hard, so I sweat a lot. Yeah. And I do sauna to 200 degrees in a dry sauna. And so we've been measuring my sodium levels, my potassium, my magnesium turned it because I thought this might be too much. But my levels are still in the ideal range. But I've been heavily hydrating with electrolytes because sometimes.
Co-host 1
And what do you take for electrolytes?
Brian Johnson
Like what we, my company has.
Co-host 1
Okay.
Brian Johnson
Yeah, we buy our own stuff. We test it for toxins and stuff like that, but by, by having the right electrolyte balance that will help you stop urinating. So if you drink too much water and your electrolyte balance is off, you'll.
Co-host 1
Urinate more because you're not holding the water right?
Brian Johnson
Exactly.
Co-host 1
That's right.
Brian Johnson
So if you have the proper electrolyte balance and you push earlier in the day, you can, you can reduce the probability you'll wake up. And then the other way you can actually address the, the wake up and the not back to sleep is. That's all about the wind down routine. So right before bed, if you're on your phone, you're scrolling, you're texting, you're doing work, you're spinning up thoughts that are arousing you so you fall asleep and you wake back up. That's the first thing you're thinking about, right? The thing you're doing just before bed.
Co-host 1
Yeah.
Brian Johnson
So that's the thing that nails you. That's why this wind down routine is so important. You need to say, like, I, I'm gonna calm my body down even though it's painful, like everyone's addicted.
Co-host 1
Oh, you're so right. You're so right.
Co-host 2
Well, what's the first thing you do.
Brian Johnson
When you wake up? Oh, don't look at my phone. Yeah, yeah.
Co-host 1
When do you look at your phone? How long after you wake up?
Brian Johnson
Depends on if there's something pressing going on, but typically 30, 60, 90 minutes, something like that.
Co-host 2
Do you have like an emergency phone in your room?
Brian Johnson
I don't, no.
Guest or Additional Participant
And you have no alarm?
Brian Johnson
No.
Guest or Additional Participant
Do you just wake up?
Brian Johnson
Oh, wow.
Co-host 2
Yeah, I'm, I'm interested in. You said at 42, you thought about this. Was there one specific reason you were like, okay, I want to live forever? Or did something change in your life where you're like, I got to attempt this?
Brian Johnson
It's just a question. If, if you lived in the year, you know, 1600 or 1700 or 1800, the question would be, what is the one thing in existence that you could do that would matter a few hundred years from now? And there's typically only one or two things per generation that has that kind of longevity. And sometimes people are born into a time and place where there's just not many things you can do. But before this, before technology really was rolling, it was maybe a great book, or maybe it was, you know, political accomplishments or some other form of artistry. Now, I think the most epic thing that a human could aspire to right now is to not die. And so that's why when I was 42, I thought like, what goal would I want to have? That's the apex goal that a human can have on planet Earth in this time right now.
Co-host 2
Do you think that's positive for everybody though, to have that goal to live forever? Because I feel like it's kind of case dependent but.
Co-host 1
So you think you'll never die?
Brian Johnson
I think that's the first time that a human can realistically have that goal in our history, in our since Earth was formed. It is the first time that a biological species could say we may not die.
Co-host 1
And based on that goal, are you relying on like the future of like medicine and science as well? Like not what's currently available?
Brian Johnson
100%.
Co-host 1
What do you think is going to become like, like we said 10 years from now? What's going to be, you know, different and what's going to be more accessible?
Brian Johnson
I mean there's things, for example, like we'll probably be able to replace our organs. You'll probably be able to replace your kidney with a new kidney. That's pretty straightforward. We can do kidney transplants. There are some things like the brain is gonna be really hard. So we have to figure out how do you reverse the age in the brain. That's going to be probably the hardest one. There's new therapies that people are working on right now where you can just reverse the age of your cells from, you know, 48 year old cell back to a baby. And so right now there's risks with that technology because there's off target effects. Like you could create cancer with that, so they need to fix it up. But still there's a possibility that in some near time frame you get a therapy that wipes out 10 years of your biological age.
Co-host 1
And this biohacking space is so new still. Right. Like with medicine and the way it's advancing in science, I can only imagine what's going to be available.
Co-host 2
I feel like you have to get some backlash because being a human I feel like part of it is death.
Brian Johnson
Right.
Co-host 2
And I think for some people there's like that daily pressure that you know you're going to die one day, so you want to accomplish as much as you can in your life.
Brian Johnson
Yeah.
Co-host 2
But that changes if you're trying to live forever. So do people come after you for like everything you're trying to do?
Brian Johnson
Certainly. And if you go back in time, you look at the big shifts that have happened in society, you know, universal human rights was not a thing. It just became a thing recently. And there's been major ideas or democracy that somebody could vote. So ideas change, society changes, people's expectations of the world change. And so in 2035, it could just be common wisdom that it's not a good idea to die. When you look back at 2025 and you're looking at them like historical figures and being like, they just accepted death and they had this YOLO mentality, which is why a lot of people do stuff. They'll, they'll drink and smoke and not sleep well and not eat well because they'll say, what else am I going to do, bro? Like, how else am I going to live life? Like you're not living life, but they're just under a certain moral framework that will be outdated. They don't understand how fast things are changing.
Co-host 2
It is important too, though. Like financial situation is going to change everything because someone who doesn't or has to go to work every day, like you made, you were successful. I know you weren't rich your whole life, but there's people that work at the corner coffee shop that go to a 9 to 5 that aren't even. This isn't even crossing their mind because they don't think it's possible for them.
Brian Johnson
Yeah. So it's situational in some ways though, you know, but the thing that, that any person has, most people have access to is if, if they need emergency help, there's a medical infrastructure that could actually help them. Whereas that wasn't the case, you know, before or when they drink water out of a tap, it's clean. There's like someone watching out for them. There's not toxins or when they get certain food supply. So we do as a society, we've built up these really basic things to increase the health and wellness of society generally. It's not perfect.
Co-host 2
Right.
Brian Johnson
But this is. My goal is not just for me. My goal is for everybody. And so people, when I bring that, they'll say, why aren't you worried about overpopulation? Sure. Like that's a downstream problem. But my goal is to say, hey, humanity, this is an epic situation. And it'd be a good idea for all of us to say, let's give it a go. It kind of the coolest adventure we could go on.
Co-host 2
What about like wrinkles?
Brian Johnson
Yeah.
Co-host 2
Do you get Botox?
Brian Johnson
I don't.
Co-host 2
So you can stop. You think you can look this way.
Brian Johnson
When you're 80 with the technology's coming? Yeah, I think so. I better.
Co-host 2
What do you got to tell somebody? You look like that and you got to tell somebody, hey, I'm 80. Like they're going to assume you're like, probably 40.
Brian Johnson
Yeah. No.
Co-host 2
So you see someone in public and you're 80 years old and you look like that. It's going to throw people off.
Brian Johnson
Exactly. And they'll probably be like telltale signs. It would be something like, we have figured out how to de. Age the skin. We figured out how to. Whatever, whatever. But we can't stop the ears from growing, you know, like as you age or your ears get bigger. And so the telltale sign may be something like a. I'm biologically 18, but my ears are like a 64 year old. And we haven't been able to solve that minus a total ear transplant, which is just too complicated. So I'm guessing there will be things we can't solve which will ultimately reveal someone's true age. Yeah, but they won't be at risk of a heart attack or cancer because the risk will be in check because they're biologically young.
Co-host 1
What's the oldest person to ever live right now?
Brian Johnson
Do you know, If I'm not mistaken, it's 121, thereabouts. 124. Some somewhere there.
Co-host 1
So you think in our lifetime, how old will people be living?
Brian Johnson
I think it's a possibility that we just won't have a cap if, if we get to a point in 20, by 2039. For. So for example, right now my speed of aging is 0.50, which means for every 12 months that pass, I age 6 months. So I'm aging at half the normal speed. So that's been one of our primary goals, is slow down your speed of aging so you're accumulating less aging damage. If I could slow my speed of aging down to 0.25. Let's just make it up then. For every year, I only age 3 or 4 months, and with that certain amount of aging, if I can reverse that aging damage to therapies, I'm back to, to zero on that year. Right. I haven't aged. So that's the goal is slow it down as much as you can. Then whatever you do, age, get, get therapies to reverse that.
Co-host 1
So what, what are you doing besides just like the stuff everyone can do in terms of obviously good sleep, good diet, like, are you doing any, like, cell stuff for the cells or like stem cell?
Brian Johnson
There's really, honestly not been any fancy therapies that have worked. I've tried, I've tried them all. I've done stem cells, I've done exosomes.
Co-host 1
Are Those bullshit.
Brian Johnson
They just need to be spec and they need to be medical grade and. But otherwise a lot of people hear.
Co-host 1
Stem cell like people hear words and it's expensive, right?
Brian Johnson
It's expensive.
Co-host 1
A lot of celebs are getting, they.
Brian Johnson
Hear stem cells, they hear peptides, they hear red light therapy and they think good, good, good. But it's not as clean as that. There's nuances, it's good in some contexts and bad in other contexts. They're not characterized fully. There's some risks. So it's just complicated. But a lot of people just hear them, they think good, I'm gonna do it. But it's not the case.
Co-host 1
So what are you doing that's so different? Like, I mean all you said so far was like good sleep, going to bed at a good time.
Co-host 2
What about for your polite, like how do you keep your heart young?
Brian Johnson
Best therapy I do by far is the avoidance of harm, which is number one thing.
Co-host 2
I don't do fasting sober and stuff and being healthy.
Brian Johnson
Don't consume sugar, I go to bed on time. I, you know, I don't sit for long periods of time, I don't breathe toxic air, I don't drink toxic water. I just avoid harm. And that is probably the most effective therapy I do.
Guest or Additional Participant
How much money do you think you've spelt spent on, on trying to stay on?
Brian Johnson
About 5 million. But that, that money's primarily allocated towards researchers and scientists who do all the research. Like they, we've been trying to go to the literature and say what things do work. Cuz the key is figuring out what works and how you do it. So for example, if, if I didn't have that kind of research, I might be spending my time cold plunging, which wouldn't have the effects that we're looking for. Or I might be doing something like juicing all the time. Because if we think juice cleanses are like the key to. But that wouldn't have the effects. So we need to figure out in a very precise manner what to do, what not to do, and then spin up all the tests. And the majority of the money I've, I've spent has been on research and then testing myself, trying to measure everything in my body.
Co-host 1
So you're kind of using yourself as like a test dummy for the future? Yeah, in a way, yeah.
Co-host 2
I wonder if like when you turn we'll go 175, you're gonna be like, all right, I'm over this shit. Like has that hit your mind? Like there might be a point where I'M just going to be over it.
Brian Johnson
This is such a fun thought experiment. Today's Wednesday. Do you have stuff going on tomorrow?
Co-host 2
Yeah.
Brian Johnson
Friday. Yeah. So when you're 175 and ask you the same question, you're going to tell me you're doing something. So living for tomorrow and living forever are the same ideas. It's just when a human thinks about living forever, it breaks their brain. They're like, I would be bored. But if you put it in the frame of living for tomorrow, you always have something to do tomorrow. It's the same idea. Living forever is just tomorrow.
Co-host 2
Well, I guess it's a good thing you got money because you're gonna have grandkids on grandkids forever.
Co-host 1
Great, great, great, great, great.
Brian Johnson
Can you imagine that? Yeah. It's gonna be insane.
Co-host 2
It's gonna be 5,000.
Co-host 1
People's gonna get out of control.
Brian Johnson
Totally out of control. But this is. I want to be very clear. Everything I learn, I share with everyone in the world for free. I don't charge for it, I don't gate it. I share everything. What works, what doesn't work. I encourage people to follow these practices. And this is not about me achieving immortality. It's about helping everybody achieve. You know, I say immortality because it's like an interesting idea, but truly it's about being healthy right now.
Co-host 1
What's the biggest cause of death? Do you know, besides, like a car crash or like anything like that?
Brian Johnson
You know, it's a good question. I think it's cardiovascular disease, if I'm not mistaken, but I need to look that up. It's a good question.
Co-host 1
How about, like, cancer? Because, like, a lot of people die from cancer.
Brian Johnson
Yeah. I mean, for example, in India, they. They would do more for their population by correcting for air pollution than by curing cancer. So there's different. Different toxins have different costs.
Co-host 1
What do you think is, like, do you have a theory or, like, do you know anything about the causes of cancer?
Brian Johnson
And, like, I mean, mechanistically, we know what happens. We know, you know, at a cellular level, we know what happens. We know what happens when you can increase the risk of cancer. When your body's in poor health, you have a higher risk of cancer occurring when you're older. You have a higher risk of cancer occurring when your immune system is not as good. So, like, for example, okay, here's for example, when you get four hours of sleep per night or less for a few days, your NK cells, which are the cells that survey your body for cancer, they go down in activity by roughly 70%. So a way to increase risk of cancer is low sleep. Because when you're, when you don't get adequate sleep, your body is so stressed about the situation, it stops looking for cancer by 70%.
Co-host 1
So what's your diet like?
Brian Johnson
The philosophy is that every calorie has to fight for its life. We went through all the scientific evidence, we ranked all foods and we said what are the power law foods? So I don't want to just eat any random food. I want to find the healthiest food in the world, the second healthiest in the world and the third, if you can rank it like that. So it's basically a lot of legumes which are beans, lentils, edamame, berries, nuts, seeds, extra virgin olive oil is basically.
Co-host 1
What I, you take olive oil shots, right?
Brian Johnson
Yeah.
Co-host 1
You like those or no?
Brian Johnson
Yeah, they're good. Like you get I olive oil with everything. It's. I eat more calories with olive. I consume more calories via olive oil than any food in my diet.
Co-host 1
So you're, are you vegan?
Brian Johnson
I don't use those words.
Co-host 1
But you don't eat meat?
Brian Johnson
I don't eat meat. I do consume collagen peptides, but the, the whole argument around paleo, carnivore, vegan, I just don't buy it.
Guest or Additional Participant
How do you maintain muscle relying protein?
Brian Johnson
So I do 130 grams of protein.
Guest or Additional Participant
Per day and shakes or.
Brian Johnson
Yeah, it's pea and hemp protein.
Co-host 1
Okay.
Brian Johnson
Lentils, edamames, beans, collagen peptides. Yeah. My muscle mass is in the top 99th percentile of all men. Wow.
Co-host 2
How many of these guys do you see on the Internet that try and do something like Liver King right. When he had his face that are just trying to promote this stuff? Like can you call them out right away and be like that's bullshit.
Brian Johnson
I try not to call anyone out. I just say measure your biomarkers and share them.
Co-host 1
Yeah.
Brian Johnson
Because whatever you want, do whatever protocol you want, I don't care, whatever your ideology is, great. Just test your body and report it out.
Co-host 1
Do you eat fruit?
Brian Johnson
I do a lot of. Bear a lot of berries, blueberries, raspberries.
Co-host 2
Do you have your girlfriend on the same regimen?
Brian Johnson
She's like the, like the 80%, the 20 to get the 80 benefit.
Co-host 2
You might be with her for a long time.
Brian Johnson
Exactly. She's. It's taken her a few years like to roll through. She used to eat a lot of. She used to work at McDonald's and she actually ate McDonald's but she's. She's made a lot of life changes.
Co-host 1
Did you ever eat McDonald's?
Brian Johnson
I did, yeah. As a kid.
Co-host 1
What was your favorite?
Brian Johnson
You know, all of it. As a kid. As a.
Co-host 1
You know, teenagers like McDonald's or Burger King.
Brian Johnson
Oh, you know, the Whopper was a. After a while, the Big Mac gets old and you want to do the Whopper. Well, what's going on?
Co-host 2
No, just famous for that question.
Brian Johnson
Yeah, you are.
Co-host 2
Yeah.
Brian Johnson
Yeah.
Guest or Additional Participant
Is there something that you thought would work but didn't? Ever something you tried on yourself?
Brian Johnson
So many things. We did this therapy trying to rejuvenate my thymus, which is this gland right behind your sternum that takes care of your immune system. We did a human growth hormone, and we did it for 100 days. It worked. It regenerated my thymus, but it gave me a whole bunch of side effects. Like I messed up my lipids and had intracranial pressure. I did plasma exchanges. So my. But. So you guys probably heard, I took a liter of plasma for my son.
Co-host 2
They took his blood, Right?
Brian Johnson
Right. Exactly. Yeah, yeah, plasma. So the. The origin of that is that my father called me and he was. He said, I'm experiencing cognitive decline, which is scary. And he said, I will do anything to have my wits about me. And so we were looking at this new therapy. There was a paper showing that a young mouse and old mouse had been sewn together. They shared a circulatory system. The young. The old mouse got younger. So there was this idea, if you take fluids from a young mouse and put into an older mouse, that it would rejuvenate. So I did this with my dad, and when I did with my dad, my son's like, hey, I'll do it as well. So we made it like a family thing. The cool thing is, my dad, it dramatically improved his health, so it lowered his speed of Asia by 25 years equivalent for six months. It had no effect in me, though, because my health is pretty similar to my son, whereas my dad is. Is, you know, not as good as health. And so. So it's. It's very, very experimental therapy. It's. Because it has a. It's going on a bunch of trials right now, but that's one experimental thing I did where it didn't work, but it did work for my dad.
Co-host 2
So your son. For you, it didn't work.
Brian Johnson
Exactly.
Co-host 1
So do you continue that with your dad, too?
Brian Johnson
We haven't. I've told my dad I'm willing to, like, if he wants it. People think it's Weird. But there's, you know, millions of blood transfers every day. It. It's a very common thing. People give people, you know, actual organs. So it's a very common practice that.
Co-host 1
I mean, this stuff's just so new too, right. That it's like. It sounds crazy, right?
Co-host 2
It's. Well, the one thing I think about is how, like, you're investing everything into this. So how cautiously do you move now from, like, being afraid of an accidental death?
Brian Johnson
Yeah.
Co-host 1
Like, do you go in the car?
Brian Johnson
I do. That's the scariest thing I do.
Co-host 1
Do you get scared going in the car?
Brian Johnson
Yeah, I know the risk profile. Yeah.
Co-host 2
It's driving high.
Brian Johnson
Right. And now. Yeah, I'm more scared from. By others, though, because I know everyone's on their phones.
Co-host 2
Is that the biggest accidental death fear is being in the car?
Brian Johnson
Yeah.
Co-host 2
Is there anything else?
Co-host 1
Planes.
Brian Johnson
I feel safe and play. I'm a pilot. Oh, wow. Yeah. So flying is so safe.
Guest or Additional Participant
What conversation led you to get to this deep into everything that you're doing now? Like, was there a conversation when you first started, like, with someone or like, what was that switch? Because there's always a switch.
Brian Johnson
Yeah. I did a thought experiment. I imagined being present in the year 2500, so a few hundred years from now. And I imagined being there listening to them. And they're looking back in time at us in the early 21st century, and they're saying, amazing that they did blank. And I thought, what would they say? Like, what would those guys say about our time and place? And I thought they would say, like, that's when humans gave birth to super intelligence and that's when they figured out they weren't going to die. Obvious. In the same way we look back at the 90s, we're like, yeah, the Internet was born and the Internet breeds E commerce and E commerce builds. We see these things as obvious of this natural build process. So what's obvious to them that wouldn't be obvious to us today? So that was like, yeah, that sounds like it's right. Like, this is. We're the first immortal generation.
Co-host 2
It just seems like there has to be something else you're doing. It just. That's just how it feels that we don't know about outside of what you've told us.
Brian Johnson
Right.
Co-host 2
How many people have come to you and been like, just rich people out there? People out there like, hey, can you help me live forever?
Brian Johnson
Oh, yeah. Every week I've got some of the world's most powerful people who come to the house.
Co-host 1
Anyone you can name?
Brian Johnson
I Never talk. I never talk about them because, you know, they're doing a thing. But no, I mean, like, it's. It's wild that I started doing this a couple years ago and people were like, who is this oddball? What's he doing? And then over the past couple years, we've. I've gotten the. We've got a lot of credibility. And so now people show up and they just want to know, but they have no idea what. Like, literally, people think that wealthy people have it figured out. They do not. They're just as lost as everybody else. So I spent time. I usually get a group of like 10 or 15 people will go through the whole house. I'll walk them through what works, what doesn't work, and get them on the right path.
Co-host 1
So what was the light thing you said you do in the morning?
Brian Johnson
Oh, it's called 10,000 lux. So when within, like.
Co-host 1
So that's not red light? No, because everyone thinks red light get in the sun right. In the morning.
Brian Johnson
Yeah, that's.
Co-host 1
This is different.
Brian Johnson
Exactly. So, Right. To get your circadian rhythm locked in. There's so many benefits of getting light in eyes. When you wake up within 15 to 30 minutes of waking up, you want to have light in your eyes, either from the sun or from a 10,000 lux device. And so if you just.
Co-host 1
That I never heard of that.
Brian Johnson
It's just. It's basically like. It looks like this almost. Yeah. It's a very similar pattern, but it won't damage your eyes.
Co-host 1
So what you just. You look right into it.
Brian Johnson
You can just have it on the periphery where it's like basically just tossing out light. So you can be doing your morning routine, like brushing your teeth and. Or reading or making your breakfast, and just have a present, and that will lock in your circadian rhythm.
Co-host 2
I feel like the major thing you're going to see when these people come through is they're going to have to stop doing a lot of what they're doing and completely change their life. And that's not going to happen in most cases. Right.
Brian Johnson
People.
Co-host 1
But anyone can do that. Anyone can. I mean, not anyone, but you can. I think anyone can improve their sleep.
Co-host 2
You're gonna have to do nearly everything that you're doing if they're trying to achieve the same goal.
Brian Johnson
So the thing is, though, people do what other people do. So when it's normal to go to bed on time, people will go to bed on time. When it's normal to exercise every day, when it's abnormal, when it's weird to vape. When it's weird to drink alcohol, people won't do it. So it's just once the cultural norm changes, everybody will change. So it's just. That's what I'm trying to do is I'm trying to normalize. Don't die like that. Of course. Like, why would we want to be sick? Why would we want to feel shitty? That's stupid. Like, that doesn't make any sense.
Co-host 1
Do you ever get sick?
Brian Johnson
Rarely.
Guest or Additional Participant
When's the last time you got sick?
Brian Johnson
Probably a couple. Like two years ago. I traveled with my son for the holiday and he had a cold and so I got it.
Co-host 2
Were you pissed at him?
Brian Johnson
That was fine.
Co-host 2
You can't. You don't have time for that.
Brian Johnson
Yeah, exactly, you motherfucker.
Co-host 2
What if your son said, hey, dad, my whole life I've wanted to go skydiving for my birthday. Would you do it with him?
Brian Johnson
No way.
Co-host 2
Too much risk.
Brian Johnson
Yeah. And I don't want to sprain an ankle or twist a knee or something.
Co-host 1
How about cage diving with sharks?
Brian Johnson
So I actually, I have done some pretty. So when after I sold my company, branch of Venmo and I did some. A bunch of adventure stuff, I drove a dog sled in the Arctic. I did. I went to an active volcano in Iceland. Like legit plated lava. I did. I raced cars in the Moroccan desert. Like, a few things like that. I really enjoy adventure a lot. Those are all pretty. Pretty safe. But what do you.
Co-host 2
What do you do now besides your routine that, like, I'd say is just different? That makes you happy or, like, normal? Like, do you watch any tv? Do you watch sports, anything like that? That's just. You still do the normal activities, like. Or is it completely different?
Brian Johnson
I'm probably pretty normal on. I. I don't drink. I don't watch TV before bed. I don't stay up late. But outside of that, pretty normal.
Nelk Host
All right, guys, it's 2026. I'm talking to a lot of people, myself included. I feel like this year is the year that if you want to make something happen, you just gotta fucking try it.
Co-host 1
Honestly.
Nelk Host
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Brian Johnson
Of the way.
Co-host 1
So if you're a small business or.
Nelk Host
A big business, they help you the same equally. They have stuff now that we didn't have back then when we were like really in the depths of fullsend.com merch drops. Now they have a bunch of AI tools. It's like having your own marketing team with you when you use Shopify. If you've had a dream that you've always wanted to try. I got you guys on a sweet deal. You guys can go to shopify.com fullsend and sign up for a $1 per month trial. One $1 trial shopify.com full send. There's never going to be a good.
Co-host 1
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Nelk Host
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Co-host 2
How much did you say this takes up of your day, your routine? It's five hours.
Brian Johnson
Yeah. I mean for me it's a full time job because I'm trying to be out in the cutting edge. So my morning routine is five hours. And then throughout the day I'll do like for example, today you see all these boxes here on the table? I did, I did over the weekend I did 5 grams of. Of psilocybin and magic mushrooms.
Co-host 1
Oh yeah, you did that recently, right?
Brian Johnson
Yeah. Today you did it on Sunday.
Co-host 2
The chocolate.
Co-host 1
Five grams?
Brian Johnson
No, just. Just mushroom powder. Yeah. Wow.
Co-host 1
Five grams is a ton.
Brian Johnson
No. Yeah, it's two milligrams shy of a heroic dose.
Co-host 2
So you were full tripping?
Brian Johnson
Yeah.
Co-host 2
Did you do it here?
Brian Johnson
No, I did it in a different state, but I live streamed it. What? Yeah.
Co-host 1
How did that go?
Brian Johnson
It went really well.
Co-host 2
Dude, that's a huge.
Co-host 1
Where'd you go? What was the vibe?
Brian Johnson
So what I did, we live streamed it and then we. I had a bunch of friends come on that my. Some of my tech friends came on. So I was tripping and they were talking about psychedelics and tech and stuff like that. Hamilton Morris came on, you know, he did the pharmacopia. Okay.
Co-host 2
Of course.
Brian Johnson
Yeah. And then he came on, was hanging out and then Grimes did a DJ set.
Co-host 2
Oh my God.
Brian Johnson
Which was crazy good. Yeah. You had a good time. This is crazy.
Co-host 2
This is. This is impressive.
Brian Johnson
Yeah. There were up at one point there was a million concurrent streamers.
Co-host 1
Would you stream it on.
Brian Johnson
We did X IG, YouTube.
Co-host 1
Wow. And hawk streaming on Mushroom since would you. Were you reading the chat?
Brian Johnson
No, no, no. I was doing my thing, but. But it was. People were so. People are awesome.
Co-host 1
So what do you think about psychedelics? Yeah, did you see that new documentary, like about the, the veterans that are going to that spot in Tijuana, Mexico? Yeah, that was a crazy documentary.
Brian Johnson
Yeah.
Co-host 1
So what do you think about psychedelics and where that's headed?
Brian Johnson
We're testing them for a longevity therapy. So for. There's the idea, like, there's an idea that that ketamine or MDMA or psilocybin can be used for PTSD or depression or anxiety or, you know, something like that. It can.
Co-host 1
MDMA isn't. That's Molly.
Brian Johnson
Yeah, it gets. Exactly. It's in trials to be treating like some kind of disorder. So there's the idea that psychedelics can fix broken things. And so we're now testing. Can psilocybin be a longevity therapy? So if someone's, if someone's rattling off their stack and they're saying, what do you do for your health? It's like, well, you know, I go to bed on time, my sauna and I do psilocybin, that it would be a commonplace thing. Like instead of doing a cold plunge. Psilocybin's part of your daily protocol or part of your protocol.
Co-host 1
I didn't know Molly would be in that category, though. So if you have ptsd, you could pop Molly and go to like Tomorrowland.
Brian Johnson
We haven't shown it yet, but we're, we. This is. We measured 249 biomarkers on the mushrooms. So it's the most quantified psychedelic experiment ever. And so we're testing to say what happens to the body, the microbiome, the brain, inflammation. We're testing all these biomarkers. So what you see in the table is this morning we tested 149 biomarkers post my treatment on Sunday. So we're saying, like, after doing the therapy, what happens to the body?
Co-host 1
And what were the conclusions?
Brian Johnson
We'll see. We'll get the results back.
Co-host 2
Wait, I have a question about the shrooms. Because when I've taken shrooms, I feel terrible the next day.
Co-host 1
What was your last. What did you do Last?
Co-host 2
Shrooms, Miami. 11 little chocolates with a couple other things. But you can't mix. Yeah, yeah, but even when I'm just taking shrooms, like, I feel terrible the next day. So you didn't have any of those side effects?
Co-host 1
Feel that bad.
Brian Johnson
Right.
Co-host 2
Well, my, like my stomach hurt. I had a little hangover kind of from it.
Brian Johnson
Well, you also. What's in the chocolate? You've got sugar.
Co-host 2
Oh, that's true.
Brian Johnson
Yeah. And there's a lot of toxins and, and so there's like if you want to control it. So this is pure psilocybin powder. Also there's this concept people talk about set and setting for psychedelics. So they talk about like your mindset going into it and your setting. Right.
Co-host 1
So important.
Brian Johnson
Also your body set. So body set is this new idea of also relevant is how well you've slept, did you exercise? Where's your inflammation in your body? What's your diet like? And so body set. And so I went into this experience with really good health markers. And so there's a, there's, there's a possibility like for example, if you didn't sleep well the night before, that could have a negative, it can have a negative tilt on your experience.
Co-host 1
So, so you got to really go prepared into a trip.
Brian Johnson
And so then if you have pure psilocybin and you are well rested, maybe you exercise, you've got some, you know, your good diet, good nutrition, maybe your experience would be very different.
Co-host 2
I wonder if there's anything you can do with sleep. Like let's say you get five hours of sleep, but is there something you can do to have the same effects where you got eight hours? No, there's nothing like that.
Brian Johnson
You can cold plunge and get that. You basically when you cold plunge or crude cryo, you snap yourself out of that.
Co-host 2
So there's nothing there that lull.
Brian Johnson
But it gives you a two or three hour pump to get back down, right? Yeah. Coffee gives you some, some kind of boost and you take it back down. You just can't fix lack of sleep.
Co-host 2
What do you think about the health benefits of ketamine?
Brian Johnson
I did ketamine actually with my brain interface company. We measured my brain on ketamine. So we did this under a study.
Co-host 1
So what do you do? You hook up like stuff to your brain?
Brian Johnson
Yes, it's in my office. It's like this, basically this helmet, bike helmet you put in your bed, your head. We built it. It took us over $75 million to build this.
Co-host 1
And that's all self funded or.
Brian Johnson
Yeah, I put over 60 million in it. Yeah.
Co-host 2
For the helmet and the.
Brian Johnson
Yeah, to measure your brain. So we, we measured my brain 30 days before during ketamine and after ketamine and what we showed was really cool. No one had ever done the study before is when you do ketamine, it opens up this Therapeutic window where your brain is in these fixed patterns, in these fixed thought processes. Like, think of your brain like a globe with, with airports all over the place. The traffic between New York and London is a high traffic hub, but New York to some smaller place in Nebraska is a lesser travel hub. When you do ketamine, it scrambles the hug the hubs, so it, it releases like this, this default structure where things are at and loosens up your patterns. So that window's like two or three days, and then the patterns start coming back and forming, which is why there's a therapeutic window. So what we're testing on psilocybin is it's potentially a stronger way to lodge your pattern, to dislodge your patterns, so you feel extremely youthful and childlike. When I did this, I felt like a kid.
Co-host 2
When you did ketamine.
Brian Johnson
No, I'm sorry. Psilocybin, it had a stronger effect than ketamine of dislodging my patterns. Because in a 48 year old, you start to get pretty stuck in the way you think and feel and act in your responses. But it just took me back to a childlike state. So we're looking at that kind of thing.
Co-host 2
But do you still even, like, enjoy the high or feel the high if you have the helmet or like it's all study based?
Brian Johnson
Yeah. I mean, I was laughing uncontrollably for most of the session on Sunday and I just couldn't stop.
Co-host 1
So you had the helmet on while you did shrooms?
Brian Johnson
Yeah.
Co-host 1
And you just like, were you like, did you have to just lie down or.
Brian Johnson
I did one when I started, one at peak and the one afterwards.
Co-host 1
But like, what setting were you in with the helmet?
Brian Johnson
You were in a room.
Co-host 1
Okay.
Co-host 2
Yeah.
Brian Johnson
We did a bunch of other tests. Like, I did a saliva test, I spit it in a tube. We did a thermal map. So we were looking at my thermal imaging. So we did a baseline when I started. Then we looked at my thermal map when I was peak. And you see the blood flow changes dramatically. So the, the body pushes all the blood to the core. So you get really hot in your chest and throat. Your face changes thermal patterns. You. Like you and it. Which shows emotions. Like the nose. Yes. You see like a. Signatures of joy, arousal.
Co-host 2
I'm pretty interested in the helmet because it's like, this is a one of one, right?
Brian Johnson
Yeah.
Co-host 2
So have people hit you up and want to get the same thing? Yeah.
Brian Johnson
You want to see it?
Co-host 2
Yeah, I really do, actually.
Brian Johnson
Can you grab the kernel? Just, just unplug it and bring it in without it. Without it plugged in. Yeah, it's badass.
Co-host 2
You don't get scared of this thing being 60 mil in the crib and people around knocking it over or something?
Brian Johnson
We have, we. I mean we have quite a few of them, but this one. Yeah, it takes, it takes like, it's like, it's like 30.
Guest or Additional Participant
A couple 60s.
Brian Johnson
30,000 to manufacturer. 35,000 manufacturer.
Co-host 1
Do you think psilocybin is going to become more accepted in society? Because it's. It's not legal, is it? Right now?
Brian Johnson
No, it's still a schedule one substance. Yeah, it's legal now in.
Co-host 2
Yeah, just looks like a bike helmet.
Brian Johnson
Yeah, exactly. It's. It's legal in.
Co-host 1
How much is this thing worth?
Brian Johnson
This costs about 30, 30, 40,000 to manufacture. So the way this works, that could be like a.
Co-host 1
You should wear. That's better than wearing a watch. Wear that to the club.
Co-host 2
Yeah, I know, it's badass. No one else is going to be competing with me.
Brian Johnson
So if you're not gonna be any other helmets in there, you could do this and get a brain age score. So you wear it for seven minutes, you watch a little video and it.
Co-host 2
Gives you a brain age, which tells you what exactly?
Brian Johnson
The age of your. The range. Brain age.
Co-host 2
Sorry.
Brian Johnson
Of your functional brain age. Yeah.
Co-host 2
Did you swear for seven minutes and watch a video?
Brian Johnson
Yeah.
Co-host 2
We should all do this.
Brian Johnson
What sure is that.
Co-host 1
I think we should. Maybe we could talk after. We should do a whole milk video with Brian.
Co-host 2
I would love to see all on our main Jimmy in the helmet.
Brian Johnson
This is the thing. Yeah, so. So this is one example. So what I normally do, like we ask like, you know, when rich and powerful people come, this is what I do. So I help them understand. 1. You can measure biological age. You can measure age of your skin and of your brain, of your heart and et cetera. And then once they get that intuition, then they connect that when you do blank thing, it either increases your age or slows down your speed of aging. And once people make that connection, it's.
Co-host 1
Like, ah, can I hold it or not?
Co-host 2
What's your brain age?
Brian Johnson
Yeah, so it depends on when I do it and what therapies I'm doing. But somewhere between like 32 and 45.
Co-host 2
Is that where you want to be?
Brian Johnson
I'm always trying to drive it down lower.
Co-host 2
My only question on that is like if is that. That's just age. It has nothing to do with how much knowledge you have. Right?
Brian Johnson
That's right. Okay. So yeah, basically you can because if you think about this intuitively, if you have an 80 year old and a 2 year old next to each other, you know, who's 80, you know who's 2, right. First by their size, but also by the skin quality, you know, by their mobility, flexibility. So if you now start narrowing to say 79 year old, 3 year old, 8, 78 year old, 4 year old, you can measure biological age. So you can look at an 80 year old heart and a baby's heart, they're different. Different cell structures, different function, different, you know, capability. So you can basically measure biological age of your entire body.
Co-host 2
I want to get a knowledge helmet. Yeah, that's what we need.
Brian Johnson
Yeah. What's that?
Co-host 2
No, to see what your brain is, knowledge wise.
Brian Johnson
Yeah, exactly. To score you on. That's cool. Yeah.
Co-host 2
Not just your age.
Brian Johnson
This can test you, for example of your, your intelligence on language, on reaction speed, on language fluency. So you can get scored on a whole bunch of different metrics on like how well is your brain and where you rank according to your, your age group.
Co-host 2
Reaction speed's a good one.
Brian Johnson
Yeah.
Co-host 2
I could see like athletes using that and stuff. Yeah, that could be good for studies. What else do you have in here? Any other cool.
Brian Johnson
So many cool things. Yeah.
Co-host 2
Anything else that's quite like that? That's just. No one else has.
Brian Johnson
Everything else we have you can buy generally out there, out there in the market. This is the only thing because I built this because I'm really interested in the idea of humans merging with AI. That's just like the thing that's happening right now. And so I thought.
Co-host 1
You think that's a good thing?
Brian Johnson
I think it's like no choice. We.
Co-host 1
That shit's so though. No, I mean, are we not.
Brian Johnson
Are you.
Co-host 1
Were you going to do that?
Brian Johnson
Yeah, I mean, I mean are, are we not merged with our phones already?
Co-host 1
I know. I've seen Elon Mus say, just like the download speed's not the same or whatever, the upload speed, but you also have a choice to, like you said, put your phone away at night.
Co-host 2
Yeah, yeah.
Co-host 1
Like what? You would get a chip in your brain, certainly.
Brian Johnson
Yeah.
Co-host 1
But then you're just.
Co-host 2
That's a huge gamble. What if that chip takes over you when it's safe?
Brian Johnson
Yeah, like so when the surgery is safe. Yes, there's issues, there's questions of what the company does and all that kind of stuff, but yes, I mean, if it's safe, augmentation, of course, you got.
Co-host 2
To know who's controlling that chip, all that.
Brian Johnson
I Feel like, certainly when do you.
Co-host 1
Think that's going to be, like, a thing?
Brian Johnson
Brain stuff is really hard. So Elon and I actually talked about building a company together. When he went down neuralink, I did kernel, I went down non invasive. He went down invasive. So he's doing. He's sticking things inside the brain. We evaluated that. We decided through non invasive. So we want it to be outside the brain so everybody could do it. It'd be easy to acquire data, pair it with AI. So just different approaches. But we're both probing the brain to try to create a link between humans and AI for improved learning, improved diagnosis, improved awareness. There's like. For example, we're doing a study right now predicting depression treatments. So if you are depressed and you're considering doing SSRI or TMS or what, what therapy do I do? You can wear kernel and get a prediction score on which things you'll be responsive to. So that's under study right now. We also are studying mild cognitive impairment. So people. When people start having neural degeneration, you can. It's happening in the brain far before symptoms arise. And so this would show you have cognitive degeneration and even when you don't have symptoms. So that's really good. You're like, okay, now I know I need to do these following things and be mindful of that, people.
Co-host 1
The chip thing, though, when that rolls out, I'm out.
Co-host 2
Well, that's what I'm saying.
Co-host 1
The chip thing is, no, I'm out. Humans are gonna, like, I'm going to an island. I'm going to, like, like, Asia somewhere. Like, I'm not. I'm not being a part of that.
Co-host 2
What I will say, crazy is people are obviously always fixated on you trying to live forever, but you can do so much positive things. Like, if you could do something for depression, where you wear something like that on your head for 10 minutes and it changes you. Whatever.
Brian Johnson
Exactly.
Co-host 2
That'd be huge.
Brian Johnson
Exactly.
Co-host 2
So why do you ever think, like, maybe I should put more focus on that? Or you're strictly.
Brian Johnson
That's all I talk about. Yes. Like, we're riffing on this, like, futuristic stuff. All I talk about, go to bed on time, eat well, exercise, avoid toxins, you know, do these therapies. Don't do these therapies. I talk about the most basic, immediate things. Because, for example, like, the. The biggest thing somebody can do for their health is to kick their bad habit of eating a lot of food before they go to bed.
Co-host 2
But don't you think that's like, the, the whole goal. Because people. There are people that just aren't gonna be able to do that. But if there's like a alternative and you can wear something like that and it still gives you those good side effects, they don't need to change their habits.
Brian Johnson
I mean, that's. That's ozempic, right? The GLP1s. Like, if you have a pro. If you have a food addiction problem that's impossible to solve, a GLP one solves it.
Co-host 2
There's a lot of negatives with Ozempic, isn't there?
Brian Johnson
I mean, I microdose it.
Co-host 2
Okay.
Brian Johnson
Yeah. I mean, the. There are some side effects. Like, for example, the dose I'm on will raise my resting heart rate by two or three beats, which is a big deal for me, but the benefits are great. So it's. It's for. It's like the GLP1s are the first legit longevity drug. If you look at the overall effect on society, it has probably had a bigger consequence on society than any drug of his class.
Co-host 1
Positive. Those people, though, everyone hates on it, right?
Brian Johnson
Why should.
Co-host 2
Like, why hates on what? Ozempic?
Brian Johnson
Yeah.
Co-host 2
I personally have my own thought on it. I don't like people that are on Oz Epic that sell this. Like, I was disciplined, got in shape story. And I think you have.
Brian Johnson
You should.
Co-host 2
If you're gonna sell that, you have to say, hey, I was on Ozempic.
Brian Johnson
Like, oh, yeah. Yes.
Co-host 2
You know what I mean?
Brian Johnson
Yeah. I mean, so there's like two different things. It worked. You're just saying how they pitch it to their. To their friends. Right? Like, yeah, but it still worked.
Co-host 2
Yeah.
Brian Johnson
We have a.
Co-host 2
We have a buddy and it's like, dude, you got to just admit that you're on that shit. Like, I don't see you in the gym. Yeah. I mean, yeah.
Brian Johnson
I don't know what the shame is. Like, there's no shame.
Co-host 2
I just think, yeah, there are people that don't have. And I think this is a problem. Either people do have access to Ozempic that don't think that they do.
Brian Johnson
Yeah.
Co-host 2
But they're out there doing stuff the old school way.
Brian Johnson
Yeah.
Co-host 2
In the gym, discipline, all that.
Brian Johnson
I mean, it's an amazing drug. Like, what else out there? There's just like nothing that rivals its efficacy. Yes, there's side effects. You have to be mindful about that. And it's not a free lunch, but, man, it's amazing.
Co-host 2
So you suggest that everybody microdose it a little bit.
Brian Johnson
It's not too far off. I Mean, there probably are exceptions too, but I'm, I'm as healthy as a person can be and I still benefit from GLP1s.
Co-host 1
Just because it suppresses your appetite or.
Brian Johnson
No, because my dose is way too low for that.
Co-host 1
So what does it do on a low dose?
Brian Johnson
There's other metabol effects. It has good neuroprotective effects like it has a lot of and that we're still discovering. But yeah, there's still effect healthy effects for me.
Co-host 1
What, what like what are those effects?
Brian Johnson
Blood glucose. Like if you look at my blood glucose, I'm in the 99th percentile for 18 year olds. So when you compare my blood glass management to an 18 year old, I'm better than 99 out of 118 year olds.
Co-host 2
For example, you talk about the like the live stream. You do it for content. Have you ever thought about like bringing in somebody who's on a. Maybe let's say they're, they got a five year lifespan left and just trying to change that or doing anything for someone like that?
Brian Johnson
Yeah, man, we have tried that so many times. The, the thing is like once you pull in somebody else, it gets so complicated.
Co-host 2
Why is that?
Brian Johnson
Because will they be compliant? It's like the Biggest Loser, right? That, that show that became very popular. You, you just kind of like own their psychology. So when they start having challenges and difficulties, can they be compliant? Not compliant. Will they have this and that issue? It just gets, it's a rabbit hole complexity and you're just chasing these issues forever. So we've tried so many times to like make a Biggest Loser style approach of this. It's just, it's so hard because the.
Co-host 1
People don't want it.
Brian Johnson
Well, it's just, there's, it's legal complications. It's like the person's preferences. It's like the risk of things going wrong. So I wish it was easier. We're actually talking to a company now of doing a TV show where we go into people's homes and just outfit their home for longevity. Basic things like get rid of plastic, don't microwave plastic, you know, get a water filter in there, get air quality under control, have routines like when lights go off in the house, get, get red light in there versus you know, LEDs. So like basic things like that people could. That's much lower risk than. I like that.
Co-host 2
That's great.
Brian Johnson
Yeah, I want.
Co-host 1
How about plastic water bottles?
Brian Johnson
So there was, so there was a study that came out that showed that water of glass water bottles have more microplastics than Plastic water bottles. So this is the thing where when you look at the data.
Co-host 2
That's hilarious. And shadow Ashton hall, by the way. What's that Ashton hall preaches? The Saratoga bottle. The glass one.
Brian Johnson
Yes.
Co-host 2
It has no plastics or whatever.
Brian Johnson
Okay. Yeah. So funny is that the microplastics don't come from the glass, they come from the lid and it's the paint that goes in the lid and then it chips off. And so that's why it's very counterintuitive. You think plastic water bottle made of plastic. A glass water bottle made of glass. The glass has more microplastics than the plastic water bottle. So this is why testing is always the best thing to do on all things. It's very dangerous to have assumptions that.
Co-host 1
So how do you drink your water?
Brian Johnson
I have a. In the house, I have a reverse osmosis water system.
Co-host 1
And then when you go, like if you leave the house, what do you put it in?
Brian Johnson
Yeah, if you take certain can. Like we packed water with those. If it's like a day trip, if we go somewhere, then we just deal with what we can find. Like if we. If a place we're going to has a reverse osmosis, great. If they don't, we just do our best.
Co-host 2
Do you wear AirPods?
Brian Johnson
I try to do wired wire.
Co-host 2
Is that actually a thing?
Guest or Additional Participant
So what's the difference?
Co-host 1
I like wired anyway.
Brian Johnson
I want to know that there's a.
Guest or Additional Participant
Difference between the wired and.
Brian Johnson
The evidence is not yet there. So people, there's a lot of people who focus on EMF, AirPods, stuff like that. I don't know how the evidence is not compelling enough yet for us to really look at this, but people focus on it because they control it if they think they can. And it makes sense. But yeah, I think the evidence is not there yet to have a strong opinion. So I try to be careful, but it's.
Co-host 2
Do you use Chat GPT?
Brian Johnson
I use all the models. Yeah.
Co-host 2
Do you have a person that you talk to or do you do the typing? Just curious.
Brian Johnson
Both. Yeah, but I use. I use Claude Gemini GPT Grok. So I use all the models and.
Co-host 2
Just for like simple questions. If you. That you might not even have the answer to, they'll answer for you.
Brian Johnson
I use them a hundred times a day. I mean, it's nonstop. It's. It's like air. All of human knowledge is at your fingertips. So you can just ask endless questions. So, yeah, I'm always engaged with the. The models.
Guest or Additional Participant
What's a supplement? You think everyone or most people should.
Brian Johnson
Take the one you're most deficient in.
Guest or Additional Participant
We're mostly like the deficit getting a blood test.
Brian Johnson
Exactly. So, so the answer is basically if, if someone's looking for the kill shot, then the kill shot is knowing what they're deficient in. Like they may be low in vitamin D, they may be low on something. And so to find that out, it's best to get a blood test and then you can, then you can really tailor it. But otherwise, like my company blueprint, we just do all the basic stuff everybody gets on a daily basis. Like everyone benefits from creatine, everyone benefits from vitamin D supplementation. E, you know, there's something glycine. So most people think that longevity is very personalized, which it is, but it's. Most of it's not. Most of it is the same stuff. Everyone does well with sleep, everyone does well with exercise, everyone does well with, with vegetables. Like most everyone. Very rare exception, they wouldn't. So most things we have in common.
Co-host 2
Talking about like physically, like, let's just say athleticism, where do you think, like, do you think you feel like your 18 year old self or you're at that level? Like if you were to play basketball, you could play at the same rate as you were 18.
Brian Johnson
Yeah, I mean my, my cardiovascular ability is, is, is better than, I think 92% of 18 year olds. Like my body's ability to use oxygen is better than 18. 90% of 18 year olds. Now, like, are my joints age 18? No. Right, right. Like I've got cartilage breakdown, I've got some calcification. So could I move like an 18 year old? Probably not. So again, this is like the idea of you could be entirely 18 to have ears of a 64 year old. You can correct for some things, but not all things.
Co-host 2
Just talking about this, I feel like LeBron's doing some of this stuff because he's 40 years old and he looks like he's 20 out there.
Brian Johnson
Yeah.
Co-host 2
So I think there are more common things that people just don't. He might, he probably doesn't preach it, but he's got to be doing some of the same stuff you're doing.
Brian Johnson
We, I mean, I know what everyone's doing. Like we're in a very small community. The key is if you stay on top of it, you just have to be ahead of it. You don't want to be chasing it. So you want to be at the beginning of your career doing the right stuff, do the right stuff, avoid the wrong stuff. But if you can stay on Top of it. The body's amazingly resilient. Like the fact that I. I trashed myself for my entire life, literally, like as a kid. Sugar, cereal, sodas, you know, never prioritized. Sleep. Did the entrepreneur thing. Grinding for a decade. I was depressed for a decade. Like, I trashed myself. And if I can do that and then stop at 42 and then bounce back this hard, I mean, my biomarkers are, you know, on par with an 18 year old on many levels. What's that, 42, 48. 48, yeah. Wow.
Co-host 2
I don't know what the rate is, but, like, for depression going off of like your routine, if there's other things that cause depression.
Brian Johnson
Yeah.
Co-host 2
Is it for people that have internal things that you can't help? Is there a solution or something they can do outside of your routine that can help them?
Brian Johnson
I said I do try on mental health stuff. I try to focus people on the basics and that it's hard because when you're depressed, the last thing in the world you want to do is go to bed on time and exercise. You don't. You want to eat garbage stuff. You want to just be lazy. Like, I've been there. So it's really hard. Also the most powerful medications is high quality sleep, exercise, and a good nutrition. And then if those things can't deliver, then you can think of secondary things. But SSRIs have really poor evidence. They're only. Which are what. So SSRIs. I think the evidence only makes sense.
Co-host 1
What are SSRI?
Brian Johnson
Oh, sorry. Typical antidepressant meds.
Co-host 1
Okay.
Co-host 2
Yeah. I was going to ask you what you think about, like, antidepressants, Adderall over prescribes, it seems like.
Brian Johnson
Yeah, yeah. If you look at the evidence. Right. I think they only statistically make sense with the effect in more severe cases. So most people are on SSRI when they shouldn't be, when the evidence is not as good. TMS, there's. There's a new protocol called the Saint Protocol, which is really good, that has like an 80 recovery rate of treatment resistant depression. So that's cool. So, yeah, TMS is great.
Co-host 2
I just remember when I was in like middle school and there was a kid on Adderall, and I just, like, this just doesn't seem long term. Like it's gonna be beneficial for you, bro.
Brian Johnson
Exactly. Yeah. Pilling things up is a tough one. Like, as a, like Americans reach for pills, it's the first line of a defense and it's just not a good move. We should go to. We should be Going daily habits as our first line of defense, then if that doesn't solve it, it makes it easier when other people are doing it with your friends. Again like it's all about our friends. Friends and family. When your friends and family are doing something, you'll do it too. So it's about changing the culture.
Co-host 1
What's your opinion on like DMT and those type of psychedelics?
Brian Johnson
So 5MEO DMT just got a breakthrough status approval by the FDA for treatment of depression. So they buy a tie. So that also is on a path for treating a disorder. So this is the thing is if in one lane it's going towards treatment of fixing problems. And then my lane is do they actually work for anti aging?
Co-host 1
Right.
Brian Johnson
And so if you, if psilocybin, if we can show interesting data that psilocybin has potential anti aging effects, that would change the conversation. Whereas right now it's trying to go through a legitimate process of FDA stamp your approval. Then there's like the underground world of people doing mushrooms for party purposes or whatever the case may be. If it were legit, longevity therapy would just change the conversation around it.
Co-host 1
And do you think the findings are kind of starting to show that it's positive?
Brian Johnson
There's early data in my studies and also human cell studies that are as promising, but I think we'll need to have more conclusive evidence. But I mean is promising.
Co-host 1
What do you think drug companies are scared of? Psilocybin and stuff like that? Like why aren't those drugs legal? But the stuff that's not working and everyone up, that's legal.
Brian Johnson
Right? I totally agree. It's crazy, right? Like we have basically anybody can sell poison in society. You can make fast food as awful as you want it to be. You can sell cigarettes. You can like all forms of awful. You can, you can sell porn, you can sell endless scroll. Like you can sell stuff that makes people miserable, sick. But you know, if you want to try to make, you know, heal yourself with something, you can't.
Co-host 1
Is porn bad for anti aging?
Brian Johnson
Yeah, you probably shouldn't do porn.
Co-host 1
What? How does that affect anti aging?
Brian Johnson
It has negative effects on your brain. Yeah, you, you probably don't want to make porn. It's like porn is kind of like vaping. It's not a therapy. It's a, it's not.
Co-host 2
Can be addictive.
Brian Johnson
Yeah, exactly. Like you, you just like it. If you're listing out like the 10 best things in my life, they don't qualify for 10 best things. Like they kind of make you up you're like, not that version of person.
Guest or Additional Participant
So people use that as therapy too. The same way as like or quote unquote therapy?
Brian Johnson
Yeah, Anything that controls your behavior you don't want to do.
Co-host 1
How about sex? Great sex is good for whatever. What's the science behind that?
Brian Johnson
Like, how does sex is great? Yeah, yeah, we love sex.
Co-host 2
But how does that affect, like, what's.
Co-host 1
The science behind it?
Brian Johnson
I mean, so one is, is there's benefits for orgasm, there's benefits for connection.
Co-host 1
What's the benefits of an orgasm?
Brian Johnson
So I think the evidence was something like dopamine. So the men had lower.
Co-host 1
This is interesting.
Co-host 2
No, I know.
Brian Johnson
Lower prostate cancer risk if they ejaculated something like 21 times per month. Thereabouts. If I remember the study right.
Co-host 1
Sub 21.
Brian Johnson
Wow.
Co-host 2
Okay.
Co-host 1
You need a steady chick for that.
Brian Johnson
Yeah.
Co-host 2
So when you get 21, nuts. When you want to have a kid, as you get older, how's that going to work? When you want to procreate? If you're age 100, are you still like, good to go?
Brian Johnson
Yeah. So right now my, my fertility markers are better than 99 of 20 year olds. And so if you look at how you control that. So for example, I've been doing a sauna. So a few things. One is getting all the basics right, like sleep, that exercise. I've been doing sauna. So a dry sauna. That's on it right over there. So it's the best dry sauna, 200 degrees Fahrenheit. And then you put ice on the boys. So if you.
Co-host 1
In the sauna.
Brian Johnson
Yes, if you.
Co-host 2
Wait, wait, wait.
Co-host 1
So walk me through that.
Brian Johnson
Yeah. So just get like a toxic free BPA free, toxic free ice pack.
Co-host 1
Okay.
Brian Johnson
Put on cotton underwear.
Co-host 1
Okay. And cotton shorts and stuff it in.
Brian Johnson
Your stuff in between your underwear shorts and get, you know, one or two. And so it's fine, you don't feel it, but keep them cool.
Co-host 1
What do you mean you don't feel it?
Brian Johnson
It's not that. I mean like you're 200 degrees.
Co-host 2
So like, you know, probably feels kind of nice.
Co-host 1
Isn't that kind of like cold plunge too? Or is the cold plunge not cold.
Brian Johnson
Enough so it could.
Co-host 1
How long do you leave it in there?
Brian Johnson
The whole time. So I did an experiment with. When I did sauna without ice, so they were heated up as much as my body, it demolished. It wrecked my fertility markers, so erected by 50%.
Co-host 1
So when you're not in the sauna.
Brian Johnson
So with. Without icing, when I did ice, my fertility markers boosted they're now again like better than 99 of 20 year olds. So yes, in that case, like apparently a 48 year old can be as fertile as a 20 year old if done well. Now how far can we extend that? We don't know. But hopefully new technologies would surface where we could. Yeah. Get better.
Co-host 1
So sauna without ice on your balls actually increase. Decreases your fertility rate.
Brian Johnson
Yes. So no man, even if you're not trying to have kids. No man should do sauna without ice on your balls.
Co-host 2
Yes, if you're trying to have kids.
Brian Johnson
No, because you. There's never a situation where you want bad fertility markers, even if you're not trying to have kids, because it has negative feedback loops.
Co-host 2
Like so wait, I'm sorry, ice is for kids and no ice.
Brian Johnson
So you will always want ice. Always.
Co-host 2
One ice balls, always.
Brian Johnson
Because if your fertility, if your fertility markers take a hit, it has a negative feedback loop in your body. So it's a bad signal for the body. You want to be robust. Always. Even if you're not trying to have kids. If you're done having kids, fine. You still want to have ice.
Co-host 1
Does that like increase your testosterone too?
Brian Johnson
Has a whole bunch of hormonal. Hormonal feedback loops.
Co-host 1
Oh, God.
Brian Johnson
Always, always.
Co-host 2
Never. Bring a cooler to Equinox, bro.
Co-host 1
This is going to get, it's going to be a problem at public gyms.
Brian Johnson
Yeah, so just talk to those guys. So I actually talking to the, the CEO of Equinox the other day, I should tell him this. They should have a way for people to do this.
Co-host 1
Like, what system would that be? I mean, you kind of got. Just got to do it yourself. Right?
Guest or Additional Participant
Can't put those back on a shelf or anything.
Brian Johnson
For sure. I know. Yeah, I'm with you. Yeah.
Guest or Additional Participant
You got to get your own. Everybody brings their own.
Co-host 2
Maybe you just keep ice by the entrance, you stuff your stuff and then you go.
Co-host 1
And how long are your sauna sessions?
Brian Johnson
20 minutes.
Co-host 1
20 minutes. So you think cold plunging for like six minutes, is that kind of also give that same effect or not really. Cause it's at different times.
Brian Johnson
Yeah. So it's a good question. And we don't know. I don't know why my fertility markers improved dramatically. I don't know if it's because the sauna or because of the ice or both, but something made it. And then also the other thing I did on fertility is I, I lowered the amount of microplastics in my ejaculate by 87%. So microplastics are a major problem. We all consume a lot of microplastics. Microplastics get stored in the brain, in all the organs and your blood. And so when I started doing this protocol, my microplastics and my semen lowered by 87%. And, like, it's a bad. Like, you don't want to have microplastics in your semen. It's not good.
Co-host 1
No, you want to have it.
Brian Johnson
So this is like the first. A first ever experiment. Nobody in the world had ever tested microplastics in blood and semen. So people. There was a few studies where people tested microplastics in semen. Every single sample had microplastics. Wow. Every single sample. So our. Our success was first in world demonstration to lower microplastics in the semen and blood at the same time.
Co-host 1
That's interesting. Cold pack on your set.
Co-host 2
Yeah, but how does that. How does stuff like that even cross your mind? Just like, you just try something out and you're like, hey, this guy has to be beneficial.
Brian Johnson
This is why it's cost so much money, is have a team. We just follow all the evidence. So we go out there and we say, like, what is. What is known about this topic? What are the gaps? What can we test as a hypothesis? And we just measure, like, our key thing is we measure everything. So people, like, they're up until now, like, no one's measured microplastics in their ejaculate. Who's doing that? You know, like, yeah, there was a study and I associated. But, like, it's not a common thing. So we just do uncommon measurements which allow us to have uncommon insights.
Co-host 2
How many, like, people do you have on your team researching this?
Brian Johnson
Small. It's like five of us.
Co-host 2
Oh, really? You'd say you have the strongest team out there.
Brian Johnson
We have a good team. Like, we're definitely doing things like in the psychedelic experiment. It's the most measured psychedelic experiment in history. We just produced today. We just showed a thermal map of my body and my face. First ever demonstration. So, yeah, we're doing cool stuff.
Co-host 2
Do you have any other tests, like, upcoming, like the magic mushroom one coming up?
Brian Johnson
Yeah, we have endless, like, anything crazy.
Co-host 2
You want to talk about?
Brian Johnson
They're all still in development right now. One thing we're doing is spicy foods.
Guest or Additional Participant
Spicy foods.
Co-host 2
Good or bad?
Brian Johnson
No good. So, yeah, yeah, I love spicy spices. Longevity therapy. So we've got that one spun up. We'll do that one probably in January, February when I'm done with a third dose of psilocybin. We. Yeah, we have so many things we're doing all the time. So like just lined up after.
Co-host 2
What about hair loss?
Brian Johnson
Yeah. So the protocol for that is I. With my company Blueprint, we've got some stuff. So you want to be on 7% minoxidil, thereabouts. Like the basic. That's like Rogaine. Like that's a basic thing that you want to do red light cap therapy, you know, six minutes a day. Then we, we created a product with a bunch of peptides and growth factors. And then if you want, you can do oral minoxidil. So I do 3.5 milligrams. I do not do finasteride the oral because it's very complicated. But that's my hair stack.
Co-host 1
Very interesting stuff.
Co-host 2
Yeah, this is interesting. I'm so. Yeah, this is very informative. I just like to learn. So this is crazy. Yeah.
Co-host 1
Trying to think about anyone gone through like your routine on video with you.
Brian Johnson
No. My co founder Kate, she did this as a female. She did it for 90 days. She did the full on thing, all the diet, exercise, everything. And we. She has a video about that. It was cool to see her biomarkers dramatically improved. Even. Even as a 27 year old, her biomarkers improved, which was cool to see. But no, no one else has done what I've done. I mean like again, like I'm. It's not reasonable for anybody to do what I do. Right. It's just like, it's too much.
Co-host 2
We've had Gary Breck on. I'm sure you know who he is. And one thing he does is he can kind of predict how long people will live. How advanced are you there? Based off of like someone's blood work, can you kind of predict how long they have to live?
Brian Johnson
You can do some rough calculations. Like there's like some good open source models to predict that. Like you could definitely. Yeah. Take alcohol mortality calculations. The more data points you have, the better your modeling. But also you can change it a lot. Right. By behavioral changes. You can move your biomarkers quite a bit. So I just say like, no matter your situation, there's hope. There's like reason to. Even if it's just feeling good the next day, there's reason to like once people realize that health is good, it's such a weird thing to say.
Co-host 2
Well, I wanted to say I like was going through clips and I see a lot like there's. People say a lot of negative things about you.
Brian Johnson
Yeah.
Co-host 2
Ask you, you got to be a vampire. Like that. But everything you've said you've backed up with evidence.
Brian Johnson
Yeah.
Co-host 2
So not enough people like talk about everything you claim. You back up the.
Brian Johnson
The private circles that I care about which is like the, you know, the most powerful people in the world, they. I do get points for credibility. Like they come to me as, you know, one of the most credible people in the world around this on. In social media you're just gonna have.
Co-host 1
That noise because you're documenting everything.
Brian Johnson
Yeah.
Co-host 1
And the, the effects of everything.
Brian Johnson
But it's because it's like it make people. It's. It's good business to say bad about me. Right. It gets clicks. So like there's incentive for people to have and it's. Honestly, it's fine. I'm totally cool with it. It's just part of the process. I'm. Brian Johnson is a normal dude in 2035. He's just.
Co-host 1
Why do you always go back to that year?
Brian Johnson
I just use it as like a placeholder.
Co-host 1
Right.
Brian Johnson
He's weird in 2025 because the world.
Co-host 2
Speaker ahead of the curve.
Brian Johnson
Right, Exactly. So in time people will be like, oh, we appreciate this guy because he was actually onto something. He was cracking like they were saying all the stupid stuff. So I'm just writing out this happens in history constantly. People see something clearly. They do. It inevitably happens. Everything changes. And they're like oh, thank you.
Guest or Additional Participant
See it on social media too.
Brian Johnson
Exactly. So it's just very. It's very predictable human behavior.
Co-host 2
You talked about toxins in your clothing and stuff like that. Do you ever think about like dropping a clothing line or opening your own restaurants where people can go and feel better?
Brian Johnson
Yeah. So we do have fresh food. My company Blueprint, we deliver that. We looked into a clothing line, but it's like the worst business ever.
Co-host 2
Is it really that big of a risk? Like what I'm wearing right now?
Brian Johnson
You don't want to be wearing synthetics. It's just not good. What do you really.
Co-host 1
So where do you shop then?
Brian Johnson
Just cottons. Yeah. Just try to try to do mostly cotton's, cottons, hemps, bamboo. Right, bamboo. Like try to avoid synthetics.
Guest or Additional Participant
Is there something different you use to wash your clothes?
Brian Johnson
Yeah, we try to do this with everything. So we.
Guest or Additional Participant
Everything like.
Brian Johnson
Yeah, toothpaste, detergent. So there's endless things to try to figure out. So we try to be very mindful. Like everything in this entire house, we try to be extremely mindful. Yeah.
Co-host 2
I was going to ask what's like the. Would you say is the just out of the norm habit that you've Picked up on where we would be like, yo, what are you doing? But it's a health benefit for you.
Brian Johnson
I'm so normalized to this, I can't even see it anymore. Yeah, like, I can't even see my own weirdness.
Co-host 2
Okay, so you, you did have bamboo toilet paper.
Brian Johnson
Yeah, exactly. There's a good example.
Co-host 2
Yeah, I tried it. It was nice. But if you go.
Co-host 1
You took a in there?
Co-host 2
No, I did a test wipe.
Brian Johnson
I've never seen that before.
Co-host 2
So I did do that.
Brian Johnson
Yeah.
Co-host 2
I'm just letting you know, I wouldn't shit in your house. Yeah, but like, if you go out in public and you have to go, you stay away from it.
Brian Johnson
No, it's fine. You just talks toxin exposure. Like, you know, you up for a. For example, deodorant. You want to avoid aluminums, you know, so there's like, this is a basic list that you want to avoid toxins on your body.
Co-host 1
So conventional deodorant's bad. Like Old Spice or like, if it has aluminum.
Brian Johnson
Yeah. You want to avoid that. Do you want to avoid. You want to have a non aluminum.
Co-host 1
And everything excessive, everything we use.
Brian Johnson
I feel like when you realize this.
Co-host 1
That'S why an American success, like we've traveled to Russia, like we went to Dagestan, and even like, it's pretty much impossible to eat bad there.
Brian Johnson
Yeah.
Co-host 1
Because everything's freshly grown.
Brian Johnson
Yes.
Co-host 1
You know, but here it's so much harder.
Brian Johnson
Exactly.
Co-host 1
Because like, there's fast food everywhere. Everything that's being sold in stores is bad.
Brian Johnson
You nailed it.
Co-host 1
It makes it so much harder.
Co-host 2
So going off what he's saying, is there a certain place in the world where it would make sense for them to live the longest based off their lifestyle?
Brian Johnson
Yeah. A friend of mine is building up. He's written this book on the best places to not die. So he's mapped out geographies on a whole bunch of different vectors, which is where he has a whole book about it. Different regions around the world.
Co-host 1
Probably Asia.
Brian Johnson
Right.
Co-host 1
The oldest lady's in Japan right now.
Guest or Additional Participant
Right.
Brian Johnson
I'm not sure, but he looks.
Co-host 1
We were just there and I think the oldest lady. 120.
Brian Johnson
You guys hang out there?
Co-host 1
No. We tried to.
Brian Johnson
That's cool.
Co-host 1
I wanted to, but it's tough.
Co-host 2
She's probably not mobile, is she?
Co-host 1
I don't know. A lot of those Chinese monks and stuff, right?
Brian Johnson
I'm not sure. I haven't seen the list of the oldest people and what regions they are. There was. Yeah.
Co-host 2
I feel like it's gonna be weird at One point, if you're out, like you're out at the club and you're talking to a girl or talking to a guy and they're mentally 150, but physically 25. Yeah, that's gonna make things a little interesting.
Brian Johnson
I think the future is gonna be a lot weird.
Co-host 1
That's gonna be weird. Like who's that old coach that's dating like that 20 year old girl?
Guest or Additional Participant
Bill Belichick.
Co-host 1
Belichick. She's like, is there gonna be like 150 year old dating like a 25 year old?
Co-host 2
Probably for sure.
Brian Johnson
Yeah, exactly.
Co-host 2
They're all going to be like CEOs and stuff. They're already doing it just a little bit.
Co-host 1
Oh my God.
Co-host 2
Dude.
Brian Johnson
I think the future is gonna really weird.
Co-host 1
It's going to be so weird.
Brian Johnson
I think when you guys about your, your disposition towards brain chips, I bet you're going to have a different opinion. Like I think now. No.
Co-host 1
Well, that my fear is like, I know you're going to need it to compete in society, but like I think.
Co-host 2
People are going to rush to do it.
Co-host 1
The government then can, can just control everyone too.
Brian Johnson
But maybe we have controls against it. So I don't think people talk about brain shifts because it's a nice way to fill the conversation. They want to, they want to basically take a futuristic concept and drop it and say like that's what I'm talking about. But I think the, the real future things will be different than that. Like Ozempic is an insane technology.
Co-host 1
It's just like a brain chip. Someone's going to control it. So it's like you're pretty much Ozempic.
Brian Johnson
Is like a brain chip. It, it eliminates your, your, your, your desire to overeat.
Co-host 1
Like there's benefits you control.
Co-host 2
When you put the Ozempic in your.
Brian Johnson
Body, you control your hunger with a, with an injection. That's crazy. And hunger is like a natural part of your biological existence and you can just turn it off. It is the craziest technology that's accessible to everybody. That's what I'm saying. Like it is like a brain chip.
Co-host 1
Level change, but that you're still in control of it. Once you have the chip in your brain, that means. So I think you're not in control anymore.
Brian Johnson
We'll have more things like that. So the brain chip is a placeholder for saying like future cool stuff. But other things are coming like gene therapies and other, other things like Ozempic, which would be equally as badass. They'll just be manifest in other like injections, pills, therapies.
Co-host 2
Yeah. I just think that people are gonna rush to do the brain chips and they're not gonna be like fully ready and something bad could happen that'll.
Brian Johnson
That's inevitable.
Co-host 2
Yeah, but it's gonna be interesting what happens to that first person where it turns on them. Yeah, gotta live stream that. I can't believe you did a lot. Have you live streamed before that?
Brian Johnson
No. Well, so I live through my first dose, but I didn't live stream me tripping. I live streamed up until the dose and then I just did photos and so yeah, so I have, my next dose is in another month, so I need to figure out what I'm going to do for that one.
Co-host 2
You're gonna have the dose though?
Brian Johnson
Probably the same I did, I did 25 milligrams of psilocybin the first one, 28 milligrams second. So maybe 30. But yeah, 20. It was, it was really strong. Like I had to lay down.
Co-host 2
I couldn't do that. No way.
Co-host 1
So where can people find all this stuff? Blueprint.
Brian Johnson
Yeah, I mean I'm on all socials so I try to publish everything x IG YouTube. Each channel is a little bit different, but I try to freely share everything I learned with everybody. So I try to make it very accessible, understandable, actionable.
Co-host 1
Awesome. I mean this is very interesting. I really enjoyed this.
Co-host 2
I got to do something after this for sure. Not like today, but soon.
Brian Johnson
Yeah. What are you guys leaving here today thinking?
Co-host 1
I mean, I don't know how anyone can hate on it. You're kind of using yourself as like a test dummy essentially. And. But you're also documenting everything you do and it seems like everything's based on like facts and you know, the results of the experiments.
Co-host 2
Yeah, I think there's a lot of people that don't want to live forever. So it is interesting that you're really taking it upon yourself. But the other thing I really think is important is like the lack of sleep for people. Even I have it and just kids growing up is so important and if there's a way to like it's tough.
Co-host 1
For people that, that work and have kids. Right. Like they're working, they come home and they got to take care of the kids, put the kids to bed, wake up, take them to school. So it is tough. Yeah.
Guest or Additional Participant
You think the perfect time to sleep is 8 o'?
Brian Johnson
Clock? No. Everyone has a different chronotype. Yeah. So some people do very well at 11pm midnight. So you seem to find out what your Thing is. And stick to that.
Co-host 1
It's all about what you're.
Brian Johnson
Yeah, yeah, exactly. But yeah, you have genetic dispositions towards a certain time.
Co-host 1
Yeah.
Co-host 2
So it's just got to be the same time every day.
Brian Johnson
Yeah. I love going to bed early, waking up early. Some people really thrive. The thing I want to be clear on is my, my shtick is not immortality at all. My thing is don't die. So the whole thing on this is, I'm saying the essence of this moment, like what's happening on planet Earth right now, on, in this part of the galaxy is we are giving birth to super intelligence, a form of intelligence that will be likely superior to us in all things. It's an absolutely insane moment. And when this is happening, the only thing that matters is that we don't die.
Co-host 1
Why?
Brian Johnson
Like, that is the most. That is the strongest biological instinct in our existence. Nobody wants to die right now. This is not about immortality. It's not about five years from now. It's not about 20 years from now. It is right now. Nobody wants to die. And so the thing is, what I'm trying to say is as humans, we're kind of crazy. We, we, we commit so slow death, suicide by doing all these bad things to ourself. We, we are doing bad things to our planet. We do bad things to each other. We're in this phase where we are a violent, we are destructive species. And I think we're going to mature past it, we're going to get past it. We're like, that's. Why would we ever want to die? Why would you things make us die? So my ideas are crazy. According to 2025, again in 2035, I think this will be very norm. Like, of course, the objective of our intelligent existence is don't die. And once you secure your existence, then you can go out and play your amazing games. But we're in this critical stage where it's not that humans have a future. Yeah, I don't know. Like, do we have a future of AI? No one knows. Like, so I'm not a, I don't believe in, I'm not a doomer. But I also am not a. I don't believe in Utopia, but it's like, it's just very practical. Like this is big, it's important. So let's not be stupid and do stupid.
Co-host 2
I also just think it's interesting that's so crazy with like religion too, because a lot of people with their faith want to go to heaven. And now it's like, you know, What I'm saying. Yeah.
Brian Johnson
Which is cool. Like, so don't die is very friendly to religions. Like, you can be Christian and don't die Muslim. Don't die. You can be democratic. Don't die in capitalism. Don't die. So you can still believe in heaven. Great. But nobody who believes in heaven wants to die to get there. They don't want to die. You don't want to die. None of us want to die. So one thing we all have in common, nobody, no matter what you believe, wants to die right now. It's the one thing that unifies the human race.
Guest or Additional Participant
Are you religious?
Brian Johnson
I'm friendly towards religions. Do I think there's an afterlife? I don't know how anyone knows that answer. Like, how is it even knowable?
Co-host 2
You may.
Nelk Host
Yeah, it's a belief.
Co-host 1
You can't say it's a fact, but it's a belief.
Co-host 2
You think you'll ever know?
Brian Johnson
I mean, I don't know how you know it. Like, how do you. How do you test it?
Co-host 2
I'm gonna ask you something. Like, how much pressure do you have? Or do you even feel pressure? Because, like, you're basically gambling on yourself. Like, let's just say it doesn't work out the way you think it is. And unfortunately, you pass away at 100.
Brian Johnson
Yeah.
Co-host 2
Like, what would be the answer for that? If you have all the answers right.
Brian Johnson
Now, it's the same as now. I mean, my. I'm imagining when I get to 100, even if I'm decrepit and I hurt everywhere and everything's awful, I probably still don't want to die. Right. Like, I still want one more breath. I still want to say one more I love you. I still want to see my loved ones one more time. Like, people hang on to life, right? And, like, no matter how bad the situation is, we all want one more breath. And so there's nothing more beautiful than the human instinct. We want to exist. We want to survive.
Co-host 1
Awesome. Well, I think this is great.
Co-host 2
This is awesome. Thank you very much.
Brian Johnson
Appreciate you.
Co-host 1
This is very, very interesting.
Brian Johnson
Thank you.
Co-host 1
Brian Johnson.
Co-host 2
Yeah.
Brian Johnson
That was awesome. Thank you.
Co-host 2
Yep. Thank you.
This episode features Bryan Johnson, entrepreneur, biohacker, and founder of Blueprint. The discussion centers around Johnson’s quest for radical longevity—possibly “immortality”—his rigorous self-experimentation, and his philosophy and daily protocols to slow, arrest, or reverse aging. The hosts push Johnson on everything from his diet and sleep regimen to psychedelics, technology, and the societal shifts he predicts if his efforts become widely adopted. The tone is lively, skeptical, and sometimes irreverent, with a mix of deep science and practical life tips.
“I think basically the insight is I'm trying to achieve immortality by the year 2039.” – Bryan Johnson [04:15]
“The best therapy I do by far is the avoidance of harm, which is number one thing.” – Bryan Johnson [32:14]
“When you don't sleep well, your prefrontal cortex goes offline and your willpower plummets... It's usually because they have no willpower reserve left…” – Bryan Johnson [14:42]
“It's like the GLP1s are the first legit longevity drug.” (60:02–61:14)
“In 2035 … it'll just be common wisdom that it's not a good idea to die.” – Bryan Johnson [27:21]
“My shtick is not immortality at all. My thing is don’t die.” – Bryan Johnson [89:42] “Nobody who believes in heaven wants to die to get there.” – Bryan Johnson [91:33]
“You can measure biological age of your entire body.” – Bryan Johnson [56:20]
“Living for tomorrow and living forever are the same ideas. It's just when a human thinks about living forever, it breaks their brain.” – Bryan Johnson [33:34]
Bamboo Toilet Paper and Toxin Avoidance (01:42–02:01, 83:52–84:40):
On Girlfriend and Relationships (07:48–08:13):
Optimizing Fertility (74:04–75:43):
On Future Weirdeness (85:31–86:07):