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Watch with a free trial now@britbox.com this is the Happy Pod from the BBC World Service. I'm Holly Gibbs and in this edition it felt really special and like good to me, like because showing my friends like this is what it feels like to make one and feel like what it feels like to have a prosthetic hand. The teenager whose classmates helped make her new prosthetic hand. How a new drug is transforming the lives of children with a severe form of epilepsy. He's able to enjoy life like any other child, which is it's everything and more to me. He has this vivacious lust for life. The students using AI to help rescue people trapped after earthquakes. We are very focused and we want to make it so that it can be used or deployed in actual like rubble zones because we want to have that impact. Plus the scientists saving a plant that's crucial in tackling climate change. We start in New South Wales, Australia, where a group of teenagers have been working together to make a new hand for one of their classmates. 14 year old Lois Agnello was born without part of her left hand. During a lesson about empathy and technology, she asked her teacher whether the class could use their 3D printer to make an improved version of her prosthetic. The idea has now grown into a passion project with the students wanting to make more for people who need them. I spoke to Lois and her teacher Lloyd Godson and started by asking Lloyd about the project. So it actually started out as just a normal technology lesson and we were looking at how designers have to put themselves in other people's shoes to understand how the people feel when they're designing a product. So we're talking about empathy. And Lois said, I've got this really cool video I'd like to show the class. She brought up the ABC video of her receiving her first hand, and she was six years old from Matt Bowtel. And the class watched this, and there was probably about five or six members of the class who were just completely taken by this video. And it was quite an emotional thing to see, too. See Lois as a young girl. After the class finished, they said, hey, We've got a 3D printer. Can we not try making one ourselves? And Lois formed a group of about 10 people that were about her age, like, 13, 14 years old. And we reached out to Matt at free 3D hands, and, yeah, it was amazing. Lois, can you tell me why you wanted to make a hand with your classmates? It just, like, came to me, and I'm like, hey, Lloyd, can we make a hand? And he's like, yeah, sure, let's do it. It felt really special and, like, good. Like, to me, like, because it's just showing my friends, like, this is what it feels like to make one and feel, like, what it feels like to have a prosthetic hand and all that. I think, for you, Lois, too, you were saying that you were quite surprised that your friends wanted to help you. Like, you were saying how it felt really nice that they actually cared. They actually cared enough to want to learn how to do this and make one for you. And, Lois, can you tell me what your favorite part of the process was? My favorite part was probably actually getting the people to join, like, the project and stuff. Seeing people, like, asking me, can I join this? It looks so fun, like. And I'm like, yeah, sure. It was amazing watching all these young people being so intrinsically motivated to do something. It wasn't something that I set as a lesson. It wasn't something that they had to do for school. It was something that just grew out of a lesson that we taught on empathy. And then the students just ran with this idea, and it kind of consumed us for the next six months. Lois, how did you feel using your hand for the first time? Shocked that we actually did it. Like, and proud. I was like. I felt like I was in a dream. I was like, this is crazy. It's actually working. I'm crazy. It's like I was going psycho. And, Lloyd, what do you think that the students got out of this? Oh, I think you Know, they got to understand that just these small steps can make such a huge impact. Like, their project's gone nationwide, it's gone global. They've, you know, directly impacted one of their peers and saw the difference it can make in someone's life just by taking, you know, half hour out of your day twice a week, they're able to have such a huge impact. Now, coming back to school this year, one of the first things the kids did were come up to me and said, can we run Design for Change again? Can we start our weekly meetings? And we've made a hand, and now the next step for us is to try printing an arm. The students are really keen to do more of this, basically. I mean, and this is why Matt does what he does. He said that the first time he made a hand for someone, he got a video back from the recipient, and he realized when he saw that video that this is what he wanted to do now, because the kid in the video that had received one of the hands was just so happy. And he put a smile on this kid's face, and that made him feel really good. And I think this is what the students are experiencing. I be right loe, but, yeah, the kids are just had that sensation, that feeling of, we've done this thing. We've made Lois feel really good. That feels really good. We want to do that again. And so I think that's why they're keen to now make an arm and find more people that they can print hands for and. And really get that sense of satisfaction of helping people in the world. Lois, why is it important that we all embrace our differences? Because if, like, everyone was the same, it'd be like a bunch of robots on Earth. We want everyone to be different. Everyone is good at what they do, and I think they shouldn't change that. Just be you. Yeah, be you. Yeah, that's good. And my final question is to you, Lois. Do you want to do something like this when you're older? I would love to be an engineer, but also my dream, ever since I've been a kid, has been I wanted to always be a pastry chef, like a French pastry chef. I think also being an engineer would be good, but I'm trying to decide. Lois Agnello and Lloyd Godson. Next to a drug that's transforming the lives of children with a severe form of epilepsy, he was having hundreds, up to thousands of seizures in a day. From the moment we started on the trial seizure length, we went from minutes to seconds. So that enabled us to Start living our lives. That's Lauren Truelove, whose son Freddie was one of the first to receive the new treatment for Dravet syndrome, which also causes developmental delays and problems with movement and communication. The small trial in the US and the UK showed that patients had up to 90% fewer seizures and the drug was safe for children and adolescents. Freddie, who's now 8, had been having seizures since he was 6 months old. Lauren says the change has been incre. He's climbed mountains. We can go out walking with the dogs, walk around the lakes and he's even been skiing. He's going to school, he's reading. He's able to enjoy life like any other child, which is. It's everything and more to me. When Freddie was diagnosed, it was really difficult to know what that future looked like and we thought we had everything taken away from us. And I think now with the alertness and the development that he's gone through in the past four years, he's able to enjoy everything about life. He loves being with his friends, he loves being at school. He has this vivacious lust for life. The trial has enabled him to find his own feet and his own path and his own mind. And that really is quite something. The new drug is injected into the spine and travels to the brain to manage the underlying cause of the condition, which in most cases is a faulty gene. My colleague Tim Franks spoke to Professor Helen Cross, one of the lead researchers from University College London. Epilepsy is a symptom. So there are many, many different causes of epilepsy and Dravet syndrome is a particular early onset epilepsy. I say early onset in the first year of life and then they subsequently get very frequent seizures, frequent admissions to hospital and get developmental slowing. So in the longer term they have a lot of other problems which include learning difficulty, walking difficulty, feeding difficulty and behaviour problems. And these seizures that you're talking about, I mean, they can be really quite severe, can't they? They can, they have different types of seizure, but also then they can be very frequent and also they can be quite prolonged, needing emergency treatment to stop them. Tell me then about this drug. How does it work? We know that Dravet Syndrome has a genetic basis and more than 90% of those with Dravet syndrome have a particular abnormality. What our traditional treatments have done have only treated seizures. They have not looked at the underlying cause of the problem. What Zeruva Nursin does is by injecting it into the liquid around the brain, it increases the production of protein from the Normal gene. All the Dravet have one abnormal copy and one normal copy. It doesn't do anything to the abnormal copy of the gene. It's increasing protein production from the normal copy. And so with that, we're hoping to tackle all the problems, not just the seizures, but the other neurodevelopmental and walking problems as well. Can I ask about how you trial a drug such as this in children? Are there particular challenges for trialling a drug such as this? It is always challenging to do clinical trials in children, but actually we have to think of it that this is the safest way to evaluate drugs. And the fact that the children are very carefully monitored throughout the trial. I mean, it's challenging. We have to make sure that the families are very aware of the risks and the possible benefits, but they are very carefully monitored. This sample was great, correct me if I'm wrong, it was relatively small. So where are you going to take this next to just, I guess, check on its efficacy and also its safety. So this was a small trial, but it was also variable in whether children had one dose or multiple doses. And it was open. We knew that they'd all had the dose of drug. The next, the double blind phase is that children are recruited and randomised to whether they receive the drug or they have what we call a sham procedure. So they don't have injection of the drug and then they are monitored. And eventually those who don't get the medication will get the medication, so they will at some point get it. So we need to recruit around 170 patients worldwide. Right before we came to you, we heard a little clip from Lauren, the mother of Freddie Truelove, 8 years old, whose life, she says, has just been transformed for the better. I mean, I'm sure it's exciting, the science that you're involved in, but it just must be glorious to see the effect this is having. I mean, it is early days, but it is tremendous to see benefits. This is in a really complicated, very difficult epilepsy syndrome, where, you know, the diagnosis is really devastating for the families because they don't see any progress in their children at all. So to see a real hope that we could do something about that cause, do something not only about the seizures, but the neurodevelopment is incredibly exciting and actually something I never thought I would be embarking on when I started my career. Professor Helen Cross. Coming up on this podcast, we meet a Japanese man who's become famous for walking dogs. This is the happiest day of my life. I finally get to see the Harajuki Dog Walking man I just met a real Life Pokemon trainer. 22 dogs is one walking. If you live in Tokyo, you already know this legend. We'll hear more from that man about a dog later. You know that goal you set at the start of the year? You can still do it. Whether you're committed to a thru hike with friends, lifting heavier or simply walking more. It's not too late to stick with it and make your future self proud. Especially with the all in One Nutrition Shake from Cachava. Because quality nutrition shouldn't be complicated. Just two scoops of Cachava's all in One Nutrition Shake and you've got 25 grams of protein, 6 grams of fiber, greens, adaptogens and so much more. Plus it actually tastes delicious. No fillers, no nonsense, just the good stuff your body craves. So instead of adding to your backstock of supplements that over promise and under deliverance, simplify your progress with just two scoops of the highest quality ingredients. Stick with your wellness goals. Go to kachava.com and use code NEWS for 15% off. That's kachava.com and use Code NEWS K-A-C-H-A-V-A.com Code NEWS. You know that wellness goal you set at the start of the year? It's not too late to stick with it and make your future self proud. Especially with the all in One Nutrition Shake from Kachava with 25 grams of protein, 6 grams of fiber, greens, adaptogens and more. No fillers, no nonsense, just the highest quality ingredients. Stick with your wellness goals. Go to kachava.com and use code news for 15% off. That's K-A-H-A-V-A.com code news. Ever wonder why we make the choices we do and how to make smarter ones? Introducing Choiceology, an original podcast from Charles Schwab. Join Wharton Professor Katie Milkman, an award winning behavioral scientist and author of the best selling book how to Change as she shares true stories from Nobel laureates, authors, athletes and everyday people about why we do the things we do and how to make better choices to help avoid costly mistakes. Each episode covers the latest research in behavioral science and dives into themes like the power of self control, shaping your mindset for success, navigating new beginnings and why starting over can feel so hard. Listen to Choiceologywab.com podcast or wherever you listen Wise, the app for international people using money around the globe. When it comes to sending money abroad, many providers claim to offer free fees and competitive rates, but don't be fooled, this can be code for inflated exchange rates. With the WISE account, you can send, spend and receive money in over 40 currencies without ever having to worry about hidden fees. Sending pounds across the pond. 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I caught up with Adil and Ada and started by asking them how it works. You place those sensors on a collapsed building and then we have an AI model that we have trained over the summer to understand the complex medium of a rebel site. The signal is processed through that model and then as a result it tells you if there is anyone trapped, if there are any survivors. And then the next step we want to work on is to be able to locate these people. A very, very simple version of it is like an app on your phone and let's say your phone has a microphone and basically the sensor that we use is a microphone, but for signals or waves traveling through like physical media, which is like rocks or like concrete rather than just air. And what we do is basically pick up those and then using our app, take out, extract noises that are created by humans that are under the rubble to be able to say, oh, there is someone here or not. Why did you want to create this device? We've always grown up with the fact that there has been earthquakes and there will be earthquakes and after the 2023 earthquake there has been a very big amount of losses in terms of both lives and a lot of buildings has collapsed as well. But also one of the provinces that has been affected the most is actually where my dad is from, where I visit every summer, and where I have most of my family at. Yeah it's really hard to grasp, I think like the notion of like growing up with earthquakes when you're not coming from a country that doesn't have them like that much. But I think like, people who are coming from like earthquake prone zones will understand that you just grow up knowing that earthquakes can happen and you have that fear inside of you as if like, it's like innate. Because, like, you grow up hearing these stories even since like you're a kid, you hear about your grandpa, you hear about your dad. Everyone, like almost every generation has experienced like a big earthquake, at least in Turkey, I can say so. Like, you hear about these stories about the losses they had. So you grow up knowing and fearing them. And what's been the reaction of your families who must be very proud that you have taken, like you say, their experience and turned it into something really, really positive. My family, my dad's side, who are from hai, has been really supportive and they're really proud about what we're doing. Even not about what we have achieved, but what we are trying to achieve. They have been very supportive and very motivated about the cause as well, obviously, so. Well, that brings me on to my next question, which is what is next for Rescube? We're right now trying to expand our reach. We're right now in the process of making our hardware better and we're also looking to focus on our models and our software side over this summer. And we're working on it all the time, like during school, after school, every weekend. It's just like we are very focused and we want to make it so that it can be used or deployed or at least people can start using it in pilot tests and actual rebel zones because we want to have that impact. The only reason we're doing this is to be able to help in the process. So we just want to have that as soon as possible. On a personal level, how does it feel to be working on something that is going to help people? It's incredibly exciting. Anytime we sit down to work or do something, it doesn't feel like work, but rather a personal motivation that we're chasing. It's very enjoyable and I'm willing to put in a lot of effort and do sacrifices if necessary to bring it into a level where it can actually be deployed for earthquakes and hopefully save lives. Adil Ida and Arda Kanchal seagrass meadows are one of the world's most valuable underwater habitats. As well as providing food and shelter to thousands of species, the plants play a vital role in tackling climate change by absorbing carbon dioxide. But seagrass is also under threat from global warming, with most species unable to tolerate water above 25 degrees Celsius. Now, though, scientists have discovered that some plants are evolving to survive at higher temperatures. Ben Wyatt has been finding out more, given the recent snowstorms. It's an icy path that leads to the Paul Sabane's Coastal Ecology center in the Assateague national park of Maryland. Hey. Just Stephen. Stephen, nice to meet you. Nice to meet you. How's it going? Yeah, good. The team here are preparing to take me across the lagoon of the Sinopuxen Bay so we can get up close to the seagrass meadows they've been working so hard to restore. While the boat thaws outside in the midday sun, I sit down with leader of the seagrass project, Professor Stephen J. Tomasetti of the University of Maryland, Eastern Shore to learn more about its focus. We're as a team working on eelgrass. It's the foundational seagrass species of the US East Coast. Essentially, we can find it anywhere from North Carolina up through Canada, but here in Maryland, we're near to the southern edge of its range. They're not the flashy coral reefs, but they serve a lot of the same function. This is Katie Tanner, a PhD student working on the project. Under Stephen's guidance, these vegetated ecosystems provide the physical structure for a lot of biodiversity. We have seahorses. I've seen sharks out in the eelgrass meadows. It's a lot of shellfish, but also a lot of culturally important fish species. All in all, it's a very useful plant to have around, only it's fast disappearing. Stephen's team turned to genetic science for help. My name is Stephanie Kamel and I'm a professor in the Department of Biology and Marine Biology at University of North Carolina, Wilmington. And I'm the genomics lead on this project. So in some meadows challenged by higher temperatures, a small number of plants have been mutating or changing genomically. When we're talking about genomic change at the very basic level, we're asking, have there been changes to that DNA sequence? Does that change enable me to be taller, live longer, be more heat resistant? So when I go out and sample seagrasses, I sequence the genome and I will find change has occurred in a gene that regulates heat shock. By comparing the DNA of the variants with that of normal eelgrass, Stephanie is able to isolate the exact genes associated with heat resistance. The team using Stephanie's data can now focus their attention on harvesting just the seeds and that contain heat resistant genes before replanting them in dying meadows. It was this technique that Katie used to seed her new eelgrass meadows last year around March, when all the pollination has occurred and seeds are developing. We then go out and we pluck these reproductive shoots. They kind of look like green beans and then hold onto them until they're ready to germinate, to grow. Then it's just a matter of moving them to where they need to be. So our hand in the genetics is very low tech. It's really just moving seeds around at the right time. And to find out how those meadows were coming along, it was time to put on some waders. It's coming up to my hips and this water is at 0 degrees Celsius. So just praying there are no leaks in the waders. The eel grass, what kind of depth does that normally grow in? Anywhere from like a couple inches to six feet. Maybe the water today is too murky to see the sprouting grass. But Katie hopes the meadow will not only have regrown, but will then also flourish in the hot temperatures of the summer. If it does, the team are that bit closer to securing the future of eelgrass meadows in Maryland. The effort here is costing $300,000 over five years, but for Stephanie, it's taxpayer money well spent. We need to take a much more active role in managing our ecosystems. We're really not sitting back. We're like, okay, we're going to try these things because the absence of that is we're just going to what? Just let seagrass loss continue? I mean, we can't let that happen. Professor Stephanie Kamel ending that report from Ben Wyatt. And for more on this story, just search for people fixing the world wherever you get your BBC pod. We end in Tokyo with a man who is not your average dog walker. If you've been to the city's famous Harajuku district, there's a good chance you might have seen and taken a photo of a man who spent years walking up to 32 small dogs around the area every day. Will Leonardo went along to find out more about this social media sensation. This is the happiest day of my life. I finally get to see the Harajuku dog looking man I just met. A real life Pokemon trainer, 22 dogs he's walking. If you live in Tokyo, you already know this legend. For anyone coming to Tokyo, one of the first things you might notice is the fact that there's so many little dogs everywhere and they're all so well turned out, many of them wearing little coats, especially because it's the middle of winter here now and they all look like they get groomed more than the human owners. One of the people that's most famous for walking their dogs around the city center of Tokyo is Nobuaki Moribe. He is known as the Harajuku Dog Walker. He's often seen interacting with tourists and local people. Well, he runs a groomer salon on a quiet street in central West Tokyo. And I've come down to have a quick chat with him. You've picked a very famous area to walk around which is full of lot of tourists. People go there to shop. I'm just wondering if that was maybe a deliberate choice or something. That just kind of happened naturally. When I started walking these dogs, I was suddenly inspired to take this route. And that's it really. And then before I realized there were lots of tourists, people from all over the world taking photos of my dogs getting on well, which really made me joyful. But originally the walks were during COVID in 2020 when there was absolutely no one around. I think from a foreign perspective, dogs in Tokyo tend to be very small. They're very well groomed. Why do you think that is? Compared to the rest of the world, Tokyo is known for its small dogs. I think that's because people's homes are smaller. Most dog owners live in apartments. And globally there aren't that many people like me who walk large numbers of small dogs. That's why I think I've stood out. The most popular breed here is the poodle. And most of them get a cut once a month, which is why I think Tokyo dogs look especially stylish. Nobaraki has told me to meet him in a corner of Yoyogi park, which if you've been to Tokyo, you might know is next to the big Meiji Shrine and just up against Harajuku where he's going to continue his four hour walk. He told me to meet him a bit into his walk, partly because he said he doesn't want me around. Well, the dogs do their business. How many dogs do you have today? 22. Now completely encircled by people taking photos, the lights turn green. Well, every other person is turning around to take a photo of Nobuyaki as he glides past in the center of his sea of dogs. Let's talk to some of them and see what they made of the spectacle. They're very well behaved. They are very well behaved, aren't they? They don't seem to bark at all. I don't know how? What happens when they go to the toilet? Do you know? I hear that he gets that done in the first hour of the war. I've seen before. So I used to come to Tokyo, but I walked the street 100%. I see him. I actually find it quite inspirational. Back home we don't have anything like that. They all seem happy. They're not fighting each other. We've been in China and then come to Japan, but everyone's got dogs in other countries. Those who walk lots of dogs tend to focus on larger breeds and big dogs are easier to handle. They move around in a more precise way. What's the common what are the kind of interactions you've had that stuck in your memory the most? Every day is interesting and every day there's different people. The fact they all enjoy themselves so much makes me feel great and some even remember me. They say, oh, I saw you a year ago before showing me a photo. I'm very happy that I've stuck in people's memory. I really hope I'm making everyone feel peace and love. Nobuaki Moribe ending that report from Will Leonardo. And that's all from the happy pod for now. We'd love to hear from you. As ever, the address is globalpodcastbc.co.uk. this edition was produced by Rachel Bulk. The editor is Karen Martin. I'm Holly Gibbs. Until next time. Goodbye. You know that goal you set at the start of the year? You can still do it. Whether you're committed to a thru hike with friends, lifting heavier or simply walking more, it's not too late to stick with it and make your future self proud. Especially with the all in One Nutrition shake from Cachava. Because quality nutrition shouldn't be complicated. Just two scoops of Cachava's all in One Nutrition Shake and you've got 25 grams of protein, 6 grams of fiber, greens, adaptogens and so much more. Plus it actually tastes delicious. No fillers, no nonsense, just the good stuff your body craves. So instead of adding to your backstock of supplements that over promise and under deliver, simplify your progress with just two scoops of the highest quality ingredients. Stick with your wellness goals. Go to kachava.com and use code NEWS for 15% off. That's kachava.com and use Code NEWS K-A C-H-A-V-A.com Code NEWS.
Podcast: Global News Podcast
Host: BBC World Service, Holly Gibbs
Theme: This uplifting edition of The Happy Pod showcases inspiring stories of young people and scientists making a difference: from Australian teenagers 3D-printing a prosthetic hand for a friend, to groundbreaking epilepsy drugs, lifesaving AI for natural disasters, seagrass restoration to fight climate change, and the heartwarming tale of Tokyo's legendary dog walker.
The episode delves into the story of 14-year-old Lois Agnello from New South Wales, Australia, who was born without part of her left hand. During a technology lesson focusing on empathy, Lois and her teacher, Lloyd Godson, launched a student-led initiative to create a prosthetic hand using a 3D printer. This grassroots project blossomed, capturing the imagination of peers and expanding ambitions.
Origin of the Project
Personal Impact and Group Dynamics
Non-Compulsory Commitment
The Big Reveal
Broader Impact and Future Ambitions
The podcast highlights a remarkable medical advance—a new drug offering renewed hope to children suffering from Dravet syndrome, a severe form of epilepsy. Featuring moving testimony from Lauren Truelove, mother of 8-year-old Freddie, and expert insights from Prof. Helen Cross (UCL).
Living with Dravet Syndrome
Results and Transformation
The Science Explained
The Road Ahead
The episode profiles Adil Ida and Arda Kanchal, Turkish university students in London, who developed 'Rescube,' an AI-powered device to help find survivors in earthquake rubble—motivated by personal connections and a desire to save lives.
How 'Rescube' Works
Motivation and Personal Story
Family and Future Plans
Personal Fulfillment
An in-depth look into the coastal ecology teams in Maryland, USA, fighting climate change by restoring seagrass meadows (specifically eelgrass)—crucial for biodiversity and carbon absorption but threatened by warming waters.
Role and Value of Seagrass
Genomic Breakthrough
Restoration Techniques
Conservation Urgency
The episode closes with a heartwarming feature on Nobuaki Moribe, a Tokyo dog groomer widely recognized as the “Harajuku Dog Walker”, celebrated for walking up to 32 small, well-groomed dogs through the city—delighting tourists and residents alike.
Local Celebrity
Personal Reflections
| Timestamp | Speaker | Quote | |-----------|---------------------|-----------------------------------------------------------------------------------------------------------------------------| | 02:12 | Lois Agnello | “It felt really special and like good to me, because showing my friends, like, this is what it feels like..." | | 06:00 | Lois | “I felt like I was in a dream. I was like, this is crazy. It's actually working... I was going psycho.” | | 10:31 | Lois | “If everyone was the same, it'd be like a bunch of robots. We want everyone to be different.” | | 13:45 | Lauren Truelove | “He's able to enjoy life like any other child, which is... everything and more to me. He has this vivacious lust for life.”| | 16:43 | Prof. Helen Cross | “We're hoping to tackle all the problems, not just the seizures, but the other neurodevelopmental and walking problems...” | | 27:01 | Adil Ida | “Anytime we sit down... it doesn’t feel like work, but rather a personal motivation that we’re chasing. It’s very enjoyable.”| | 34:26 | Prof. Stephanie Kamel| “We need to take a much more active role in managing our ecosystems... We can't let [seagrass loss] happen.” | | 38:23 | Nobuaki Moribe | “I really hope I'm making everyone feel peace and love.” |
The podcast radiates optimism and humanity—showcasing grassroots action, scientific progress, and community joy. The hosts and contributors maintain an engaging, warm, and determined tone, amplifying stories that celebrate innovation, empathy, and resilience in the face of challenges.
For listeners who missed it: This edition of the Happy Pod lifts the spirit with tales of collective ingenuity and the simple joys that connect us—across continents, disciplines, and species.