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Could computer simulations redefine diabetes care? In this episode, we focus on a real medical product and the role of in silico trials in the transition from the Medtronic Guardian Sensor 3 to the Guardian 4 sensor, central to the Medtronic 780G pump system, which aims to simplify diabetes management by eliminating the need for fingerstick calibrations. Discover how computer simulations, clinical studies, and real-world data converge to evaluate this significant shift, revealing slight shifts in glucose metrics but proving the reliability of in silico methods in predicting real outcomes.

Join us to uncover the potential of digital modeling to transform healthcare, making it more precise while retaining safety, and contemplate how these advances might accelerate personalized medicine delivery, bypassing some traditional trial limitations.

Source:

Grosman B, Parikh N, Roy A, Lintereur L, Vigersky R, Cohen O, Rhinehart A. In Silico Evaluation of the Medtronic 780G System While Using the GS3 and Its Calibration-Free Successor, the G4S Sensor. Ann Biomed Eng. 2023 Jan;51(1):211-224.

44:T926,

Evaluating Continuous Glucose Monitoring Sensors with in Silico Trials: A Real-World Exemplar