A new book by the acclaimed neuroscientist Lisa Genova is always a big event. Genova, best known for her best-selling 2007 novel, Still Alice, has a new novel out this week, More or Less Maddy, which follows a 20-year-old aspiring stand-up comedian who is diagnosed with bipolar disorder. The protagonist, Maddy, grows up in affluent suburban Connecticut with a father who disappeared when she was young, leaving mysterious boats stranded on their front lawn – a hint at his own undiagnosed bipolar disorder. In our conversation, Genova emphasizes the importance of accurate representation in her fiction, having conducted extensive research with psychiatrists, psychologists, and people living with bipolar disorder. She explains that bipolar disorder affects about 2% of the general population and has a genetic component, with children of bipolar parents having a 10% chance of inheriting the condition. Our conversation explores how bipolar disorder manifests through episodes of mania and depression, with Genova noting that the average time to correct diagnosis is 7-10 years. She discusses the challenges of treatment, including medication side effects and the stigma associated with mental illness. Genova advocates for using the term "neurological disorder" rather than "mental illness" to reduce stigma. She explains that the new novel uses stand-up comedy as a backdrop, not just for its inherent ups and downs that mirror bipolar episodes, but also to explore themes of normalcy and identity. Genova stresses that while bipolar disorder is a serious condition, with proper treatment and support, individuals like the fictional standup comic Maddy can live functional and fulfilling lives.

Acclaimed as the Oliver Sacks of fiction and the Michael Crichton of brain science, Lisa Genova has captured a special place in contemporary fiction, writing stories that are equally inspired by neurological conditions and our shared human condition. She is the New York Times bestselling author of the novels STILL ALICE, LEFT NEGLECTED, LOVE ANTHONY, andINSIDE THE O'BRIENS. Her first TED talk, "What You Can Do To Prevent Alzheimer's" has been viewed over eight million times. Her most recent TED talk, "How Memory Works--and Why Forgetting is Totally OK" was the sixth most watched TED talk of 2021. A sought-after speaker/edutainer, she has headlined in speaker series alongside Barack Obama, Joe Biden, Gloria Steinem, Jay Leno, Malala Yousafzai, Bryan Stevenson, and Goldie Hawn.

Named as one of the "100 most connected men" by GQ magazine, Andrew Keen is amongst the world's best known broadcasters and commentators. In addition to presenting KEEN ON, he is the host of the long-running How To Fix Democracy show. He is also the author of four prescient books about digital technology: CULT OF THE AMATEUR, DIGITAL VERTIGO, THE INTERNET IS NOT THE ANSWER and HOW TO FIX THE FUTURE. Andrew lives in San Francisco, is married to Cassandra Knight, Google's VP of Litigation & Discovery, and has two grown children.

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Episode 2304: Lisa Genova on the connection between bipolar disorder and standup comedy