Dr. Deb Muth

0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on

0:08 peptides. And so, if you haven’t heard our first conversation about peptides,

0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we

0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual

0:26 wellness, immune function, growth hormone, and all the amazing fun things

0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle

0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do

0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this

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1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today

1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You

1:29 know, this has really become a big issue for people um of all ages. It’s not just

1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction.

1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t

1:48 reach orgasm. A lot of it is around desire and um the thought of it and

1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching

2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m

2:08 really excited to be able to talk about those today. So the first one is called PT-141.

2:14 This targets the brain not the periphery. Right? So for many women I

2:20 will always tell you sex starts between here. It is a brain thing for us. It is

2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our

2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to

2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do

2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And

2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid

2:57 that day. I’m just being honest. When you guys say things that make us upset,

3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And

3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be

3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this

3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter

3:28 this name, Vali, and it represents a fundamentally different approach to

3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra,

3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by

3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by

3:54 modulating neural s neural circuits involved in the sexual desire and

4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid

4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor

4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes.

4:20 It’s actually a metabolite of the melanotan 2, a peptide originally

4:26 developed for tanning that was also found to enhance sexual desire in early

4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis

4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically

4:48 for the treatment of acquired generalized hypoactive sexual desire

4:54 HSDD in permenopausal women. So for the first time we have a medication that was

5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of

5:07 these seialis tedataphil viagros for men but we had nothing for women. And so

5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first

5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral

5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong.

5:35 So I if you’ve had sexual dysfunction your entire life, this medication was

5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or

5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here.

5:53 Now, it’s also not just um supposed to be used if you dislike your partner,

5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help

6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And

6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You

6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only

6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different

6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh

6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire

6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about,

6:53 side effects to medications or other substance use. This specifically reflects the importance of differential

6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only

7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in

7:10 people who have sexual dysfunction issues as a result of using

7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it

7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the

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