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What happens when one of the toughest challenges in vascular medicine—severe arterial calcification—meets breakthrough engineering?

In this episode of Med Tech Gurus, we sit down with Dr. Robert Chisena, Co-Founder and CTO of Amplitude Vascular Systems (AVS). With a PhD in mechanical engineering and a portfolio of five patents, Robert has dedicated his career to tackling one of the most stubborn barriers in cardiovascular health: hardened arterial blockages that resist traditional interventions.

From the labs at the University of Michigan to the founding of AVS, Robert shares how he and his team are developing a next-generation intravascular lithotripsy platform designed to fracture calcium safely and effectively—combining the familiarity of angioplasty with the power of shockwave technology. Along the way, he offers lessons on building IP-rich startups, fostering innovation cultures, securing clinical adoption, and navigating the high-stakes path from spinout to commercialization

Whether you're an engineer, entrepreneur, or investor in medtech, this conversation shines a light on the strategies, setbacks, and breakthroughs required to transform a complex clinical challenge into a scalable, life-saving solution.