Jay McClellan (61:04)
Yeah. So the conviction that it's important for people to realize this idea is actually one that has been reinforced for me by the work of a man who studies addiction. And he thinks of addiction as being a sort of a extreme form of a natural process. The natural process involves things that cause one pattern of activation to produce another pattern of activation, which might be the action of doing something. Ultimately the act of reaching for that glass and guzzling another half a glass of beer in a single swallow. Okay. On the one hand, and the sort of experience that you have of what happened after you ingested that, which is what the standard theory says is why you did it. Okay. This impulse, the tendency to pick up that glass of beer and swallow the beer, is something that we can understand as happening through connections in a physical system that's wired up in a certain way to produce that effect. And, you know, I. There was a period in my life when I found myself in that very situation. Very frequently I would be like sitting there with this empty glass of wine and then some waiter would come and fill it up, and then it would be empty again, and then it would be filled, and then it would be empty again. And I was like, what's happening here? And I'm like, I'm not feeling good anymore. This isn't great. You know, I, like, can't even get my thoughts to come together in a coherent way. So something. Some process was occurring inside of me that just subconsciously caused me to pick up that glass and pour it into my throat, you know, So I had a very palpable, experiential kind of basis for kind of agreeing with this guy's theory, which also he's done a huge amount of careful experimental work to validate, right? And one of the things that you can show is that there's a part of the brain where you could destroy it, right? You could put an electrode in there and burn it out. Something we don't do in humans, but, you know, doing them with care. Under conditions that minimize the pain that the animal will experience. When you do that, we can perform these lesions and find out what their consequences are. And in this case, he found that there were. It turns out that rats love ice cream. You know, that everybody loves ice cream. Well, rats love ice cream, too. They will work really hard to get the ice cream. And if you give them ice cream, they'll sort of go, ah. You know, it's like they. You could see them sort of relax and sort of almost smile. And he uses those, and he measures physiological things that go along with that, which he thinks of as the liking response to that ice cream. The thing is, this little lesion that we made in the brain can take a rat that will work really hard to get ice cream and turn it into a rat that will never do anything to get any reward at all. It'll just sit there, even though if you put the ice cream in its mouth, it'll still go, ah, right? So that liking, that experiential pleasure that comes from the ice cream is not itself enough. The other system that controls the impulses is what actually gets the rat to the ice cream so that it can. So evolution has built particular structures into our neural networks that allow us to have the. That cause us to have these impulses that make it so that we don't die of starvation or thirst. But when we talk about our minds are imperfect, they often, you know, have deleterious consequences. And especially in addiction, the deleterious consequences are that these circuits run away. They get hijacked. The connections in them get Strengthened in such a way that the presentation of the stimulus causes an excessively strong impulse. Yet the pleasurable or liking aspects may no longer be even occurring at all, or you're definitely going to have that horrible hangover after you've drunk down that, you know, whole pint of whiskey that you just bought right at the corner store. So it's, it's. I find this research sort of really palpably connecting this notion that what impels what, what underlies the action that we actually take may be very, very different than the, you know, the consequence that actually ensues upon having undertaken that action. Yes. In. In that when things are working together in a constructive way, the impulses align with the subsequent liking. You know, the wanting and the liking are aligned, but they can get dissociated. And I think that this happens so too easily. Certainly addictive substances are, you know, contribute to this, but there are other sorts of impulses that. And other sorts of addictions that are much more purely behavioral, like addictions to engaging in sexual activities that can be entrenched, or addictions to gambling, which is, you know, the outcome of gambling is purely symbolic, but it's a whole pile of chips or dollars in the bank. Right. It's not that direct, but it, it. These things are things that we can work to understand as scientists and that if we do understand them better, they will enable us to be more able to figure out how to help people avoid getting stuck in those traps, helping ourselves learn to tell the waiter to take the wine glass away, you know, so you won't even be there for you to pick it up and guzzle it down. And so this is one of the reasons why I was actually so impelled to want to write this book with Rob. I, you know, that the ability to sort of communicate that there can be things that cause behavior and also cause experiential emotional reactions that are set up by experience, but that are not necessarily always constructive.