CRITICAL FAILURES: How Police May Have Lost Nancy Guthrie  Did critical investigative mistakes in the FIRST HOURS of the Nancy Guthrie case compromise the entire investigation? In this Police Off the Cuff episode, retired NYPD detectives analyze the Nancy Guthrie investigation, breaking down crime scene failures, lost evidence, and investigative mistakes that may have changed everything. We examine improper crime scene response, failure to secure the crime scene, evidence contamination, and missed forensic opportunities that can destroy a case before it even begins. In major cases like this, the first 24 hours of an investigation are critical—and early procedural errors can impact forensic evidence, suspect identification, and prosecution outcomes. Was the Nancy Guthrie crime scene handled properly? Were key pieces of evidence lost or contaminated? Did investigative decisions in the first hours weaken the case?