
We all think we know the story of pregnancy. Sperm meets egg, followed by nine months of nurturing, nesting, and quiet incubation. this story isn’t the nursery rhyme we think it is. In a way, it’s a struggle, almost like a tiny war. And right on the front lines of that battle is another major player on the stage of pregnancy that not a single person on the planet would be here without. An entirely new organ: the placenta. In this episode, which we originally released in 2021, we take you on a journey through the 270-day life of this weird, squishy, gelatinous orb, and discover that it is so much more than an organ. It’s a foreign invader. A piece of meat. A friend and parent. And it’s perhaps the most essential piece in the survival of our kind. This episode was reported by Heather Radke and Becca Bressler, and produced by Becca Bressler and Pat Walters, with help from Matt Kielty and Maria Paz Gutierrez. Additional reporting by Molly Webster. Special thanks to Diana Bianchi, Ju...
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Jad Abumrad
Radiolab is brought to you by Progressive Insurance. You chose to hit play on this podcast today. Smart choice. Make another smart choice with Auto Quote Explorer to compare rates from multiple car insurance companies all at once. Try it@progressive.com Progressive Casualty Insurance Company and affiliates. Not available in all states or situations. Prices vary based on how you buy. And now a word from our sponsors at Betterment. When investing your money starts to feel like a second job, Betterment steps in with a little work life balance. They're the automated investing and savings app that handles your money so you don't have to. It's diversified and optimized day after day, again and again, all while you focus on what matters most. Because your money doesn't need a work life balance, you do make your money hustle with Betterment. Get started@betterment.com Investing involves risk. Performance not guaranteed.
Lulu Miller
Hey, Lulu here. So, a few months back, our illustrator Jared Bartman got a difficult prompt. We asked him to design a cute tote bag based on our incredibly morbid episode, cheating death. And Jared was stumped. How do you create something plucky and cheerful and design forward about the inevitability of dying? So he brooded and he doodled, and then one day, it hit him. It is easily my favorite design ever. And because it's sort of this secret code about death, it has the effect that it's kind of like carrying Carpe Diem around on your shoulder. And you can get that tote bag right now if you become a member of the Lab. You knew it was coming. The Lab is the way we have designed to support the show. It's super easy. Just a couple clicks. You send a few bucks our way a month in exchange for, you know, public radio currency, tote bags, and other perks. Whether you support us or not, we are so grateful for you. But if you've ever been on the fence, I would say that now is a really good time. Because not only does the tote bag have a very cool surrealist design, it also has a zipper. So go take a peek@radiolab.org join. That's Radiolab.org join. And that's all. Thank you. On with the show.
Molly Webster
Yeah, you're.
Harvey Kleiman
Wait, you're listening.
Molly Webster
Okay.
Harvey Kleiman
All right.
Molly Webster
Okay.
Harvey Kleiman
All right.
Lulu Miller
You are listening to Radiolab Radio from wnyc.
Molly Webster
Rewind.
Lulu Miller
Oh, my God.
Becca Bressler
Oh, my God.
Lulu Miller
It's really similar. Hey, I'm Lulu Miller.
Molly Webster
And I'm Molly Webster.
Becca Bressler
This is Radiolab, and today, it's like red velvet bread. Look at that.
Molly Webster
It does look like a Loaf of bread.
Lulu Miller
We are dredging up an episode from the archives. It's called Everybody's Got One. And I really love this story so very much.
Molly Webster
I hope you enjoy a round loaf.
Lulu Miller
Of homemade bread with veins that's purple and red.
Molly Webster
We have a story about a thing, but also, like blood sausage bread, a thing that we've all had at some point.
Lulu Miller
It is Patty like.
Molly Webster
But most of us, we never even knew it.
Lulu Miller
And it comes to us from our contributing editor, Heather Radke.
Molly Webster
Yeah, I'm not even on staff, and.
Becca Bressler
I wish you were producer Becca Bressler.
Molly Webster
Well, I think. I think I can take it. Okay. I was thinking about getting pregnant, and I started to. To do a bunch of research. And, you know, pregnancy is this thing, at least for me, where I was like, I know about that. You know, I took, like, 14 years of sex ed in my public high school. But I'll just say, the more I learn about it, the more I realize how little I know and maybe, like, how little anyone knows about pregnancy. And one of the very first things I discovered was that when you're pregnant, you don't just grow a baby, you grow an entirely new organ.
Becca Bressler
Let me turn it down.
Molly Webster
Your whole life, you've got your heart, your lungs, your bone, your skin, your eyes, et cetera.
Harvey Kleiman
So this is the main hospital.
Molly Webster
But then all of a sudden, during pregnancy, a whole new organ shows up.
Harvey Kleiman
Here is our cabinet of placentas, and.
Molly Webster
That organ is the placenta.
Harvey Kleiman
Whole placentas, pieces of placentas.
Molly Webster
I had heard of the placenta before, but I really didn't know anything about it.
Harvey Kleiman
It's called the afterbirth for a reason. It's an afterthought that no one thinks about.
Molly Webster
I think I thought a thing a lot of people think, which is that the baby grows inside the placenta. I definitely thought balloon baby was inside of.
Lulu Miller
I mean, okay, I was pregnant, and I think I thought it was just, like, extra lining on my uterus, but it's not.
Molly Webster
It's not even yours.
Harvey Kleiman
The placenta belongs to the embryo, to the fetus, to the baby.
Molly Webster
So it's actually grown by the fetus, which means that every single one of us has had a placenta.
Harvey Kleiman
I was kind of like you. I literally had no idea what it did, what its purpose was.
Becca Bressler
This is Harvey Harvey Kleiman. He studies the placenta, M.D.
Harvey Kleiman
Phd, physician, scientist at Yale University, where.
Becca Bressler
He has a cabinet of placentas.
Harvey Kleiman
We're sort of running out of room, which we visited.
Becca Bressler
We'll come back to that.
Harvey Kleiman
Kristen, I think we need another cabinet.
Becca Bressler
But before we do, I'm interested in.
Molly Webster
How you got interested in the placenta. Presumably it wasn't because you got pregnant.
Harvey Kleiman
Serendipity.
Becca Bressler
So about 40 years ago, Harvey's just gotten out of medical school, and I'm.
Harvey Kleiman
Now a resident at University of Pennsylvania, and I'm in a laboratory studying ovaries. And in the lab, there was somebody else who was working on the placenta, and they were chopping up the placenta and homogenizing the placenta.
Becca Bressler
And these other scientists in the lab ended up with this thing called a gradient, where the different kinds of cells in the placenta were sort of separated out. They can look at them independently.
Harvey Kleiman
And they wanted me to take a picture of the gradient. Why? Well, on the side, I'm a photographer. I've actually done bar mitzvahs and weddings and things like that. Yeah, I love visual things, I think is what interests me in general. And so I took a picture of the gradient, and I asked Jerry, who was running the lab, I said, gerry, would you mind if I looked at what they are? He said, sure, go for it.
Becca Bressler
And what Harvey saw was something that.
Harvey Kleiman
No one had ever seen before.
Becca Bressler
He saw these cells, sort of a bubbling cauldron of cells.
Harvey Kleiman
They were like amoeba.
Becca Bressler
Later, he'd make movies of them.
Harvey Kleiman
They started moving around, and then they came together. They aggregated, then the membranes broke down, and they fused to make these multinucleated giant cells.
Becca Bressler
They were growing very aggressively in a way that surprised him.
Harvey Kleiman
I said, that is super cool. What's going on here?
Molly Webster
Eventually, he figured out that what he was looking at were stem cells, placental stem cells. And over the next few decades, he and a bunch of other scientists would start to piece together the story of the placenta.
Becca Bressler
And that's the story we're going to tell you. Cool.
Molly Webster
Okay.
Lulu Miller
I'm so excited. Educate me on this organ I have had and know nothing about.
Molly Webster
All right, so before we start, we just want to say a note on the word mother. Not everyone who gets pregnant or has a baby identifies as a mother, but it's a word a lot of people use when talking about pregnancy, including some of our sources. And so we're using it in addition to more inclusive language like pregnant person and parent.
Lulu Miller
Got it.
Harvey Kleiman
So let's start from the beginning. You have an egg, and then if there's sperm around, the sperm will fertilize that egg.
Molly Webster
And then it divides.
Harvey Kleiman
Divides into two, and then four, eight.
Molly Webster
And 16, et cetera, et cetera.
Harvey Kleiman
By the time it gets to about.
Molly Webster
32, the cluster of cells sort of forms into two layers.
Harvey Kleiman
It's like a tennis ball.
Molly Webster
Now there's a little cluster of cells.
Harvey Kleiman
On the inside that will become the embryo, that will become the fetus, that will become the baby, those little inside group of cells, but the cells on the outside, those cells will become the placenta.
Molly Webster
So from the very first few days of pregnancy, these placental cells are wrapped around what's going to become the embryo like a little blanket. And as Harvey explained all this to us, and he walked us deeper into the story of the placenta, we started to see that pregnancy isn't a peaceful nursery rhyme kind of a story about a pregnant person nurturing a fetus until it becomes a cute little baby. It's actually more like a struggle and not like a calm college debate. It's like a cage match, like a knockdown, drag out boxing match or a tiny war. Maybe even on one side is the pregnant person, and on the other side is the fetus. And in the middle, or maybe not like actually in the middle, more like actually like in the corner, rubbing the shoulders of the fetus is the placenta.
Harvey Kleiman
So what happens?
Becca Bressler
Well, okay, so Harvey says the first thing you have to understand is that that tiny embryo with its little baby placenta cells wrapped around it like a blanket, it is not welcome in the mother's body.
Harvey Kleiman
From the mother's point of view, this is immunologically foreign.
Becca Bressler
You know, the pregnancy is a little bit genetically the mom, but also a little bit the dad.
Harvey Kleiman
Exactly.
Becca Bressler
Which for the mother's body is not normal.
Harvey Kleiman
If we took a piece of tissue from whoever the father was of a pregnancy and put it into the mother, she would reject it.
Molly Webster
Right, because not self shouldn't be there. Not self is a virus. Not self is a bacteria.
Becca Bressler
Melissa Wilson, geneticist at Arizona State.
Molly Webster
We need to get rid of not self.
Harvey Kleiman
It's a foreign invader.
Becca Bressler
And so if an embryo just waltzes into a uterus one day without a little placenta blanket around it, the mother's body would gather up a squad of white blood cells, send them out to find it, shred it apart, and kill it.
Harvey Kleiman
So that's definitely a problem.
Molly Webster
But before the mother's body even has a chance to attack the embryo, the placenta blanket hides it.
Harvey Kleiman
The placenta is going to become invisible to the mother.
Lulu Miller
What?
Harvey Kleiman
Yeah, the mother literally doesn't even see that the pregnancy is there.
Lulu Miller
Mom's still at the bar.
Molly Webster
She sure is. Okay, so for the first week or so of the pregnancy. The placenta is pretty much just hiding the embryo from the mother.
Harvey Kleiman
But then the next problem that the placenta faces is nutrition.
Molly Webster
The embryo gets hungry and the placenta is like, I gotta feed this thing. And this is when the battle lines really start to get drawn, because essentially this war between the placenta and the pregnant person is a war that's about food. The placenta, Harvey says, has one mission.
Harvey Kleiman
To make the biggest baby possible, to suck as much nutrients out of the.
Molly Webster
Mother as possible, and the pregnant person's.
Harvey Kleiman
Mission, not to die.
Becca Bressler
So the placenta is in the uterus looking around for food, and it does this thing, something kind of tricky, something that when we heard about it, actually feels like it's skipping ahead nine months. Harvey says it produces this hormone. Hcg, happens to be the hormone that activates pregnancy tests. But one of its other jobs is.
Harvey Kleiman
That it causes the lining of the uterus to secrete a protein that our.
Molly Webster
Friend Harvey likens to milk.
Lulu Miller
Wait, what?
Molly Webster
Like, no.
Harvey Kleiman
The vitality you get from milk lasts far longer than energy from other drinks. The lining of the uterus makes milk for the embryo. Time to get back to the refills.
Lulu Miller
That is wild.
Becca Bressler
Yeah, but this milk is like a snack for the placenta. What it really needs is blood. So at this point, about two weeks into the pregnancy, the placenta goes on the offensive. By now it's actually latched onto the side of the uterus. And at this point, the placenta forms tendrils, like long skinny claws that actually.
Molly Webster
Try to invade in, up through the uterus into the maternal body, into the.
Harvey Kleiman
Blood vessels and attack the walls to open them up.
Molly Webster
Like, eh, I'm gonna suck all your nutrients from you. But the uterus stops them, basically putting.
Harvey Kleiman
Up a brick wall, very dense tissue.
Molly Webster
To block those claws from getting in.
Harvey Kleiman
Now the placenta doesn't give up easily.
Molly Webster
It keeps digging, but then the uterus blocks it.
Becca Bressler
And what you start to see is this push and pull where the placenta keeps digging, digging, digging.
Harvey Kleiman
We're talking pretty aggressive here.
Molly Webster
And the uterus keeps blocking it, blocking, blocking it.
Lulu Miller
Wait, wait, wait. Can I just ask, like, what isn't this, like, isn't our whole point to carry on? Like, isn't that what evolution has built us to do? Why would this moment, where it's about to happen, be so combative?
Molly Webster
It's a really good question, and we will get to it after the break.
Jad Abumrad
Radiolab is supported by Capital One. Banking with Capital One helps you keep more money in your wallet with no fees or minimums on checking accounts and no overdraft fees. Just ask the Capital One bank guy. It's pretty much all he talks about in a good way. He'd also tell you that Radiolab is his favorite podcast too. Ah, really? Thanks Capital One Bank Guy. What's in your wallet? Terms apply. See capitalone.combank Capital One NA member FDIC Radiolab is brought to you by Progressive Insurance. Do you ever find yourself playing the budgeting game? Well, with the name your price tool from Progressive, you can find options that fit your budget and potentially lower your bills. Try it@progressive.com, progressive Casualty Insurance Company and affiliates. Price and coverage match limited by state law. Not available in all states.
Molly Webster
This week on the New Yorker Radio Hour, Kaitlan Collins, the chief White House correspondent for cnn.
Lulu Miller
My dad will see things on Facebook.
Harvey Kleiman
About me and then call me to ask if it's true.
Lulu Miller
Sometimes it just shows you that people.
Harvey Kleiman
Can choose their own narratives.
Molly Webster
Kaitlin Collins and I'm Claire Malone.
Lulu Miller
Join us on the New Yorker Radio Hour from WNYC Studios. Listen wherever you get your podcasts. Lulu, Molly, Heather, Becca, Radiolab Today we are telling the story of the placenta, a story which has revealed to us just how much pregnancy itself is like a war between the fetus and the parent's body. And what we were just getting around to was why?
Molly Webster
Right, so you all actually already answered this question on the show.
Becca Bressler
Oh well, this came as a total shock to me because after all, the thing.
Molly Webster
So basically the story we told then is that before placentas, think about fish, you think about all animals that would become mammals laid eggs. And an egg is a special little thing. It's a self contained little package where the fetus has everything it needs to eat until it's ready to hatch. And all of its waste products stay inside the egg and nothing comes in and nothing goes out until the animal is ready to leave its egg.
Harvey Kleiman
But then long, long ago, some ancient mammal ancestor got a virus.
Molly Webster
A virus infected an ancient proto mammal and changed its DNA so that eventually, many generations later, the eggshell transformed from a hard shell that exists outside the body to a sort of permeable layer that exists inside the body which then becomes the placenta. And this was a huge advantage because it made it possible for the blood of the mother to actually feed the fetus so it could get tons more nutrients. It wasn't limited to just like whatever yolk was inside the egg from the beginning. And the individual was so reproductively successful that it spread across all Eutherian Mammals geneticist Melissa Wilson. Again, that's mind blowing because it made it possible to actually make a baby with a big, giant brain like a human being or a dolphin. And that was great. But it also had this downside, this wonky interaction between the pregnant individual and the placenta, because the placenta is not the DNA of the pregnant individual. The placenta is the DNA of the offspring. Okay? And this is how we've ended up four weeks into what's basically a war between the mother and the placenta, with the placenta trying to suck blood out of the mother and the mother basically trying to box it out.
Becca Bressler
And this fight is just getting started. Week five goes by, then week six. Week six, week seven, the embryo's growing. Eyes, ears, bones.
Harvey Kleiman
It has a heart, kidneys, liver.
Becca Bressler
Meanwhile, the placenta is digging, digging, digging, trying to get to the blood to get this thing, more nutrients, but the placenta just can't break through.
Harvey Kleiman
It's just like, hey, I need to be growing. I need more nutrients for my passenger. The fetus.
Molly Webster
And the uterus just says, nope, get out.
Harvey Kleiman
But the placenta has a couple tricks.
Becca Bressler
Up its sleeve, Specifically one trick called PP13. It's a protein that Harvey says creates a diversion.
Harvey Kleiman
Here's an analogy. If we wanted to rob a bank, I don't want the police to be near there. So what I'm gonna do is blow up a grocery store, wait for all the police to sort of go around the grocery store, and while they're busy doing that, I'm gonna sneak into the bank.
Becca Bressler
So in the world of Harvey's analogy here, PP13 is blowing up the grocery store. The placenta produces it. It goes off to some other part of the uterus that the placenta isn't trying to invade.
Harvey Kleiman
And there the PP13 attracts the entire police force, SWAT team, everybody of the mother's immune system.
Becca Bressler
And while the whole police force is over there dealing with the PP13, the placenta's digging claws bust through.
Harvey Kleiman
And blood fountains into the placenta. It's bathed in all these nutrients and goes, buffet time. Let me see what I need.
Molly Webster
As the mother's blood starts rushing into the placenta, the fetus just starts growing and growing. It's the size of a grapefruit by week 15, a pineapple by 24, a watermelon by 36.
Harvey Kleiman
And that fetus is demanding more and more horsepower, more and more nutrients to actually grow.
Molly Webster
So the placenta starts releasing more and.
Harvey Kleiman
More of this hormone called human placental.
Molly Webster
Lactogen, which sort of hijacks the mother's.
Harvey Kleiman
Digestive system says, okay, you're eating, I get that, but none of that actually is for you. You're not going to get to store it. All those nutrients are going to stay in your blood. So I. The placenta can suck up those nutrients.
Molly Webster
And all the while, the placenta is gobbling up more and more of the mother's blood. And by the third trimester, Harvey says.
Harvey Kleiman
20 to 25% of all the blood flow of the mother is going into the placenta.
Molly Webster
And this is where things can get dangerous for the mother.
Harvey Kleiman
If the placenta and the fetus together say, hey, I'm not getting enough blood. I'm just going to force her body to start pumping more blood into me, into the fountaining system. And this is a condition we call preeclampsia.
Molly Webster
Preeclampsia is very, very scary. And it's basically when the mother's blood pressure spikes so high that she can actually die. Whoa. And it's really serious. It's one of the leading causes of maternal death. And I think it's easy to sort of think, like, high blood pressure, you know, not such a big deal, but it's actually the placenta, you know, sucking so much blood out of the mother's body that she can't continue to survive.
Becca Bressler
And this can also go wrong in the other direction.
Harvey Kleiman
Mom, of course, doesn't want to die. She doesn't want the fetus to take all her nutrients. But if she is successful and wins the battle, if you will, the placenta is too small, the fetus is too small, and the pregnancy may not survive.
Becca Bressler
But if neither side wins the war, then after nine months, give or take a few weeks, poof, you have a baby.
Lulu Miller
And poof is exactly what it feels like.
Molly Webster
But the placenta's still in there. And so the placenta actually also kind of has to be born. I'm getting the sense that the placenta may be underneath this blue cover.
Becca Bressler
Is that right?
Harvey Kleiman
Good guess.
Molly Webster
So we didn't actually see anyone give birth to a placenta, but Harvey did show us one in his lab.
Harvey Kleiman
All right, are we ready for the moment?
Molly Webster
Harvey grabs the blue cloth and he pulls it back.
Becca Bressler
Oh, my God.
Harvey Kleiman
And this. This is the placenta, which is in the standard Ziploc bag. That's what it's in right now.
Becca Bressler
Oh, my God.
Molly Webster
I mean, it looks so. It looks very organy.
Harvey Kleiman
It's kind of bloody, isn't it?
Becca Bressler
It's so bloody.
Harvey Kleiman
And so I'm going to open the Ziploc bag.
Molly Webster
Oh, My God, it's so bag. Like. It's sort of bluer than I thought.
Becca Bressler
It also kind of looks like raw meat, like you were making a hamburger or something.
Molly Webster
It is raw meat. So I'm gonna pick it up and see how heavy it is. So I grabbed the placenta. It's kind of heavy. Like what?
Harvey Kleiman
Like a normal term placenta is about 550 grams, which is just about a pound. It's about 8 to 9 inches in diameter.
Molly Webster
About as wide as a volleyball. It's really weird. It's. Okay, first of all, it's cold. Maybe sleep. Slimy is the word. And it's got a lot of texture. When you're in the beefy part, you can feel what I imagine are the veins, and it has, like. It's not all one texture. It's, like, hard in spots and soft in spots. It feels sort of like, crazy.
Becca Bressler
And then Harvey told us how the placenta, this little alien invader and all its thirsty veins and tendrils and hooks, how it leaves the body.
Harvey Kleiman
I think this is another miracle.
Becca Bressler
So the baby goes first, and the.
Harvey Kleiman
Uterus is elastic and has, you know, muscle, so it contracts down, and it's that contracting down that actually shears the placenta off the lining of the uterus and the placenta gets delivered. And then all those blood vessels that have been supplying blood to the placenta for all those weeks and months have to close down.
Becca Bressler
And they do, like, immediately, there's this river of blood fountaining into the placenta that just shuts off.
Molly Webster
And what's kind of cool is it leaves no scar. It's like one of the only things like this in the body. Maybe the only thing like this where something sort of gets sheared off and there's no, like, no mark remains. Oh, that just makes me think that.
Lulu Miller
While from the outside it feels like.
Molly Webster
Such a push and pull and like, they're competing against each other, that, like.
Lulu Miller
In the scarlessness, there is, like, a.
Molly Webster
Camaraderie and a peace of sorts.
Becca Bressler
Yeah. In some sense, I think of it as, like, the OG Parent for the baby. It's one mission is to help that embryo grow into a healthy fetus and deliver a baby. And it has this. It's developed this sort of, like, incredible way of somehow making sure all of its needs are met in such a selfless sort of way that I've started seeing it as the first parent.
Molly Webster
Yeah. I don't know. It's sort of. I feel almost like I'm gonna cry. It feels sort of like here's this thing. This was somebody's baby's life thing. I don't know.
Lulu Miller
But so, okay, placenta comes out, it releases, it leaves no trace. It leaves no scarlet. It knows it's time to like, let those grappling hooks go. Comes out and then what's the end of the journey?
Becca Bressler
I mean, I guess it goes in the garbage most of the time. I feel really sad that I can't meet mine. I think once you know all that it's done for you, I just wish I could meet it and thank it.
Molly Webster
Yeah.
Harvey Kleiman
And hold, hold it, Santa, for making me survive and be alive.
Becca Bressler
Put it in my closet. I don't know.
Molly Webster
But also, a lot of people don't throw it away.
Tina Delisle
Only recently are we beginning to see that scientific discourse is taking the placenta seriously.
Molly Webster
This is Tina delisle. She's a professor of history at the University of Minnesota, Twin Cities, and she's writing a book about the placenta.
Tina Delisle
Indigenous people were understanding the placenta for a long time.
Molly Webster
She explained to us that this dawning we were having that the placenta is kind of like a parent. It's something that a lot of people had already been thinking about the placenta for a really long time.
Tina Delisle
In native cultures, the placenta is a friend, a companion, grandmother.
Molly Webster
And when you think about the placenta.
Tina Delisle
That way as a relation, they're going to treat it very differently. And that explains why throughout a lot of native cultures, the emphasis is on proper burial of the placenta.
Becca Bressler
Tina explained that you see this practice of burying the placenta all over the.
Tina Delisle
World in various African cultures, in native American culture, in Hawaii, French Polynesia, in Aotearoa, Tahiti, Vanuatu.
Becca Bressler
And where she's from, born and raised.
Tina Delisle
In Guahan in the Marianas for Chamorros.
Becca Bressler
The indigenous people of Guam.
Tina Delisle
When you bury the placenta or the gatung, it ensures that baby's safety. You know, even examples like when they're, when they're young and they're learning how to walk, it protects them so they don't fall down. It was a way of protecting children into adulthood.
Molly Webster
Huh. Okay, so you're saying that the placenta isn't just looking after the well being of the child when it's in the womb, but also into adulthood.
Tina Delisle
Yeah, but also for the well being of the land. Because when you plant the placenta, it connects people to place. The idea is that if someone moves away, they always remember my placenta is buried there and they will take care of that land.
Becca Bressler
Did you bury your kids placentas No.
Tina Delisle
I had inquired about the possibility of taking home the placenta.
Becca Bressler
This was 2006. Tina was living in Michigan.
Tina Delisle
When I was there, I was told that. And when I say there, this is when, you know, in the. In the middle of labor. And I was told that they wouldn't let me take home my baby's placenta.
Becca Bressler
And why is that? Like, why, why wouldn't they let you?
Tina Delisle
Because of the law. And I was told that I'd have to go to court to get that. It would be really difficult.
Becca Bressler
How did that make you feel when you heard that?
Tina Delisle
You know, I felt really bad about that. I had my partner, my husband, take pictures and video of the placenta. Right. I was like, okay, I need something to remember my baby's placenta with. Right.
Molly Webster
But things have changed some since Tina gave birth in 2006 in states like Hawaii and Texas and Oregon. Now you can legally take your baby's placenta home with you.
Tina Delisle
The only consolation I had really was maybe this will be different next time around for my daughters.
Becca Bressler
This placenta was delivered yesterday.
Harvey Kleiman
Monday. Actually Monday, late afternoon Monday. Yes. So there's a little cute baby someplace who is happy and alive because of this placenta.
Becca Bressler
We gotta send that family this podcast. I'm sure we can't know who they are. Hip bub.
Harvey Kleiman
We can't know who they are. That's part of the reason we have the placenta.
Molly Webster
But let's thank them anyway.
Becca Bressler
Thank you.
Molly Webster
More spiritual way.
Harvey Kleiman
Yes, we will thank them spiritual.
Lulu Miller
This episode was reported by Heather Radke and Becca Bressler and produced by Becca Bressler and Pat Walters with help from from Matt Kilty and Maria Paz Gutierrez. Special thanks to Diana Bianchi, Julia Katz, Sam Bajati, Celia Bardwell Jones and Hannah Ingraham. Special thanks also to my placenta for getting me here. Thanks thanks to the placentas of all the people who made this program. Thanks for building such talented humans. And finally to the placenta that made you listener. Thanks for making such a darky human who likes our program. Really appreciate it.
Molly Webster
Hi, I'm Parisha and I'm from Ottawa, Canada and here are the staff credits. Radiolab was created by Jad Abumrad and is edited by Soren Wheeler. Lulu Miller and Latif Nasser are our co hosts. Dylan Keefe is our director of sound design. Our staff includes Simon Adler, Jeremy Bloom, Becca Bressler, W. Harry Fortuna, David Gable, Maria Paz Gutierrez, Sindhu Nyana Sambandam, Matt Kielty, Annie McKeown, Alex Neeson, Sara Khari Sarah Sandbach, Anisa Vitsa, Arian Wack, Pat Wolters, and Molly Webster. Our fact trackers are Diane Kelly, Emily Krieger, and Natalie Middleton.
Harvey Kleiman
Hi, this is Evan. I'm calling from Menlo Park, California. Leadership support for Radiolab science programming is provided by the Gordon and Betty Moore Foundation Science Sandbox, a Simons foundation initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan foundation.
Becca Bressler
And now.
Harvey Kleiman
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Becca Bressler
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Harvey Kleiman
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Becca Bressler
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Harvey Kleiman
Learn more@att.com 5G Network.
Tina Delisle
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Lulu Miller
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Molly Webster
Coverage from WNYC and Gothamist every morning, midday and evening.
Lulu Miller
By sponsoring our programming, you'll reach a community of passionate listeners in an uncluttered audio experience. Visit sponsorship wnyc. Org to learn more.
Radiolab Episode Summary: "Everybody's Got One"
Radiolab, hosted by Lulu Miller and Latif Nasser, delves deep into the enigmatic world of the placenta in their March 21, 2025 episode titled "Everybody's Got One." This episode unravels the complex relationship between the placenta, the fetus, and the mother's body, blending scientific inquiry with cultural insights to present a comprehensive exploration of this often-overlooked organ.
The episode begins with the hosts introducing the placenta as an entirely new organ that develops during pregnancy. Lulu Miller reflects on the common misconceptions surrounding pregnancy, highlighting how the placenta is central to fetal development.
Notable Quote:
Molly Webster [04:09]: "When you're pregnant, you don't just grow a baby, you grow an entirely new organ."
Central to the narrative is Dr. Harvey Kleiman, a physician and scientist at Yale University, who has dedicated his career to studying the placenta. The episode introduces Kleiman's fascination with placental stem cells, emphasizing his groundbreaking work and the extensive placental collection he maintains.
Notable Quote:
Harvey Kleiman [05:25]: "We need another cabinet."
Delving into the science, the hosts explain that the placenta is genetically distinct from the mother, carrying DNA from both the mother and the father. This genetic difference makes the placenta immunologically foreign to the mother's body, setting the stage for a biological tug-of-war.
Notable Quote:
Harvey Kleiman [09:52]: "Exactly."
The episode traces the evolutionary history of the placenta, revealing that a virus infection in an ancient mammalian ancestor led to the development of the placenta. This mutation transformed eggshells into a permeable layer within the body, facilitating a direct nutrient exchange between mother and fetus.
Notable Quote:
Molly Webster [16:11]: "A virus infected an ancient proto mammal and changed its DNA so that eventually... the eggshell transformed from a hard shell that exists outside the body to a sort of permeable layer that exists inside the body."
A significant portion of the episode is dedicated to illustrating the placenta's aggressive quest for nutrients. The placenta secretes hormones like PP13 and human placental lactogen to manipulate the mother's body, ensuring a steady supply of nutrients for the growing fetus. This manipulation can lead to conditions like preeclampsia, where the mother's blood pressure becomes dangerously high.
Notable Quotes:
Harvey Kleiman [18:09]: "PP13 is blowing up the grocery store... the placenta's digging claws bust through."
Molly Webster [20:10]: "Preeclampsia is very, very scary. It's basically when the mother's blood pressure spikes so high that she can actually die."
Beyond the biological aspects, the episode explores the cultural significance of the placenta in various indigenous communities. Tina Delisle, a history professor, shares insights into how native cultures view the placenta as a companion or guardian, leading to rituals like proper burial to ensure the child's protection and connection to the land.
Notable Quote:
Tina Delisle [26:25]: "In native cultures, the placenta is a friend, a companion, grandmother."
Throughout the episode, the hosts express a mix of awe and emotional response to the placenta's role. From handling a freshly delivered placenta to contemplating its journey out of the body, their reflections add a personal dimension to the scientific narrative.
Notable Quote:
Becca Bressler [25:11]: "I just wish I could meet it and thank it."
The episode concludes by emphasizing the placenta's crucial role in human reproduction and its often-overlooked contribution to fetal development. The hosts highlight the placenta's seamless exit from the body post-birth, leaving no scar—a testament to its specialized function.
Notable Quote:
Molly Webster [24:03]: "And what's kind of cool is it leaves no scar. It's like one of the only things like this in the body."
Final Thoughts
Everybody's Got One sheds light on the placenta's intricate and often conflicting relationship with the mother's body. By intertwining scientific exploration with cultural practices, Radiolab offers listeners a profound appreciation for this vital organ, challenging preconceived notions about pregnancy and maternal-fetal connections.
Notable Quotes with Timestamps:
This comprehensive summary encapsulates the essence of Radiolab's "Everybody's Got One," providing listeners with an in-depth understanding of the placenta's biological significance and cultural reverence.