In this episode, we break down the pharmacology of selective serotonin reuptake inhibitors (SSRIs) with a focus on the high-yield clinical pearls pharmacists, medical students, and healthcare professionals need to know. We compare the major SSRIs—including fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and fluvoxamine—based on adverse effects, drug interactions, pharmacokinetics, and board exam relevance. Topics include serotonin syndrome, discontinuation syndrome, CYP450 interactions, QT prolongation, sexual dysfunction, weight changes, and SSRI selection in special populations such as older adults and pregnancy. Whether you are preparing for exams, clinical rotations, or looking to sharpen your psychopharmacology knowledge, this episode provides practical and memorable insights into one of the most commonly prescribed medication classes. This is Part 1 of 2.

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