Podcast
Sean Carroll's Mindscape
Hosted by Sean Carroll · EN
Mindscape provides a bridge to the biggest ideas in the universe, as shared by the most creative and intelligent thinkers.
Sean Carroll is Homewood Professor of Natural Philosophy at Johns Hopkins University, and author of numerous books. Every week he talks to a guest who is a world expert in some fascinating subject, and they talk about it in a way that is both informal and deeply informative.
Learn about the complex dynamics of social systems, the mystery of quantum superposition, the origin of life and the search for it on other planets, and more.
Sean Carroll is Homewood Professor of Natural Philosophy at Johns Hopkins University, and author of numerous books. Every week he talks to a guest who is a world expert in some fascinating subject, and they talk about it in a way that is both informal and deeply informative.
Learn about the complex dynamics of social systems, the mystery of quantum superposition, the origin of life and the search for it on other planets, and more.
11episodes
Episodes
Newest firstAll episodes
361 | Bonnie Bassler on How Bacteria Talk and Work Together
6d ago01:19:38Tap to summarizeOne of the characteristics of life is that living organisms gather information and put it to use. Even one of the simplest lifeforms, bacteria, are able to sense features of their surroundings and alter their behavior accordingly. Most impressively, they are able to sense the presence of similar bacteria by a process called quorum sensing. Today's guest, Bonnie Bassler, is a leader in this field, and explains how quorum sensing allows groups of bacteria to do things (including in our bodies) that wouldn't be possible for individual bacteria. Blog post with transcript: https://preposterousuniverse.com/podcast/2026/07/20/361-bonnie-bassler-on-how-bacteria-talk-and-work-together/ Support Mindscape on Patreon. Bonnie Bassler received a Ph.D. in biochemistry from Johns Hopkins University. She is currently Andrew K. Golden University Professor of Molecular Biology at Princeton University and a Howard Hughes Medical Institute Investigator. She is a member of the National Academy of Sciences, National Academy of Medicine, and the American Academy of Arts and Sciences. Among her awards are a MacArthur Fellowship, the Gruber Prize in Genetics, and the National Medal of Science. Lab web site Princeton web page Google Scholar publications Wikipedia
Transcribe →Mindscape Ask Me Anything, Sean Carroll | July 2026
2w ago04:06:23Tap to summarizeWelcome to the July 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with transcript: https://preposterousuniverse.com/podcast/2026/07/13/ama-july-2026/ Support Mindscape on Patreon.
Transcribe →360 | Marc Berman on the Science of Touching Grass
3w ago01:30:22Tap to summarizeModern life has, in many ways, removed us from the environments in which our ancestors lived and adapted. Not only do we spend time looking at screens, but we spend time indoors, or outdoors but in urban spaces. How does this affect how we think and feel? Psychologist Marc Berman is a pioneer of "environmental neuroscience." In his recent book, Nature and the Mind: The Science of How Nature Improves Cognitive, Physical, and Social Well-Being, he presents evidence that spending time in nature not only puts us in a better mood, it makes us better thinkers. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/07/06/360-marc-berman-on-the-science-of-touching-grass/ Support Mindscape on Patreon. Marc Berman received his Ph.D. in psychology from the University of Michigan. He is currently Professor of Psychology and Faculty Co-Director of the Chicago Center for Computational Social Science at the University of Chicago. Among his awards is the American Psychological Association Distinguished Scientific Award for Early Career Contributions. Environmental Neuroscience Lab U. Chicago web page Google Scholar publications Amazon author page
Transcribe →359 | Solo: Theories of Dark Energy
4w ago01:57:23Tap to summarizeThe cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, and demonstrating that would be yet another foundational discovery. In this episode I discuss what is required to invent a plausible theory of dynamical dark energy, This includes considerations from particle physics, possible experimental tests, and the option that we should modify gravity rather than adding a new source of energy to the equations. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/29/359-solo-theories-of-dark-energy/ Support Mindscape on Patreon.
Transcribe →358 | Solo: Vacuum Energy and the Cosmological Constant
Jun 2202:02:44Tap to summarizeThe most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe, announced in 1998. The most straightforward explanation for these observations is a positive cosmological constant, or vacuum energy. I talk about the origin of the idea with Einstein, how quantum physicists started to think about it and understand the "cosmological constant problem," as well as how its discovery also raised the "coincidence problem." This is the first of two connected solo episodes; the next will be on theories of dark energy that are not the cosmological constant. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/22/358-solo-vacuum-energy-and-the-cosmological-constant/ Support Mindscape on Patreon.
Transcribe →357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics
Jun 1501:21:03Tap to summarizeMessenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used to produce proteins. RNA may even have been the first molecule to kick-start the origin of life. Today, scientists are learning how to manipulate mRNA to cure and prevent diseases, whether through vaccination or literally editing one's DNA. Jeff Coller explains how it all works and how mRNA is revolutionizing medicine as we know it. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/15/357-jeff-coller-on-mrna-vaccines-and-bespoke-therapeutics/ Support Mindscape on Patreon. Jeff Coller received his Ph.D. in cell and molecular biology from the University of Wisconsin-Madison. He is currently Bloomberg Distinguished Professor of Biomedical Engineering and Director of the RNA Innovation Center at Johns Hopkins University. He is co-founder of Tevard Biosciences and the Alliance for mRNA Medicines, and leads the REPAIRx consortium. He is a fellow of the American Association for the Advancement of Science. Web site Johns Hopkins web page Google Scholar publications "This May Be the Most Important Medical Story of the Decade," New York Times, April 9, 2026
Transcribe →356 | Andrea Wulf on Enlightenment, Nature, Romanticism, and Modernity
Jun 801:17:54Tap to summarizeAll ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanity, and the self. Andrea Wulf is a writer of narrative histories, examining the origins of ideas through the lives of the people who explored them. In this episode we discuss three of her books: The Invention of Nature, about Alexander von Humboldt and environmentalism; Magnificent Rebels, about the Jena circle of Romantics including Goethe, Schiller, Schlegel, and others; and most recently The Traveller, about George Forster, an early naturalist, ethnographer, and champion of human equality. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/08/356-andrea-wulf-on-enlightenment-nature-romanticism-and-modernity/ Support Mindscape on Patreon. Andrea Wulf was born in India, raised in Germany, and studied design history at the Royal College of Art, London. She is the author of seven books. She is a Miller Scholar at the Santa Fe Institute and a Fellow of the Royal Society of Literature. The Invention of Nature won multiple prizes, including the Royal Society science book prize and the LA Times book prize. Web site Amazon author page Wikipedia
Transcribe →AMA | June 2026
Jun 103:58:41Tap to summarizeWelcome to the June 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2026/06/01/ama-june-2026/ New paper I talk about in the beginning of the episode: S.M. Carroll, N. Diachenko, and S. Dulani, "Toward a Phenomenologically Acceptable Quantum Cyclic Universe."
Transcribe →355 | Solo: Looking Quantum Mechanics in the Eyeball
May 2401:45:38Tap to summarizeOne of the major obstacles to understanding quantum mechanics is the difficulty we have in simply accepting what the theory itself is telling us. The problem is that we know what the everyday world looks like -- stuff, arranged in space, evolving through time. So we can't resist the temptation to impose that picture on the quantum description, even if it's not actually there. In this solo episode I talk about what it means to take quantum mechanics at face value, and the difficult work involved in understanding how the everyday world of our experience fits into the picture. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/25/355-solo-looking-quantum-mechanics-in-the-eyeball/ Support Mindscape on Patreon. Here is the survey on physicists' opinions about unsettled big-picture questions: Afshordi, Halper, Rini, and Schirber, "Big Mysteries Survey: Physicists' Views on Cosmology, Black Holes, Quantum Mechanics, and Quantum Gravity." And here is a short technical overview on the ideas described in this episode: Carroll, "Reality as a Vector in Hilbert Space." If you want further papers, look at the papers cited in this one.
Transcribe →354 | Christian List on Free Will and Levels of Reality
May 1801:28:38Tap to summarizeDid I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. Today's guest, Christian List, is a philosopher and political scientist who has arguably done the most to articulate the "compatibilist" perspective on free will, according to which the freedom of rational agents is entirely compatible with underlying mechanistic laws. The reconciliation depends on thinking carefully about emergence and the relationship between levels of reality. Take your personal data back with Incogni! Use code MINDSCAPE at this link and get 60% off an annual plan: https://incogni.com/mindscape #sponsored Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/18/354-christian-list-on-free-will-and-levels-of-reality/ Support Mindscape on Patreon. Christian List received his D.Phil in Politics from Oxford University. He is currently Professor of Philosophy and Decision Theory and Co-Director of the Munich Center for Mathematical Philosophy at LMU Munich. He is a Fellow of the British Academy and a member of Academia Europaea the Bavarian Academy of Sciences and Humanities. Among his honors are the Joseph Gittler Award from the American Philosophical Association. He is the author of Why Free Will Is Real and (with Philip Pettit) Group Agency. Web site LMU web page Google Scholar publications Amazon author page Wikipedia
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