Skin Anarchy Episode Summary
Episode Title: Breakthroughs In Growth Factor Delivery and Oleosomes With Core Biogenesis
Host: Dr. Ekta et al.
Guest: Tony Abode, Chief Commercial Officer at Core Biogenesis
Release Date: May 5, 2025
1. Introduction to Core Biogenesis and Tony Abode’s Journey
Dr. Ekta opens the episode by introducing Tony Abode, the Chief Commercial Officer at Core Biogenesis, highlighting the company’s focus on ingredient innovation and biotechnology in skincare.
“I couldn’t believe that I could sort of leverage this wonderful scientific principles into the business world and making a difference to human lives.”
— Tony Abode [01:21]
Tony shares his transition from biomedical research to the skincare industry, emphasizing his passion for translating scientific discoveries into consumer products rapidly.
2. The Shift from Traditional Protein Manufacturing
Core Biogenesis distinguishes itself by producing high-purity, bioidentical proteins from plants rather than traditional sources like human cells or fermentation.
“We kind of felt like, there gotta be other ways to make proteins. There gotta be other ways to make biomimetic proteins or proteins that are human identical.”
— Tony Abode [04:24]
He explains the limitations of existing protein manufacturing methods, such as safety concerns with human-derived proteins and the high costs and environmental impact of fermentation processes.
3. Leveraging Oleosomes for Enhanced Protein Stability
A pivotal innovation discussed is the use of oleosomes—a natural delivery system found in oil seeds—to stabilize growth factors, significantly enhancing their shelf-life and efficacy.
“We can improve stability of growth factors by 10x.”
— Tony Abode [19:53]
Tony details how oleosomes protect proteins like epidermal growth factor (EGF) from denaturing, ensuring they remain effective throughout the product’s lifespan.
4. Clinical Validation and Exceptional Results
Core Biogenesis conducted a rigorous 12-week placebo-controlled study demonstrating the superior stability and efficacy of oleosome-delivered EGF compared to traditional “naked” EGF.
“After 12 weeks in the oven, the oleosome EGF we retained 93% of the protein, whereas the naked EGF we're only able to recover 8%.”
— Tony Abode [20:41]
These results underscore the potential for oleosome-based delivery systems to revolutionize skincare formulations.
5. Addressing Consumer Frustrations with Current Skincare Solutions
Dr. Ekta and Tony discuss the high frustration rate (90%) among female consumers dissatisfied with current skincare products, primarily due to slow results and ineffective actives.
“If you've got something that works in seven or 14 days, trust me, that consumer is buying for life.”
— Tony Abode [22:53]
This frustration is attributed to the reliance on traditional actives like retinol, which require long periods to show results and often cause skin irritation.
6. Bioidentical Proteins as the Future of Anti-Aging Skincare
The conversation shifts to bioidentical proteins, particularly growth factors, which are naturally produced by the body and decline with age. Core Biogenesis aims to replenish these proteins topically to address the root causes of aging.
“We believe that the bioidentical protein revolution is coming.”
— Tony Abode [11:12]
They highlight that bioidentical proteins can stimulate collagen and elastin production without the irritation associated with synthetic actives.
7. Superior Performance Compared to Retinol
Tony reveals promising preliminary results from a head-to-head study comparing Core Biogenesis’s oleosome-delivered growth factors to traditional retinol.
“We are beating retinol on almost every single, single criteria from wrinkles to firming to TEWL, transepidermal water loss to ITA value, which is hyperpigmentation.”
— Tony Abode [36:49]
These findings suggest that their growth factors not only outperform retinol in efficacy but also offer faster results with fewer side effects.
8. Critique of Emerging Technologies: Exosomes
Tony critiques the hype around exosomes in skincare, emphasizing that Core Biogenesis’s oleosome technology is a more scientifically grounded and safer alternative.
“Exosomes are an incredibly... We're not there though.”
— Dr. Ekta [43:19]
They argue that exosomes lack the precise targeting and safety profile that oleosomes provide, making oleosomes a preferable choice for effective protein delivery.
9. Strategic Advice for Beauty Brands and Consumers
In the closing segment, Tony advises beauty brands to prioritize scientifically validated technologies over marketing trends to ensure product efficacy and consumer satisfaction.
“Look for the science. Don’t look for the subjective sort of qualitative research.”
— Tony Abode [46:12]
Dr. Ekta echoes this sentiment, encouraging brands to invest in robust technologies and urging consumers to seek out clinically proven products.
10. Future Directions and Invitation to Collaborate
Tony announces ongoing studies and invites brands to collaborate with Core Biogenesis to integrate their innovative proteins into new skincare formulations.
“corebiogenesis.com is our company website. Or if you go, poforia.com is more of our ingredient website.”
— Tony Abode [49:47]
Dr. Ekta encourages listeners to reach out and explore these groundbreaking advancements, reinforcing the episode’s theme of science-driven beauty innovation.
Key Takeaways
- Core Biogenesis is pioneering the use of plant-derived oleosomes to stabilize and deliver bioidentical growth factor proteins in skincare.
- Oleosome technology offers significantly enhanced stability and efficacy compared to traditional protein delivery methods, addressing common consumer frustrations with slow and ineffective anti-aging products.
- Bioidentical proteins, particularly growth factors, present a promising alternative to synthetic actives like retinol, providing faster results with fewer side effects.
- Scientific validation through rigorous clinical studies is essential for developing effective skincare products, a principle both Core Biogenesis and Dr. Ekta strongly advocate.
- Future of Skincare lies in leveraging advanced biotechnology to create sustainable, effective, and safe products that address the root causes of aging.
Notable Quotes with Timestamps
- “If you have something that works in seven or 14 days, trust me, that consumer is buying for life.” — Tony Abode [22:53]
- “We believe that the bioidentical protein revolution is coming.” — Tony Abode [11:12]
- “We are beating retinol on almost every single, single criteria...” — Tony Abode [36:49]
- “Look for the science. Don’t look for the subjective sort of qualitative research.” — Tony Abode [46:12]
- “Our factory is alive and vibrant. Instead of extracting resources, we cultivate them.” — Tony Abode [09:34]
Conclusion
This episode of Skin Anarchy delves into the innovative advancements in protein delivery systems within the skincare industry, spotlighting Core Biogenesis’s groundbreaking oleosome technology. Through insightful discussions and compelling clinical data, listeners gain a comprehensive understanding of how biotechnology is transforming beauty, offering more effective and sustainable solutions for anti-aging and skin health.
For more information or to collaborate with Core Biogenesis, visit corebiogenesis.com or poforia.com.