← Skin Anarchy
Skin Anarchy
How Biotech Is Powering The Next Generation of Microbiome Skincare ft. NanoSpun
00:28:58
Treatments of Tomorrow
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- [00:00]
Host
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- [00:32]
Ohad Bendor
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- [00:36]
Host
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Ohad Bendor
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Host
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- [00:46]
Ohad Bendor
Thanks Ma.
- [00:47]
Host
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- [01:01]
Ohad Bendor
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- [01:23]
Host
Hey guys, welcome back to Skin Anarchy. Today is a very special episode because we're going to be talking about the future of spinning skin care. I know a lot of you have heard about the microbiome. You've probably seen skin care related to the microbiome, you know, out there. There's a lot of brands that have popped up that are kind of buzzing about this topic. You know, whether they're talking about the actual bacteria or like, you know, what feeds those bacteria. So within all of that noise, there are very few brands and technologies that are really disrupting the space. And so we've had, we have the opportunity to, to speak to one of those technology founders today. So without further ado, please welcome founder and CEO of nanospin Technologies, Ohad Bendor. Welcome, Ohad. I'm so excited to host you and to talk to you.
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Ohad Bendor
Thank you so very much. Happy to be here and thank you for having me.
- [02:12]
Host
Yeah, no, I'm really excited to have this opportunity to talk to you because what Nano Spawn is doing is extremely novel, you know, in the space and I, I know you and I know about it, but I can't wait to tell everybody about it and like, you know, just to get us started. Ohad, you know what, where did this original inspiration come from? The. The aha moment for the technology?
- [02:35]
Ohad Bendor
Yeah, I Think the beauty about nanospan is that we've got the constant aha moments and eureka feelings. The core technology was conceived at the Technion Israel Institute of Technology and since then was developed and even leapfrogged by the company team. And the essence is our ability to create this functional live active tissue that enable the, to realize the full effect and the full promise of biological cells and biological cells products.
- [03:09]
Host
Yeah, I mean it is really interesting because you know when it comes to the biotech in this industry there's, I mean there's so many, so many directions you can go in, you know, so you guys, you going in the direction of the microbiome and, and paying attention to that is I think very relevant because, because there's a lot of products. I know even last year I've seen so many brands pop up, you know what I mean, trying to figure out how does the microbiome work for the skin? What is it, you know, what can we do? And there's, it's a very, very complex topic to, you know, to go down. So I want to ask what exactly you know, you know, you described it, the brand as the Nvidia of biotech skin care. What exactly do you mean by that?
- [03:52]
Ohad Bendor
Nanospell enables in, creates actually a new reality of cell based products. So like Nvidia, like Intel that create, creating a new enabling environment by their electronic processor, Nanospan creates a biological working unit that enable us to take the right cells, bring them in the right concentration to the right place, activate them at the right time and benefit both from the presence of the cells as well as the sales product in skincare. It's the presence of freshly produced postbiotics that's so fascinating.
- [04:29]
Host
You know this is, this is something I think we need to learn a little bit more about because I don't even think most people know truly what postbiotics are. Od. You know, I think there's a lot of lack of knowledge, you know, out here in the space and I, I would love for you to kind of go into this. Why are the products and the probiotics so important? Like what is their relevance?
- [04:49]
Ohad Bendor
Wonderful. Probiotics says it. This is a very important question and probiotics are extremely important and vital to our overall human health and well being. Most people are familiar with probiotics in the context of the gut microbiome and the gut probiotics. However, probiotics is extremely important for our body and for our health from head to toe. Nanospan is focusing on the skin microbiome and the skin probiotics, which is very important from two directions. One is the protection against harmful bacteria, the colonization, photogenic bacteria. But more importantly, or as importantly, is it a source of certain proteins and bioactives that are nourishing the skin. And by creating this very advanced tissue that is made from the right probiotics, deliver it the right time to the right place in the right concentration and actually activated and produce the active ingredients fresh and oxidized in their fullest effect. We are enabling the industry and enabling mankind to benefit from the full potential and realize the full potentials for probiotics.
- [06:06]
Host
Yeah, that's really huge actually because, you know, no one really discusses how postbiotics have. You have to be very specific with these things. You know, it can't be that every product, you know, that I see in the, in the industry for skin, right, for skin purposes is kind of gearing towards, I don't know, like this one size fits all model, which is fine. But then the science doesn't make sense because to be able to have that, you know what you're saying, with that freshly made versus it's been sitting in a jar, you know what I mean, for however many months since it was manufactured, that's a night and day. And then what that actually does for your existing microbiome, no one discusses that topic, you know what I mean? So it's like we hear about brands when they're made, but then we don't hear about, you know, there's a big disconnect there. So that's very, very fascinating. Now I want you to walk us through this. I know there's a, there's something that you call the four layer disruption. Can you walk us through this? What does that mean, four layer disruption in layman's terms?
- [07:06]
Ohad Bendor
So we've got prebiotics, which are those element that's supposed to nourish the existing microbiome. The microbiome, as I said before, is this layer of the good bacteria that are nourishing or protecting our skin. However, this layer is being damaged on a daily basis. Pollution, cosmetic products, soap. So the industry trying to revive this miracle layer by various or substituted by various means that so far were, let's say with a limited effect. The first attempt were done by prebiotics. Prebiotics are those element that's supposed to nourish the damaged microbiome. Very little effect or limited results since does not address the real problem. The real problem is the constant damage. The other approach was to take the probiotics product, what Called postbiotics, those proteins and bioactive ingredients and try to produce them in factories, in production sites and add them into the product. This is a novel and interesting idea. However, the problem is that those proteins are being oxidized from relatively quickly, within minutes, within hours, within a day. So just adding them, not necessarily even in the right concentration into products, is less effective. And the last attempts were done by this prebiotics. The attempts to add probiotics into, whether water based or oil based solution, here again because of lifespan of the biology, it has a very limited effect. And when the actual product reached the end users, the probiotics is not really alive. This four layer disruption that we created is affecting the industry and disrupting the industry in various layers. The first layer is the fact that nanospan product, because it's a physical solution, because we take the cells and print them as a structure, as a working unit, we are bringing into the equation real life active cells that as you will see in the second layer, are stable for a very long period of time. So we've got stability and shelf life of the cell themselves for a period of time. The third layer, so the first layer was the real life active cells. The second one was that we maintain their livelihood for a long period of time. The third layer is the large quantity of cells. We bring a huge number of cells as a product. Every square centimeter of nanospan product include around 1 billion bacteria. A face mass for example, is 100 billion bacteria. And the last layer, innovation and disruptiveness, is the fact that the sales product, the proteins are produced in real time. At the end user side, we called it institute on demand. So the end user, whether it's a doctor or whether it's the consumer at home, activate the product, produce the active ingredient, the postbiotics, the proteins fresh and immediately apply them to his skin or her skin and therefore achieve the maximum effect of those proteins on our skin cells.
- [10:21]
Host
Wow, that is really fascinating. I mean that's truly, truly cutting edge. And I'm curious, how did you solve the shelf life problem and the stability problem when you were trying to keep the ingredients bioavailable and natural? Like, like, you know, you don't have preservatives in your product, so how did you solve that problem?
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Ohad Bendor
This is a really key point and I think one of the main challenges that the industry coped with pre nanospan. So nanospan, this game changing magic fabric solution of nanospan, addressing the problem on two levels. The first level is the probiotics cell themselves. The Second level is the probiotic products, the postbiotics. So with the probiotic, the actual tissue, our processes has a unique proprietary elements which enable us to leave the cells alive. They are dormant, they are not in high activity level, but they can be triggered back into full activity when required. And as I said before, we activate them at the end user. The second level is the postbiotics, the proteins level. Here we completely circumvent the problem of stability and shelf life by creating a mechanism, a working unit that is actually activated by the end user. Produce the active ingredient then and there to achieve the best skin treatment results.
- [11:52]
Host
That's great. So it's like kind of as they need it, it's activated there and then you activate it and then you use it. That's the idea.
- [12:00]
Ohad Bendor
Absolutely. In simple layman words, nanospan created the freshly squeezed oranges of skincare.
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Host
Yeah, yeah. This is amazing.
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Ohad Bendor
Vitamin C. Similarly, again, it's, it's, it's a unstable molecule. When you produce the orange juice on site, in your own kitchen or in your own in the restaurant and serve it, it saves the full effect, the full vitamin effect on your body. Nanospan is the same thing. We produce the postbiotics fresh at the right time by the user, whether it's a doctor or home user, and then they're benefiting from the full promise and realize the full promise of postbiotics.
- [12:43]
Host
Absolutely. Now this is truly novel. And you know, the interesting part also is we talk a lot about delivery systems in the skincare industry. You know, but the really unique part about what you're doing with nanospond is that it's biological. You know, this is biological delivery, not chemical. What makes your tissue tech a leap rather than a tweak to this whole conversation?
- [13:08]
Ohad Bendor
Yeah, I think the whole space of delivery of and controlled release of active ingredients is being in the central of attention for many years.
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Host
Yeah.
- [13:24]
Ohad Bendor
And again, the industry so far try to approach things by creating some kind of a capsule, surround the cells in, in all the active ingredients in various manners, or immobilize them to the surface. And it's important to note that the more active the ingredients are and the less stable they are, it becomes 10 times harder to maintain them stable and relevant. The beauty about nanospan solution, again, is this, our ability to circumvent the whole stabilization and shelf life issue by creating a working unit. The nanospan product, the first line of product looks like a mask, but in reality it's not a real mask, it's a factory. And the factory can be activated and, and trigger into production by the end user. And therefore we are creating a working unit. We are not a delivery tool, but a factory that can be utilized by the user.
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Host
I love that. That's brilliant. That's absolutely brilliant. And I think that's the, you know, I think for consumers it's very interesting what this is going to do, you know, to a normal consumer, because when I first heard about technology, I was just, I was so intrigued, you know, that how is this possible? But I mean, you're bringing a whole different way of like viewing truly like fresh skin care, you know, out here. And it's like going to set a huge, I think, a new benchmark for all skincare products. I think this is something that I've been thinking about for a long time where it's like, you know, people talk a lot about personalization of skin care, you know, using biotech to make products more personable to consumers. But the hard part, I think about all of that is that many times the biotech can be very, very exp. So my question is, how is nano spun building for both scale and customization at the same time? Have you guys ever noticed that everything has changed except our healthcare and our annual labs? I mean, think about it. Taxis became rideshares, TV turned into streaming, maps turned into a whole GPS system. But our annual labs were still stuck with the Same basic like 20 marker approach that was ran decades ago. That's exactly why I chose Function Health. It's the only healthcare platform that gives you access to the kind of data most people never see. And it explains what to do with that data. With Function, you can test over 160 biomarkers like heart health, hormone levels, stress levels, inflammation. Plus you can add on things like MRIs, CT scans, and then track everything in one place over time. It's real information, all in plain language. And honestly, this is by top health leaders like Dr. Mark Hyman, Dr. Andrew Huberman, Architect, are getting behind Function Health. Those old labs always told me I was quote, unquote fine, but I didn't feel fine at all with function. I found out my vitamin D was super low. I have Hashimoto's hypothyroidism. This explained a lot of my symptoms like the fatigue, the brain fog, the constant exhaustion, function checks what regular labs are skipping things like T3, T4, thyroid antibodies, ferritin insulin, APOB. So you can actually know what's going on and what to do about it. If you're ready for answers, check functionhealth.com skinarchy the first 1000 people to get a $100 credit. When you use Skinarchy at signup.
- [16:56]
Ohad Bendor
This.
- [16:57]
Host
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- [17:15]
Ohad Bendor
So then what Nanospan built is a platform. We are actually indifferent to the type and the consortia of probiotic bacteria or even other type of cells that we are integrating into our production machinery. So by having this broad platform, it enable us actually very easily to tailor the product for different users for different needs. We are already offering, by the way, four products for skincare, Skin Essentials, Age Rejuvenation, Acne Prone Skin and Sensitive skin solution, more towards addressing issues related to rash. And we also offering, by the way, and will come into the market soon, scalp and hair treatment solution. The reason that we can offer so many or actually targeted solutions is the fact that we can choose the right consortia, the right probiotic that are we, that we are integrating in our production machinery to create a product that is as tailored as you can get. So a full personalized solution that include the right bacteria for a specific person, for a specific period of time. And the question whether we will go as far between the tailored and personalized is more an economic question and not a capability question.
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Host
That makes sense. Well, that's really fascinating actually, that we're, we can go down that road eventually. Because, you know, one of the conversations I had that I've had a lot of on the podcast about the microbiome is how it's unique to everybody. You know, the microbiome is like our fingerprint. So we have to really approach it from this lens of understanding that's very, very complex. And everybody's microbiome is different. So I would love to see the day, you know, and when consumers can say no, I want something custom to me, you know, and I want this to be specific to my microbiome and something that they can track. That would be so amazing to see that, you know, on a mass scale when people are looking for that in their skincare, other than just buying, you know, whatever is made, many, many products that don't work at the end of the day. So it's very interesting what you're doing. What's the role? I want to talk about this a little bit because AI is obviously everywhere. So, you know, With AI on the rise, you know, it's in every industry. And I'm really curious, what is the role of AI and also microbiome diagnostics enabling more personalized solutions through your product, the Butica 1905 brand.
- [19:47]
Ohad Bendor
In, in this era when there is this exciting development of AI and actually also diagnostic in skincare, and there is a tremendous focus, both diagnostics and AI, NanoSpan is becoming the enabling technology. As weird as it sounds, the enabling technology for the AI and the diagnostic. And the reason is that gathering knowledge and data is always extremely important, can be very valuable as long as you've got a solution, as long as you've got a means to translate it into better product. And in this era where you are trying to understand what is our microbiome problem, what can we improve in our microbiome with diagnostic and AI to have a better skin care results and skin health? If you do not have the tool to translate this information into a better skin care product, basically that the data is meaningless. The vision and mission of Biotica is to be this exact bridge between the valuable AI and diagnostic information and creating a true microbiome probiotics tool to improve biological skin care into the highest level possible. And of course at the highest level possible is having this ability to test the specific microbiome of a specific person, try to understand what he needs today, what he will need as we move forward and produce to him a product that is completely tailored to him. Nanospan can do exactly that. Nanospan can take this information and translate it into the most effective skincare products and hopefully change the the industry, the skincare industry and the cosmetic industry for years to come.
- [21:38]
Host
That's very fascinating and I'm curious, I know you mentioned there that you have different solutions available, you know, under nanospun, but specifically the mass component. Why did you choose to lead with masks as your delivery format?
- [21:53]
Ohad Bendor
Yeah, when you look on the mask, remember that the mask has actually two roles, two functionalities. The first one is a factory. This tissue is a very sophisticated and advanced tissue structure that produce the postbiotics when required, when we trigger the activation of the cells. The second role is it can be used as a delivery tool. Face masks are extremely common, one of the fastest growing sectors in the market. And we are using the same fabric as a delivery tool of the active ingredients to the skin, whether it's by the way in the shape of a face mask or other kind of skin patches. However, we will introduce within few months a serum product as well, when we will just Use the fabric as a factory to produce this rich serum, this postbiotic serum. And then it will be. The user will be able to apply to the skin as a more liquid type of solution without even the mask.
- [23:02]
Host
Oh wow. So the mask is actually like, it's part of the tech, you know of like creating this, this end product which is the serum. That's really interesting.
- [23:12]
Ohad Bendor
We are using the structure that was producing the postbiotics to begin with now as a delivery tool and a very effective delivery tool to cover the skin for user or applications where the serum will be required. We will introduce a product that is a serum based solution as well to cover and offer solution for the whole market, whether it's a personal preference of the user and whether is a topography of the skin and a better application of a serum versus a mask. So we actually covering the whole industry, starting with a low hanging fruit of face masks or other skin patches, but growing them there to cover the rest of the industry which is a serum based solutions and a serum based treatment.
- [23:59]
Host
Wow, that's very, that's, that's amazing. And now I want to dive like a little bit onto into your data because I know you guys have very, very, very strong clinical data to support the tech and why this is a better option. I would love for you to dive into that with us and tell us, you know, what did you guys test for? What were some trials that you ran?
- [24:20]
Ohad Bendor
The data behind nanospan can be seen from two different angles. The first one, there is huge amount of data in the industry and knowledge about what my why microbiome is so important, what is the real effect of probiotic cells? How can they affect different skin conditions? The problem, as I mentioned before, or the challenge was the delivery and the stability. And these challenges were met by nanospan and we succeed to overcome those very difficult hurdles. The second approach that we took is actually testing clinically our product. Not testing clinically postbiotics, but taking our product to our testing partner and test it with a very large group where the application of the product was very reasonable, three times per week and seeing the results. And we already demonstrated that nanospan products and nanospan technology can be effective, for example in increasing hydration, in reducing redness, in reducing wrinkles, everything by the way, already within two weeks and furthermore within four weeks. So within six applications and 12 applications you can already see meaningful statistically proven results.
- [25:43]
Host
So you know, I, that's very fascinating because I think those are some of the hallmarks, you know, of what we are looking for. In any kind of skincare routine. You know, when it comes to redness and just irritation of the skin especially, that's where the microbiome really is very important for us to understand. So this is very, very interesting. Now I know with the whole company you've positioned nanospun as more of a platform. Now what does that mean? Does it mean that brands can then license your tech and integrate their own actives into your structure? Or how does all of this work if a brand wants to work with you?
- [26:20]
Ohad Bendor
Nanospun brings the nanospun revolution into the market under three models. The first model is our white label model where where we've got the the our product under our partners brand empowered by nanospan. Similar by the way to the intel model that you've got intel inside. And enable the NanoSpan solution to tell their story even better by utilizing and maximizing this natural probiotic tool. The second model is our own brand Beautica 1905 which is a very advanced premium professional brand that as I mentioned before can be tailored or already being tailored to specific skin condition by choosing the specific right consortium for various skin challenges. And the third one is partnership model where we are in relatively advanced or various stages of discussions with potential market market players in developing new kind of product, new solutions in our partners space.
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Host
So what do you think is holding back the rest of the beauty industry when it comes to embracing true lifestyle technology?
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Ohad Bendor
The main challenge so far was stability and shelf life. There is, we live in a biotech era and we already see a growing exponential growth of the focus on natural solution and then probiotics and you know, treating the microbiome solution. So there is a huge focus on this microbiome as a solution. However, the problem so far or the challenge so far was this shelf life and stability as well as the bringing meaningful concentration of the cells as product Nanospan. Solve those two obstacles and we are leapfrogging now the industry into the ability to deliver a true probiotic treatment solution. Not just the marketing aspect of it, but a true solution that open the door for new generation of cell based product and solution starting with probiotics. But of course it does not end with probiotics. There is various other type of cells, organism and biomolecules that can be delivered by the nanospan concept of in situ on demand activation and usage.
- [28:51]
Host
That's very interesting. Can you share more on your long term roadmap for the company? You know what, what do you hope to do in the future with with the technology?
- [29:01]
Ohad Bendor
Our Starting point, as I mentioned, is the four applications that I mentioned before taking pro the right consortium of probiotics for those specific skin care applications. The next stage will be to expand our solutions into other specific skin care conditions by electing different consortia, other consortiums of probiotic bacteria. Then we will take this solution, as I mentioned before, into the more tailored and personalized side of things. Using AI, using diagnostic in order to enable us to make even a better choice, not just a generic choice, but almost a personalized tailored choice as to what bacteria you need and at what time and create even a long process treatment all based on the nano span platform.
- [29:55]
Host
That's amazing. I can't, I really, I'm excited to see this take off and to this, for this to start a new movement in the, you know, the personalization industry, especially when it comes to skin care. I think, you know, we've been hearing about microbiome stuff for a long time but it's very difficult to get behind because it's not anything like this, you know, it's, there's no customization in the other products that I've seen and you know, this is very, very exciting for me as a consumer to see this and as a scientist because it can open up so many doors, you know, to how we approach skin care and understanding our own skin better, you know. Right. I think that's the most fascinating part about the microbiome. It tells you so much about yourself and it tells you about what do you need versus what everybody's using. You know, it I really believe in that like skin is not a one size fits all. It had. There has to be personalization customization there. And I'm just so excited to see what you guys are doing and, and the novelty of this technology. It's very great.
- [30:56]
Ohad Bendor
Thank you so very much. And again, I think what nanospanners succeed to do is a bring back nature to do what nature originally intended and what was created by nature to treat our skin. And by that we're covering probably 90 something percent of the market. The beauty about and the opportunity here about enhancement technology is our ability to take it one step further. And then with the existing already knowledge about what various people may need in a certain seasonality or age group or locations, try to build as much personalized solution as we can. So we are doing the right thing at the right time and with the most amazing technology, one of the most amazing technologies that exist out there. Thank you so very much.
- [31:50]
Host
Yeah, I know, thank you. And for all the any brand founders out there listening. If you are curious about Nanos one technologies, make sure you scroll down the show notes. We're going to be linking all of the information that's relevant, the website, the information that you need to get, you know, in touch with Ohad and his team if you would like to work with them. But Ohad, thank you so much. This was so wonderful to chat with you and to learn all about nanospun.
- [32:12]
Ohad Bendor
It was my pleasure. Thank you so very much.
- [32:17]
Host
You have five new messages. Hey Karl, it's Jen from Finance. Could you submit your expenses this week?
- [32:24]
Ohad Bendor
Hey Carl, happy Friday.
- [32:25]
Host
It's Jen.
- [32:26]
Ohad Bendor
Finance. Just need those receipts today. Me again.
- [32:29]
Host
Carl really need those receipts like last week. Please just tell me where they are. Are you by your desk right now?
- [32:36]
Ohad Bendor
Finance teams, you shouldn't be chasing down Carl or any else with Ramp. Expenses are sent with a text and reminders happen automatically. Switch your business to ramp.com today and love finance again. Ready to elevate your everyday Quince has the luxe staples insiders swear by minus the markup. From 100% European linen styles and 14 karat gold jewelry to gorgeous leather bags and elevated home finds, Quint has it all. And by partnering directly with top artisans and ethical factories, Quince delivers premium quality at half the cost of similar brands. Discover everyday luxury without the markup at quints. Go to quince.com styleupgrade for free shipping and 365 day returns. Quince.com styleupgrade hey, it's Marc Maron from.
- [33:24]
Host
WTF here to let you know that this podcast is brought to you by Progressive Insurance. And I'm sure the reason you're listening to this podcast right now is because you chose it well. Choose Progressives. Name your price tool and you could find insurance options that fit your budget so you can pick the best one for your situation. Who doesn't like choice? Try it@progressive.com and now some legal info.
- [33:48]
Ohad Bendor
Progressive Casualty Insurance Company and affiliates price and coverage match limited by state law.
- [33:54]
Host
Not available in all states. Hey guys, so I hope you love that episode. Please make sure to hit subscribe if you're tuning in to us on any podcast platform. We are available on so many different platforms, so wherever it is that you're tuning in, just go hit subscribe. You'll be immediately notified when we publish new episodes. This way you're able to tune in to amazing insights from experts, brand founders, industry leaders, authors, all the wonderful people that we host. And that's very important for me because I love to hear from you guys and really understand what you love and what you want to hear more of. Also, make sure to give us a follow on all of our social media outlets. We're available on Instagram, TikTok, X, you name it, we're there. We also have a blog on Medium, so if you're a reader and you love Medium blogs, check us out on Medium. We publish some really great articles on there that do deeper dives than just what's available on the podcast, and it's really a great place for all of you science geeks out there that want to learn a little bit more. We go above and beyond with our research and making sure we're bringing you information that you usually probably won't hear about in other outlets. So check us out, leave us a comment, leave us a review, and we'll be back next time with another episode. Thank you.