Podcast Summary: Skin Anarchy

Episode: Pioneering Protocol-Based Solutions for Skin Longevity

Guests: Dr. Yannis Alexandrides & Eva Alexandridis (Founders, 111SKIN)
Host: Dr. Ekta
Date: January 12, 2026

Episode Overview

This episode explores the intersection of advanced medical science and skincare innovation through the journey of 111SKIN, a brand co-founded by plastic surgeon Dr. Yannis Alexandrides and Eva Alexandridis. Dr. Ekta leads a candid discussion on the origins of their protocol-based products, the evolution of skincare rooted in surgical expertise, the role of regenerative medicine, and the meaning of “longevity aesthetics.” Listeners gain an inside view into how medical-grade practices are influencing consumer skincare products, the importance of patient/consumer education, and the shift toward lasting, science-backed skin health.

Key Discussion Points & Insights

1. Origins of 111SKIN: Clinic to Consumer

Timestamps: 01:44 – 03:18

• Dr. Yannis shares how 111SKIN began not as a consumer brand, but as a solution for post-surgical healing in his clinic.
• Unmet need: No satisfactory products to accelerate post-op healing.
• Research initiated with a team of scientists to create the Dramatic Healing Serum.
• Expansion driven organically by patient feedback—patients continued to use the serum for overall skin health.

“The first step was really to create a dramatic healing serum, the product I still use in my clinic... And then the rest happened on its own. My patients showed me the way.”
— Dr. Yannis Alexandrides [01:44]

2. Science, Synergy, & Long-Term Skin Health

Timestamps: 03:18 – 05:18

• Eva emphasizes the original vision: not just quick fixes but sustained skin health.
• Protocol mirrors surgical seriousness, aiming for formulas that fundamentally change skin behavior.
• Beauty of experience is valued alongside efficacy.

“If you treat skin with the same seriousness as Yannis treats his patients during surgery, you can fundamentally change how the skin behaves.”
— Eva Alexandridis [04:25]

3. Research, Development & Quality Control in 111SKIN

Timestamps: 05:58 – 08:06

• Products start in clinic: tested on real patients for honest feedback and measurable results.
• Only move to clinical trials and retail after meeting strict efficacy and safety benchmarks.
• Examples: Years spent perfecting the Exosome product before retail release, demonstrating the brand's commitment to clinical standards.

“If we have a product that really hits a satisfactory and very effective effect, then we will proceed…we do clinical studies in all our products in order to prove what results they deliver.”
— Dr. Yannis Alexandrides [05:58]

“Sometimes it takes us years to produce a product...We only launched [the Exosome] product on the retail environment one year ago because we wanted to make sure.”
— Eva Alexandridis [07:02]

4. Exosomes: Protocol-Based Regenerative Skincare

Timestamps: 08:06 – 11:40

• Explanation of exosomes: cellular communicators beneficial for collagen promotion.
• The Exosome product is a 4-week intensive protocol, not meant for continuous use, aligning with regenerative medicine approaches.
• Thoughtful formulation: two-part system—microneedle delivery plus healing mask, based on clinic treatments.

“Exosomes are small particles that cells produce to communicate…we have harvested the best of them…It’s something you shouldn’t need everyday.”
— Dr. Yannis Alexandrides [08:44]

“For us, this product is very much about supporting the skin's intelligence, not overriding it—it’s a combination of ingredients borrowed from treatments that Janis does in the clinic.”
— Eva Alexandridis [10:07]

5. Surgical Innovation & Trends in Aesthetics

Timestamps: 11:40 – 16:03

• Deep-plane facelifts: Dr. Yannis explains new minimally invasive techniques that offer natural results with minimal scarring, now accessible to younger patients as preventative measures.
• The shift in aesthetic surgery: preference for maintaining a natural, youthful look earlier rather than dramatic changes later.

“The deep plane technique...allows us to release the ligaments...reposition in a higher position...By doing that in a deeper layer, we don’t need to put pressure on the skin.”
— Dr. Yannis Alexandrides [12:07]

6. The Hype & Limitations of “Aesthetic-Level” Skincare

Timestamps: 16:03 – 18:45

• Eva highlights challenges with consumer expectations—skincare cannot replicate filler- or facelift-level results.
• Emphasizes the clinical boundary between what’s achievable with procedures versus topical products.
• Responsible innovation: only bringing to market products that are proven safe and effective over long-term testing.

“The intersection between advanced cosmetic procedures and skincare innovation is really where the most meaningful progress happens—but it's also where misunderstanding exists.”
— Eva Alexandridis [16:03]

7. Fillers vs. Micrografting: New Solutions for Volume Loss

Timestamps: 18:45 – 20:25

• Market shift: moving away from fillers to micrografting, using patient’s own fat for natural, long-lasting results.
• Micrografting is favored for its biocompatibility, longevity, and safer profile.

“It’s the ultimate filler because it comes from the patient’s body…it will not go through a rejection process and it looks natural.”
— Dr. Yannis Alexandrides [19:11]

8. Longevity Aesthetics: Philosophy & Patient Education

Timestamps: 20:25 – 24:22

• Longevity in aesthetics means sustaining healthy, natural appearance over time—not excessive intervention.
• Eva and Dr. Yannis caution against overdoing treatments or falling into fads.
• Emotional dimension: goal should be looking like yourself for longer, not radical self-transformation.
• Importance of educating patients/consumers about expectations and responsible beauty choices.

“For me, longevity values looking like yourself for longer rather than becoming a different version of yourself.”
— Eva Alexandridis [22:28]

“We want to…help them make the right decisions instead of just offering a treatment…It is harder work, of course, and we like to do that as a team.”
— Dr. Yannis Alexandrides [24:51]

Notable Quotes & Memorable Moments

• “The first step was really to create a dramatic healing serum… The rest happened on its own. My patients showed me the way.” — Dr. Yannis Alexandrides [01:44]
• “If you treat skin with the same seriousness as Yannis treats his patients during surgery, you can fundamentally change how the skin behaves.” — Eva Alexandridis [04:25]
• “Sometimes it takes us years to produce a product...We only launched [the Exosome] product on the retail environment one year ago because we wanted to make sure.” — Eva Alexandridis [07:02]
• “The intersection between advanced cosmetic procedures and skincare innovation is really where the most meaningful progress happens—but it's also where misunderstanding exists.” — Eva Alexandridis [16:03]
• “For me, longevity values looking like yourself for longer rather than becoming a different version of yourself.” — Eva Alexandridis [22:28]
• “I always believed in 360 approach to aesthetics and to medicine…The duty of a doctor is to really inform the patient about the best practice…” — Dr. Yannis Alexandrides [24:51]

Key Timestamps & Sections

• Origins & Practice-Based Skincare: 01:44–03:18
• Product R&D & Clinical Rigor: 05:58–08:06
• Exosome Protocol Discussion: 08:06–11:40
• Facelift & Surgical Trends: 11:40–16:03
• Fillers vs. Micrografting: 18:45–20:25
• Longevity Aesthetics & Education: 20:25–24:22

Closing Note

This episode provides a compelling look into how clinical practice and strict scientific standards elevate skincare, while also advocating for nuanced education and realistic expectations in the pursuit of beauty and skin longevity.

To learn more about 111SKIN and the topics discussed, visit @skincareanarchy on Instagram.