What does it take to build a thriving startup ecosystem?

In this episode of Innovate South Texas, host Matt Duke sits down with Sebastian Garzon, Executive Director of the , to explore the opportunities and challenges shaping innovation across South Texas.

The conversation covers Alamo Angels' record growth, the increasing flow of venture capital into the region, and why funding alone isn't enough to create successful startups. Matt and Sebastian discuss the critical distinction between small businesses and venture-backed startups, the importance of experienced founders and operators, and how mentorship, exposure, and ecosystem collaboration can accelerate innovation.

They also dive into success stories like Nopalera and Darkhive, the growing influence of the Rio Grande Valley, the impact of SpaceX on regional entrepreneurship, and what it will take for South Texas to produce its next generation of high-growth companies.

Whether you're a founder, investor, entrepreneur, or community builder, this episode offers an inside look at where the South Texas innovation ecosystem stands today—and where it's headed next.

Welcome! (00:00)

The Evolution of Alamo Angels (00:25)

Weaknesses in the Community - Financing (05:45)

Startups vs Small Businesses (08:15)

Tech Bloc's Tech Fuel 2026 (11:00)

San Antonio's Community of Makers (12:40)

Weaknesses in the Community - Lack of Operators (13:45)

Highlighting Operators in the City (15:30)

Sharing Stories Within Our Community (18:55)

The Importance of Exposure (20:18)

Lessons from the Spurs Finals Run (23:05)

The Flywheel (26:00)

Alamo Angel's Impact in The Valley (28:50)

Thank You! (36:30)