
Hosted by 3Rs InfoHub by Vivian Kral, Christian Zoschke and students · DE

Within this episode Prof. Dr. Ellen Fritsche, Toxicologist from the Leibniz Research Institute for Environmental Medicine in Düsseldorf, gives answers to our questions about the neurosphere assay, starting with 'What are neurospheres anyway?'. She gives insight into how these are developed and analyzed. She describes advantages of this method and mentions opportunities for improvement.

Within this episode Dr. Jan Bruder from the Max Planck Institute in Münster gives answers to our questions about organoids, starting with “What are organoids anyway?”. He gives insight into the procedure of the automated production of organoids and describes their advantages. He explains new testing methods, which are for example used in the research of Parkinson's disease. Also ethical questions concerning mini brains are addressed.

In dieser Folge erzählt Dr. Landsiedel über die Etablierung von Alternativmethoden und geht dabei beispielhaft auf die Testung der Hautsensibilisierung ein. Auch die OECD-Richtlinien werden in diesem Zusammenhang thematisiert und deren Entwicklungsprozess anhand des Beispiels der Richtlinie 497 diskutiert. – In this episode Dr. Landsiedel talks about the establishment of Non-Animal-Methods and goes as an example into testing of skin sensitization. Also the OECD guidelines are discussed in this context and the process of their development is exemplified on the basis of guideline 497.

In der Fortsetzung der Spezialfolge mit Herrn Prof. Dr. Kurreck wird nochmal detaillierter auf die Vielfältigkeit des 3D-Bioprintings eingegangen. Es werden Zukunftsfragen gestellt, technische Herausforderungen angesprochen und nach dem Nutzen des 3D-Bioprintings mit Hinblick auf das SARS-CoV-2-Virus gefragt. Die Zuhörer*innen dürfen sich auf spannende Fragen und lehrreiche Antworten freuen. - In the continuation of the special episode with Professor Kurreck, the diversity of 3D bioprinting is discussed in more detail. Future questions will be asked technical challenges will be addressed and the benefits of 3D bioprinting with regard to the SARS-CoV-2 virus will be discussed. The audience can look forward to exciting questions and informative answers.

In the first interview with Prof. Dr. Horst Spielmann the three moderators enter in the question, what the phrase "3Rs" stands for and where non-animal methods (abb. 'NAM') are already established. This includes e.g. tests for skin irritation and eye irritation