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Dr. Mark Hyman
Coming up on this episode of the Dr. Hyman Show.
Kelly
But if you have omega 3s at adequate levels, it lowers inflammation, it lowers reproductive system inflammation and supports hormone function. Now, if you if you're a guy and you have omega 3s in your diet or from supplements, it affects sperm quality, sperm count, sperm motility, the amount of semen you make, your testosterone levels, and even the rates of in vitro fertilization. So just taking fish oil or eating a lot of sardines can have all these benefits.
Dr. Mark Hyman
Are you feeling stressed, sluggish or struggling with sleep? You might be low in magnesium and trust me, it's a bigger deal than you think. Most magnesium supplements miss the mark. But magnesium breakthrough by Bioptimizers gives you all seven essential forms in one capsule. So your body gets the full benefits. Better energy, stress relief and deep restorative sleep. I take it every night and it's a total game changer.
Kelly
Try it now with an exclusive discount.
Dr. Mark Hyman
Go to bioptimizers.com hyman and use code HYMAN10. Your body will thank you.
Kelly
Before we jump into today's episode, I'd.
Dr. Mark Hyman
Like to note that while I wish I could help everyone via my personal practice, there is simply not enough time.
Kelly
For me to do this at scale.
Dr. Mark Hyman
That's why I've been busy building several passion projects to help you.
Kelly
If you're looking for data about your.
Dr. Mark Hyman
Biology, check out Function Health for real time lab insights.
Kelly
And if you are in need of.
Dr. Mark Hyman
Deepening your knowledge around your health journey, check out my membership community the Hymenhive. And if you're looking for curated and trusted supplements and health products for your health journey, visit my website@drhyman.com for a summary of my favorite and and thoroughly tested products.
Kelly
93.2% of Americans have some level of metabolic dysfunction, meaning they were on somewhere in the spectrum from insulin resistance to pre diabetes to type 2 diabetes. And this is the thing that screws up both men and women's fertility. Now sex hormones are regulated by our diet. You may not have known that, but sex hormones are directly regulated by what you eat. Pretty much everything is regulated by what you eat. If you don't know by now, listening to me, ultra processed foods and sugar and starch are causing massive shifts in our sex hormones and that's driving having the infertility crisis. Our SAD diet or standard American diet is 60% or more from ultra processed foods the average American consumes anywhere you look at it. From 113 to 150 pounds of sugar and about the same amount of Flour every year per person. That's almost a pound a day of sugar and flour per person. And that is not something we're used to eating. That's a pharmacologic dose of sugar that's causing dramatic hormonal shifts in our biology. The spiking sugar leads to high insulin levels, that leads to insulin resistance. And then we get blood sugar and hormone imbalances as results. So what happens? What is the, what is the biology here for women? Let's talk about it. It's a little bit different for men and women. When women have high sugar and starch, it drives the insulin that leads to increased androgen production. Androgens are testosterone. That leads to free testosterone being increased. And that will lead to all sorts of problems, like pcos, for example, which causes irregular, painful, heavy periods or clotting, heavy bleeding, a weight gain, hair loss on your head, hair growth on your face, acne, lack of ovulation, as we mentioned. And so this is really not a fun problem to have for women, but it's often solvable by addressing the root causes of diet and lifestyle. Endometriosis is another factor we talked about that can be driven, but not necessarily by the high sugar diet, although there's some evidence that this is an autoimmune disease, which can be caused by leaky gut and other drivers of inflammation caused by our diet. Now, what happens with men when they have too much starch and sugar? Well, they get insulin resistance. And that leads to the opposite, leads to low testosterone levels in men. That leads to damage to their blood vessels because of the insulin resistance that causes inflammation. And blood vessels are needed to have good erection. So they, they get erectile dysfunction. And it also, because of low testosterone, affects sperm quality. And what's even worse, when they gain body fat as a result of insulin resistance, they make more estrogen because there's an enzyme in your fat tissue called aromatase that converts testosterone to estrogen. So that's really bad. They get higher body fat, they lose the hair in their bodies, and they have low sex drive, low sex function, low fertility, low sperm count, and the list goes on. So when you have this higher body fat, you get all these problems, and that leads to more inflammation. And then more inflammation for men and women leads to more infertility, more endometriosis, more pcos, worse pregnancy outcomes. Even if you're using IVF or advanced fertility treatments, ovulation problems, as I mentioned, you get poor quality of eggs and sperm. So the very seed of a new life is being damaged by your Diet, and we're going to talk about that. This can also lead to miscarriages, Inflammation can lead to that, and also birth defects. So all around our toxic diet, lifestyle, environmental toxins are driving so much of these problems. As I mentioned, inflammation is a big driver in fertility. So what's causing inflammation? Of course, inflammation. As you know, listening to me forever. Dr. Almost every known chronic disease, heart disease, diabetes, cancer, dementia, autoimmune diseases, the list goes on depression. And it's not just driving those things, it's driving fertility issues. Right? So it's our processed SAD diet. It's excess sugar, it's the insulin resistance that results the blood sugar imbalances, the chronic diseases that result, type 2 diabetes, obesity, and damage to our gut microbiome. We're going to talk about how the gut microbiome plays a big role in hormones and fertility that leads to leaky gut. Also, our sea of environmental toxins is not good for our hormones. The sea of industrial chemicals and pollutants, sometimes latent infections can cause inflammation, but those are the main causes. And then we also see damage to our mitochondria because anything that causes inflammation will affect our energy production. And energy production is essential for every factor of life, including healthy sperm and eggs. So we need healthy mitochondria to have healthy sperm and eggs. It's our energy factories. It's involved in ATP production. And ATP is the energy, it's the gas. So sperm have to swim, right? Eggs have to grow, mature. That takes energy and we lose energy, and that leads to more fertility issues. After fertilization, if you're lucky enough to have a fer embryo, then the embryo has mitochondria from the mother. And that's good. If you don't have healthy mitochondria from our diet and from toxins and so forth, we can't have proper embryonic development. We can't have proper cell division and differentiation, which is necessary for the developing fetus to grow into a healthy baby. Also, sex hormone synthesis takes place in the mitochondria. So poor mitochondrial function is connected to hormone balance. The estrogen progesterone are produced in special cells inside the ovaries, and these cells require mitochondria functioning at a good level to do this. Testosterone is also produced in cells called the Leydig cells, which contain mitochondrial mitochondria. Those are your testicles, and that is necessary for producing testosterone. So you can see the whole hormone production cycle requires energy. And we do a lot of things that cause mitochondrial dysfunction. Again, our poor diet, it's all the same stuff, right? It's not like different things causing different problems. It's all the same stuff. It's our diet, nutrition, lack of exercise, insulin resistance, inflammation from all the causes, oxid, chronic diseases, environmental toxins, all these things. Aging will affect the quality of sperm and egg microbiome, another big factor in causing infertility. Again, these things are not addressed. Think about it. Who's addressing mitochondria, who's addressing inflammation? Who's addressing the issues around microbiome when it comes to fertility? These are not things you're going to hear about when you go to your fertility specialist, but they're critically important in providing the right environment for having a healthy baby. So what is problems in your microbiome cause dysbiosis. That's imbalances in the floor. That's bad bugs. Symbiosis is good, good balance, right? Dysbiosis is bad. Bad influences and this influences inflammation and causes inflammation throughout the body, including reproductive organs. It can cause even other things like obesity. Even having bad bugs in your gut can make you gain weight. And this negatively impacts the microbiome. It causes ovarian inflammation, it affects the gene expression in your eggs, it causes poor egg quality. The dysbiosis also affects estrogen levels. One of see, and this is really important is that your gut microbiome plays a role in regulating estrogen levels. And, and often when you have high estrogen levels, it causes something called estrogen imbalance or estrogen dominance where you have too much estrogen, not enough progesterone. And that is often found in pcos. And when you have certain bad bugs in your gut that produce an enzyme called beta glucuronidase. A little technical here, but I explain it. What happens is that enzyme takes the estrogen that you excrete from your liver that's already packaged and ready to be pooped out and unpacks it. That enzyme cleaves the estrogen from its basically carrier molecule. Then estrogen becomes free in your gut and you reabsorb it into the body, into the intestinal circulation and then it goes in to your body, creating higher levels of estrogen, leading to more estrogen dominance and hormone imbalances and then other problems like estrogen related cancers, breast cancer, ovarian cancer, uterine cancer, endometriosis worsens pms, worsens pregnancy complications. When you look at the data, actually probiotics can be very helpful in improving pregnancy outcomes and, and even IVF outcomes. So giving probiotics when you're Getting your fertility treatments can be a good thing. It also affects not only women, but men too. So having bad bugs in your gut affects your testosterone levels. Antibiotics and hormonal contraceptions will affect the gut microbiome. So a lot of things will mess up your gut microbiome. Taking the pill, antibiotics, stress, certain acid blocking drugs, which you take all the time. Obviously alcohol and other things are not good for fertility too. Obviously you should probably not smoke, you shouldn't have too much pot. All those things are bad for you. Certain medications can, can be problematic. Obviously birth control pills, antidepressants, antipsychotics, obviously anabolic steroids. If you're taking testosterone as a guy, it's going to decrease your sperm production. Calcium channel blockers, because, you know, we need various pathways in our biochemistry to make things work. So these are blood pressure pills, but they can affect sperm motility. Antibiotics can interfere with menstrual cycles. All this stuff is just to say that there's a lot of factors that we have control over that affect our fertility that are not being addressed, from inflammat to metabolic health, to mitochondrial function to dysbiosis to the medications we're taking. And all those things can be addressed. So let's talk a little bit more about where conventional medicine just misses the mark, no pun intended. Why does it miss the mark? Well, it doesn't get to the root causes of the hormone imbalances and other factors that cause this decline in fertility. It doesn't address diet, inflammation, mitochondrial health, dysbiosis, environmental toxins, stress, autoimmunity, you know, and they give you like, you know, general advice, okay, lose weight, eat more veggies. I'm not quite personalized. It doesn't really measure what needs to be measured to understand what's going on in your biology. You look at farmers, they're testing the soil, they want to know what nutrients are in there, what the levels of nitrogen, potassium, phosphorus. They're so deep into understanding soil health as a way to predict what's going to happen to the plants that they're growing in there. How do we not test for what's going on in a woman or man to find out whether or not the sperm and egg are going to be healthy or whether the baby's going to be healthy. They don't check inflammation levels, they don't check nutrient levels, they don't check toxin levels. So we really need to do proper testing for fertility, looking at all sorts of things from metabolic health to hormonal health to nutrient status to toxin Levels looking at something called amh, which we'll talk about for women, which measures the quality of their, their eggs. So we kind of have to look for what's really going on and not just ignore the symptoms. Right. We need to look at how is a woman doing? Does she have hormonal imbalance clues, right? Does she have painful periods? Does she have pms, does she have weight gain, acne, Is she on the pill? You know, what's going, that we need to address that can help to regulate hormones better. So, you know, when women have hormonal issues, they don't really address in conventional medicine, the root causes, they just kind of treat you with hormones, right? They give you the birth control pill. So the first sign of hormonal balance is there's painful periods, pms, heavy bleeding, clotting, acne, pcos. Boom, you get the pill. That does not get to the root cause. It doesn't address how we regulate our hormones. It doesn't actually help us support our natural cycle. There's a lot of side effects with these digestive issues. It causes yeast overgrowth in the gut and balances the microbiome. It depletes nutrient levels that you need for pregnancy like folate, B12, B6 and vitamin B2, as well as vitamin C and E and magnesium, selenium and zinc. All these are necessary for fertility. Traditional approaches kind of fail in my view and I've worked with so many women and so many couples and help them have healthy babies simply by addressing these, these phenomena. What is the functional medicine approach then? What do I do? What is the functional medicine approach? It's, it's really important to best overall health, right? Not just looking at hormones. You need a deep dive on your biomarkers. And this is really what we do at Function Health. This is why I co founded the company Function Health, which is a way for you to get access to all this data about yourself, to get over 110 biomarkers, including all the things we're talking about today for less than 500 bucks. It's a membership model. We have a big waiting list. But you can jump the line if you go to functionhealth.com/forward/mark and you can sign up and get, get a lot of these diagnostic tests. And most of these things are not going to be tested by your doctor when you go in for your fertility checkup or your pregnancy pre pregnancy exam or they're not going to look at the man. And it's really important to do a deep dive and correct these things and this is what I do all day long in my practice and it's why I see such good results. So first you need to test for nutrient deficiencies. The most important is folate. It's critical for egg quality, for implantation of the egg in the womb. Deficiencies can lead to increased levels of something called homocysteine, which is a marker of folate insufficiency as well as B. Again, something not tested typically. I'm just going to share a quick story with you about a woman who I was working on a film with. She was the director of this film called Fed Up. It was, I think came out in 2014, it's still on Netflix about childhood obesity. She told me the story where she had had miscarriage after miscarriage after miscarriage and even had babies that were born with anencephaly, which means no brain, terrible condition. And she told me the story that she read this article I wrote about methylation and about the importance of checking homocysteine and B vitamins and the genes that regulate this on called mthfr. And so she went to her doctor and she made him test for this. And he she found very high levels of homocysteine. She made him test the gene called MTHFR, which we know affects about 35% of people that have this variation in this gene that can cause this problem. And we know that, that these problems of deficiency and folate lead to all sorts of bad pregnancy outcomes, including infertility and miscarriages. So she said to the doctor, well, this is what I want. And she got the test and sure enough, she was positive. And he said, okay, just take, you know, prenatal vitamin folate. Dr. Hyman says I need to take methylfol because I read in this article and I want to take the right kind. So she took the right kind. And when I saw her during the publicity tour for the movie, she had this beautiful 10 month old baby and we're hanging out before going on TV and stuff. And I was like, wow, this isn't a miracle story, but it's not a miracle, it's just using good science. Men also need to worry about folate because folate's important for sperm DNA and integrity. So low levels can also lead to decreased sperm counts and motility issues. So sperm aren't great swimmers. Vitamin D also important, it influences it's a production of estrogen and progesterone in women and also sperm quality and testosterone in men. And deficiencies in vitamin D have also been associated with pcos and get this guy's erectile dysfunction. Now, low levels, less than 40, I would say. You know, the lab says less than 30, but less than 40 is really probably what's considered low, maybe even 45. But low levels of less than 40 in published data show there was an increased risk of infertility if your level was under 40. And this is probably accounting for 80% of the population who are not taking vitamin D supplements. Supplements. And we test this as part of your Function Health Panel. Super important vitamin D supplementation in infertile women in another study significantly increased clinical pregnancy rate outcomes and pregnancy outcomes. So just taking a simple vitamin D makes a huge difference. What about B12? B12 is another important one. It's required for the development of your nervous system, for DNA synthesis, for cell division, cell tissue formation of red blood cells. And if you don't have adequate levels of B12, it can affect ovulation. It can cause trouble with implantation of the embryo. And you can check your homocysteine levels, also called methymalonic acid. What we check with with Function Health Panel. And if you had high levels of homocysteine, it has high rates of miscarriage. As I mentioned in this recent story, I told you at increased risk of birth defects we call neural tube defects like spina bifida and the baby. And also affects sperm motility and concentration and prevents DNA damage. And, and B12 also has amazing benefits. It increases sperm motility, it increases the concentration of sperm so you got more sperm. And it prevents DNA damage in the sperm so you have healthier sperm. Homocysteine, an important thing to ch your blood. Really important. As I mentioned, it can increase the risk of preeclampsia by threefold. This is a high blood pressure condition in pregnancy. It's very dangerous. And the best way to test for B6, B12 and folate is to measure your homocysteine level. What about iron? Iron, another important nutrient, really important because you get a lot of blood loss during menstrual cycles. And the deficiencies of iron are so common. It affects so many women. We saw so many people in our Function Health cohort that are iron deficient. This leads to problems with ovulation and ovulatory cycles where you don't ovulate. You can get anemia. You can have trouble with fetal development and making red blood cells. And get this, 35% of women less than 50 are iron deficient. Over a third of women trying to get pregnant are iron deficient. And listen to all the bad things. It does the next thing that's important to test and measure, and it's important to understand is omega 3 fatty acids. Now, there's a lot of reasons for that, but if you have omega 3s at adequate levels, it lowers inflammation, it lowers reproductive system inflammation, and it supports hormone function. Now, if you, if you're a guy and you have omega 3s in your diet or from supplements, it affects sperm quality, sperm count, sperm motility, the amount of seme you make, your testosterone levels, and even the rates of in vitro fertilization. So just taking fish oil or eating a lot of sardines can have all these benefits for women. Also important, it helps egg quality, endometrial health, which is the lining of your uterus, critical for implantation and maintaining an early pregnancy so you don't have a miscarriage. It helps uterine blood flow, helps the embryo implant, helps pregnancy rates. Again, just from eating sardines or taking omega 3s. And 2/3 of adults are not meeting the dietary guideline requirements of two servings of fatty fish or a week or 250 milligra of EPA and DHA per day. This is from British Medical Journal Open. That's two thirds who are not meeting the Dietary guidelines. But the dietary guidelines are the minimum amount of something you need to not get a deficiency disease. So 90% plus, I'm sure, are low in this, and we know this from other data. Another important nutrient, magnesium. Again, all these things we test for, and your typical prenatal visit or your fertility visit will not be checking these things. Magnesium is critical because it balances estrogen and progesterone, it helps a lot with menstrual cycles and cramps, helps helps a healthy uterine lining, it helps with DNA synthesis and repair, helps with healthy egg production. And of course, it's the relaxation mineral because it makes everything in your body relax. So I call it the stress reduction mineral. And of course, stress adversely affects fertility. Magnesium helps with blood sugar control and insulin sensitivity. PCOS really important. It's also essential for sperm production, development of healthy sperm. And magnesium is really important because it's linked to sperm motility and qualities. All these nutrients play a role in reproductive health. What about zinc? Zinc is really important for ovulation, women and menstru cycle. And if you don't have enough zinc, it can affect all these processes affecting fertility. For men, it's even more important. It's important for sperm quality. And sperm deficiency can lead to low sperm count and low testosterone levels. So that's not good. Selenium Another important mineral, again, something we test for and function, health. We can look at all these things, we can see what's going on. And selenium is important for thyroid function, which it regulates hormones necessary for fertility and man. It's important for sperm motility and sperm health. And if you don't have enough selenium, it can impair these functions. And many soils are depleted in selenium. If we're not taking a multivitamin selenium, we're often low. And again, it's something we can test for. So it's so important not just to check for nutrient levels, but also your hormone levels. So women, obviously you want to check. Estradiol, which is the main female hormone, regulates the menstrual cycle. It prepares uterine lining for pregnancy. And if you're having abnormal levels, it can kind of give you a clue that there's problems with the ovaries, with your menstrual cycle. Fertility, often infertility can be explained by what we call estrogen dominance. Estrogen dominance means you have too much estrogen, either relative or absolute, in relation to progesterone. And you get a lot of symptoms from that. Heavy bleeding, breast tenderness, fluid retention, premenstrual migraines, pms, blood clotting, fibroids. I mean, it's kind of a mess and it's not normal. And there's a lot of causes for it. Our high sugar, starch diet, alcohol, environmental toxins, change in our microbiome, all things that we can treat for men who are actually having high estrogen levels, which they can because they're eating a lot of sugar, starch and alcohol, all that will increase men's estrogen levels, that will affect their fertility. So if you have high levels, it can disrupt the balance of testosterone, it affects sperm production, it makes you have low sex drive and erectile dysfunction and infertility and weight, weight gain. So it's just bad news. As I mentioned, the fat tissue is a site that has this enzyme called aromatase, and it converts testosterone to estrogen. And that can lead to all sorts of problems with men, like I mentioned, like loss of body hair, libido, all the things we talked about. And it's really driven by high sugar, high star starch, ultra processed food diet. Another important hormone to check is progesterone, really important for women. This is called progesterone for a reason. It's the pro gestational hormone and it prepares a uterine lining for an egg and it supports early pregnancy. So you need adequate progesterone and often women don't have this, particularly in their later reproductive years. And if you have low levels after ovulation, it can affect your ability to maintain a pregnancy or to conceive. So it's really important. And you want to look at the estrogen progesterone ratio. You want to test it at the right time of the cycle, usually about 18 to 23 days of your cycle. And that' give you a sense of where you're at. Did you know that over 75% of.
Dr. Mark Hyman
People are deficient in magnesium?
Kelly
That's a problem because magnesium is essential.
Dr. Mark Hyman
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Kelly
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Dr. Mark Hyman
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Kelly
I've noticed a huge difference in my.
Dr. Mark Hyman
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Kelly
It's a game changer.
Dr. Mark Hyman
Right now, Bioptimizers is offering my listeners a special discount.
Kelly
Just go to bioptimizers.com hyman and use code HYMAN10 at checkout. Don't wait.
Dr. Mark Hyman
Your body will thank you.
Unknown Expert
There was actually a recent public published study out of Mount Sinai that looked at over a thousand women, and it researched blood levels of PUFAs between 2015 and 2017, and they found up to a 40 decrease in fertility. And so that can be overwhelming because you hear the word endocrine disrupting chemicals. Forever chemicals. They're omnipresent. They're in everything from your nonstick cookware, waterproof clothing, the Lycra food packaging, the lining inside your coffee cup, coatings on your carpet upholstery. You're like, wait, my whole life is covered in this stuff. But what I always like to give is a promise of hope. And that is when we look at urine excretions of PUFAs, if someone removes these endocrine disrupting chemicals, they can see the decrease of the urine excretion of PUFAs by half within a few days or a week. So we have so much power in our ability to make decisions around these forever chemicals that cause oxidative stress to our body and our, you know, future, the DNA that we'd be passing down for future children. So when it comes to these types of chemicals, there are so many things you can do from using storing your food in glass, swapping out nonstick cookware, even Just taking a stainless steel coffee mug to your coffee shop or sitting down and having it in instead of in a to go mug, in a to go cup, have it at the coffee shop. Avoiding those plastic water bottles. A lot of these like PUFAs, these are made to make things resistant to water, oil and grease, whereas phthalates make plastic malleable free things you can do. Open your windows, take your shoes off at your door, all of these are going to lower a lot of those forever chemicals that making their way into our house. You know, it is critical in those three months or four months prior to conception to really think about, well, where would I be coming in contact with these things the most and how do I lower my exposure to them? Because we do have so much power in the decisions we're making every single day.
Dr. Mark Hyman
That's true. You know, it's what we're eating. It's what we're eating from like the containers, right? It's our household cleaning products and it's our body care products and those things we have control. And you know, I don't know if you know this, but I'm on the board of the environmental working group.
Unknown Expert
And there you go, skin deep.
Dr. Mark Hyman
Skin deep. And you go to ewg.org and they have guides on body care products, household cleaning products, what foods, vegetables, fruits, animal products, how to reduce your exposures from every potential source of environmental chemicals. And so you can't be perfect, but it's something you can actually have a fair bit of impact in. Like you say, if you reduce these consciously, you see a drop in the urine levels very quickly. Now, Kelly, you know, most of fertility doctors focus on women, but the truth it takes two. And, and even though men are 50% of the equation, they're not really often considered even 25% of the men in infertility couples are not even evaluated as part of dealing with infertility. So, you know, what are, what are your thoughts for how men need to think about fertility too and how they need to think about improving their likelihood of conceiving a baby with their partner?
Unknown Expert
Yeah, well, men are 50% of the equation and how their lifestyle factors, how they're taking care of themselves, their nutrient status, their health is going to have an epigenetic effect on the DNA that they're passing down. And so it's critically important that they take care of themselves, especially during that spermatogenesis period, which is around 74 days on average to produce sperm. And so for men, fertility does drop. And it, and it drops about 52% in their early to, to mid-30s. And so just like women, we're, they're experiencing a drop in fertility around the same amount of time. And what we've seen in studies over and over and over again is that introducing antioxidants into the diet, these are, you know, leafy greens, things that are going to provide vitamin C. You know, your wild fish, your, your lean pasture, raised meats, all the things you talk. When you think about your book Forever Young, a lot of those steps.
Dr. Mark Hyman
Young Forever. Young forever. That was Bob Dylan. That was Bob Dylan.
Unknown Expert
When you think about all of the ways that we are protecting our own health, we're protecting our men are protecting their sperm's health. And so when we look at it, we can see that vitamin C, vitamin E, L, carnitine, zinc, all of these nutrients are critical in producing sperm. And when we look at sperm, we're looking at, at quantity, we're looking at morphology, we're looking at DNA, and their lifestyle is impacting it. You know, we look at the research and we can find that men who walk over 4,000 steps a day versus those who have less than 4,000 steps a day have an increase in their testosterone levels. But what's so interesting is 1,000 more steps a day on top of that, 4,000 increases testosterone, 7 nanograms per milliliter. And when you look at that, that's pretty powerful. Like getting out there and getting active increases the quality of your sperm that you're passing on to your children. And testosterone does that, which is so great because we have power to make these healthy choices, to increase the nutrients and antioxidants on our plate, to move our bodies to sleep, to decrease stress. You know, I think we forget that stress doesn't just come in the form of endocrine disrupting chemicals and in the form of our lifestyle choices or undiagnosed issues. It's coming psychologically too. And sleep and activity really combat that. And it is just equally as, equally as important for the man and the woman to get active and get healthy together prior to conception.
Dr. Mark Hyman
Definitely exercise helps, but watching sports may not. Because one study actually showed that if your team won, your testosterone level one up, but if your team lost in the sports game, your testosterone level went down. So better exercise. Now one of the things that that's important is, is sperm quality. And, and you know, I think, you know, people think, oh, you know, men don't really have a time clock, right? They're not, they don't have a biological clock, but they do. And, and yet Men can conceive. I think the oldest man ever to conceive was 96, which I think is pretty impressive. But. But it's, it's not the same as men get older in terms of the quality of the sperm, the fertility rates, or the consequences for their offspring. I mean, I think we see more autism rates with older fathers. So can you tell us more about man sperm health and why we see this decline and what do we know about how to address it?
Unknown Expert
Yeah, well, one study looked at, like, the genetic changes in sperm health from young men to older men. And what we see is you are, you are going to see the DNA involved is going to have an increased risk of autism, Alzheimer's, type 2 diabetes, even heart disease. And when those genes are implicated based on a man's lifestyle choices, they're actually passing that down to their children. And if they end up having a baby girl, they're actually passing those genetic changes down to their grandchildren. And so what we really want to do for men is to increase the antioxidant status. When we look at men who increase their antioxidant status by taking things like L, carnitine, vitamin C, zinc, all of those nutrients of concern that I Talked about, even CoQ10, CoQ10 is shown to improve sperm concentration, quality, motility and morphology. And when you pair that with B12, it actually improves DNA, lowers the rate of DNA damage, which is also really impressive because we have this control. We can add NAC to our diet. We can look at our vitamin D status in the same way women will prior to pregnancy. It's equally as important. And I think this research is building and building, and that's why you see companies like wenatal, which I know, you know, both of us love very much, coming out with a prenatal for men, because we can protect sperm quality, we can protect the morphology, and we can increase the chances that someone gets pregnant. And actually, men on antioxidants, they have a four times higher rate of getting. Getting pre. Getting their wife pregnant and a five times higher rate of that woman having a live birth when they're taking antioxidants prior to conception.
Dr. Mark Hyman
Your gut microbiome plays a huge role in hormone regulation and fertility. Now researchers are discovering there's a lot of roles for gut microbes and optimal gut health and how it contributes to obesity, to pcos, to hormone imbalances and lots more. So it's important to tend your inner garden. And I always just talk about that, but it's really important to learn how to take care of Your inner garden. And you need gut supporting foods, things like fermented foods that are have probiotics in them. There are other things that are great in there like fiber and, and great probiotics. Prebiotic foods are important like fruits and veggies. And you get 8 to 12 servings of non starchy fruits and veggies. Certain gluten free whole grains can be helpful. Cruciferous vegetables also really important for the gut health because cruciferous vegetables like broccoli, collards, kale, brussels sprouts, collard greens, they help to regulate excess estrogen in the body. They help with estrogen dominance which is something that is happens commonly as women enter their later reproductive life where they get higher estrogen than progesterone. They're relative or absolute. And that can help lower beta glucuronidase, which is a really important compound that's produced by certain bacteria in your gut that can actually lead to higher estrogen levels and more problems with cancer and fertility. So there's a lot of really important things to, to kind of consider. Also there's another class of foods that are great for your gut which the garlic family. Garlic, onions, leeks, shallots, they're anti inflammatory. Certain gluten free whole grains can add fiber like amaranth, teff, buckwheat, I like Himalayan tari, buckwheat, I like my Himalayan tartary buckwheat, Sprouted powder which is great. I put it in my smoothie. Wild rice is great, although it's technically not a grain. Black rice, quinoa, all, they're fine. Fermented probiotic rich foods are great. Sauerkraut, go to sheep, yogurt, kefir, kimchi, natto, tempo, tempeh, miso, all these are great for helping your gut health. So you really need to learn how to take care of your inner garden. And you might even need to take probiotic supplements.
Kelly
Now if you have a messed up.
Dr. Mark Hyman
Gut, it's important to work with somebody on this. If you have leaky gut or irritable bowel, you want to work with a good functional medicine practitioner to fix it. And you need to learn how to do that with the 5R program, which is avoiding the minimizing the foods that create problems using pre and probiotics and gut repair tools. All right, so once you've dialed in your nutrition and you're focusing on eating specific food foods to support your hormones, your reproductive health, your sperm and egg health, it's really important to clean up your diet, not just add the good Stuff, but take out the bad stuff and reduce your intake of more problematic foods that cause insulin resistance, oxidative stress and inflammation, which definitely reduce fertility and cause impaired fertility. And what are those foods? No surprise if you're listening to me, right? Ultra processed foods. Basically, foods that contain ingredients that you wouldn't have in your kitchen and that are made in factories and are deconstructed science projects. You do not want to eat those. Even though they may look like food, they're not actually food by definition. Refined grains, refined flours, added sugars, all bad. Now, potato chips, crackers, pretzels, candy, microwave popcorn, muffins, donuts, sandwich bread, I mean, it's not even really bread. Cookies, flavored yogurts, puddings. These foods, why are they bad? Well, they contribute to the epidemic of metabolic dysfunction, which affects 93% of the population and is somewhere on the trajectory of insulin resistance. They lead to oxidative stress, they reduce the chance of fertility, they increase pcos, they cause sexual dysfunction, erectile dysfunction, and poor blood flow. Yep, that's true. Guys, that's what happens when you eat junk. And, and it contains a lot of forever chemicals. These endocrine, endocrine receptor chemicals that you don't want to be having in your body, like BPA and others. You want to get rid of all those. Those are very much significant endocrine disruptors. We call this whole class of chemicals endocrine disruptors because they disrupt your hormone system. They also contain a lot of bad stuff. Chemical additives, artificial sweeteners, emulsifiers, thickeners that all contribute to inflammation through damaging the gut lining, leading to a leaky gut. They also often contain low quality fats like trans fats and inflammatory oils like soybean oils, sunflower, canola, vegetable seed oils, GMO corn, soy, all that crap. Sugar sweetened beverages. Definitely a no no because that'll drive in some resistance, including sodas, diet soda, although artificial sweeteners work in a different way. Fruit juice, green juices, unless they're truly green juices, a lot of them are just jacked with pineapple juice and sugary fruit stuff, which is just as bad. Of course, there's maybe more antioxidants and other good stuff in there, but it's a lot of bad stuff. Obviously don't have soft drinks, lemonade, iced teas that are sweetened alcohol, sports drinks, meal replacement drinks, protein drinks like Boost, fairlife, Core Protein, Power, Slim, Fast, are all garbage. There are good plant proteins out there, there are good animal protein products out there, but just be careful. And also be careful with the plant milks. They can be flavored, sweetened, they can have emulsifiers, thickeners. They can be some good ones. But make sure they're just simple ingredients like almonds, water, salt, for example. Energy drinks definitely do not have those. Those are full of colors, dyes, artificial sweeteners, flavored coffees. I mean, you go to Starbucks, you're getting tons of sugar, probably as much sugar as a can of coke or sometimes more, depending on what you're getting. Fruit juices, creamers that are weird, creamers. Just stay away from all that. Also, you want to stay away from conventional dairy. Dairy is a hugely hormonally disruptive food, unless you're eating sheep or goat cheese, which is less. Most conventional dairy has antibiotics, hormones, pesticides, a lot of hormone disrupting compounds in them. And it's one of the things for women who have menstrual issues or hormonal issues, I, I very strongly recommend they avoid. Caffeine can be fine, but be careful of too much. Um, it can wear out your adrenal glands. Alcohol, definitely not a good thing for fertility. It, it affects your obviously liver and your ability to regulate hormones through your liver can cause dysregulation of estrogen, testosterone, many other hormones. And now alcohol and consumption in men can lead to lower testosterone levels and higher estrogen levels, which can cause all sorts of issues like lower libido, fertility issues. You can increase breast size in men, it can cause loss of hair in the body. It's just not a good thing. So what are the practical dietary adjustments for enhancing fertility? Let's go through them a little bit one by one here. What are the practical tips for creating a diet that's incorporating fertility boosting foods into your everyday meals? Build your meals around protein and veggies and fiber, which makes you feel full and less likely to overeat. Try food stacking. Start the day with protein and fat for breakfast. Breakfast, you can have a savory breakfast. You're gonna have a protein shake. That's really fine to do. I mean, I, I, I don't know why. We've sort of in America gotten to a place where we think sugar for breakfast is a good idea, but it's the worst possible thing that's ever happened to us. So what can you have for breakfast? What does that mean? Well, eggs are great. They're rich in vitamin D, B12 and protein. They're great for hormone balance. You can have an omelet with spinach, tomatoes, added folate, vitamin C. You can have poached or hard boiled eggs. Eggs I like. For example shishuka, which I buy the kind of jarred version and I put the eggs in there and put in the oven and cooked in like 10, 15 minutes. Pretty quick. Don't eat those quick cooking oats. Get rid of those. If you're going to eat oats, only have steel cut oats. But you want to add protein and fat. So flax seeds, chia seeds, almonds, nuts. You can also put in some butter in there, grass fed butter or some other kind of oil like flax oil. You want to get protein, fat and fiber in there. Chia seed pudding is a great breakfast. Coconut yogurt, berry smoothie with protein powder. I like that one, it's my favorite. What about snacks? Well, I don't really snack that much, but if you're hungry, nuts and seeds are great. Handful of almonds, walnuts, pumpkin seeds are great. Snacks that have zinc, selenium, lots of good fats. Meat sticks are great. I like the Maui Nui Paleo Valley. They're great. Raw veggies and homemade hummus is an option. Low glycemic fruit is fine. Berries, apples, cherries, citrus fruits. What about lunch and dinner? Well, salads are great. They're, you know, you can put a base of leafy greens like arugula or just dark leafy greens. Mix mixed greens. You can use spinach or kale to increase folate intake. You can add avocado for healthy fats. Sprinkle some sunflower seeds for vitamin E. And I basically use olive oil. So you get a fat salad with nuts and protein and fat. And you can even add a can of sardines or, or salmon on there. It's also great you can include fatty fish like salmon or mackerel. I get some of the canned salmon or mackerel. I love that with my salad. That helps boost your omega 3s. It helps sperm quality and your reproductive health.
Kelly
If you love this podcast, please share.
Dr. Mark Hyman
It with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman.
Kelly
Please reach out.
Dr. Mark Hyman
I'd love to hear your comments and questions. Don't forget to rate, review and subscribe to the Dr. Hyman show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on the Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness center, my work at Cleveland Clinic and Function Health where I am Chief Medical Officer. This podcast represents my opinions and my guests opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educators educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the Ultra Wellness center at ultrawellnesscenter.com and request to become a patient. It's important to have someone in your corner who is a trained, licensed healthcare practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public. So I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening. What if I told you that you could change your Life in just 10 days? That you could reset your metabolism, break free from food addiction and feel better than you have in years? Years? You'd probably be skeptical. Most people are, including doctors. They don't think radical health transformation can happen in such a short time. But I do. Why? Because I've seen it happen over and over the last 20 years with more than 10,000 patients. I call it the 10 day detox and it's my fast track plan to help you relieve your most frustrating chronic health symptoms. Heartburn, bloating, joint pain, brain fog and headaches. Sinus issues, even acne, eczema and psoriasis may get better or disappear completely. Plus, you can lose weight without calorie counting or starving yourself. That's the power of the ten day detox. To learn more, go to Dr. Hyman.com detox to get all the details. That's Dr. Hyman.com detox.
The Dr. Hyman Show: From Inflammation to Conception – Solving the Fertility Puzzle
Episode Release Date: March 31, 2025
In this enlightening episode of The Dr. Hyman Show, Dr. Mark Hyman delves deep into the intricate relationship between inflammation, diet, and fertility. Featuring expert insights, the discussion emphasizes the profound impact of metabolic health, nutrient deficiencies, gut microbiome balance, and environmental toxins on both male and female reproductive health. This comprehensive summary captures all the key points, discussions, and actionable strategies presented in the episode.
Dr. Hyman opens the conversation by highlighting a startling statistic:
Kelly: "93.2% of Americans have some level of metabolic dysfunction, meaning they were somewhere in the spectrum from insulin resistance to prediabetes to type 2 diabetes."
This widespread metabolic dysfunction significantly disrupts fertility in both men and women. The root cause? A diet heavily reliant on ultra-processed foods, high in sugars and starches, which leads to hormonal imbalances and insulin resistance.
For Women:
Insulin Resistance and Androgen Production: High sugar and starch intake drive insulin levels up, increasing androgen (testosterone) production. This imbalance can lead to conditions like PCOS, characterized by irregular and painful periods, weight gain, hair loss, and ovulatory issues.
Endometriosis and Inflammation: While not directly caused by high sugar diets, endometriosis is linked to autoimmune responses and inflammation, often exacerbated by poor dietary choices.
For Men:
Dr. Hyman emphasizes:
Dr. Mark Hyman: "The very seed of a new life is being damaged by your diet."
Chronic inflammation emerges as a pivotal factor undermining fertility. It disrupts mitochondrial function—the cell's powerhouse—thereby impairing energy production essential for healthy sperm and egg development. This energy deficit leads to poor embryonic development and increased risks of miscarriages and birth defects.
A balanced gut microbiome is crucial for regulating estrogen levels and overall hormonal health. Dysbiosis, or an imbalance in gut bacteria, leads to:
Dr. Hyman underscores the importance of specific nutrients for reproductive health:
Magnesium ([01:27] – [21:31]): Essential for over 600 bodily functions, including hormone balance and stress regulation.
Kelly: "Over 75% of people are deficient in magnesium."
Folate and B Vitamins: Crucial for egg quality and sperm integrity. Deficiencies can lead to miscarriages and birth defects.
Dr. Hyman: "Low levels of folate can lead to increased homocysteine, a marker of deficiency."
Iron ([28:01] – [39:18]): Necessary for ovulation and preventing anemia. Over a third of women trying to conceive are iron deficient.
Omega-3 Fatty Acids: Lower inflammation and support hormone function in both genders.
Kelly: "Taking fish oil or eating sardines can improve sperm quality and testosterone levels."
Zinc and Selenium: Vital for hormone production and sperm health.
Dr. Hyman: "Zinc is important for ovulation and sperm quality, while selenium supports thyroid function and sperm motility."
Dr. Hyman critiques conventional medicine for its superficial approach to fertility, which often overlooks root causes like diet, inflammation, and mitochondrial health. In contrast, functional medicine:
Dr. Hyman: "Conventional approaches just treat the symptoms. Functional medicine digs deeper to address the root causes."
Fertility is a shared responsibility between partners. Dr. Hyman highlights that:
Men’s Fertility: Often overlooked, male fertility can be significantly improved through diet, antioxidants, and lifestyle changes.
Unknown Expert: "Men on antioxidants have a four times higher rate of getting their wife pregnant."
Women’s Fertility: Requires careful monitoring of nutrient levels and hormonal balance to ensure egg quality and reproductive health.
Environmental toxins, especially endocrine-disrupting chemicals (EDCs) like BPA and PUFAs, severely affect fertility by:
Unknown Expert [24:09]: "Removing these endocrine-disrupting chemicals can halve their impact within days or a week."
Solutions:
Foods to Include:
Foods to Avoid:
Meal Planning:
Breakfast: Opt for protein-rich options like eggs with vegetables or protein shakes instead of sugary cereals.
Dr. Hyman: "Chia seed pudding or a berry smoothie with protein powder are great starts."
Lunch and Dinner: Build salads with leafy greens, healthy fats, and added proteins like sardines or salmon.
Kelly: "A base of arugula or spinach with avocado and a sprinkle of sunflower seeds forms a nutrient-dense meal."
Snacking:
Lifestyle Adjustments:
Exercise Regularly: Increases testosterone levels and improves sperm quality in men.
Unknown Expert [26:22]: "Men who walk over 4,000 steps a day have increased testosterone levels."
Manage Stress: Utilize magnesium and other relaxing minerals to reduce cortisol levels and support reproductive health.
Dr. Hyman: "Magnesium helps with stress relief and deep restorative sleep."
Adequate Sleep: Ensures hormonal balance and overall well-being.
Dr. Hyman concludes by reinforcing the importance of taking a proactive, informed approach to fertility. By addressing metabolic health, nutrient deficiencies, gut microbiome balance, and reducing exposure to environmental toxins, individuals can significantly improve their chances of conception and ensure healthier pregnancies.
Dr. Mark Hyman: "You have the power to make healthy choices that enhance your fertility and secure a healthier future for your family."
The episode serves as a comprehensive guide for anyone struggling with fertility issues, offering scientifically-backed strategies to overcome the challenges posed by modern diets and lifestyles.
Notable Quotes with Timestamps:
Key Takeaways:
By integrating these insights into daily life, listeners can take meaningful steps toward solving the fertility puzzle and achieving their dream of parenthood.