
Depression and anxiety often feel overwhelming, but breakthrough research shows that your brain is far more adaptable—and healable—than you might think
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When it comes to gifting, everyone on your list deserves something special. Luckily, Marshall's buyers travel far and wide, hustling for great deals and amazing gifts so you don't have to. That means your mom gets that cashmere sweater, your best friend that Italian leather bag, your co workers unwrap their favorite beauty brands, and your nephews the coolest new toys. Go ahead. A price is this good, you can grab something for yourself too. Marshalls, we get the deals. You gift the good stuff. Shop now@marshalls.com or find a store near you. What if I told you that the most powerful antidepressants in the world aren't pills? It's your dinner plate and your purpose. Now, new research shows that changing what you eat on a regular basis tied with spiritual transformation is a more effective medication than traditional medications for depression and anxiety. And today, I'll be walking you through the exact foods that the supplements, the daily habits and the spiritual practices that have been proven to rewire your brain chemistry and transform your mood and mind naturally. Welcome to the Dr. Josh Axe Show.
Well, I'm incredibly excited about today's episode because we're going to be diving into how to truly cure and heal depression and anxiety and transform your mood. Listen, if you're a person who has struggled with depression, if you've struggled with anxiousness, if it's also impacted your health, you know, what I've noticed in working with thousands of patients is that when you have depression that affects your immune system. It can increase your risk of autoimmune disease, cancer, and a number of other health problems. I've seen anxiousness cause major digestive issues and other health issues as well impact sleep causing issues like insomnia. So there's no doubt that our mood greatly impacts not only our mental health, but it also impacts our physical health. And so today's episode, it'll be a real blend of diet and physical remedies along with spiritual and mindset remedies that are so important for improving mood. I love this quote by Jim Carrey. He says, I think everybody should get rich and famous and do everything they've ever dreamed so they can see that it's not the answer. Okay, now, depression and anxiety don't discriminate. Even those who have it all can lose joy and direction. In fact, one of the things you'll notice even reading the Bible is you have these amazing saints who are called by God to do things. And we see everybody from King David to Jonah to Hannah to other spiritual figures in the Bible who also Struggle, depression. We see today's celebrities, everyone from, you know, I'm thinking about Justin Bieber and many other people who deal with depression as well. And here's the great news is that both today's modern science, ancient medical wisdom, and the Bible have the cure to depression. And today we'll explore what science, spirituality and ancient wisdom all agree on. The path to joy, happiness and mental wellness starts inside the soul. But even food impacts us in this way. Now I want to share with you some personal examples of the times in my life. There's two specifically where I struggled with the greatest level of depression and anxiety. One was when I was 21 years old, another when I was 42 years old. And I also want to talk to you about how I've worked with thousands of patients with depression and anxiety and how we were able to in most cases, cure and remedy their depression and anxiety. Now, for me personally, it really started when I was 21 years old. This is the first time I really experienced what I would call a certain level of depression. I was in college and I went away to college. And for my first two years.
I wasn't really involved in church. For the first time in my life, I was really going out and just partying. I started drinking alcohol and I just started feeling this great sense of lack of meaning in my life. And I had this low grade depression. And I realized it's because I didn't have God in my life and I was really lacking any sense of purpose. One of the things I realized at the time was I was surrounded by a very different group of people at the time. These people were not necessarily encouraging. They weren't iron sharpens iron. They weren't the sort of Christian people I'd surrounded myself with that were looking for my best interest and wanting me to grow.
And so I prayed this prayer. I said, God, would you send a flood of just positive Christian influences and men into my life? And I decided to show up to a church event on a Wednesday night. This was a college campus event. And I ended up meeting other men my age who then I built actually lifelong friendships with some of them.
And it literally completely changed my entire mindset and my entire demeanor. I went from being depressed and feeling like I had this emptiness and lack of meaning in life to filling myself with God and connecting with other people and feeling like, wow, I have eternal significance. And that radically changed my life. And so really the key for me at 21 years old was rediscovering God and finding a purpose in life. And that was to love others, love God, make earth a heavenly place. And it changed my life. And so that was my experience. And then at 42 years old, this was years later when I had my spinal infection. And so this was just really two to three years ago.
And I was diagnosed with a spinal infection and was told I would likely be permanently disabled.
And that hit hard and I didn't walk for an entire year. So I was in bed bedridden for an entire year. With my diagnosis being that you will never be the same, that your spine is decayed and degenerated to the point we're going to have to probably do a spinal fusion and you're going to have chronic pain every day the rest of your life. This is what a doctor told me.
And I'll tell you there, my depression the first time at 21 years old was due to a lack of purpose and a lack of God in my life. The second time I struggled with depression was a lack of hope. The way that I remedied that was I went to God again and I said, God, you are the great physician, not this physician.
I pray for a healing miracle in my life. And something I realized at the time was focusing on the negative, focusing on the wrong things, that's not going to help me heal. I needed to focus on my best possible outcome. And you know what, living and what I decided to do as well is what could my best possible outcome be? It's a healing miracle. It's I am walking. In fact, I'm just as good or better than before. I'm running, I'm throwing my 2 year old daughter in the air, in the pool. I'm, you know, imagining all those things I was going to do in my 40s, 50s, 60s, 70s, 80s, being physically active and healthy. And I focused on that and I did it while living in a state of gratitude and praise. Every day, multiple times a day, I would sing praise and worship music and I would say thank you God for healing me. Thank you that you're working out a miracle in my body. And it was really just a perspective shift. I went from focusing on what the worst outcome could be to changing my focus on what a God sized, miraculous, hopeful outcome the best possible outcome could possibly be. And I just focused on that and that helped heal my depression. And I'll say this as well, I believe also that's why I'm 100% today and my back is fully healed and restored, is partly due or number one, the greatest reason is due to faith, gratitude and hope. And by the Way, I've seen a very similar thing as I've worked with thousands of patients. I found that diet, by the way, does make a tremendous difference, which I followed a really healthy diet in those times as well. You know, a diet high in omega 3 fatty acids, a lot of healthy fats, more proteins and amino acids, lower carbohydrate, more active in exercise, spending more time outdoors. And certain herbals, which I'll get into in a little bit, are very impactful, according to clinical studies. So we'll get into all of the diet, the supplements, the herbs, vitamins, all of that here in a minute, and natural treatments. And that made a big difference with my patients with anxiety and depression. But in addition to that, we can't look over the greatest causes of depression, which tends to be lack of faith, lack of purpose, identity confusion, lack of hope. Those key pieces that impact our mental and spiritual health are the greatest contributors to depression. And then the secondary is diet and lifestyle, which we will get into here in just a moment. But I found working with patients, I always triedi always do both. Even today when I work with patients, I really look at them and I say, okay, let's do all the dietary things, let's do the blood work, let's figure out the nutritional deficiencies, let's correct that. And then in addition to that, let's look at childhood trauma, let's look at your mindset, let's look at where you're at spiritually, and let's grow in those areas as well in order to address depression. Now, here are the current statistics. In the United States, more than one in five adults will experience depression at some point in their life. And anxiety disorders affect nearly 1 in 3, and by the way, 1 in 5, this is clinical depression. Of serious depression, I would say closer to 80 to 100% have low grade depression or a level of depression at some point in their life. Now in Europe, the rates are even higher. Anxiety and depressive disorders affect around 20 to 30% of all adults, making them among the leading contributors to global disease burden. And people with depression have a 40% higher risk of developing cardiovascular and metabolic diseases like diabetes than the general population. So we see this if you have depression, if you have anxiety, and it causes other physical illnesses like heart disease, prediabetes, infertility, low testosterone, a number of health conditions, okay, People with serious mental illnesses are nearly twice as likely to develop medical conditions. And over 13% of U.S. adults take antidepressant drugs. And that jumps to 25% among women over the age of 60. In fact, we're seeing a lot of young girls in high school start to take antidepressant and antianxiety drugs.
Are you interested in functional nutrition tips to burn fat, reduce inflammation, improve your brain and energy levels, and heal naturally? Then I want to encourage you to listen to my friend Dr. Dave Jocker's podcast, the Functional Nutrition Podcast. This podcast is designed to help you with easy, actionable steps to improve your nutrition and lifestyle, understand your lab work, and address the root cause factors that may be driving up inflammation in your body. Now, I've been friends with Dr. David Jockers for 20 years and he's truly a world expert in functional nutrition, cellular healing, and so much more. If you want to learn the best nutrition and natural healing tips, tune into the Dr. Jockers Functional Nutrition Podcast on Apple, iTunes, Spotify, YouTube and wherever you can listen to podcasts worldwide.
All right, let's switch gears here and I'm going to touch on a little bit more of the spiritual and psychological aspect and those studies here at the end. But I want to dive into the the ideal diet, foods, supplements and herbs for improving depression according to modern day functional medicine. And there was a landmark study that showed that a Mediterranean diet greatly improved symptoms of depression. In fact, it showed that people with major depression who switched to a Mediterranean style diet, and this diet is high in wild caught fish, omega 3 fatty acids, extra virgin olive oil, that that type of Diet had a 32% remission rate versus only an 8% remission rate in the control group. So you see 25% of people had a complete cure rate of their depression when they changed their diet. I mean, that's really significant there with this Mediterranean diet. And as I talked about, the diet includes, as we talked about, a lot of fish, a lot of olive oil, fruit as well. And it's very similar to, as I've talked about as well, a biblio diet or a diet based on the Bible. And this is where again, you're doing a lot of fish, you're getting red meat, as I mentioned, that's great for building the blood. So it's grass fed red meat. It's fruits like pomegranates and figs, it's extra virgin olive oil. These sort of foods are incredibly healing to the body. And these results prove that both a Mediterranean diet and very similarly a biblically based diet improve brain health, reduce inflammation, restore digestive health, and reduce symptoms of depression and anxiety. And of all of those foods, the most clinically researched in BAK to fight depression are Fish like salmon. And taking a fish oil supplement, your brain is made up of approximately 60% fat. And DHA, a specific type of omega 3 is about 40% of this. It makes up 15 to 20% of your entire cerebral cortex of your brain. And a meta analysis study found that high EPA fish oil supplements can reduce depressive symptoms, including when paired with antidepressants. But overall, this is why if you have depression or even ADHD or anxiety, any sort of issue tied to mood disorders, the single most important thing you can eat is wild caught fish like salmon, sardines, mackerel, black cod, sea bass, any sort of fatty fish is going to be incredibly helpful along with taking a fish oil supplement. Now, in addition, after that, green leafy vegetables like spinach are also very beneficial. Greens as well as legumes are rich in folate and magnesium. These are two nutrients you need for mental well being. Folate deficiency is found in up to one third of patients with depression. Folate also helps in the production of neurotransmitters. It also helps repair of the myelin sheath and other brain activities. In fact, it's also important because both vitamin B2, B9, which is folate, which is what we're talking about in B12, are also critical for something called your methylation pathway. So supplementing with B2, B9 and B12 can help enhance serotonin creation in your body. So there are multiple biological reasons, if it's more food related, of why you have depression. I want to hit on a few of those. One is, listen, your brain is made of fat and if you're not getting enough fat and fat soluble vitamins, you're not gonna be well, okay? You're gonna have depression, anxiety. So that's the first one that's the most common, okay. And that's gonna include omega 3 fatty acids, that's gonna include healthy saturated fats, that's also gonna include things like vitamin D, a fat soluble vitamin. So getting enough fat, fat and fat soluble vitamins, that is the most common reason why you have depression. From a dietary standpoint, maybe the second or third most common is your methylation pathways. Okay. If you are not methylating properly, your body can't create certain hormones and neurotransmitters. So that's another major causative factor. And this is where if you have the MTHFR gene variant, which you don't methylate as well, which means your detoxification pathways don't work as well and your body has trouble then also creating cellular energy and some other Things there that's tied again to a vitamin B2, which is riboflavin, folate and vitamin B12 deficiency can impact that. Now let's jump into another reason, which is your gut microbiome. If you have leaky gut or major gut issues and you're having proteins leak through the gut like gluten and casein, heavy metals, parasites, and those are recirculating, causing brain inflammation that will also cause depression, anxiety and even things like brain fog. So that's the third most common biological and the fourth is what I mentioned earlier, a blood deficiency. That's where you're living with low grade anemia, maybe low platelets, low ferritin levels and lack of oxygen in your blood. So if you have poor oxygen, poor iron and some of those things in your blood, if you stick out your tongue and it's a pale color, it's not like a bright pink or red, then that's a sign there. And that's the other cause of depression. But those tend to be the most common reasons why people have depression. Now I want to continue to talk more about the foods that are important for this. And berries and colorful, antioxidant rich fruits and herbs are also really, really great for mood. According to studies, blueberries, blackberries, pomegranates are among the highest antioxidant foods on the planet. Several studies have found that just four weeks daily blueberry intake improved positive mood and reduced depressive symptoms in children and young adults. Also fermented foods. Now this is tied more to the gut microbiome that we talked about. Yogurt, kefir, sauerkraut and kimchi increase microbial diversity. A 2019 study showed that people who ate more fermented foods had lower social anxiety symptoms, likely due to healthier gut, brain connection and less leaky gut. Did you know that around 90% of your body's serotonin is created in your gut? That's why it's one of those top four reasons why people get depressed from a dietary standpoint is due to leaky gut and unhealthy gut lining. And because your body can't create the proper amounts of serotonin if your gut isn't healthy. So taking a probiotic supplement, getting, getting more probiotic rich foods. Also more polyphenol rich foods like berries that we talked about and pomegranate, extra virgin olive oil. That's also great for the gut there as well. And then here's the other big thing, avoiding processed foods in sugar. Here's what happens. You increase Your sugar intake. Insulin gets high. Well, insulin is a hormone. When that hormone gets high, you know what it does that can decrease your body's ability to get rid of excess estrogen. That for men, can lower testosterone. What happens men, if your testosterone's low, you're not as motivated, you don't feel like working out, it leads to depression. Okay, women, a very similar thing. Estrogen gets too high or and progesterone gets too low. And then you know what that also does? That impacts your thyroid hormone. When thyroid hormone then gets off, you gain weight, your hair gets thin, your energy goes down. That then leads to depression. So processed foods and sugar will make all of these things worse. Of course, toxins will also decrease estrogen and impact estrogen and testosterone negatively. So diets high in processed foods, refined sugar, refined grains, and unhealthy fats lead to a higher rate of depression and anxiety. In fact, a 2023 study conducted on over 31,000 US women found that those with the highest intake of ultra processed foods had a 49% higher risk of depression compared to those with the lowest. So think about that. Nearly a 50% higher risk of depression with an unhealthy diet. So we see there a very, very deep connection between your diet and your mood. And by the way, there was another study that was done in 2023. This was where they took 17 studies combined. And this was on 385,000 people. And they found that ultra processed foods were associated with a 53% higher odds of common mental disorders, including depression and, and anxiety. So simply switching to less sugar, less refined grains, less processed foods, and more whole foods. Apples and pomegranates and berries and whole organic meats like a grass fed burger and wild caught salmon, filet and rice and sweet potato and extra virgin olive oil. Just eating real food, real whole food, is one of the greatest cures for depression. All right, let's now dive into the supplements. By the way, supplements and lifestyle have been recommended for thousands of years. The ancient Greeks used saffron for depression. Hippocrates prescribed sunlight and exercise and even fasting. These early healers knew how physical things impact mental and spiritual things. The first one here is saffron. Now this is something I covered on a friend of mine's podcast, Dr. Daniel Amen. And we talked about saffron. It's his favorite herb. He's known as the brain doctor. It's his favorite herb for depression. But numerous studies have shown that around 3:30-90mg of saffron is as effective as SSRI drugs for treating mild and moderate depression with far fewer side effects. These results were found in one meta analysis on 11 different trials with over 580 participants. So this isn't one study. This was 11 studies combined showing Saffron is likely the most effective natural antidepressant on the planet. And beyond depression, it was also shown to improve anxiety scores by 33% and have great benefits for reducing brain inflammation, supporting your neurons, reducing oxidative stress. So it also acts as an antioxidant. So saffron is at the very top of the list of herbs for depression. Next up is Ashwagandha and other adaptogenic herbs. An eight week study found that Ashwagandha significantly reduced anxiety, morning cortisol and inflammatory markers versus the placebo. So we see this as well, Ashwagandha, what it does when it lowers cortisol, right, that improves insulin, that improves all your other hormones and oftentimes depression is linked to hormone imbalance. Very, very often, very often, obviously, because serotonin in a way is a neurotransmitter hormone in that way as well. Number one, saffron. Number two, Ashwagandha. Number three, Sam E same is involved in methylation and neurotransmitter synthesis. It improves mood by increasing the availability of serotonin, dopamine and norepinephrine. These are three key brain chemicals that regulate mood, motivation and focus. So again, it's really key here for your adrenals, for your brain, for serotonin in the gut. So same is really effective predominately though because it improves methylation as we talked about earlier. And it was shown to be nearly as effective as SSRI drugs. And this is why you know what you can do in many cases rather than taking the synthetic drug that's going to have major, major side effects, you can combine many of these herbs together with improving your diet and these herbs and have a tremendous improvement. Another herb I really like, there's great clinical research on is St John's Wort. In fact there was a multi study review that found that it was as effective as SSRI drugs for mild to moderate depression as well. So we see it being as effective without the side effects. And then vitamin D, right? Vitamin D acts like a neurosteroid hormone influencing serotonin production and brain inflammation pathways. If you are lower than 30, you absolutely have to take vitamin D. But even if you're lower than 50, you really want your levels to be up there closer to 80. And I would do if it's low. 5,000 I use twice a day with a really healthy diet to make an impact. And then once you get closer to that range, well above 50, you could drop to 5,000 I use daily. But the best way is actually get sunshine as much as you can on a regular basis. Next up is Omega 3 fish oil. Taking an Omega 3 supplement, especially ones high in EPA and DHA will have the most meaningful impact on your overall depressive symptoms. So again, you want to take EPA and DHA there as well. And then in terms of nutrients, we talked about the B vitamins earlier, the B2, B9, B12. Basically taking a mitochondrial supplement or a methylation based supplement that has methylated B vitamins, that's what you'll want to take. For those along with magnesium in particular, magnesium threonate is probably the most effective because it crosses the blood brain barrier. Several studies have shown that magnesium threonate had positive impacts on depression in just six weeks. And then outside of supplements, exercise of course is very important. In fact, it is more powerful in many cases than actually taking an SSRI drug. In fact, studies show that even moderate aerobic exercise, like walking 30 minutes three to five times a week can reduce depression, often rivaling antidepressants. And then a 2023 meta analysis of 97 different studies found that exercise is 1.5 times more effective than SSRI drugs for mild to moderate depression. So think about this, exercising, just regularly exercising is more effective. It outperforms antidepressant drugs every single time. Now let me ask you this. Why are so many doctors not prescribing exercise first and diet first when studies are showing that herbs diet are equally as effective and exercise is more effective at treating depression. And then meditation is also very effective. An eight week trial and over 200 people found that mindfulness based stress reduction and the way that I encourage you to do this is meditate. Read the Bible and meditate on what it means and think about it for your life. Just go deep spiritually. Meditate in that way is incredibly beneficial. And there's also studies showing that infrared sauna, changing your body temperature, getting cold, getting hot has a great impact on this. And there I would just recommend take a cold shower, get an infrared sauna. Those also have a positive impact on our mood and then being in nature. Of course we know in Japan they call this forest bathing. This has been shown to show a measurable reduction in cortisol levels, improving HRV balance overall, just really improving the health of your nervous system. You know, I can tell You. It's interesting. Chelsea and I went snow skiing twice last year. We went to Park City, family vacation, had a great time. You know, I'm a snow skier, she's a snowboarder. And we brought the girls, we taught Arwen to snow ski and snowboard, put her in lessons. Her and I also went tubing and sledding. We had a great time. And we got back from that vacation, we went for a week both times. And I went to see, I see an acupuncturist every other week. And he would feel my pulse and he would say, he told both Chelsea and I said, wow. He said, this is the best I ever have felt your pulse this year after we went both times. And I think part of it was we were outside playing in the snow with the girls all day, every day. But there was something about just being in that state of nature, fresh air, what we were getting. And then a similar thing happens when you go to the beach. But just being in nature itself has so many benefits for our mental health. Now here's a few other things I want to mention. Avoiding alcohol and sleep deprivation have a major impact on your mental health. Alcohol is a depressant. Now, when you're drinking lifts your mood, but right after it decreases your mood. So you might feel good and happy for 3, 4 hours, but then for the next 24 to 48 hours you will feel worse. At least it disrupts your REM sleep and your deep sleep cycles. And heavy drinking is known clinically as a major risk factor for depression. In fact, one study showed that even moderate drinking shrinks the gray matter in your brain and increases your depression risk. And sleep loss, even for one night, impairs emotional regulation and worsens your mood. Okay, so we know that that's big there as well. And then last major negative before I touch on just the last few positives, things that can really impact you. And then we'll close up. Is this limiting social media? A 2022 study found that reducing social media use to just 30 minutes per day for three weeks significantly lowered symptoms of depression and loneliness. It also found that a two week social media detox is improved smartphone and social media addiction as well as sleep satisfaction with life, stress, perceived wellness and better relationships. So listen to this. You don't have to completely do away with social media, but if you just said, I have 30 minutes a day, you put it in your schedule and that's all you use it, period. The benefits are tremendous. Or do a full detox. Two weeks of no social media only has benefits, only has positive benefits. And new research shows that excessive social media use actually decreases the gray matter in your brain and increasing your risk of pretty much any brain issue, everything from Alzheimer's to low self esteem to depression, dramatically. Now I want to dive back into this idea that our spiritual and mental health is tied to, believe it or not, your spiritual and mental health, okay? Jordan Peterson, the famed psychologist, says this on healing depression. He teaches that meaning, not happiness, is the antidote to despair. So finding your meaning in life. Finding meaning in life. And so this is what it is. And I've shared this before on the show. If you go back and watch some of the past episodes where I've covered things like finding your purpose in life and your identity. But, you know, if I believe my role as a father has no meaning at all, that leads to depression versus if I believe that I'm going to live for eternity and I'm raising kids to live for eternity. And being a father is one of the most important roles and jobs in the entire world that I am raising up. Divine human beings. And I'm going to help them grow in their character to become Christ, like where they become world changers. And I'm going to help find their unique gifts and skills that God's given them and elevate those and take those to the highest level possible. And I see that as a role that has eternal and massive, massive significance. Whoa. You know, I remember another psychologist says this, both Mother Teresa and Hitler, both of them had parents. And so thinking about if they knew that at the time, being able to realize that the way you raise your kids is so important. So my point is this and Jordan Peterson's point is this. You want to live a life worth living. You want to live a life of meaning. You want to tie great meaning to what you do. And this is why I think religion is so important. And believing in God is that when everything you do has eternal significance, it gives your life more meaning and purpose. Jordan Peterson says this. You have to carry a load that is worth bearing. He encourages taking more responsibility, creating structure in your life, telling the truth. Three habits that give Life Direction and Restore the Dignity and Self respect. And then one of my favorite books of all time is by Viktor Frankl. He is a survivor of the Holocaust. He wrote the book Finding Meaning and Suffering and Man's Search for Meaning. And when I read Man's Search for Meaning, I read this when I was dealing with my spinal issue. I was living in this state. I felt I was dealing with depression and I read the book and it gave me such hope. Because if somebody can have hope in those circumstances, then so can I in my circumstances. He wrote this in his book Man's Search for Meaning. Those who have a why to live can bear almost any how. When you have a big purpose in life, you can bear almost anything, and it gives your life meaning. Frankl saw purpose as the single greatest predictor of psychological survival. For those in the Holocaust, purpose transforms pain into something usable, into something good. You know, when my mom went through her cancer battle, she had a level of she had depression, she had anxiousness when she was going through it. But now she has greater purpose in her life after cancer than she did before because she turned her pain into purpose. You know, the great saint, Saint Francis of Assisi, said this. Where there is despair, let me sow hope.
You know, if you or someone you know is battling depression or anxiousness, so hope. That's the key. So hope. It's one of those three great virtues that the apostle Paul talks about. He says. He says faith, hope and love. Right? Hope. So sowing hope, looking at the best side of things, believing the best possible outcome, living in a state of gratitude. That is a cure for depression. Remember, when it comes to finding purpose and fulfillment, there's the Harvard's Human Flourishing program that found people who attend weekly worship services live 17 to 14 years longer on average. If you're going to church or synagogue on a regular basis, you will live 17 to 14 years longer. Think about the power in that. Even if you're not religious, why would you not do it? If you're into longevity, regular prayer and Service correlates with 30% lower risk of depression. If you pray regularly. Faith communities increase oxytocin and reduce loneliness. So we see that having a sense of faith and purpose is so connected to creating the right neurochemicals to resilience and living a meaningful life. Here are some Bible verses I would encourage you to meditate on when it comes to beating depression and anxiety. Psalms 3418. The Lord is close to the brokenhearted and saves those who are crushed in spirit. Read the Psalms regularly, including Psalms 34, Jeremiah 29:11. For I know the plans I have for you, says the Lord. Plans to prosper you, plans for a hope and a future. And then Philippians 4, 6, 7. Do not be anxious about anything, but with everything through prayer, perdition, with thanksgiving, present your request to God. And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus. And Romans 12:2 Be transformed by the renewing of your mind. Take every thought captive. Be transformed by the renewing of your minds. Listen Depression and anxiety are complex, but science is clear. Food, supplements, movement, and daily habits play a massive role in how our brains function and the Bible and psychology is clear today. Living out your life purpose, spending time in the Bible, building close relationships with others and with God will also help you overcome depression. Everything from saffron to salmon, from prayer to meditation, can make a big impact in your brain in fighting depression and anxiety. I want to say thanks so much for tuning in here to the Dr. Josh Axe show, where each and every week we explore how to grow in body, mind and spirit and take your health and your life to the next level. By the way, the greatest thing you can do to support the show is subscribe. Listen. There are so many people today living and struggling with depression and anxiety. Share this episode it's going to be great medicine for all who listen. And again, thank you so much for subscribing. I'll see you on the next episode.
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Episode Title: If You've Ever Felt Depressed... WATCH THIS
Host: Dr. Josh Axe
Date: December 8, 2025
In this insightful solo episode, Dr. Josh Axe delves into the root causes and powerful natural remedies for depression and anxiety. Drawing from personal experience, patient case studies, scientific research, and spiritual wisdom, he explores how nutrition, spiritual health, lifestyle habits, and mindset work together to transform mental health and create lasting joy. Dr. Axe provides practical, actionable advice interwoven with memorable quotes, making this episode especially useful for those seeking holistic ways to heal depression and elevate mind, body, and spirit.
Depression and anxiety are widespread, affecting 1 in 5 adults in the U.S. and up to 1 in 3 with anxiety disorders.
Mental health deeply affects physical health, raising risks for conditions like autoimmune diseases, cancer, heart disease, and more. ([01:24])
"Our mood greatly impacts not only our mental health, but it also impacts our physical health." – Dr. Axe ([01:50])
First episode (age 21): Lost sense of purpose and meaning, linked to lack of spiritual connection and unsupportive social circles.
Second episode (age 42): Health crisis (spinal infection, year-long immobility) led to loss of hope.
"The way that I remedied that was I went to God again and I said, God, you are the great physician, not this physician... I pray for a healing miracle in my life." – Dr. Axe ([06:15])
Primary causes: Lack of faith, purpose, identity confusion, and hope.
Secondary causes: Diet, lifestyle, and physiological imbalances (nutrient deficiencies, gut health issues).
Comprehensive approach is key: address both physical and spiritual/mental health aspects. ([08:36–09:45])
"We can't look over the greatest causes of depression, which tends to be lack of faith, lack of purpose, identity confusion, lack of hope." – Dr. Axe ([08:57])
Improves brain health, inflammation, and depression symptoms.
Landmark study: Mediterranean diet led to a 32% remission rate for major depression vs 8% in controls. ([11:31–13:44])
Key foods:
Microbiome + Mental Health: 90% of serotonin made in the gut; healthy gut key for mood stability.
"The single most important thing you can eat is wild caught fish...any sort of fatty fish is going to be incredibly helpful along with taking a fish oil supplement." – Dr. Axe ([13:35])
Avoid processed foods, sugar, and excess alcohol; these disrupt hormones and gut health, dramatically increasing depression risk.
Saffron: Most effective; as powerful as SSRI drugs with fewer side effects. 30–90mg daily.
Ashwagandha: Lowers cortisol, balances hormones.
SAM-e: Supports methylation and neurotransmitter synthesis (serotonin, dopamine, norepinephrine).
St. John’s Wort: As effective as SSRIs for mild/moderate depression.
Vitamin D: Acts as neurosteroid; keep levels above 50 ng/mL, best up to 80.
Omega-3s: High EPA/DHA critical for brain health.
Methylated B Vitamins: Especially B2, B9 (folate), and B12; support methylation.
Magnesium (especially threonate): For mood and nervous system.
"Saffron is likely the most effective natural antidepressant on the planet." – Dr. Axe ([21:20])
Meaning and Spiritual Health:
"You want to live a life worth living. You want to live a life of meaning. You want to tie great meaning to what you do." – Dr. Axe ([31:40])
"Those who have a why to live can bear almost any how." – Viktor Frankl (quoted by Dr. Axe) ([32:20]) "So hope. It's one of those three great virtues that the apostle Paul talks about... faith, hope, and love." – Dr. Axe ([32:53])
Scriptural Encouragement:
Dr. Axe’s blend of science, natural medicine, psychology, and faith offers a holistic roadmap to overcoming depression. By nourishing body and spirit, cultivating healthy habits, and living with purpose, listeners are empowered to not just treat symptoms—but to truly thrive.
“Everything from saffron to salmon, from prayer to meditation, can make a big impact in your brain in fighting depression and anxiety.” – Dr. Axe ([35:45])
If you or someone you know struggles with depression or anxiety, this episode is a valuable, hope-filled resource packed with practical steps and encouragement.