← The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
Aging Starts In Your Legs (Here’s The Fix) : 1408
00:08:19
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- [00:01]
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What if quantum physics could make your supplements work at a whole new level? Igniton is the only company that quantum charges their clinical grade supplements so they work better than the same ingredients without the charge. This isn't some woo woo idea. This is real physics with real results. University studies show Ignaton's cognition formula improves memory, attention and mental performance more than the non charged version. And their longevity formula supports healthier aging markers like IL6, CRP and blood pressure better than the same ingredients without Quantum charging. They do this with absolutely no fillers and no stimulants, just clean inputs carrying the same kind of life force energy that ancient cultures called world spirit. Think of what Google and Nvidia do for quantum computing. Ignaton does that for your biology. I spent time in their Colorado lab. I saw the tech, I used the supplements. In fact, I believe in it so much that I invested in the company. So if you're serious about living longer and having a brain that works better, this is for you. Go to ignaton.com and use code DAVE for 15% off your first order. That's IGNITE. Code Dave. Igniton Born from light Backed by science.
- [01:18]
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When people think about getting old, they think about wrinkles or gray hair or losing your memory. But that's not really where aging starts. It starts when getting out of a chair takes more effort when you need the handrail going upstairs, or when your body feels feels tired even if you're rested. Those aren't just signs of getting older. They're warning signs that something inside your body is breaking down. Something that once it breaks, makes you weaker every single day. Something so important that your entire body depends on it to function. No, it's not your brain and it's not your heart. It's the most overlooked part of your body. Your legs. By the end of this video, you'll know why your legs make you age faster and how to fix it before it's too late. You see, your legs are different from every other part of your body. They contain the biggest, strongest muscles you have. In fact, your legs make up about 60% of all the muscle in your body. That's more than half your total muscle mass. And inside every single muscle in your legs, there are tiny energy makers called mitochondria. Think of them like little batteries that take the food you eat and turn it into usable energy. Your leg muscles are absolutely packed with mitochondria because they need so much power. Scientists estimate that your thigh muscles alone contain billions of mitochondria, all working together to keep you Moving. But this is where the problem starts. As you get older, those mitochondria start breaking down. They get damaged from years of use, just like an old phone battery that doesn't hold a charge anymore. And when they break down, they start producing toxic waste inside your muscle cells. It's like having a battery that's leaking a little bit. It's not just useless, it's actively making things worse. Now, your body's supposed to have a cleanup system that removes those broken batteries and replaces them with new ones. The system is called mitophagy. And when you were younger, in your 20s and 30s, mitophagy worked perfectly. That's why you had so much energy back then. It's why your legs never felt tired or heavy. But this autophagy process starts slowing down in your 40s and is almost completely shut down by your 50s. And that's exactly why your legs go first. Remember, your legs have the most muscle. That means they have the most mitochondria. But when mitophagy stops working, your legs end up with the most damaged mitochondria. Researchers at UCLA followed over 4,000 adults for more than a decade, and they found that the people with the weakest leg muscles, specifically their thigh muscles, were the ones who died earliest. But most people don't notice this happening until they've already lost years of muscle strength. It's not the same as face wrinkles. You can't see it in the mirror. You can't feel it until the damage has been building up for years. By the time you notice your muscles are weaker, mitophagy has already been shutting down. Now, if you want to understand exactly how mitophagy works at the cellular level and why your body needs to activate it, I made a complete video breaking down that entire process. You'll find the link on the screen or in the description below. So now you understand what's happening inside your leg muscles. The mitochondria are breaking down. Mitophagy has slowed down or stopped completely. At this point, people try to fix it. They do what seems logical. For example, they start exercising more, eat more protein, or push themselves harder at the gym. But none of that works. If mitophagy has stopped working, let me explain why. When you lift weights or do squats or walk more, you're telling your leg muscles to get stronger. You're sending a signal that says, build more muscle, get more powerful. But that signal only works if your muscle cells can actually produce the energy needed to build new tissue. It's like trying to Build a house with no electricity. You can have the best construction plans in the world, but there's no power running to the site, so nothing gets built. That's what's happening in your leg muscles. Right now. You're doing squats, but your muscle cells can't use the workout signal because they don't have the cellular energy to respond to it. You're eating protein, but your muscles can't turn the protein into new muscle tissue because the mitochondria that power the process are broken. So when you exercise with broken mitochondria, you're actually creating more reactive oxygen species or more damage. Every time you work out, you're asking your muscle cells to produce more energy. When the mitochondria are already damaged, forcing them to work breaks them down faster. You're not fixing the problem, you're making it worse. But you still should exercise. That's why so many people over 40 say things like, I'm working out harder than ever and I'm still getting fatter, or I'm eating more protein than I used to, but my legs feel tired all the time. They're doing everything right on the surface. But at the cellular level, the fundamental system that makes all that work is shut off. Even doctors and trainers don't understand this. They'll tell you to exercise more, to eat better, lose weight, or take some supplements. But none of those things addresses the root problem. Because you can't exercise your way out of broken mitochondria. You can't eat your way out of it. You can't supplement your way out of it with regular vitamins. First, you have to fix the cleanup system. You have to turn mitophagy back on. You have to give your muscle cells the ability to remove damaged mitochondria and replace them with working ones. And once that system is running again, only then is exercise going to help you. Only then the protein you eat can build muscle, and only then can your legs start responding the way they used to. But how do you turn mitophagy back on so your leg muscles can actually start repairing themselves? That's where one specific compound comes in. A compound that most people have never heard of. A compound that only 30 to 40% of people can even produce naturally in their bodies. And without it, mitophagy stays off. Your mitochondria stay broken, and your legs keep getting weaker no matter what you do. It's a compound called urolithin A. Now, you've probably never heard of it. Most people haven't, unless you're deep in the longevity field like I am. But scientists have been studying this compound for over 15 years, and what they've discovered is remote, remarkable. Urolithin A is a signal that tells your muscle cells to activate mitophagy. It goes directly into your leg muscles and flips the switch that starts the autophagy process. It tells your cells to find the damaged mitochondria, to remove them and build new ones. Without this compound, mitophagy stays off. Unless you practice very long fasting, your leg muscles can't clean out the damaged mitochondria. The toxic waste keeps piling up, and you keep getting weaker. But there's a problem. Your body doesn't make urolithin A automatically, which means you can't produce it on your own, and you have to get it from food. When you eat certain foods, like pomegranates, lots of berries, and lots of walnuts, those foods contain special nutrients that enter your gut. And if you are lucky enough to have the right kind of bacteria living in your gut, your body can make a little bit of urolithin A. Only 30 to 40% of people even have the right gut bacteria to do this. The rest of us either don't have the right bacteria at all, or we have some bacteria, but not enough to make meaningful amounts of urolithin A. What that means is the majority of people walking around right now can't make enough urolithina keep mitophagy running in their muscles, and that's why their muscles are getting weaker year after year. Now, even if you're one of the lucky 30 to 40% who could produce urolithin A naturally, there's another problem. You're not making enough of it. So for years, this was a dead end. Scientists knew urolithin A was the key to turning mitophagy on. They knew it could restore leg muscle strength. But there was no practical way for most people to get enough of it to make a difference. Until researchers figured out how to create urolithin a directly without needing your gut bacteria to do the conversion. They developed a pure, bioavailable form of urolithin a that you can take as a supplement. It goes straight into your system, bypasses the whole gut bacteria problem, and it delivers the exact dose to your leg muscles so that you can reactivate mitophagy. Oh, it also gives it to your brain. The most extensive research version of the supplement is called mitopure. It's the one that I take. It's made By a Swiss company called Timeline. And it's the only form of urlithinate that's been tested in multiple human clinical trials over the past 15 years.
- [08:12]
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You eat clean, you train hard, you sleep well. But if the air you breathe is toxic, none of it matters. You take around 20,000 breaths a day. Each one delivers oxygen or pollution straight into your bloodstream. Most homes carry mold spores, VOCs, wildfire smoke, and microscopic particles small enough to slip past ordinary filters. Once they're in your body, they trigger inflammation, stress your mitochondria, and drain your resources long before you even feel it. That's why I use Air Doctor. Its ultra HEPA filter traps particles down to 0.003 microns. That's a hundred times smaller than what standard HEPA filters catch. Built in sensors track your air quality in real time and adjust automatically when your environment changes. Plus, it's sleek and quiet. Clean air isn't optional if you want to perform at your best when your air is clean, everything works better. It's why I have an air doctor in every room, in my house and in my office. It's that important. Go to airdrpro.com daveasprey to breathe like it actually matters. Because it does.
- [09:19]
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And the results are what you'd expect when you turn mitophagy back on. In one study, people who took Mitopure for 16 weeks saw a 40% increase in mitochondrial renewal in their muscle cells. That means their bodies were cleaning out damaged mitochondria and building new ones at a rate 40% higher than all the people around them. In another study, middle aged adults who took mitopure daily for four months showed a 12% improvement in muscle strength. And they didn't change their diet. They just start a new workout program. They just gave their bodies mitopure, which it needed to restart mitophagy, and their leg muscles started working again. But mitopure isn't a magic pill because it doesn't work overnight. It takes time for your body to clear out years of accumulated damage and to rebuild your mitochondria, especially in your legs. But the research shows that within 6, 16 weeks, you'll see measurable improvements in how your muscles function at the cellular level. So now you know that aging doesn't start with wrinkles or gray hair. It starts when the mitochondria inside your leg muscle cells break down and when mitophagy slows down. But you also know this isn't permanent and you can do something about it. Mitophagy isn't dead. It's just turned off and you can turn it on again with the right intake of mitopure urolithin A. And you can do all this in about four months. So now it's on you. You can either start taking action today and get stronger even if you don't change your workouts, or you can wait till there's no going back. The choice is all yours. If you want to do what I do. Take Mito pure. I take four capsules a day.
- [10:48]
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A human Upgrade Formerly Bulletproof Radio was created and is hosted by Dave Asprey. The information contained in this podcast is provided for informational purposes only and is not intended for the purposes of diagnosing, treating, curing, or preventing disease. Before using any products referenced on the podcast, consult with your healthcare provider carefully read all labels, and heed all directions and cautions that accompany the products. Information found or received through the podcast should not be used in place of a consultation or advice from a healthcare provider. If you suspect you have a medical problem or should you have any healthcare questions, please promptly call or see your healthcare provider. This podcast, including Dave Asprey and the producers, disclaim responsibility for any possible adverse effects from the use of information contained herein. Opinions of guests are their own and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guest qualifications or credibility. This podcast may contain paid endorsements and advertisements for products or services. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. This podcast is owned by Bulletproof Media.