Biohacking News Weekly Update : 1363

Summary

Podcast Summary: The Human Upgrade: Biohacking for Longevity & Performance

Episode: Biohacking News Weekly Update : 1363
Host: Dave Asprey
Date: November 14, 2025

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Episode Overview

This week’s edition of The Human Upgrade delivers Dave Asprey’s rapid-fire rundown on the most impactful updates from the worlds of biohacking, longevity, and performance optimization. In just ten minutes, Dave explores a landmark cocoa extract study, advances in at-home health diagnostics, the generational surge in organ supplements, new science on spirulina, and crucial debate around personal health data and privacy law.

The tone is direct and energetic, with Dave’s trademark enthusiasm for science-backed, actionable biohacks.

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Key Discussion Points and Insights

1. Cocoa Extract: From Dessert to Cardiovascular Biohack

Segment Begins: [01:26]

• Headline Study: The massive COSMOS trial from Mass General Brigham found that daily intake of cocoa extract rich in flavanols led to a 27% reduction in cardiovascular deaths among older adults.
  • “Not better markers, not trends. Real measurable drops in mortality.” — Dave Asprey [01:36]
• Cocoa flavanols also substantially lowered inflammation (notably HSCRP).
• Sex-Specific Effects: Women showed unique anti-inflammatory cytokine shifts not seen in men.
• Mechanism: Improved nitric oxide production for relaxed blood vessels and better oxygen delivery—similar to beetroot or arginine.
• Caveat: Benefits pertain to high-flavanol cocoa extract, not chocolate bars—sugar and dairy negate benefits.
• High-quality cocoa extract may soon be considered a longevity staple alongside omega-3s and magnesium.
• “That’s a major shift for something that comes from a bean we've been eating for thousands of years.” — Dave Asprey [01:58]

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2. AI-Powered At-Home Diagnostics: Lapsi Health’s Kekou 2.0

Segment Begins: [03:03]

• Breakthrough Device: Kekou 2.0 becomes the first FDA-cleared AI digital stethoscope for both home users and clinicians.
• How It Works: Users hold it to their chest; it records heart and lung sounds, transcribes, and analyzes them instantly for irregularities.
• Impact: Enables proactive (“predictive”) rather than reactive medicine. Early detection is possible—before symptoms appear.
  • “A device like this lets you intervene while it’s still early. That’s the whole point of biohacking.” — Dave Asprey [03:44]
• Data is stored for longitudinal tracking and easily shareable with practitioners via telemedicine.
• Dave predicts this tech will become mainstream in every “quantified self toolkit” within five years.

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3. Organ Supplements: A Social-Media-Driven Shift in Women’s Nutrition

Segment Begins: [04:09]

• Trend: Sales of beef organ supplements have exploded by over 8,000%—driven primarily by women.
• Reported Benefits: Increased energy, hormonal balance, improved mood and skin clarity. Online testimonials show better lab results for ferritin, thyroid, and menstrual health compared to synthetic multivitamins.
  • “Women online are posting lab results showing improvements…after replacing synthetic multivitamins with clean organ supplements.” — Dave Asprey [04:31]
• Organs like liver, kidney, and heart are termed “nature’s multivitamins”—rich in vitamin A, heme iron, B12, copper, and choline.
• Key Message: This is a move from “fear-based nutrition” to evolutionary nutrition—“nature already built multivitamins, they just came wrapped in biology.”
• Debate continues over sourcing and purity—quality and transparency are crucial.

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4. Spirulina: Revival of a Plant-Based Longevity Superfood

Segment Begins: [05:15]

• Renewed Interest: New studies show spirulina supports collagen production, DNA protection from oxidative stress, and glucose and lipid regulation.
  • “Spirulina is one of the most complete plant based proteins you can get.” — Dave Asprey [05:27]
• Bioactive Compounds: Phycocyanin reduces mitochondrial oxidative damage; contains B vitamins, peptides, trace minerals.
• Trend: “Green stacking”—combining spirulina, chlorella, chlorophyll, and polyphenols—boosts detox and immunity.
• Audience Application: Athletes report improved recovery and endurance; longevity-focused biohackers use it as daily insurance against oxidative stress.
• Environmental Impact: Highly sustainable—low water use, high yield, eco-longevity flagship food.

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5. Health Data Privacy: The Coming Legal Upgrade

Segment Begins: [09:08]

• Major News: The U.S. Senate is considering The Health Information Privacy Reform Act to extend HIPAA-level protections to wearables, apps, and genetic testing services.
  • “Right now, those platforms aren’t covered under federal medical privacy law, which means companies can legally share or monetize your biological data without much restriction.” — Dave Asprey [09:18]
• Scope: Would apply privacy rights to devices and apps not traditionally seen as medical, such as OURA, Whoop, glucose monitors, and wellness apps.
• Implications: Puts data control back in the hands of users, letting them decide who sees, stores, or sells their “biological signals.”
• Warning: Tech pushback expected, but shift reflects the need for privacy in light of how revealing health data can be.
  • “Your biology should belong to you, not the cloud.” — Dave Asprey [09:52]

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Weekly Upgrade Protocol & Practical Takeaways

Segment Begins: [10:23]

• Cocoa Extract: Add high-flavanol cocoa extract to your daily regimen for vascular and brain health.
• Track Your Physiology: Use devices—stethoscopes, wearables, glucose monitors—to spot trends and intervene early.
• Micronutrient Audit: Consider quality beef organ supplements for foundational nutritional support, especially given modern dietary gaps.
• Daily Greens: Pair spirulina with chlorella or chlorophyll for detox, metabolic, and collagen benefits.
• Data Privacy Check: Audit your permissions on health-related apps. “Your biology should belong to you.” — Dave Asprey [11:18]
• Summary Point: “Curiosity and data are the real upgrade… You don’t have to wait for the future of personalized health. You’re already living in it.” — Dave Asprey [11:45]

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Notable Quotes & Memorable Moments

• “This doesn’t mean chocolate bars are a longevity hack. Sugar and dairy offset the benefits. But high flavanol cocoa extract—that’s now looking like a legitimate foundational nutrient for heart and brain health.” — Dave Asprey [01:56]
• “We’re rediscovering that nature already built multivitamins. They just came wrapped in biology. This is ancestral meets modern…” — Dave Asprey [04:48]
• “A device like this lets you intervene while it’s still early. That’s the whole point of biohacking.” — Dave Asprey [03:44]
• “Your biology should belong to you, not the cloud.” — Dave Asprey [09:52]

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Important Segment Timestamps

• [01:26] — Cocoa extract’s clinical breakthroughs
• [03:03] — FDA-cleared AI stethoscope for home diagnostics
• [04:09] — Beef organ supplement surge, driven by women
• [05:15] — New science and trends around spirulina
• [09:08] — Health data privacy law update
• [10:23] — Weekly protocol and action steps
• [11:18] — Closing thoughts on curiosity, data, and human enhancement

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Summary

Dave Asprey’s weekly upgrade delivers a blend of scientific rigor, actionable health protocols, and forward-looking cultural commentary. From surprising findings on cocoa flavanols and practical AI diagnostics, to grassroots changes in supplementation habits and essential legal reforms for personal data, the episode is a packed value-driven update for anyone serious about living longer, thinking faster, and performing better—now with the data, tools, and awareness needed to do it right.

Transcript

[Dave Asprey]

I'm Dave Asprey. That's Dave spelled D A I V.

[Podcast Host/Co-host or Advertiser]

E and this is your 10 minute.

[Dave Asprey]

Weekly upgrade on the biggest stories in.

[Podcast Host/Co-host or Advertiser]

Biohacking, longevity and the world of health.

[Dave Asprey]

Let's go.

[Podcast Host/Co-host or Advertiser]

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[Dave Asprey]

Foreign here's your first story of the week and it's one that's blowing up across the longevity world because it takes cocoa, something most of us think of as dessert, and turns it into a legitimate cardiovascular biohack. A massive Cosmos trial led by Mass General Brigham found that older adults who took a daily cocoa extract rich in flavanols saw a 27% reduction in cardiovascular deaths. Not better markers, not trends. Real measurable drops in mortality. They also saw lower inflammation, with markers like HSCRP going down significantly. And the wild part. Women showed unique anti inflammatory cytokine shifts that men didn't. Now, cocoa flavanols aren't new. They improve nitric oxide production, which relaxes blood vessels, supports blood flow and and enhances oxygen delivery. The same mechanism you see with beetroot or arginine. What's new is large scale clinical proof that it can save lives. That's a major shift for something that comes from a bean we've been eating for thousands of years. This doesn't mean chocolate bars are a longevity hack. Sugar and dairy offset the benefits. But high flavanol cocoa extract that's now looking like a legitimate foundational nutrient for heart and brain health. Harvard's expected to publish even deeper analysis soon. And if those results hold, cocoa extract might join the short list of daily longevity staples right next to omega 3s and magnesium. Your next story is about a technology that's redefining what at home healthcare actually means. Lapsi Health's Kekou 2.0 just became the first FDA cleared AI digital stethoscope to designed for both clinicians and home users. You hold it to your chest, it records heart and lung sounds, and the AI instantly transcribes, analyzes and flags anything off, like an irregular rhythm or wheeze you might not notice yet. It stores the data so you can watch your body's signals change over time. This is one of those tools that moves us from reactive to predictive medicine. Subtle changes in heart sounds often happen days or weeks before symptoms show up. Most people only find out something's wrong after damage has already happened. A device like this lets you intervene while it's still early. That's the whole point of biohacking. It's also compatible with telemedicine, so you can send the data straight to your practitioner. Think about that clinical grade diagnostics sitting in your bathroom drawer. In five years, this won't be a novelty. It'll be part of every quantified self toolkit. Story three takes us to the nutrition world, and this one's a social movement that no one saw coming. Beef organ supplements have exploded up more than 8,000% in sales this year. And what's surprising is who's leading the charge. It's women. They're reporting major shifts in energy, hormonal balance, mood and skin clarity. Liver, kidney and heart are some of the most nutrient dense foods on earth. Packed with vitamin a, heme, iron, B12, copper and choline, these are the same nutrients modern diets often lack, even in people who think they eat well. Women online are posting lab results showing improvements in ferritin, thyroid and menstrual health after replacing synthetic multivitamins with clean organ supplements. Now there's still debate sourcing heavy metal purity and brand transparency matter a lot. But what this really shows is a shift from fear based nutrition to evolutionary nutrition. We're rediscovering that nature already built multivitamins. They just came wrapped in biology. This is ancestral meets modern, and it's changing the conversation about what women's supplements should look like. Your fourth story moves us into the plant based longevity world, and this one's all about Spirulina? Yes, that bright green powder that's been around forever and that I've covered on the podcast with the company Energy Bits a few times. Now it's back in the spotlight because new studies show it supports collagen production, protects DNA from oxidative stress, and helps regulate glucose, G and lipids, all without synthetic additives. Spirulina is one of the most complete plant based proteins you can get. It contains phycocyanin, which reduces oxidative damage in mitochondria, plus trace minerals, B vitamins and peptides that help with cell signaling. It's also being shown to enhance skin elasticity by supporting collagen synthesis pathways. On social media, the green stacking trend is catching fire. People are combining spirulina with chlorella, chlorophyll drops or polyphenols to amplify detox and immune benefits for athletes. It improves recovery and endurance for biohackers focused on longevity, it's a daily insurance policy against oxidative stress. And because it's so sustainable, low water, high yield, it's becoming a flagship food for the eco longevity movement. Hey everyone, Sorry to interrupt, but I'm watching a substack newsletter and here's why you should care. I'm done with algorithms deciding what you see. This is a direct line between us. Deep insights on trending biohacking topics delivered straight to your inbox. Free subscribers get weekly analysis and curated recommendations from my favorite protocols and brands. Paid subscribers get exclusive deep dives, weekly monthly Q and A sessions with a coach, the live streams of our podcast recordings and full archive access, all for just $15 a month. Plus I'm offering limited VIP member spots with quarterly calls with me, a monthly call with a biohacking coach, and more to come. Start [e-mail] upgrade whenever you're ready. No algorithms, no BS. Just us. See you in your inbox.

[Podcast Host/Co-host or Advertiser]

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[Dave Asprey]

Your fifth and final story is about something that affects every biohacker who uses wearables and health apps or genetic testing. And it's a big shift in how your data may be protected. The Senate Help Committee just introduced the Health Information Privacy Reform Act, a bill that would expand HIPAA level protections to the kinds of tools most people use today. Wearables like Aura and Whoop, glucose monitors, genomic services and even wellness apps that track sleep, fertility or mental health. Right now, those platforms aren't covered under federal medical privacy law, which means companies can legally share or monetize your biological data without much restriction. This bill aims to close that gap. It would give users the right to control who sees their health signals, how they're stored, and whether they can be sold or used for advertising. For anyone living a quantified lifestyle, this is a major upgrade. Your hrv, blood sugar trends, genome data and daily biometrics say more about you than any social profile ever could. And it's time the law caught up. It's early and big tech will push back, but the message is clear. Your biology should belong to you, not the cloud. So here's your weekly upgrade protocol to tie it all together. Start by adding 1 high flavanol cocoa extract to your routine. You'll support vascular health, lower inflammation and strengthen the nitric oxide pathways that keep both your heart and brain performing well. Track your physiology Whether you're using a digital stethoscope, a glucose monitor or an OURA ring, the sooner you spot a trend, the sooner you can intervene. Your data is only useful if you're watching it. Revisit your micronutrients Beef organs, when sourced, cleanly fill gaps that modern farming and processing have created. These nutrients are foundational, not fringe. Support your cells with greens, spirulina paired with chlorella or chlorophyll helps with detox, metabolic balance and collagen support in a way you can feel. Check the Energy Bits episode for a discount code. And because this week brought a major shift in health data policy, take a minute to audit your digital footprint. Check the permissions on your apps and make sure you're only sharing what you choose to share. Your biology should belong to you. Curiosity and data are the real upgrade. These breakthroughs, from Coco and spirulina to AI stethoscopes and stronger privacy laws, show how fast the landscape is evolving. You don't have to wait for the future of personalized health. You're already living in it.

[Podcast Host/Co-host or Advertiser]

All right, guys, that is your weekly biohacking roundup. Join me again next Friday for another.

[Dave Asprey]

Run rundown of the biggest health stories in the news. Enjoy your weekend.

[Podcast Disclaimer Narrator]

A Human Upgrade Formerly Bulletproof Radio was created and is hosted by Dave Asprey. The information contained in this podcast is provided for informational purposes only and is not intended for the purposes of diagnosing, treating, curing or preventing any disease. Before using any products referenced on the podcast, consult with your healthcare provider carefully, read all labels, and heed all directions and cautions that that accompany the products. Information found or received through the podcast should not be used in place of a consultation or advice from a healthcare provider. If you suspect you have a medical problem or should you have any healthcare questions, please promptly call or see your healthcare provider. This podcast, including Dave Asprey and the producers, disclaim responsibility for any possible adverse effects from the use of information contained herein. Opinions of guests are their own and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guest qualifications or credibility. This podcast may contain paid endorsements and advertisements for products or services. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. This podcast is owned by Bulletproof Media.