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Dave Asprey
Do you think that there are people or entities, like government entities or whatever who actually have that kind of tech now? Nano cameras and nanotech?
Dr. Ted Achicoso
I think so, because. And this was in the 90s. I was at George Washington University and we already had a nanotech lab and there was already a nanotech fabrication facility at the University of Maryland. My lab was raided by, I won't tell you who because I wasn't supposed to have the secret information. My inspiration was the movie Limitless. Yeah. I was like, no, I want something like Limitless.
Dave Asprey
Funny drugs. It's not morphine. It's just called that.
Dr. Ted Achicoso
Yeah.
Dave Asprey
And it was the first ED drug. It creates desire but not necessarily interaction.
Dr. Ted Achicoso
Yeah.
Dave Asprey
So you're like, God, I really want some. But you still might need some other help if you have problems there. Pharmacological lust plus mitochondrial enhancement equals. Wow.
Dr. Ted Achicoso
Yeah.
Dave Asprey
I didn't think we're gonna go there on this, but let's go deep. You're listening to the human upgrade with Dave Asprey.
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Dave Asprey
Literally.
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Dave Asprey
This is going to be a really fun episode because we have Dr. Ted Achicoso returning to the show, who's one of my favorite guests in the past because he's just this insanely qualified guy, like neuro, interventional, radiology, pharmacology, medical informatics. Invented the connectome from C. Elegans, which we use for longevity research in. Those are roundworms, right?
Dr. Ted Achicoso
Yes. Yeah.
Dave Asprey
And it's like one of the brightest guys, but he's also pretty much like a weird medicine shaman in his other life. And so, man, like, I don't get to interview aliens very often, but I got one right here. And today we've also got Boomer Anderson, his partner in multiple businesses, and they're.
Boomer Anderson
The shaman in training.
Dave Asprey
Shaman in training.
Dr. Ted Achicoso
Nice.
Dave Asprey
And I think that we're most known for is troscriptions, which makes methylene blue trochees and a bunch of other cool trochees. And if you don't know what a trochee is, shame on you. Troche. Just sublingual little squares.
Dr. Ted Achicoso
Yeah. Buckle.
Dave Asprey
Buckle.
Dr. Ted Achicoso
Yeah. Between. In the pocket.
Dave Asprey
In the pocket. All right. God, there's so much that I want to talk about in the time that we have.
Dr. Ted Achicoso
Have.
Dave Asprey
But the other thing that you're doing that I really like is you're the founding pioneer of health optimization medicine, and I love it that you fully own the trademark on that term for health optimization, because, you know, we need to protect it from people who would misuse it and things like that.
Dr. Ted Achicoso
Appreciate that.
Dave Asprey
So we. We see things very similarly around, like, balancing networks and making things work. What made you decide you needed to create a new field in medic?
Dr. Ted Achicoso
Well, the usual stimuli. For example, I was lecturing my mitochondria, and I asked the body to give me CME credits for the mitochondria. And the response to me is like, oh, that's mitochondria. Doctors already know that. I said, no, they don't. I was so mad. Okay. That's the thing. And then when I work with other physicians on the health of my patients, it's like, it's Something like this, it's like achozo. What are your vitamin supplements and other things that you're giving my patient going to affect my drug therapy? I said, you're seeing this all wrong the other way. Look, my vitamins, mineral supplements, etc. Have been measured and they have been seen by the body. In evolution, your drugs, they're synobiotics. They never have. The body doesn't know what to do with them.
Dave Asprey
Right.
Dr. Ted Achicoso
So, you know, you tell me what your, what your drug is going to do to my levels of vitamins, minerals and nutrients.
Dave Asprey
Well said. Put things in the right order. You might not even need the drugs if you have everything else lined up.
Dr. Ted Achicoso
Right.
Dave Asprey
And that said, I'm a huge fan of drugs because there are some pathways for longevity that you can only activate with molecules the body doesn't make. And I'm okay with that.
Dr. Ted Achicoso
Yeah.
Boomer Anderson
Label uses of these drugs is perfectly acceptable.
Dr. Ted Achicoso
Yeah. So we've been trained, you know, as a society, as a culture to look at root causes of health. This. Root causes of disease. Right, Root causes of disease. It's like if this disease is a prescription. And then lifestyle medicine came along and I'm seeing three prescriptions for diabetes and hypertension and neurologic conditions. It's like they come to me with three different lifestyle advice. And I said, this is totally insane. So I said, let's go and take a look not at the root causes of disease, but the root causes of health. And then all of this lifestyle stuff that you're just guessing is going to help in the disease is actually going to optimize the health of your patient. And then whatever happens to the disease is a beneficial side effect, like the blood pressure drops, the blood sugar gets controlled, et cetera. There are no claims there. Once you get into the fundamental cell, for example, and give it what it needs, give it the energy that it actually uses, fix whatever the mitochondria needs because it's another organism in there. And when you do that, you take a look at the network that is, you're a computer guy, you know, you took the network was in. And basically you engineer around that. Right. You engineer around that fact. And you've been doing this. In fact, you are the first person, this is my judgment, who ever gave permission to those who are interested in the health population to experiment on themselves in an end to one. And that for me, you know, you're the father biohacking, etc. For me, that that takes a backseat to the fact of the permission that you gave.
Dave Asprey
Yeah.
Dr. Ted Achicoso
And that's Really a big change or big shift in the way we think.
Dave Asprey
It's been a change in like society consciousness, which is part of my goal. Why are we not doing this?
Dr. Ted Achicoso
You mean that lsd?
Dave Asprey
It's kind of funny. I just gave a, a talk at a big room full of longevity people and like, okay, so who do you want to be in charge of your health? Do you want it to be your employer? Do you want it to be your insurance company? Do you want it to be your government? Because they're so good at it and realize who's your health daddy? You shouldn't want one, but you have to be your own health daddy, which always triggers people. But that's triggering people is my love language. So it's okay.
Dr. Ted Achicoso
And actually taking after you, I said, I see all these biohackers where they are very competent, right. But they have no confidence in actually helping others. So when I started health optimization medicine, right. Is to teach in, in more formal academic settings like, okay, here's where you hang your biohacks.
Boomer Anderson
Right. That's actually a good framework for deciding which biohacks to.
Dave Asprey
Yeah, that's the thing. It's just randomly. I've had so many people come to upgrade labs and they take a picture of the equipment and then they go out and they buy it. And I'm like, oh, it doesn't work, does it? Because you got to know what to do in what order for one person and yeah, but I have an invitation for you.
Dr. Ted Achicoso
Yeah.
Dave Asprey
Next year at the Beyond Biohacking Conference in May in Austin. Here we have a day of CE credits for physicians. So if you're interested in giving a lecture to make that happen.
Dr. Ted Achicoso
Absolutely, yeah. Yeah. As I said earlier to you, I haven't gone out to any podcasts in over a year. And when I heard you invite, I said, okay, well thanks for making the trip. Yeah, I'll be here.
Boomer Anderson
It's quite hard to pull Ted away from a computer these days. Or the computer is actually conveniently right next to a lab. So we seem they can in the.
Dr. Ted Achicoso
Lab while waiting for the AI model to actually get fine tuned. You know, you go there in the lab and start your start making something new. Making something new. Wow. So, and it's fun because I love, I've always loved medicinal plants. Right. And in pharmacology and toxicology, actually specialize in psychopharmaceutical agents. So you know, when I was looking at nicotine, for example, one of your.
Dave Asprey
Favorite nootropics, it's like, okay, I should take some yeah.
Dr. Ted Achicoso
It's like, okay, compare the dopamine bursts. Right. Of this and this and this particular. Your epomorphine and all of that. It's like, okay, do the comparison of all of this. Wow. But after that, you know, it's nice on paper, but then you have to actually make it and then realize that apomorphine can cause nausea. It's like. Like, oh, I'm so horny right now. And then, you know, apomorphine throwing up.
Dave Asprey
Apomorphine is a funny drug because it's not morphine. It's just called that.
Dr. Ted Achicoso
Yeah.
Dave Asprey
And it was the first ED drug. Yeah. But it's interesting because it creates desire but not necessarily interaction.
Dr. Ted Achicoso
Yeah.
Dave Asprey
So you're. I really want some. But you still might need some other help if you have problems there. But if you don't need any help there and you take it. Hold on. So, yeah, that's an interesting trochee. One that I can get from troscriptions.
Dr. Ted Achicoso
Not yet. Not yet. I'm working on it. So you don't throw up.
Dave Asprey
I've never borrowed from it, but maybe it's just because I'm distracted by other things.
Dr. Ted Achicoso
But the thing, Dave, about it is that no matter what you do, you have to like the person that you're going to engage with.
Dave Asprey
I don't know that that's true for everyone. For me, yes.
Boomer Anderson
Increase the dose.
Dave Asprey
I'm all about, like, the energetics of the person I'm with. And, you know, I'm selective, but. But I know guys who are like, I don't seem to care.
Dr. Ted Achicoso
No. Even if it's just a sexual attraction, a little bit. Just a tiny bit of lust would help.
Dave Asprey
There you go. There you go.
Dr. Ted Achicoso
It helps your root energy.
Dave Asprey
Pharmacological lust plus mitochondrial enhancement.
Dr. Ted Achicoso
Yeah.
Dave Asprey
Equals. Yeah. I didn't think we're going to go there on this, but.
Dr. Ted Achicoso
So let's go deep.
Dave Asprey
All right, guys. I'll do a whole episode on sexual enhancement sometime, but it won't be this one.
Dr. Ted Achicoso
We were talking about health optimization earlier, and one of the things that I said is that people don't realize they want instant health. They want it tomorrow, done for your health. It's. It took you 40 years to reach this fucking state. Do you expect me to optimize you overnight? No, you can't. So it takes about 6, 9, 12 months before they actually get everything optimized. In the meantime, we have to have symptomatic relief, Right. For sleeplessness, anxiousness, you know, focus, you know, and so on. So that was the genesis of, you know, the prescriptions company. The first product was Blucanatine. Right. And that was intended for me because like you, you know, like you now, you know, 15, 20 years ago, I was never in a single place for two weeks. And my definition of heaven equals being in, in. In. In a single time zone for two weeks. That was my heaven.
Dave Asprey
I am missing that right now so bad.
Boomer Anderson
Me too.
Dave Asprey
I. I've been, in the last two months, I've been in Ecuador.
Dr. Ted Achicoso
What were you doing in Ecuador? Sorry.
Dave Asprey
The unlimited life concierge Longevity. We bring our members there for five days and go deep on longevity and do a mushroom ceremony. Oh, there like five star resort in the middle of the jungle. And I'm having a ton of fun just partnering with doctors and doing lab work and it's great. But I did that and then I was in Romania and then I was in Dubai. Just in the last six weeks or.
Dr. Ted Achicoso
Eight weeks, you are the worst offender to your mitochondria.
Boomer Anderson
And then you're going to Paris tonight.
Dave Asprey
Yeah, I'm going to Paris tonight. And so I couldn't do that. Even in my 20s. It would have broken me for months. And with all the biohacks, it's still not optimal. But as long as I control my jet lag with light and food timing and I take handfuls of supplements, I'm pretty resilient. But I just kind of miss being at home in one time zone with sunshine and friends. So I'll slow down a little bit.
Dr. Ted Achicoso
You know, one of the things that I wanted to do before for me in my travel was light travel pack, where you have, you know, the, the thing that they use for psoriasis, which is pure vitamin D. It's like, it's portable. And it was portable red light, portable.
Dave Asprey
Stuff with UVB in it. I want that. I have a portable red and infrared, but I need the ultraviolet. Yeah.
Dr. Ted Achicoso
And I said, why doesn't this get assembled together and be your first, you know, treatment for your jet lag?
Dave Asprey
Yeah, man, you're just reminding me. In January, I'm doing a big event in London which will. Which will be fun.
Dr. Ted Achicoso
Oh, they. They need the light.
Boomer Anderson
Yeah.
Dave Asprey
Yeah, no kidding, right? They totally bring a UVB there. So. So now you're making me sad about all my travel. I'm like, I'm actually having fun, but I want to talk about something that happens when you travel and something that you don't really hear about in biohacking circles, but something that is central to my thoughts about the consciousness of mitochondria and cells. It's the cell danger response. And I know because I was on antibiotics for 15 years and was pretty darned unhealthy. I still have some food sensitivities that are ultimately mediated by this response. What is the cell danger response?
Dr. Ted Achicoso
Well, I look just as anything in health optimization medicine, we look at everything from an evolutionary lens. So the cell danger response is really you put in any stress on a cell, right? And it only responds eight ways to it, right? So there's a stressor to the cell which could be physical, chemical, emotional, psychological.
Dave Asprey
Like a mother in law.
Dr. Ted Achicoso
Or partner. So, so, and those actually will, you know, raise the Ross levels and activate your innate immunity and then your endoplasmic reticular response and so on. Because the, the cell, if you look at it evolutionarily is trained to fight off viruses. So it will try its best to. Okay, I am not going to give you resources to produce more viruses. So it cuts on a polymer synthesis. Everything is just blocks. Assemble it yourself. It strengthens the membrane so there would be no more invasions. It emits microbials and viruses in the exterior and then it changes the DNA by using jumping genes, right? What's a better combination? So I could survive this next time. It also decreases, changes methylation to say, okay, how can I turn off these genes that are put on by this virus, right? And then the important thing there is the mitochondrial fission and fusion, right? It's like, no, I said those mitochondria are providing power for me. So they, they do a lot of fission and autophagy and then in the end, essentially there is warning to the other cells. And interestingly, it's the extracellular ATP that actually does the warning to other cells. Right? Because it's a purine and it's a very, very old purine.
Dave Asprey
I love chatting with you. And you know all this stuff. Yeah, the extracellular ATP. Tell me more.
Dr. Ted Achicoso
See, in the normal detection of energy by ampk, because it's a central regulator and sensor of energy. Mitochondria also sense energy, but in a evolutionarily primitive way. Right? Which means it's closer to physics. They detect the loss of electrons or electron steel that are being stolen by the virus to produce more of itself. So it senses that. That's why it's like, oh no, no, no, we're not.
Dave Asprey
What if it wasn't a virus, it was like a toxic MRNA sequence that somehow got injected into the body.
Dr. Ted Achicoso
Same, exact same. It will do the same effect. I know what you're referring to.
Boomer Anderson
The Crystal cell senses the drop in voltage, Right?
Dr. Ted Achicoso
Yeah, yeah.
Dave Asprey
Like Dr. Tennant's, right?
Dr. Ted Achicoso
Yeah, yeah. And then after that, you have the behavior change. So essentially, with any stress, it will behave as if it's being inflated by a virus. Right, Right. So. And that's in fact the basis of CRISPR Cas 9. Right. The chopping off of primitive immun. It a primitive immune system. A cell that. No, that is the immune system. The cell where our body. Our body's immune system is just a fractal of that. Right.
Dave Asprey
So, okay, how do you turn off the cell danger response then? Because if you don't want it.
Dr. Ted Achicoso
Yeah. So the body actually does the cell danger response. And then with the correct healing of the body's process, right, you provide your. Your supplementation. You provide rest, you know, which is very important. You balance the sympathetic parasympathetic par areas. As for us, we balance the metabolites. Right? And the reason why we do that is that the metabolites are the primary drivers of the cell danger response.
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Dr. Ted Achicoso
Metabolites, for example, leucine, right. Is a branch chain amino acid. It's called a summer metabolism. It can cause growth, it can also cause inflammation. Right. And then there are winter metabolites. For example is alpha lipoic acid. Right. Because it drives ampk.
Dave Asprey
These are metabolite, but the cells aren't making leucine, they're eating it.
Dr. Ted Achicoso
No. Yes. They're basically obligate, Right? They're obligate for vitamins. And then alpha lipoic acid is of course a co factor. But these are simple examples of how, you know, we can map it into a summer and winter metabolism. One is a period of growth and the other one is a period of healing. So it's like one is sympathetic and one is parasympathetic. But for me, those periods actually occur within the day. Right. When you're pre pronged, you're hungry. It's just like a winter metabolism. Right. Your body is in a rest and maintain mode. And when you're actually postprandial. Right. Your body is now in inflammation mode. Right?
Dave Asprey
Yeah. A lot of people don't know that no matter what you eat for about six hours afterwards, there's a huge increase in white Blood cells and inflammatory cytokines.
Dr. Ted Achicoso
Yeah. And that's actually the main issue that I have with lowering LDL for too much. Right. Because LDLs mop out lipopolysaccharides from bacteria.
Dave Asprey
LDL is a bad idea.
Dr. Ted Achicoso
Yeah. And this actually happened as a source of. I still see patients when you see that, like, where is this fucking myocarditis coming from? Right?
Dave Asprey
Lipopolysaccharides.
Dr. Ted Achicoso
Yeah, it's from the very low ldl.
Dave Asprey
Oh. And so for listeners, lipopolysaccharides or lps, these are bacterial toxins made in the gut, usually that cross the gut barrier, especially if it's damaged, and then they cause havoc in your metabolism. They're basically poisons. And some LPSs are very toxic and some are less toxic. But if you have low ldl, you can't stick to these things and then you can't excrete it, which is why the people who live a very long time have high, higher ldl, not lower ldl.
Dr. Ted Achicoso
Yeah, okay. Yeah. And. And for me, that came from experience. So you, you could see all of, all of these things being balanced by the body. A summer metabolism, winter metabolism. That's all my, My contribution to it is that, no, these are all occurring within the day. Right. So. And that's how we can balance all of these metabolites. Right. The, for example, heavy metals, molds, for example, are a stressor, Right?
Dave Asprey
Yeah. I hate mold, man. I've dealing with. Always dealing with it one way or another. That turns on the cell danger response quite a bit.
Dr. Ted Achicoso
Yes. And chronic. So you ask, you know, so you turn it off, you balance all of these metabolites because they are the main driver of the cell danger response.
Dave Asprey
And that means that you're changing what you eat or changing what comes out of cells.
Dr. Ted Achicoso
Both. The first thing is I have this model of the body which is very simple. Imagine a sphere with a straw in the middle. Yeah. Right.
Dave Asprey
That's pretty much what we are.
Dr. Ted Achicoso
Yeah. And then on the left side would be the structural side, the structure function. The right side would be your mitochondrial energy provider. At the center would be your gut and the food that you push in there. Right. And then decorating the tube will be your gut microbiota, which pre. Processes all the food. And then after it's absorbed, there's your immune system. Right. Which is the largest immune system. I keep on repeating this. When I was in med school, the largest immune system was a brain bone marrow.
Dave Asprey
Oh, yeah. Sometimes they just don't really know.
Boomer Anderson
So.
Dr. Ted Achicoso
So and then, then, then they brought inside the cell for now, you were the mitochondrial function, et cetera. So for me, when I'm looking at, you know, we love first principles type of reasoning, for me it's like, first examine the food. Examine what, what food are you. Is this toxic? Is it, you know this? And then when you take MNS to take a page from illness medicine, which is like, where's your objective measure? Okay, here's the metabolome, here are the values of metabolome. Okay, here's what needs to get repleted. Right now you have saying, no, this is the same thing as you're doing, except that we're actually not looking at a fucking organ. We're looking at a cell. There you go. Learn how to look away. Because the cell underlies all of the body, right? It underlies all the human body. And all the other cells are just specialized one way or the other. But, but if someone takes care of the nucleus, the cytoplasm, the mitochondria, the liposin in their cell membrane and the immediate networks, you are already doing health optimization. You're not curing any disease, you're not treating any disease, right? And then anything that happens with your disease I say is a beneficial side effect.
Boomer Anderson
I mean, you're actually taking somebody through this three stages of the cell danger response by just doing that.
Dave Asprey
There's a field called subcellular psychobiology. And just from shamanic experiencing a neurofeedback, altered states work. Yeah. There's a consciousness in a mitochondria and in the lysosome. And so even the subcellular components have very basic stupid, below insect level intelligence, but they have consciousness and behaviors, and then those roll up eventually to your liver.
Dr. Ted Achicoso
Oh, I have a question for you. With all of this shamanic stuff, do you think, think consciousness is an emergent property of organisms or is it intrinsic to the universe?
Boomer Anderson
This is like our dinner talk.
Dave Asprey
I'm a hundred percent inherent.
Dr. Ted Achicoso
Or is it inherent or is it emergent?
Dave Asprey
I believe that the body and the entire universe is created by consciousness.
Dr. Ted Achicoso
Oh, so it's inherent.
Dave Asprey
Yeah, perfect. It's inherent.
Dr. Ted Achicoso
You know, I used to be with my book on the C. Elegans and you know when people tell me about the hexilicans, blah, blah, blah, I said no shit. I did my lab work on that. You know, actually it's counting worms to corkscrew and find out how many worms were actually corkscrewing to the right and how many worms are corkscrewing to the left. Because I Was actually proving that, you know, handedness or chirality is already wired into us. Right. But the real experiment there is that when I model all the sub networks, like, you know, sub networks are feeding, mating for the commotion and so on. Is there a network that's left that says now I feed, now I mate, now I move and you find out there's not.
Dave Asprey
No, it's an emergent property from a complex system, as is the ego, as all these things they're coming from. Really? I think it's an operating system in the body run by mitochondria primarily.
Dr. Ted Achicoso
Yeah, that was my major mistake actually that I just corrected recently when I interviewed Donald Hoffman for a podcast. They put me in front where I had to study their material for about a month before I interview them. But he basically I said, I think I know what mistake I did at the time because I said consciousness emergent. No, consciousness is intrinsic to the universe or inherent to the universe. Consciousness is inherent. The ego or the self is emergent. And that's I think the distinction I like to make in there. It's the, you know, between inherent and emergent. One is actually just a network that is very ephemeral, right? It's very context sensitive.
Dave Asprey
The good news is you can train those systems the same way you train a dog, right? They're responsive and really that's what meditation is. That's what all the transpersonal psychology, trauma resolution stuff, the reset process we use at 40 years in, it's all just telling them mitochondrial networks to behave and to be more reality based and less fearful.
Dr. Ted Achicoso
Right. So, you know, and the reason I actually early on in my career really, really focused on mitochondria. And I said, someone's got to power this. Some, something's got to power up this body. Because at that time Dave was actually looking at developing a camera, a nano camera that's half the size of red blood cel. Mind you, this was in 1990, right?
Dave Asprey
I saw that movie.
Dr. Ted Achicoso
And my lab was raided by, I won't tell you who, because I wasn't supposed to have the secret information. They captured all of my. I said, look, Fuji made this camera, 8 millimeter camera. It's public information and so on.
Dave Asprey
They did that to Royal Rife too, when he invented a way to those sentence.
Dr. Ted Achicoso
Yeah, but Dave, the, the thing this is they got everything but my mentor then Billy Mamoto, who founded the entire field of medical informatics, said, did you tell them how you were going to power this up? No, for, for all they know is these two huge Big bags of heavy batteries. Yeah, no, but it was not. I, I was going to do. I was going to do it magnetic, but I shut down that research.
Dave Asprey
Do you think that you're not the first person who's come on the show and talked about intervention from dark sunglass people? Do you think that there are people or entities like government entities or whatever, who actually have that kind of tech now? These nano cameras and nanotech?
Dr. Ted Achicoso
Yeah, I think so. I think so because. And this is in the 90s, I was at George Washington University and we already had a nanotech lab and there was already a nanotech fabrication facility at the University of Maryland. I was going to collaborate with them in fact, before my grandkap.
Dave Asprey
So do you think you have nanobots in you right now?
Dr. Ted Achicoso
I wish I did. It's like erection nav. Yeah.
Dave Asprey
As long as I get to own the code and it's open source, I'm not opposed to that. One of the reasons it's called biohacking is hackers made Linux because they didn't know what was inside. Microsoft Windows does. And so like we're. This is a. Something that, that is about autonomy.
Dr. Ted Achicoso
Yeah.
Dave Asprey
And no, sorry Mark Zuckerberg, I don't want your crap in my head. Or frankly, Elon. Elon would, would do less evil of the two. But I like. Sorry, if I don't own the code and I don't own the cloud servers, if there are any, then fuck off.
Dr. Ted Achicoso
Did you know that I wrote graphics driver for Linux in Hex?
Dave Asprey
People do not understand the level of brilliance in multiple domains remains.
Dr. Ted Achicoso
This is just fun.
Dave Asprey
Yeah, exactly. You're a very unusual human.
Boomer Anderson
What's funny is that you were trained as a medical doctor and you went into this field and managed to teach yourself how to code and do all this yourself.
Dr. Ted Achicoso
But the thing is, Dave, you and I know this is that for all of these things that have manifested in our lives, all the abundance, all the love and all of that wonderful, you know, you know, you. There's always a thing that I teach these guys which is to give back.
Dave Asprey
Right? Yeah.
Dr. Ted Achicoso
And giving back is not only in money, it's in service. Like these guys are, are in Health Optimization Medicine association. Right? And they don't receive anything. We give our service, we give everything else. The tuition fee of students are actually, you know, just allowed back to, to. To better the, the curriculum and so on because we don't need your shit money. Ten years after, you know, you made an exit and you say, oh, I'm going to give 50 million. No between now and that, our oceans won't be swimmable anymore. Right. So we need the changes now.
Dave Asprey
You gotta, as soon as you make some money, you gotta start investing in people who are gonna fix the problem. And it doesn't necessarily mean donating. Yeah, I. Years ago there's a carbon Capture X prize and it wasn't going to get funded. So the first $50,000 that went into that was me. I convinced a bunch of other billionaires to pile in as other. I'm not a billionaire, I'm not even close. But basically got a bunch of people wealthier than me to jump in and eventually Elon funded it for 100 million. But without that first $50,000.
Dr. Ted Achicoso
Oh yeah.
Dave Asprey
So sometimes you just have to do that. And so I encourage all the entrepreneurs I work with, like fund a 23 year old with a crazy idea and give them some good advice. And I do that all the time because some of them are going to really change things and other ones will probably just fall into egoic nonsense. But you got to do it because otherwise why are you here.
Dr. Ted Achicoso
Yeah. In fact, there's a very trite meme I tell the people I teach that this may be trite, but in order to do something, always remember that a journey of a thousand miles always begins with the first step. You got to. In biochemistry, that's so old school.
Dave Asprey
Mine starts with a jet.
Dr. Ted Achicoso
You got to get over that energy of activation. Right. In, in, in biochemistry, right. You have to get over and you need to exert energy to get over.
Dave Asprey
Yeah. And the body will tell you not to. It'll make it look unattractive to exert. Because mitochondria don't want to spend energy. They're like too much work. Internal resistance. And then to that I'm like, how about you have some methylene blue, right. You know, you, you just pound a bunch of stuff and because if you have more energy, it's just takes less, less excess energy to overcome the internal resistance that's naturally there to keep you from starving.
Dr. Ted Achicoso
Right. And that's why I put methylene blue in my first product.
Boomer Anderson
Yeah.
Dave Asprey
Come here with that. Blue canteen.
Dr. Ted Achicoso
Yeah, blue canteen. Because I'm so jet lagged all the time. And when you land, you're supposed to see 500 doctors lecture to them. Meat heads of tape. There's no excuse for falling asleep right in front of you. How do you perform on, how do you perform on this? On day one and just landed. So I created a gum, actually a sapodirasin. You know, I said I was Looking at methylene, I said, I said, this is an electron recycler. It can actually grab electrons directly from NADH and bypass complex one and three. Oh, I like shortcuts, you know, on the complex four, et cetera. And then I took a look at all the studies on it and I said, I'm going to start putting this in my gum. And then, you know, with. Along with 1 milligram of nicotine. I'm a nicotine wasp, by the way. You know, 0.5mg will is good enough for me.
Dave Asprey
It's only 1mg.
Boomer Anderson
Not sure he needs it.
Dr. Ted Achicoso
Yeah. And then because the nicotine can be a little spiky, right? Oh, absolutely, yeah. So I actually put some CBD in it in order to round out that thing. And Boomers are always saying, is that synesthesia for you? It's like spiky, you know, taste with a, you know, you round out the taste, as you say, I was referring to it in geometric figures. I didn't even realize I was doing that. Right. And then I realized, oh my God, my brain is cross connected. This is really bad. On an LSD trip when I went to manufacture, right. And actually went to one in Rhode island, said, yeah, we could do your gum, but we're not going to do it it because it's turning all of our equipment blue.
Boomer Anderson
Methylene blue is a dye, right. And so just to throw it into a confectioner gum making machine dyes everything blue. And we even still face this with our trochee molds, like all of our trochee molds, at least for that matter.
Dave Asprey
Who cares if they're blue?
Boomer Anderson
Yeah, yeah, exactly.
Dave Asprey
Screw them in blue.
Dr. Ted Achicoso
Yeah. So I had to redo the same formulation but different dosage form. And the dosage form was a buccal trochee. And, and I wanted it here in the buccal cavity essentially because it was closer to the basilar circulation of brain. So you'd feel that. In fact, my inspiration was the movie Limitless. Limitless? Yeah.
Dave Asprey
Oh, yeah.
Dr. Ted Achicoso
It's like, no, I want something like Limitless. And then my friends actually liked it. I said, can you make more of this? And then they said, oh, okay. Instead of me doing this all the time, why don't you just turn it into a small thing? And then it after a while. When I met Boomer, he said, dad, I want something for anxiety, correction, anxiousness.
Boomer Anderson
Right.
Dr. Ted Achicoso
And so that's when Trocom evolved and so on. So essentially what I was looking for here and we didn't expect this to actually hit because the marketing group in California that I hired and I fired said, no, your product will never fly. It turns people's tongues blue. I said, you see, you have this wrong impression of the Internet. It's a very visual medium. Oh, yeah. Like, it will. Blue tongues will attract people.
Dave Asprey
I've taken transcriptions and people like, what's going on? I just. I made out with a Smurf.
Boomer Anderson
And we like to say blue is the new smart.
Dr. Ted Achicoso
Yeah.
Dave Asprey
So.
Dr. Ted Achicoso
So that's the genesis of the first product with methylene blue.
Dave Asprey
And then people can swallow it if they don't want.
Dr. Ted Achicoso
Yeah. And that's the thing, is that you can. Can swallow it. It's 98% absorption swallowed. It's also faster. It's like when you're. When you're rushing out in the morning, you just pop the.
Dave Asprey
Yeah.
Dr. Ted Achicoso
What I do is I even cut it into quarters and then swallow the whole thing. So it's faster absorption. Right.
Dave Asprey
You're a maniac. Yeah, I love it. All the pharmacokinetics.
Dr. Ted Achicoso
You know, the next product that just blew was a request from our customers.
Dave Asprey
They wanted just the.
Dr. Ted Achicoso
Yeah, no, they. They actually said. Said, ted, we need something for the cognitive decline of our aging patients. So I took a look at the studies done by NIH, and there was an ongoing study then of 16 milligrams for Parkinson's and 8 milligrams for Alzheimer's. Yeah, I think it's. Yeah. So I said, I'm gonna use these doses.
Dave Asprey
Okay.
Dr. Ted Achicoso
Right. And so that's why our method is 16 milligrams and you can cut it 8 milligrams.
Boomer Anderson
And that was. I mean, talk about luck and timing. Yeah, that was, you know, 2020, when, you know, the whole world was shut down and, you know, methylene blue became somewhat of a. I mean, in certain pages of the Internet, it was one of the. The ingredients or molecules that people used for a particular.
Dave Asprey
Who would have thought that if something damaged your mitochondrial membrane, something spiky, maybe, that. That anything that was a mitochondrial cancer or resuscitant would increase people's odds of recovering fully. Who would have thought?
Boomer Anderson
And also, you have people that were, you know, on metformin, which damages complex 1 of the mitochondria, and then they're taking methylene blue, which actually can bypass complex one.
Dave Asprey
Yeah. Yeah, I'm a fan of metformin.
Dr. Ted Achicoso
Yeah. I actually tell my patients whose diabetologists insist that they take metformin. I said, I tell them, take it for six Months. You're going to experience the following side effects and then. Then take a break for six months.
Dave Asprey
Yeah, that happened in 2004. I started taking it for longevity. And yeah, after six months to a year, this is kind of Yankee. And it does lower VO2 max, too.
Dr. Ted Achicoso
Yeah. One of my pride and joy is actually a patient who's now in her 80s, and she's been taking metformin for 30 years. And two years after health of the musician, she didn't need to take Metformin anymore. And I said. And she was saying, why don't you make claims? I said, no claims. I said, we are just optimizing your. Your fundamental cell.
Dave Asprey
It's. And it's really hard to make claims because if you fix mitochondria, everything gets better.
Boomer Anderson
Yeah.
Dave Asprey
Right. And so what are you going to say? Well, it fixes, you know, lung disease or some nonsense. Well, of course it does if you have it, but.
Dr. Ted Achicoso
And it also delays aging. Right. Because I was spending to these guys last night, the Mitochondrial theory of Aging by Douglas Wallace. Yeah, brilliant. Yeah. Where about 45 to 47, you start creating more mutations in your mitochondrial DNA and that starts shifting your energy production lower and lower. It's like when I read that I was 45, like, holy fuck. At this stage, it's time for me.
Dave Asprey
To get on methadone. So we're running up on the end of the show. I want to know, when do you take it? Is this a morning? Is this a nighttime? Do you take it every day?
Dr. Ted Achicoso
It tends to energize me, so I take it in the morning.
Boomer Anderson
I mean, we've got enough data on this now. There are certain populations where it appears to energize you and take it in the morning. Those people take it in the morning, preferably on an empty stomach. And then others like me, I can take it at night, too.
Dave Asprey
I do, too.
Boomer Anderson
I think there's a question about bioaccumulation and sort of the half life of methylene blue. And. And that usually takes place at much larger doses than we're talking about with our products.
Dave Asprey
Okay, so you're doing what, 8 milligrams is the thing.
Dr. Ted Achicoso
Me personally. Okay, this is not for public use, but if you want to do it, you know. So I take 16 milligrams in the morning, and then in the evening, I actually do full tromune, which is the cordycepin, which is a cordycepin. Pure cordycepin. Right. And that actually helps my sleep drive.
Boomer Anderson
Cordycepin is really cool. It comes from cordyceps militaris mushroom. It's 2% of the actual mushroom. But we found a way to isolate it. This is one of those stories where at the time I was living in Amsterdam. Ted texts me at, let's say 3am Washington D.C. time and says, you gotta go out and source this. But cordycepin, Most people think of Cordyceps mushroom as a stimulant, provides energy, et cetera. Cordycepin itself, the structure of it is very similar to adenosine and so it's a partial adenosine agonist, helps with slow wave sleep, has a lot of benefits to inflammation and immune system function.
Dr. Ted Achicoso
Yeah, it's not being investigated as a anti cancer drug. Right. Because it's adenosine. It's mistaken for that. It's also being used as NF kappa B suppressant.
Dave Asprey
Oh, okay, I've gotta order more of your stuff then.
Dr. Ted Achicoso
So these are my two staples.
Dave Asprey
I'll try that at night. Yeah, you wouldn't know this, but about 10 years ago on my regenerative farm in Canada, we started growing Cordyceps militaris. And then we found out that that's not legal in Canada.
Dr. Ted Achicoso
And you need for the amount that we put in our troch is actually need about 7 grams of dried mushroom to equal the trochee. So essentially we're the first one to actually put in pure cordyceccolin in a trochee.
Dave Asprey
I can't wait to give this stuff a try. I mean I tried it years ago, but I didn't know what to do with it. I take it in the morning. Morning. So I'm gonna try it for sleep. That's really interesting.
Dr. Ted Achicoso
Yeah, I did at night for sleep. And you know the difficult thing with health optimization medicine is that it's looking at the rear view mirror. Right. You don't get sick. And therefore it's like. So my patients, like, Dr. Ted, I've been with you for a year and I haven't felt anything yet. I was like. And it's like, how many, how many times do you get sick? Last year and you're at me or six times this year? Oh, I haven't gotten sick yet. So it's that kind of rear view mirror assessment that you have to present to the patient. Right. It's like what I say, if the World Trade center were never bombed, no one would ever know what took place in order to actually making that not happen. So for me it's a simple way of saying, well, take care of your healthy self, they take care of your back.
Dave Asprey
Beautiful. Well guys, thanks for making the trip to Austin. I wish I wasn't flying to Paris tonight so we could go hang out some more, but what a beautiful conversation. And you're doing some really good stuff. And I'm really excited to have you come and speak at the Biohacking conference or Beyond Biohacking Conference in May. It'll be really great to have you teaching doctors stuff that really matters. And, guys, as you know, whenever I invite Founders onto the show, I'm like, you gotta. You got to share a discount with listeners. So troscriptions.com, use code Dave and you'll get a discount on it. Guys, thanks for providing that and thanks for sponsoring the show. I appreciate your support and just. Man, you're doing the coolest stuff. I'm always just blown away when you have these conversations because you actually know how it works, and very few people understand that.
Dr. Ted Achicoso
Thanks for your leadership.
Dave Asprey
You're very welcome.
Boomer Anderson
Thank you. Dave.
Dave Asprey
Yeah.
Dr. Ted Achicoso
You led this.
Dave Asprey
Oh, thanks.
Dr. Ted Achicoso
It's all your fault.
Dave Asprey
Yes.
Dr. Ted Achicoso
Well, we're so used to blame, blame, blame. Right. Except us.
Dave Asprey
Yeah, I can take some responsibility for that. I appreciate your friendship and just all this stuff, you know, and so I'm going to try my cordycepin for sleep. That's a new one for me. And I think I know all the sleep hacks, but I missed that one.
Boomer Anderson
So it's a good one for flights, too.
Dave Asprey
Okay, well, if you have any spare ones, give it to me.
Boomer Anderson
Yeah, in the bag downstairs.
Dave Asprey
All right, see you guys on the next episode. See you next time on the Human Upgrade Podcast.
Podcast Disclaimer Narrator
The Human Upgrade, formerly Bulletproof Radio, was created and is hosted by Dave Asprey. The information contained in this podcast is provided for informational purposes only and is not intended for the purposes of diagnosing, treating, curing, or preventing any disease. Before using any products referenced on the podcast, consult with your healthcare provider, carefully read all labels, and heed all directions and cautions that accompany the products. Information found or received through the podcast should not be used in place of a consultation or advice from a healthcare provider. If you suspect you have a medical problem or should you have any healthcare questions, please promptly call or see your healthcare provider. This podcast, including Dave Asprey and the producers, disclaim responsibility for any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guest qualifications or credibility. This podcast may contain paid endorsements and advertisements for products or services. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. This podcast is owned by Bulletproof Media.
Podcast: The Human Upgrade: Biohacking for Longevity & Performance
Episode: 1401
Host: Dave Asprey
Guests: Dr. Ted Achicoso (Founder of Health Optimization Medicine, Polymath, Co-founder of Troscriptions), Boomer Anderson (Business partner, Shaman in training)
Date: January 20, 2026
In this lively and intellectually rich episode, Dave Asprey welcomes back Dr. Ted Achicoso, a multi-disciplinary physician, researcher, biohacker, and entrepreneur, joined by his business partner Boomer Anderson. The conversation delves deep into health optimization beyond traditional medicine, cutting-edge supplements, the realities and myths of nanotechnology, and the underlying science of how we can upgrade our health and longevity. Dr. Ted’s approach synthesizes advanced biochemistry, evolutionary biology, and consciousness theory—offering a radically holistic yet data-driven pathway to human enhancement.
Timestamps: 03:02–07:47
"Let's go and take a look not at the root causes of disease, but the root causes of health. And then all of this lifestyle stuff that you're just guessing is going to help in the disease is actually going to optimize the health of your patient." — Dr. Ted (06:08)
Timestamps: 07:47–09:12
Timestamps: 09:47–13:12, 35:33–43:18
"I was looking at methylene blue, I said, this is an electron recycler. It can actually grab electrons directly from NADH and bypass complex one and three. Oh, I like shortcuts." — Dr. Ted (36:13)
Timestamps: 14:54–18:45
Dr. Ted explains the evolutionary and cellular stress response called "Cell Danger Response" (CDR)—how cells defend against threats like viruses, chemicals, and psychological stress.
CDR involves shutting off external resources, strengthening cell membranes, activating innate immunity, changing gene expression, and warning other cells via extracellular ATP.
Dave connects CDR to chronic illness (antibiotic-induced, food sensitivities, mold), noting its centrality within biohacking.
"The cell, if you look at it evolutionarily is trained to fight off viruses. So it will try its best to—okay, I am not going to give you resources to produce more viruses... It emits microbials and viruses in the exterior and then it changes the DNA by using jumping genes, right?" — Dr. Ted (15:55)
To turn off CDR: balance metabolites, support the body's healing, rest, nutrition, and the parasympathetic system.
Timestamps: 21:56–26:55
Dr. Ted introduces the concept of "summer metabolism" (growth, e.g., leucine) and "winter metabolism" (healing, e.g., alpha lipoic acid), happening within a single day.
LDL cholesterol’s protective role is discussed; aggressive LDL lowering can decrease the body’s ability to remove bacterial toxins (LPS).
"Some LPS are very toxic and some are less toxic. But if you have low LDL, you can't stick to these things and then you can't excrete it, which is why the people who live a very long time have higher LDL, not lower." — Dave Asprey (24:10)
Dr. Ted outlines a “first principles” model of the body: food, mitochondria, gut, and microbiome—arguing that optimizing cellular rather than organ function leads to broad health improvements.
Timestamps: 27:00–29:45
Timestamps: 30:03–32:49
Dr. Ted recounts working on nano-cameras in the 1990s, secret government raids, and being at the forefront of nanotech and medical informatics.
The group speculates on current state-of-the-art nanotech, implicating government and military-level secrecy.
Dave draws a parallel between open-source hacking (Linux) and the ethos of biohacking—personal autonomy, code ownership, and decentralized control:
"As long as I get to own the code and it's open source, I'm not opposed to that... Sorry, if I don't own the code and I don't own the cloud servers... then fuck off." — Dave Asprey (32:17)
Timestamps: 32:58–35:03
Timestamps: 42:10–45:40
"Cordycepin itself... is a partial adenosine agonist, helps with slow wave sleep, has a lot of benefits to inflammation and immune system function." — Boomer Anderson (43:18)
On giving people permission to self-experiment:
"You are the first person, this is my judgment, who ever gave permission to those who are interested in the health population to experiment on themselves in an end to one."
— Dr. Ted Achicoso (07:12)
On the blue side effects and Internet culture:
"It's a very visual medium. Blue tongues will attract people." — Dr. Ted (38:23) "I've taken transcriptions and people like, what's going on? I just... I made out with a Smurf."
— Dave Asprey (38:56)
On consciousness:
"Consciousness is inherent... The ego or the self is emergent."
— Dr. Ted (28:57)
| Timestamp | Segment or Topic | |-----------|------------------------------------------------------| | 03:02 | Dr. Ted’s background, HOMe origins | | 05:38 | Food/supplements vs. pharmaceuticals | | 09:47 | Product innovation: Troscriptions | | 14:54 | Cell danger response explained | | 21:56 | Metabolite mapping (growth/healing, daily rhythms) | | 24:39 | Mold, LPS, and health optimization model | | 27:00 | Subcellular consciousness, emergence vs. inheritance | | 30:03 | Nanotech, informatics, "hackers" ethos | | 32:58 | Service and philanthropy | | 35:33 | Methylene blue and product design | | 43:18 | Cordycepin for sleep and immunity | | 45:40 | Real-world evaluation of health optimization | | 46:56 | Travel biohacking wrap-up, sleep tips |
This conversation offers an entertaining yet profound look at the future of medicine, health sovereignty, and what it means to truly "biohack" aging—fusing ancient wisdom, futuristic tech, philosophical rigor, and pure scientific curiosity.
Fans of biohacking, longevity, neurochemistry, and systems biology will find plenty of inspiration, as well as concrete product tips and frameworks for taking charge of their own health journey.
Discount & Resource:
Listeners get a discount at troscriptions.com with code “Dave”.
End of Summary