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What are the four things most likely to kill you? One of them is Alzheimer's. Well, if you don't want Alzheimer's, microdosing nicotine might be a great way to feel better now, have more energy, more focus to lose weight, and to not get Alzheimer's. Misusing nicotine can be bad for you, and not using nicotine can be bad for you. I consider nicotine to be as important as caffeine and ketosis. If you really want to have a brain that's going to last for more than 100 years and you want to feel like you love your life, it's that big of a difference. If you want to stay sharp with creativity. Nicotine Nicotine improves reaction time and vigilance. It makes it easier to pay attention. Now, what's the difference between smoking and taking a pharmaceutical nicotine product? You're listening to the Human Upgrade with Dave Asprey.
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Alcohol kills your sleep and ages your brain every time you drink it. If you want to relax and connect but still feel clear the next day, there's a better way. And that better way is Tru Kava. Kava calms your nervous system and enhances social connection by increasing gaba, dopamine and serotonin activity. In the South Pacific, they've used kava for over 3000 years for relaxed mental clarity, social connection and resilience, all while supporting brain health and longevity. I'm excited because Tru Kava just released their new instant powders. For the first time, you can get the authentic whole food kava experience in a clean mix and go sachet format. I travel with these powders because they actually deliver all of the relaxing social benefits I want without destroying my sleep score or metabolic health. If you want the relaxing effects of alcohol without the downsides, this is the Upgrade. Go to Trucava.com and use code DAVE10 for 10% off. That's T R-U-K-A-V-A.com for 10% off. Poor recovery speeds up aging when you don't recover from stress properly, your cells get weaker and accumulate damage. HeartMath changes that the inner balance coherence plus trains your body to recover at the source your nervous system. The setup is pretty simple. You connect a sensor to your ear that pairs to the HeartMath app, which guides you through an HRV exercise. In five minutes a day, your body shifts out of stress mode and into coherence, the state where recovery, focus and peak performance happen. Most devices only track recovery. HeartMath trains it. It works by targeting heart rate variability or hrv, your body's most reliable marker of resilience. Higher HRV means faster recovery, deeper sleep, and stronger performance. Decades of Science prove that HeartMath works. Over 400 studies show measurable results in as little as six weeks. That means less anxiety, better sleep, more energy, and sharper focus. That's why elite athletes, hospitals, and the US Military all use the interbalance coherence. Plus, this is one of the things I think everyone should be doing. Don't just track recovery, train it to get 15% off. Go to heartmath.com Dave.
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Hey guys, quick reminder. If you're listening to this on your favorite audio podcast app and you haven't been over to my YouTube channel, check it out. Join Just search for the Human Upgrade or find me under Dave Asprey bpr. I post full video versions of every episode and a bunch of other cool content outside the pod. It's a great way to go deeper into the content and connect with other biohackers like you. So leave a comment for me. Yeah, I'm actually going to read them and poke around while you're there. There is a lot of stuff specifically for you. It really helps and it means a lot to me. Here's the deal. Nicotine has gotten a big bad rap. In 1986, Dr. Newhouse from Vanderbilt University published the first groundbreaking study that said pharmaceutical nicotine not smoking, not chewing tobacco, but pharmaceutical nicotine reversed Alzheimer's disease in patients. And since then we've all confused tobacco, which is bad for you, with nicotine, which at low doses has profound beneficial health effects. Because of this research, I started using nicotine at the very beginning of starting the biohacking movement. One milligram per day. Now a cigarette has 12 to 20 milligrams per day. This is a tiny microdose, a little mint and the difference in my brain function. My focus was profound and for five years I used one milligram a day. And then I said I really like this and the research is getting better and better, so I'm going to use two. And today I recommend a little bit more than that. And there are profound benefits to nicotine that have nothing to do with smoking. They are not pro cancer, they are anti Alzheimer's. They're pro metabolic. And I want you to understand this because misusing nicotine can be bad for you and not using nicotine can be bad for you. I consider nicotine to be as important as caffeine and ketosis. If you really want to have a brain that's going to last for more than 100 years. And you want to feel like you love your life. It's that big of a difference. It's just very different from the world of addiction that you're probably thinking about right now. And here's the deal. I am an unlicensed biohacker, author of multiple New York Times best selling science books. And I've changed the way we talk about health with the biohacking movement. But I'm not a doctor. And nicotine is addictive, especially if you do it above the levels I'm going to talk about in this episode. It'll raise your heart rate and your blood pressure. Don't use it if you're pregnant, don't use it if you're a kid. Don't use it if you have any contraindicated condition, especially if you know you have cancer at that point. If you're following western cancer treatments, nicotine might not be good for you. If you're following alternative treatments, there's an argument for it. And this entire episode is about nicotine. Not smoking, not chewing, not snuff, nothing. It's not tobacco, it's nicotine. Here's what you get to learn in today's episode. Talk a little bit about the history of nicotine because it has just played an incredibly important role in the evolution of consciousness, really. And we're going to talk about the mechanism so you understand receptors, what your dopamine does and doesn't do with nicotine and the anti inflammatory effect of nicotine. We'll talk about human data risks of nicotine and who should avoid it, how to get it, delivery methods that are not going to cause more problems than the benefits. And we'll talk about personalization stacks and what synergizes with nicotine and how to avoid tolerance or dependence and what to do if you do have dependence. And I'll teach you the protocols for microdosing, for deep work and for tapering. And then I'll summarize it all for you at the end because, well, I am a good teacher. At least I like to think so. So with no further ado, let's talk about nicotine and let's not talk about smoking. Nicotine is a plant alkaloid and it is a defense chemical, just like caffeine, just like polyphenols, like most of the beneficial medical effects from plants are plants designing themselves to not be over consumed by insects, fungus, bacteria or other animals. So the right chemical at the right dose made by a plant can have profound beneficial or Negative effects on you, depending on the dose, depending on the plant, depending on the chemical. And what nicotine does is it binds to the nicotinic acetylcholine receptor. These are go switches for attention, arousal and learning in the brain. You've probably heard of acetylcholine because it's a stimulatory neurotransmitter. And even the nootropics that I designed that are there for cognitive enhancement, they increase acetylcholine levels just a little bit. And that's what nicotine's doing by binding to those receptors and activating them. Now, nicotine is just not smoking. The disease burden from tobacco largely comes from combustion products, not pharmaceutical grade nicotine. It's also worth noting that most tobacco plants have high amounts of cadmium in them from the soil. But nicotine, when it's purified, doesn't have that. Nicotine is not risk free, much like life, but it is addictive also much like life. But nicotine is not classified as a human carcinogen by itself. Combustion is the problem, along with some of the other things that come from combustion, like tar. Think about it like this. Acetylcholine is your brain's laser pointer for attention. And these acetylcholine receptors are the light switches. So small amounts of nicotine flip a switch so it's a bit brighter. Can we talk about the history of nicotine? It has a beautiful ritual use. You might have heard of ayahuasqueros or shamans who use ayahuasca, and I've interviewed many on the show. But there's another type called a tobacconero. These are people who use in the jungle, ancient forms of tobacco with far more nicotine than what we normally expect in the West. And they take it until they hallucinate and they go to the same places that we go with these ayahuasca journeys, like very, very deep work. And it has been revered for its ability to help us get into the spiritual world, especially in North American shamanistic practices. And we've used smoking as a way to connect with others for a long time. I don't recommend smoking, and I'm actually trained by a medicine person to administer hape, which is a powdered form of tobacco. I wouldn't do that very often, but. But I don't mind doing that if I'm sitting around a fire and we're connecting with our ancestors. That's how you do it. And there is nothing wrong with that. I actually have a practice to honor the spirit of tobacco, which Actually still wants to help us, even with all the mean things we've done to tobacco over the years. That's not what we're talking about here. We're talking about the extract of tobacco nicotine. Why would we call it nicotine? Because in 1560, Jean nicotine Nico nicotine and brought tobacco to French court and they named it nicotine because of him. In 1828, another couple of these French and now German people. This is posuit and Reinman isolated pure nicotine from Tobacco 1800s. It's a very long time ago. And it was a colorless oil and very potent. And then Jean Stas in 1850, developed the first forensic nicotine detection so we could actually figure out whether it's in something. And it wasn't until the 20th century that we started making industrial cigarettes. Until then, you'd roll your own or have a cigar, or you just chew on it or you'd use snuff. And the problem was when we started making industrial cigarettes, we started getting tar and benzopyrenes. And modern cigarettes have hundreds of added ingredients, some of which radically increase the addictiveness of smoking versus nicotine. The washout period for nicotine is three days for a physiological addiction, same as caffeine. You quit caffeine and you're gonna have headaches for three days. And then it gets better. If you're taking low dose pharmaceutical nicotine and you stop taking it, your washout period's three days. If you do high dose pharmaceutical nicotine, it's a little bit more complex. Where we are today is we have these nicotine replacement products, things like gum, although most gum has bad sweeteners in it, and even one sweetener that's particularly addictive, we have patches with nothing addictive but nicotine itself. But you don't really feel the kick as hard. And we have sprays and we have these little microplastic packets that go up in your gum, things like Zen. So I don't recommend those. But in a pinch, maybe. So it's time as biohackers and as people interested in longevity, that we take a serious look at nicotine as a nootropic and a longevity anti aging drug. And this is particularly important if you read Superhuman, my big longevity book. Well, what are the four things most likely to kill you? One of them is Alzheimer's. Well, if you don't want Alzheimer's, microdosing nicotine might be a great way to feel better now, have more energy, more focus to lose weight. Oh, and to not get Alzheimer's. Let's get a little bit sciency about how nicotine works. So there are different subtypes of acetylcholine receptors. There's alpha 4 beta 2 high affinity and alpha 7, which are fast calcium ion permeable. And these are important for cognition. If you want your brain to work, you have to hit those receptor subtype. Why do we need to do that? Because in your prefrontal cortex, where your conscious thinking really happens, your ability to regulate your emotions, and to a certain extent in your thalamus, you can get a better signal to noise. You feel locked in, but not buzzed. And if you chronically use nicotine, people who just are constantly taking it all day long, at high doses, you get desensitized. And when that happens, you get upregulation in days. So then you kind of get dependence. So a quick tap on a key would improve typing. Holding it down until it sticks doesn't work. That's what desensitization is. And if your brain adds more keys, you get upregulation of your receptors. One of the most pleasurable parts about nicotine, even low dose, is that it excites these cholinergic inputs to your mid brain dopamine neurons. Why would you care about that? Because if you turn up dopamine in the midbrain, you like your life. A modest bump in that will increase your motivation and it makes it easier to stay on track. It is not like an amphetamine or a sledgehammer. It is subtle at low dose, but it's just like, wow, everything just got easier. And that reward assist does contribute to habit formation because we like it when things just feel like they have less effort required for them. So this is about dopamine. But those alpha 7 receptors in your brain are also on your immune cells in the brain and everywhere else. And when you activate those with low dose pharmaceutical nicotine, it's like a brake pedal on inflammation, which lowers something called TNF alpha, which is a primary inflammatory cytokine. And if you've read my books or heard other episodes of the show, you know that inflammation is expressed in different types of cytokines. And you might remember that TNF Alpha is a primary cause of inflammation, especially with autoimmunity and with aging. So lower TNF Alpha is one reason that nicotine likely contributes to longevity and certainly is anti Alzheimer's. And guess what other part of your body uses that pathway? The vagus nerve. This is something that controls whole body inflammation. I've done probably six or seven episodes on vagus nerve simulation with Dr. Stephen Porges, who's a leader in the field on that. And we just talked recently about how there's 200,000 different parts of the vagus nerve. And I've talked about Zenbud, the new ultrasonic vagus nerve simulator. All of these are about controlling the vagus nerve. But nicotine, well, because it uses this alpha 7 receptor, it affects the vagus nerve for less inflammation on the thing that controls the whole body. And tiny doses can actually, surprisingly make you feel calmer. And you can feel much less muscle and body ache from low dose. Conversely, if you take a high dose, you will barf. Many, many years ago, my first podcast producer, she heard about nicotine on the first episode. So she took a 25 milligram patch and she stuck it on. And an hour later calls me and goes, this is the best day of my entire adult life. I love everything. And she called me an hour later and said, my face is green and I'm barfing. There you go. Don't overdose. Now let's talk about something called pharmacokinetics, which is something that you should learn about. For any supplement or any medication you're using, go to your favorite AI that you trust may not be ChatGPT anymore because it's a lying bastard. And look at that. That tells you how a medication is metabolized in your body and how long it's going to last. What that'll tell you is that nicotine has a half life of about two hours. And if they were going to test you to see if you'd had nicotine, Cotinine is the main breakdown product. It lasts for about 16 hours, and there are some that last for about 60 days. So if you're going for life insurance or something, you're going to have to go cold turkey for a while. And the speed of how nicotine hits you really affects how you feel. And the lungs are the fastest route. The oral route is pretty fast but moderate, and the patch is slow and steady. So if you want to get the metabolic benefits, but not really the cognitive benefits, go for the patch. If you want to get pretty good benefits, go for a spray, which is not available in the US unfortunately, or use something like a little mint that just goes up inside your lip. If you're an athlete under 30 or you're over 30 in general, your cartilage is already breaking down faster than your body can rebuild it. That's the reason your joints feel stiff or less mobile after workouts and even just during daily life if you ignore it, you set yourself up for pain and limitations that only get worse with time. There's a brand new supplement based on a ton of research called Cardiogenics HP by Calroy that directly changes that. Calroy designed this product to directly target the foundation of joint health, which is your cartilage, and they lead with real science. This one's personal for me because I've had three knee surgeries to repair cartilage in my knee when I was in my early 20s and I don't have knee pain and anymore. The Cardiogenics HP formula went through three published human trials. Two of them were randomized, placebo controlled. That's the gold standard. And the results are shockingly good. In just 90 days, participants saw a 67% average drop in pain scores. They walked 50% further on average. Even biomarkers of cartilage regeneration improved in a meaningful way. Kalroy already is one of my go to supplements because of Arterosil hp, which I've taken for almost a decade. It's a core part of my longevity program. Now they've done it again with Cardiogenics HP, so go to kalroy.com Dave, you'll see the research, get the discount and you get their 45 day money back guarantee. So if your joints matter to you, and they should, don't wait until the damage locks you in. Just go to kalroy.comdave and feel better. What if it feels like you don't have any energy, but it's not because of bad sleep, eating seed oils or bad food, or even just because you're stressed, but from something you can't see. I'm talking about invisible things, EMFs from Wi Fi phones and all the other devices. Pretty much WI fi toasters are the standard these days. They're everywhere. And your body is constantly reacting to these waveforms. That's where heal360 from Leela Quantum Tech comes in. It's not a supplement and it's not even a gadget. Heal360 is a quantum frequency, which is a scientific pattern of energy that's reproducible and studies that's infused into something you already use. Things like a necklace, a shirt, even a water bottle. And yes, I do use this. I use it because science says that it works and I can feel that it works. And you should have both of those on your list of how you evaluate things. Heal360 has over 45 tested frequencies, including ones that support tissue repair, gut balance, blood flow, even your stress response. It's like giving your body the information it needs to reset. There's no battery, there's no maintenance, just ongoing support for your body's own systems. It sounds like it's too good to be true or like it's woo woo, but it isn't. There are many scientific studies that back this up and frankly reality would be easier to understand if it didn't work. However, it does work and we do live in a quantum world. Even though we don't really see it, we can now manipulate it. So try it and you'll feel it like I do. You can check out all the Heal360 products and the research and get 10% off at least. Leela Q.com Dave L E-E-L-Q.com Dave so what is it going to do in scientific research? Nicotine can increase your attention, it can improve your working memory. And they say really acute, like short term improvements. And this is a meta analysis of many different studies. They can be small to moderate. It's dependent on the type of task. And this is really important. It is a U curve that's inverted. What that means is that if you have no nicotine you don't perform very well. You have a little bit, you perform better, you get more, you don't get the improvements. So you want to be at the Goldilocks zone. And if you're dealing with something called mild cognitive impairment, which is a huge number of people as we age and a lot of people who just maybe got exposed to something against their will over the past five years, I can't imagine what that would be. But if you're one of those people, there's research showing that for non smokers 15 milligrams a day in a patch which is moderate dose for six months, improved working memory, improved attention, and it doesn't cure things, but it's a credible signal that it's helping with mild cognitive impairment so you don't feel impaired. And this is really cool if you want to stay sharp with creativity. Nicotine improves reaction time and vigilance and it makes it easier to pay attention. And that anti inflammatory signaling is my favorite effect because it's not going to give you full self treatment of disease. But if you have a chronic low grade inflammation signal like I did, with a background of autoimmunity and weighing 300 pounds before I got on top of it, I feel better on low dose nicotine. I've gone off for months at a time. My life is better with low dose nicotine in every way. I Can measure. So of course I'm going to use it. So here are the risks of nicotine. Again, not the risks of smoking. We're not talking about smoking in this episode. You could get addicted. And you will see receptor changes and dopamine reinforcement. And if you withdraw, it peaks around days two to three and it fades in two to four weeks. And you can have irritability, low focus, problems sleeping, you'd have cravings for nicotine. But there's a problem with this. If you're on high dose oral nicotine, the withdrawal can also cause whole body muscle tension and you get stuck that way for a long time. Which is why if you made the mistake of using 6mg ins every five minutes, well, you're gonna have problems when you start doing it. So you gently, gently, gently taper off, ideally using patches. Do not go cold turkey. If you're on very high doses of nicotine, you, you will have muscle tension like you've never experienced in your life. Yes, I've tried it. There's also from excessive nicotine, cardiovascular strain, your heart rate, blood pressure goes up. Never been an issue for me. I have low blood pressure. That's because I'm a biohacker. So basically, if you have uncontrolled high blood pressure, you have had a recent heart attack or you're having arrhythmias, you might want to avoid all stimulants, including nicotine. And if you do have uncontrolled high blood pressure that is caused ultimately by insulin resistance and nicotine may help with that. But do not do things that's going to increase your blood pressure to unsafe levels. And if you take nicotine in the afternoon and especially before bed and you're not used to it, it can fragment your sleep, lower your dream or REM sleep. And most people who aren't used to nicotine, if you do an overnight patch, you can expect really vivid dreaming. And this is where it gets really interesting. We talk about metabolism. So many of the studies in the head of the paper, they completely talk about smoking and nicotine as if they're the same thing, even though smoking has a thousand compounds. And you'll see studies out there that say smoking causes insulin resistance and they'll say therefore nicotine does, which is not scientific. Smoking causes insulin resistance because the smoking byproducts are bad for your mitochondria. And we know that you could just also breathe, I don't know, forest fire smoke, and have the same problems with your mitochondria and therefore your insulin so nicotine alone could impair receptor sensitivity. And if you're diabetic or insulin resistant, you can look what happens with the continuous glucose monitor. I haven't seen problems with it. And low dose, not high dose nicotine theoretically should help with insulin resistance. But if you start pounding it all the time, it's going to raise your stress hormone levels, which is going to move your insulin in the wrong direction. If you are pregnant, do not do this. It crosses the placenta. Nicotine can alter development. And if you're a teen, for God's sake, like, nicotine is not for your brain. It needs to finish baking before you do that. And I know so many teenagers, you've gotten into trouble, especially with vaping. Vaping is worse than smoking. Don't do that. There's so many other ways to experience pleasure than that. A friend of mine who hadn't tried much nicotine took a spray and suddenly just started barfing from one milligram. She was pregnant. Her body gave her a hard no on that. And using nicotine once if you're pregnant isn't the end of the world, not by a long shot. It's just your body saying, don't put that in me anymore. And if you are pregnant and smoking, you must stop. Earlier I mentioned nicotine is not a carcinogen, but it can stimulate signaling for angiogenesis. And angiogenesis is when the body builds more blood vessels. Now, angiogenesis is beneficial throughout the body. You want more blood flow in the brain. You want to grow new blood vessels, especially if you have some blocking of the arteries in your heart because of plaque or because you had Covid or something like that, which causes damage to your arteries. So angiogenesis, good. But if you have cancer, cancer will also want angiogenesis to fuel tumor growth. So it's not a good idea to be on nicotine if you have cancer, especially if you're undergoing a cancer treatment that cuts off angiogenesis or creation of new blood vessels. However, if you're doing a metabolic treatment for your cancer, you should work with your cancer specialist. But if I had a tumor, I wouldn't do nicotine. Out of an abundance of caution. And most of the studies are on high dose, not low dose. And this really is important. If you have delicious little mints, don't put them out where kids can get them. It can be poisoning. In fact, nicotine is ultimately there to keep insects from eating tobacco. And it does this because when you stimulate those acetylcholine receptors a little bit, it Feels good. If you've ever seen a cockroach sprayed with poison and it starts, like, seizing up and twitching, that comes from excess acetylcholine. So nicotine can kill adults and children and pets. So keep it away from them. Now, what's the difference between smoking and taking a pharmaceutical nicotine product? Cigarettes are way more addictive because smoke has something called an MAO inhibitor in them. It's actually something that's a part of ayahuasca as well, and that can amplify your dopamine. You don't have MAO inhibitors in pharmaceutical nicotine. Okay, so now you know, you should probably try this if you want these types of benefits. But I haven't told you exactly the right dose yet. And I'm going to talk first instead of dose about how it gets in there, because the speed that it gets in affects the dose. And here's the rule. The faster it hits you, the better it feels and the more habit forming it is. Slower in is smoother and steadier. It's less grabby, but it also may be less focusing. If you can do a gum of 2 to 4 milligrams, I recommend do the 2 milligram. You're gonna feel it in 15, maybe 30 minutes. It's important that you chew on it and then park it. Three chews and just let it sit right up in here. Do not just keep chewing it because, number one, you'll look like a cow and you'll probably sound like one, too. But more importantly, you'll get all the dose in. It'll go down into your stomach, and then you might get nauseous from it. And most nicotine gum, like Nicorette, is full of crappy ingredients that I would never put in my body. The only safe gum that I know of is from a company called Lucy Gum. And full disclosure, many years ago, I wrote a very small check to be an investor and advisor in Lucy because I believe in the power of nicotine. So I'm not trying to sell you on it here, just to mention that that is one of the brands that doesn't use bad sweeteners in some of their products. But sadly, some of them do have it. You can also use a lozenge or a pouch. I do not recommend pouches right now because all of them, as far as I know of, have microplastics and you don't need a pouch. Plus, you have to spit it somewhere. You can get a similar effect from a lozenge. And lozenges offer delivers slightly more than gum and pouches vary by branding. And the best lozenges, you just park them up here and they go away. My very favorite feel good way to get it is an oral spray. Nicorette makes the only oral spray I've seen. It is approved in every country on the planet except the US And I don't know why. I bought it in Mexico, I bought it in Norway, I've bought it in Amsterdam, I bought it in Dubai, and certainly in Canada, but not here. You can just find it on ebay. Someone will buy it and import it and then sell it to you. If you're at the FDA and you're listening to this guys, this is better than smoking. Now, there's a patch. Patches come in 7, 14, or 21 milligrams. And they say in big letters, do not cut this patch. The reason they don't want you to cut the patch is that it's bad for their profits. If you want 7 milligrams, buy a 21 milligram patch and cut it into three pieces. Because 3 times 7 is 21. You just open it up, take a pair of scissors, and you stick it on your arm. And this gives you slow, steady release, they say for 24 hours, probably closer to 16. It could disturb your sleep, it could give you better dreams. And some people just stick it on in the morning and take it off in the middle of the afternoon, and you just feel great. This is the least likely to be addictive with some metabolic benefits. Now, if you were to smoke your nicotine, which is gonna be vaping, if we're not talking about smoking tobacco here, which we're not, that's the highest dependence, the highest toxicant, the highest reduction of organ size, increases in cancer and all the bad stuff. So just never vape. It's not worth it. There's another form that I would do long before I would vape that you don't see in the US but you'll see it in Europe. And it's called heated tobacco. And it turns out if you have a little bit of tobacco and you heat it electrically to a certain temperature, you get nicotine and you get a little taste, but you don't get all the bad stuff from burning. And it uses less tobacco if you wanted to do that. It's typically something you'd find in Europe. And it technically is tobacco. And I don't know that I have enough information to tell you that it's better than these other ways. I know it's better than smoking. Here's some basic technique notes from 10 plus years of using nicotine for longevity and cognitive function. Do not swallow the gum and lozenge. Don't swallow the spit and it wastes your dose and it just causes nausea. And if you have an acidic drink when you're dosing it, it doesn't work as well. You can take half a piece of gum, just bite it once and park half the gum here. That'll give you like 0.5 to 1 milligram. Remember, a cigarette's like like 12 to 20 milligrams, so you're talking about a small dose. And there's nothing wrong with cutting patches unless it's a reservoir patch and most of them are just a matrix. You don't have to worry about it. So you can cut most of them and that's the trick. So there you go. Now you have your intro and in Part two I'm going to go deeper on personalization, genetics, longevity use, metabolism testing, timing, and if you're saying I gotta know right now, keep it under 5 milligrams a day every day and your risks are lower. But I'll give you all the reasons, all the methods, all the other stuff you need to know in Part two. See you next time on the Human Upgrade Podcast.
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A Human Upgrade, formerly Bulletproof Radio, was created and is hosted by Dave Asprey. The information contained in this podcast is provided for informational purposes only and is not intended for the purposes of diagnosing in treating, curing or preventing any disease. Before using any products referenced on the podcast, consult with your healthcare provider carefully, read all labels and heed all directions and cautions that accompany the products. Information found or received through the podcast should not be used in place of a consultation or advice from a healthcare provider. If you suspect you have a medical problem or should you have any healthcare questions, please promptly call or see your healthcare provider. This podcast, including Dave Asprey and the producers, disclaim responsibility for any possible adverse effects from the user. Use of information contained herein. Opinions of guests are their own and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guest qualifications or credibility. This podcast may contain paid endorsements and advertisements for products or services. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. This podcast is owned by Bulletproof Media.
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Host: Dave Asprey
Episode: Nicotine Masterclass (pt. 1) - Episode 1345
Date: October 14, 2025
In this solo “Nicotine Masterclass,” Dave Asprey demystifies nicotine usage beyond its association with smoking, reframing it as a potentially powerful biohacking tool for cognitive enhancement and longevity, particularly in Alzheimer’s prevention. He explores the pharmacology, historical context, risk/benefit profiles, practical dosing, and the distinction between pharmaceutical nicotine and tobacco products. This episode lays the groundwork for responsible, science-based nicotine use, advocating microdosing and personalization, and addressing the misconceptions that have stigmatized nicotine.
Alzheimer’s, Longevity, and Brain Health:
Nicotine (specifically, pharmaceutical grade) may help combat cognitive decline, improve energy, focus, creativity, and act as a neuroprotective agent.
Nicotine’s Role Among Biohacking Staples:
Dave equates its potential with that of caffeine and ketosis for brain longevity.
Importance of Correct Usage:
Misusing or not using nicotine can both be detrimental. Dose and delivery are crucial.
Mechanism of Action:
Anti-inflammatory Pathways:
Name Origin and Isolation:
Origin traced to Jean Nicot’s introduction of tobacco to French court in 1560; pure nicotine isolated in 1828 (Posselt & Reimann).
Ritual and Medical Use:
Available Formats:
Gum (2-4mg): Chew and “park” for absorption, don’t overchew/swallow.
Lozenges: Slightly more bioavailable than gum; “park and dissolve” method preferred.
Patches: 7, 14, 21mg options; deliver slow, steady release; can be cut for dose control.
Oral Sprays: Dave’s favorite, available ex-US; rapid onset.
Heated Tobacco (not recommended; less harmful than smoking, but still contains tobacco).
Vaping: Strongly discouraged—high dependence, toxicants.
"The faster it hits you, the better it feels, and the more habit-forming it is. Slower in is smoother and steadier." — Dave [29:38]
Safe Use Practices:
Addiction & Withdrawal:
Cardiovascular:
May raise blood pressure and heart rate; not advised for those with uncontrolled hypertension, heart arrhythmias, or recent heart attack.
Sleep:
Taken late in the day can fragment sleep, lower REM, or induce vivid dreams.
Insulin Sensitivity:
High-dose or chronic use could impair insulin response; low-dose may help.
Developmental Risks:
Contraindicated in pregnancy and for teens—fetal and adolescent development risks.
Cancer Concerns:
Nicotine can stimulate angiogenesis; avoid if you have cancer or are in anti-angiogenesis therapy.
Toxicity/Exposure:
Keep all forms away from children and pets—nicotine poisoning is dangerous.
Dose Matters:
Microdose; stay under 5mg/day for low risk (to be detailed in part 2).
Risks Are Delivery-Dependent:
Fast-acting methods (vape, smoke) more addictive; slower (patch, lozenge) less so, though possibly less powerful for cognition.
Don’t Swallow Nicotine Forms:
Gum/lozenge should not be swallowed or chewed excessively.
Personalization/Dependence:
Will be covered in greater depth in Part 2: genetics, timing, metabolism, tapering protocols, and stacking.
"Nicotine has gotten a big bad rap... since then we've all confused tobacco, which is bad for you, with nicotine, which at low doses has profound beneficial health effects." — Dave [03:40]
"I consider nicotine to be as important as caffeine and ketosis. If you really want to have a brain that's going to last for more than 100 years." — Dave [04:32]
"One of the most pleasurable parts about nicotine, even low dose, is that it excites these cholinergic inputs to your mid brain dopamine neurons... it makes it easier to stay on track. It is subtle at low dose, but it’s just like, ‘wow, everything just got easier.’" — Dave [12:24]
"Never vape. It's not worth it." — Dave [29:21]
Barfing Story:
Dave describes a producer who overdosed on a 25mg patch, resulting in euphoria quickly followed by nausea and vomiting—clear illustration of the importance of respecting dose. [16:10]
Product Advisory:
Advice to ignore “do not cut” patch labels for matrix (not reservoir) patches, due to profit motives rather than safety. [28:52]
Direct, irreverent, science-driven, anecdotal, and occasionally wry—Dave is careful to distinguish his advice as non-medical, biohacker-to-biohacker, with a focus on empowering informed, safe experimentation rooted in current research.
Ideal For: Anyone curious about nicotine's role in nootropics and anti-aging, concerned about Alzheimer's risk, or seeking actionable, up-to-date biohacking insights.
[End of Nicotine Masterclass (pt. 1) summary]