The Skinny Confidential Him & Her Show

Episode: The Key To Eliminating Inflammation, Supplement Quality, & How To Perform As Your Best Self
Guest: Angelo Keely (CEO of Kion)
Hosts: Lauryn Bosstick & Michael Bosstick
Date: October 31, 2025

Episode Overview

This episode marks Angelo Keely’s fourth deep dive on The Skinny Confidential Him & Her Show. Lauryn and Michael invite Angelo, CEO of Kion, to break down the foundational basics of supplementation, with a focus on how to reduce inflammation, why supplement quality matters, and how to build daily routines that support optimal health and beauty over the long run. The discussion is packed with actionable science-backed tips, supplement myths, and the critical ways basic habits and a simplified supplement stack can profoundly impact wellbeing.

Key Discussion Points & Insights

1. Why Omega-3s Are Essential for Lowering Inflammation

• Angelo: “There is nothing nutritive that you could add to your diet that would lower inflammation in your body than omega 3s.” (04:30)

• Omega-3s (specifically EPA & DHA) are crucial for:

  • Brain and heart health
  • Flexibility of red blood cells (improves cardiovascular health)
  • Lowering chronic inflammation—reducing risk for heart disease, diabetes, dementia, cancer, and even supporting skin, hair, and nail health

• Memorable Metaphor:

  • Inflammation = road crew fixing a pothole (ibuprofen just sends the crew home, Omega-3s actually repair the hole) (06:00)

• Chronic inflammation is at the core of most lifestyle diseases and beauty issues.

2. Understanding Modern Inflammation

• Inflammation is the body’s natural healing response, but chronic inflammation results from modern dietary and lifestyle habits, not acute injury alone.
• Angelo: “You can actually look at this thing called C reactive protein levels in your blood… when those levels are higher, you get higher rates of cardiovascular disease, dementia, cancer, type 2 diabetes, all these terrible things.” (10:00)

3. The Most Foundational Supplements—and Why Basics Beat Trends

• “What are the most important supplements that are actually worth taking consistently on a daily basis that I want to take in my own life and I want to give to my family and to my kids.” (14:28)

• Angelo’s List of Worthwhile Basics:

  • High-quality protein powder (sometimes)
  • Essential amino acids (especially leucine-enriched)
  • Creatine
  • Omega-3 fish oil (ideally triglyceride form)

• Collagen is commonly overhyped—not enough research as compared to essentials.

• Multivitamin: Only necessary if the diet is poor in fruits and vegetables.

• quotable:

  • “Rather than someone selling you...this new breakthrough and they’ve got this new study behind it… I look more towards what’s been studied for a long time and clearly has a lot of benefit.” (23:21)

4. Supplement Quality: The Rancid Fish Oil Trap

• Many cheap supplements (especially omega-3s) are either low potency or outright rancid, which can create more inflammation instead of helping.
• Angelo: "If you take a cheap omega...you have, like, the fish burps...if you do that with most omegas, it will taste gross. You'll have this gross fishiness flavor. But then the oxidation thing is like, it creates...more inflammation." (19:20)
• Only purchase from trusted brands with transparent, clean sourcing and high concentrations of EPA/DHA.

5. How To Choose THE RIGHT Omega-3 Supplement

• Fish source: Small, cold water fish (anchovies, sardines) have lower pollutant levels.
• Form: Triglyceride form is 70% more bioavailable than ethyl ester form. (61:11-61:30)
• Non-GMO, third-party tested, free from contaminants and stabilized with clean antioxidants.
• Angelo demos eating a capsule live to show purity and taste. (60:34)

6. Most Common Mistakes in Building Your Supplement Cabinet

• Buying based on Instagram trends, not personal goals or science
• Falling for the latest “breakthrough” versus long-proven essentials (protein, omega-3, creatine)
• Quote: “It's funny, the things we'll spend money on. Sometimes it's like, well, I'll spend money on these certain clothes or car or alcohol or whatever, versus what's actually going to create...the best life for you.” (39:01)
• Opt for quality over quantity; “If you’re going to go cheap, you’re maybe better off not spending the money at all.” (34:39)

7. Dietary Context & Fish Consumption

• American median omega-3 intake: essentially zero.
• Japanese: almost 1g/day, associated with 5 years longer average lifespan (44:09–44:42)
• To reach optimal omega-3 blood levels, you’d need at least 8 servings of fatty fish a week—impractical and costly for most.

8. Omega-3s, Brain Health, and Dementia

• Especially vital in families with a history of Alzheimer’s/dementia—correlates with reduced risk.
• Should begin supplementation early (even from youth), not just as an age-related intervention. (41:44–42:57)

9. Plant Sources Are NOT Enough

• Plant-based omega-3s (ALA from chia/flax) do NOT convert efficiently (~2%) into the critical EPA/DHA your body needs.
• Angelo: “ALA is not the secret sauce that we're looking for. The much higher levels of ALA don't really… have these outcomes that we're talking about.” (66:22)

10. Kids and Supplementation

• Ample aminos are “like the equivalent of their daily protein intake.” (59:54)
• For omega-3s: break open a capsule and mix in food; Kion Omega is clean enough for taste.
• Creatine can be beneficial for kids in modest doses.

Notable Quotes & Memorable Moments

• Angelo:
  • "There is nothing nutritive that you could add to your diet that would lower inflammation in your body than omega 3s." (04:30)
  • “The more that [Omega-3s] make up your red blood cell, the easier it is for that red blood cell to basically be flexible and move around.” (05:27)
  • “I think the biggest risk is that it is already rancid and oxidized before you even put it in your body, and... it has the risk of creating more inflammation.” (19:11)
  • "Ethyl ester is 70% less bioavailable than...triglyceride form" (61:21)
  • "Rather than being some perfect formula... it was more just, what are awesome products that are worth taking every day?" (17:54)
  • “If you wanna put it in your body every single day, like, don’t go cheap on it either. Just like, don’t do it or like, do it, do it.” (39:01)
• Lauren:
  • "You can actually look at this thing called C reactive protein levels in your blood, interleukin levels...that show you exactly how much inflammation is occurring." (10:00)

Key Timestamps for Important Segments

| Timestamp | Segment Description | |------------|----------------------------------------------------------------------------| | 04:30 | Why Omega-3 is the #1 supplement for inflammation | | 06:00 | Angelo’s “pothole” metaphor for inflammation vs. healing | | 14:28 | Why Kion focuses only on essential, proven supplements | | 17:54 | Angelo’s supplement philosophy: “If I won't give it to my kids, we won't make it.” | | 19:11 | Risks of bad omega/fish oil supplements | | 23:21 | How to approach new supplement fads vs. perennial basics | | 34:39 | Discussion on whether to buy cheap or premium supplements | | 39:01 | Why food, not material things/wellness splurges, is the best investment | | 41:44 | Omega-3s and dementia prevention | | 44:09 | Comparing American and Japanese omega-3 intake/lifespan | | 61:11 | Ethyl ester vs. triglyceride fish oil—what to look for on labels | | 66:14 | Plant-based omega-3s don’t cut it—ALA conversion explained |

Rapid Fire: Supplement Myths & True/False

1. All fish oils are the same?

   • FALSE. Quality, concentration, source, and purity vary widely. (65:21)

2. Even heavy fish eaters need supplementation?

   • Depends, but most people aren’t eating eight servings of fatty fish per week. (65:51)

3. Fish oil helps hair growth?

   • YES. Mainly by reducing inflammation and supporting healthy cell function. (66:10)

4. You can get enough omega-3 from flax/chia?

   • NO. Plant omega-3s (ALA) don’t convert well enough to the active forms. (66:14)

5. All fish oils cause “fish burps”?

   • NO. Only cheap, rancid, or poorly formulated products. Quality omega-3s should be tasteless and odorless. (67:51)

Actionable Takeaways

• Prioritize basics: Stick with foundational supplements proven by robust science—protein/amino acids, creatine, omega-3s.
• Spend on quality, not quantity: Cheap supplements are a waste—or even harmful.
• Check the label: Look for triglyceride form omega-3, cold water small fish source, non-GMO, and third-party testing.
• Routine is everything: Attach supplement use to daily habits for maximum consistency.
• Don’t be distracted by fads: New “sexy” ingredients can't match the long-term, widely validated benefits of proven essentials.
• For kids: Focus on quality protein/amino intake and work omega-3s into their diet creatively if they can’t swallow pills.
• Beauty from within: Inflammation reduction and healthy cell function support skin, scalp, hair, and nail health.

Episode Mood & Tone

Relatable, deeply practical, candid, and conversational—Lauryn and Michael’s banter keeps the episode light and personal. Angelo’s science-backed explanations make supplement details clear without being intimidating. The emphasis is always on real results, sustainability, and integrity in wellness choices.

For a full resources and timestamps, refer to the original show notes or listen to the full episode via Dear Media.