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The Bossticks
The Truth About Detoxing, Hidden Environmental Toxins, & Supporting Cell Longevity Ft. David Roberts & Dr. John Gildea Of Mara Labs
00:58:49
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- [00:00]
A
The following podcast is a Dear Media Production. She's a lifestyle blogger extraordinaire.
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B
Fantastic.
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A
And he's a serial entrepreneur, a very smart cookie. And now Lauren Everts and Michael Bostick are bringing you along for the ride.
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C
Get ready for some major realness.
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A
Welcome to the Skinny Confidential him and her. Welcome back everybody to another episode of the Skinny Confidential, him and her show. Today we're sitting down with David Roberts and Dr. John Gildea, the founders of Mara Labs. And today we're talking about how to help the body clean house from the inside out and fight back against hidden environmental toxins like microplastics and other modern disruptors. David founded marlabs after his late wife was diagnosed with breast cancer. A personal journey that sent him deep into the science of molecules and natural compounds to figure out what actually supports cellular detox, brain health and longevity. Joining him is Dr. John Gaudea. He's the co founder and chief science officer at Mara Labs and together they're in creating this incredible company which you're about to hear more about. So if you've ever wondered which supplements are actually worth the hype, how to protect your body from invis stressors like microplastics, how to boost your metabolism without trendy quick fixes like GLP1s. This episode is packed with practical science back insights you can actually use with that. David and John, welcome to the Skinny Confidential, him and her show. This is the Skinny Confidential, him and her.
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C
All right, in this episode we're going to get into microplastics, GLP1s, invisible toxins, inflammation, poor sleep hormone imbalance and detoxing made simple.
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A
Well, allergies as well now that we've.
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C
Oh no, he loves to talk about allergies. Yeah, he loves it.
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A
So where should we start? With YouTube? I feel like we're going to cover a lot of ground in here. We typically just jump into it and go topic by topic. But I guess to start for just to get a brief background on both of you, maybe just a brief introduction on both of you and then we'll dive right in.
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D
Yeah, so my background's in public health and biomedical engineering and basically I've been in supplements for the last 13 years. My late wife Maura got breast cancer and so was sort of catapulted into learning about supplements. And specifically for her cancer, she wanted to treat it integratively and that's how I met John the first week she was diagnosed and we've been fast friends ever since. John's wife had breast cancer and that he helped her treat successfully and she's a survivor. And he was in a kind of a famous cancer lab and knows not only everything about cancer, but everything about natural products in cancer.
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C
So you both have had wives that have had breast cancer?
- [02:39]
D
Correct.
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C
Wow, that is not a fun club to be a part of. I'm very sorry to hear that. When you guys connected, what was the conversation like behind the scenes?
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D
So, yeah, I mean, basically I would, I still have a background in sciences, so I would read about different supplements and cancer and I was like, john, what do you know about this? Is this true? It's not true. That's actually how we, you know, found out about the. I found out about the good molecule in broccoli called sulforaphane that basically John actually grew Mara's cancer cells in our lab and we put 60 different supplements on him to see what killed her type of cancer. And the sulforaphane was number three in killing her type of cancer. So went out to buy it, couldn't find it because it didn't exist because all the broccoli supplements on the market are the precursor molecule called glucoraphanin. And so I was like, you know, we ended up just growing a lot of broccoli sprouts for years. And you know, at the time I had a one and three year old boys. And you know, so you're caring for them. We were growing like enough broccoli sprouts for like the joke is like 10 families. Because it was like an operation. We were juicing them every day. And I'm like, you know, if in the summer sometimes they get moldy, sometimes if you're traveling, you can't take them with you. So kind of John and I were at lunch and I was like, kind of matter of fact, it'd be really nice if there was a stable form of this. So that's the issue. If you basically try to harness the sulforaphane, it degrades quickly. And so you can't.
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C
So how did you know, John? To take the cancer cell, put it under a microscope and look to see what could fight it.
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B
I did that with my wife's cells when this is all 10 years shifted. So probably my background that would help is I. I'm have been in a lab forever, so my whole life last 35 years. And so they don't let me out very often. So this is a nice, nice break for me. I'm just kidding. But so I have a really broad background. I did before my, my PhD. I did germ warfare testing for the army. I did retrovirus testing. So I'm an analytical chemist by training. And, and so I've been in a lot of different places developing tests. And so during my postdoc, I studied metastatic cancer. And then right when I, I would say it was the height of my scientific career, you know, made national news and a couple of papers and things like that found the first metastasis suppressor for, for bladder cancer. And, and right at that time, my wife got cancer. And so I'm doing all this genetic manipulation things and I had to, you know, step back and say, what can I really do to help my wife? You know, I don't have access to genetic modification of my wife, which she's probably pretty glad I don't have that. But. So natural compounds were what I focused on and just went crazy reading everything on it and matching the pathways. They already knew about cancer and then came up with the idea to grow the actual cancer cells. And so for the longest time we did that trying to start a company. So I'm able to grab cancer cells from in a person's blood and put them in a culture dish and grow them.
- [06:26]
C
What kind of pushback do you guys get from the medical community when you come to them and you say that broccoli sprouts is something that helps fight cancer?
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D
Yeah, I mean, you know, the general training for a doctor on nutrition is like something like 30 minutes of their whole four year medical school. And furthermore, they're kind of conditioned that supplements are the enemy. They're worthless. And, and so, but you know, sulforaphane was discovered up at Johns Hopkins and they have a whole chemo productive center there that's based around this molecule. And they have a broccoli sprout growing. Used to actually up until about five years ago, broccoli sprout growing, just operation for all this research. So there are 2,000 research papers on the molecule. So that one is a bit more, it's a bit more efficacious than a lot. But yeah, by and large, people are like, you're crazy.
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A
You know, it's funny, we've done this show for a long time and whenever we have doctors on and we talk about this and many doctors that I guess would come on this show discuss what you just said, they say, you know, you go to medical school or you go through and you don't get a lot of nutritional background or training. And so this show has been labeled in the years if we, you know, if once in a while we get bad press, which is almost never. But it'll say like woo, woo. But I say, you know, like we have real doctors and medical experts come on and say some of this medical training they get does not incorporate some of the things we're talking about from a nutritional supplemental standpoint. It's just you kind of jump into the. All the other things and I would wonder, Dr. John, from your perspective, you know, we've had doctors write in and have problems when we have this discussion. But how what you would say to your colleagues.
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B
Yeah. So the jump that everybody has is from, you know, the type of research that's out there. So if you have a cancer cell from a person, it holds on to its genetic status. And I think that the toughest thing that people run into is that it's very difficult to get any kind of a clinical study done with the natural compound on something like that. So there isn't the placebo controlled trial where a doctor is used to looking to find out, yes, this is legit.
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A
And why is that hard to. To get done?
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B
There's no funding. Who's funding?
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A
Because it's natural.
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D
Because it's natural.
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A
There's no money.
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C
Yeah, you mentioned something. You said that when you put the cancer cell under the microscope, it was number three.
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D
Correct.
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C
What was number one and two?
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D
The top two things that killed more as cancer were vitamin C was number one and curcumin. So the good molecule from turmeric.
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C
How come everyone can't put their cancer cell underneath a microscope and look what would cure it?
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B
I think that that study's been done so many times that you don't have to do it again. Like when you take a cancer cell and you get the concentration of vitamin C above a certain level, close to 1 millimolar, it's really high. That cancer cell dies and a normal cell that's right next to it in the dish doesn't. It's like the most selective cancer killing molecule ever in history. Just whether you can get that concentration to the cell that's the skinny of it is funny was the.
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C
That's amazing.
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B
Didn't even try. But the, the, the those molecules, if you get it to a particular concentration, it does activate the, the pathway. Pathways that they're known to, to activate. So if you get it to that concentration, it does that thing.
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A
So from everything you've learned and everything you guys have discovered, I think a lot of people are wondering like what are you the main contributors to cancer or what are the main lifestyle factors? Is it genetic? Is it, lifestyle, is it what you're eating? Is it where you live? You know, like, there's. I think so many people are so scared of cancer because they don't quite know what cause. I mean, we have ideas like, you know, like, if you eat bad foods or. But are there certain things you guys have discovered that make somebody more likely to get cancer compared to others?
- [10:54]
D
I think it's pretty simple. I mean, you can look at it the flip side, right? Instead of like, what causes cancer? What, like what. How do you just maintain your health? And I mean, I didn't come up with this saying, but I use it frequently as exercise is king, nutrition is queen. Together you have a kingdom. And if you're exercising, you know, regularly, vigorously, some cardio, some high intensity interval training, some resistance, you know, training, and then you're eating well, then it's. It's not, it's not, it's not magic. You know, I do get asked like, what. What's the top food you suggest avoiding? And. And I. But just without a, without a hesitation. It's high fructose corn syrup. So it's the corn that's genetically modified to receive Roundup. And that active ingredient in the Roundup is glyphosate, which is just awful. And you know, a lot of basically all the genetically modified foods, corn, soy, canola, those have just very small trace amounts of the glyphosate in it. It's not much, but because it's everywhere, it's in most. It's basically in every processed food. Oh, one version of those, then you're just getting microdosed constantly and that can build up and cause issues.
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C
What I found too, by having someone on the podcast, is that glyphosicate, I
- [12:30]
D
always pronounce it glyphosate.
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C
It's on all oatmeal too. So that's a really tricky one because, you know, you think, oh, oatmeal, it's safe, it's healthy. I found only one brand, I think it's called 1%. And it's the only oatmeal that I have found that's not sprayed with it. It's really scary because you have oatmeal cookies, oatmeal breakfast, oatmeal everywhere. It's really wild.
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D
Yeah. And if you get organic, they by definition of organic, can't spray.
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A
We had a woman on here earlier, before you guys came in, that works with farmers and farmlands. You're saying the problem is sometimes the organic farm is next to a non organic farm. The wind blows and then all of a sudden it's like, oh my God. So it's just, you know, it's we again like we talk about these things all the time. I think the general, the average consumer, the average person of society, it's really frustrating and scary because you are trying to do the thing and then you hear something like that and you're like, well, does this even all make a difference? And so I guess from both of your perspective, what are things that people can do to make sure that they're not exposing themselves to these things?
- [13:38]
B
I think that at least the way I explain it to people, anybody that sits down in front of me, the cancer causing duo is basically, I use the example of Bruce Ames, probably the most referenced scientist in history. He developed the Ames test carcinogenicity test. So he can take compounds and say what causes genetic mutation from that, that's a carcinogen, changes your genome, basically. So he studied that his whole life and, and figured out, you know, all the carcinogens and that's, that's a great thing. We know a giant list of them and they're swimming in everything all the time. So they're everywhere. You think, okay, that's the cause of it. Well, this unbelievable researcher, Bruce Ames, later in life figured out that it was actually not only toxins, it's also nutrient deficiencies. So when you're missing a nutrient, the cells react exactly the same way. You're missing a piece of what's necessary for your machinery to work. Well, and so it's the combination. Toxins mess up the machinery directly, use up extra nutrients to buttress the cell and then you get a nutrient deficiency and both of them together cause genomic instability which is the driving force for cancer.
- [15:01]
C
When you both look back on your wives journey, do you both think that you know the reason that they got their breast cancers or is that too hard to diagnose?
- [15:11]
D
I mean I. So you don't know, but I could guess. Very.
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C
Take a guess. I want to ask.
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D
Yeah, so she was a night nurse and so night nurses are known for getting breast cancer because of melatonin issues. So that's one.
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C
So you're not exposed to the sun like a normal person and your circadian rhythm's off because you're awake.
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B
Yeah.
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C
Wow. I've never thought of that.
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A
See that in shift workers as well.
- [15:36]
D
Shift worker. Yeah. We won't like with our company, we won't let, we will never have a night shift.
- [15:41]
C
Wow.
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D
Because of that, because it's so unhealthy.
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C
So you think that was one of the reasons.
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D
It's one of the reasons, you know, early on in. So the other, like, another one is if the breast is mashed, that's known to cause.
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C
I'm, like, checking my bra, because the bra. If the bra is too tight because the lymphatic system isn't getting the circulation around the breast because it's too tight.
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D
Yeah.
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A
The baby would be against the chest.
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D
No, honey, it could be bra. It could be like. There's a study in England where women actually got crushed. The breast got crushed through an accident with the steering wheel. And, like, a good amount of them unknowingly had, like, after they died, had breast cancer, like, years later. But Mara actually had. She had mastitis when she was breastfeeding and had me work on it to kind of get it unplugged. And so there was some mashing there. And I think. I mean, John would agree with this. He talked about two things, but I think stress. Stress is a huge cause of cancer. In fact, you know, no, typically you're not born with cancer, right? And so you have. It could be physical stress, it could be emotional stress that play a part in expressing genes that would otherwise be hidden.
- [17:05]
C
But when you say that squishing the breast can cause breast cancer, my first thought goes to a mammogram. That's what a mammogram does. And your smile. And a lot of people smile when I ask this question. It's almost. They give me a look like, I'll tell you off air.
- [17:22]
D
No, I'll tell you right now. I mean, you know, we could tank the episode, but yeah, a great alternative to that. So basically, with mammogram, you're irradiating, which causes cancer. You're crushing, which causes cancer. Okay. Just to get an image. You can get an image of your breast with an ultrasound. All you have to do is ask. And most people don't know that they can ask. And I guarantee you they'll look at you like you have no idea. They have no idea what you're talking about.
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C
They already did. I asked.
- [17:52]
B
Oh.
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C
I mean, there's.
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A
There's been a full, like, article on this show. When we had somebody on who said this very thing and she was in the middle.
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C
So. So when they look at you like you're crazy, what do you say?
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D
You say, no, I would like an ultrasound. I do not want a mammogram. And then they can keep it up, and you keep it up and you win.
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C
So why do they continue to do Mammograms, if that's squishing the breast, from
- [18:12]
A
a doctor's perspective, how does, if, if, if you can say that from a, I guess a factual basis that we know these, not a mammogram, but from a squishing and a radiation could, like, why does it, why do we continue with those practices if another alternative exists that is effective?
- [18:28]
D
I mean, it's more. The ultrasound is pricier. And, you know, I think also, like, there is, you know, from a kind of a public health standpoint, there is a point where it may make sense even with the risks, but at a certain point, women could be in their 40s or certainly in the 50s. It does not make sense to do that anymore. From a, A cost benefit, you get a benefit of the image, but there's a cost because of those two risks.
- [18:58]
C
Do you think it's a little bit like, this is the way we've done it, so we're just going to keep doing it this way because this is the way we've done it.
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B
And they do those, those balancing studies where you, you know, risk versus prevention, you know, where you're, you're promoting it by those two mechanisms. And a long time ago, I would say the data was much more clear because if you did 10 mammograms, then you, you crossed that threshold. That's the general, general idea. And so for people that were really worried, they're doing it very often and, and you cross that threshold and then it increases your chance of breast cancer. But I would say that the good news is that the amount of radiation going into a mammogram and the detectors have improved dramatically. And so now that's good.
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C
It's improving.
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A
You know, I don't know if you guys saw the news with James Vanderbeek. He passed today and he's been battling cancer. Young guy.
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D
I didn't know that. I saw that he passed. I didn't know why.
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A
Terrible. And what some people were saying is that nowadays they're starting to say for men recommending getting colonoscopies or looking earlier. And I don't know. This is a new subject for me. But from what you've learned about cancer, do you agree with that? Do you think people should check earlier,
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C
do you think, or should they do an ultrasound?
- [20:17]
A
Lawrence of the Mind? Sometimes they're like, oh, could that cause things? And I think, again, this is a topic that comes up all the time in private conversations, even on the show.
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C
People are worried. It seems like if something's dormant and you go and disrupt it and you move it around and you squish it and you move it and you manipulate it. That doesn't seem, it seems like hitting a bee's nest.
- [20:33]
D
Yeah, I mean if you, you know, if you don't want a colonoscopy, there are other ways to go about figuring out if you have colon cancer. You can have your feces examined now and that's highly, highly accurate. You can do a blood test now as well. The function, function health blood tests. They have a cancer option.
- [20:56]
A
We've had Dr. Mark on this, on the show.
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C
Dr. John, what, when you look back at your wife's journey, was there things that you think caused her breast cancer?
- [21:07]
B
Thing that comes to mind for me is that there were, there were quite a few things in her life that were very stressful, including me. And so I take self awareness. Yeah, I take a little bit of credit there. But I would say that when you're talking about all those things that you have to keep in mind in order to avoid it, that wasn't on her mind. So she taught at a prep school and ate the food that they produced for the whole time before she had cancer. So that was 15 years or so, 17 years of that type of food where she didn't get to make a choice about her food, food choices and, and then stress on top of that. Being a very go getter type person. Yeah, she was top of her class and always go, go, go as a teacher as well. Super stressful. So I, I definitely agree with the stress component and I think the connection to stress a lot of people don't realize is how much downstream effect that has. Like stress releases cortisol, one of the many stress hormones. And, but then that raises blood glucose. So then your blood glucose ends up being a toxin. So your, your blood glucose being high causes these things called advanced glycation end products. And so you're doing the same thing that radiation would do. It's randomly damaging things. And so that's why you want your insulin low, you want your blood glucose low. And especially at night before you go to bed, because if you eat right before you go to bed, your blood glucose will go high. Melatonin turns off your insulin and that, that high blood glucose just sits in your blood all night glycating.
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A
So it's another reason you don't want to eat close to bedtime.
- [23:02]
B
Right.
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D
Or if you do take, I mean, because sometimes you can't help it. Right. That's why we have a berberine product that specifically we're like Take two at night because. So it deals with. In case you eat late. But berberine is also great for sleep. There's a paper how berberine outperforms Valium as a sleep aid.
- [23:21]
C
I also have heard that Berbene. How do you.
- [23:24]
D
Berberine.
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C
Berberine has similarities to a GLP1.
- [23:28]
D
Yeah. The social media loves to say berberine is nature's ozempic, which I guess we may, depends on the day whether we agree with that or not. But today I'd say, yeah, sure, we'll agree with it.
- [23:43]
C
How is nature's ozempic?
- [23:45]
D
Yeah. And so what are you.
- [23:47]
B
Yeah, me too. So this one, without getting too technical, is berberine is known to induce GLP1, which is the hormone that does the satiety piece for. For, you know, blocking your eating. So it slows down digestion slightly. So berberine, the easy way to understand what berberine is, it's a. It's a fasting mimic. And so when you fast, GLP1 goes up. Same with taking berberine. They're kind of. You can look at them the same way. I'm not sure if you've ever done this, but when you fast for a while, you stop getting hungry. That's part of that. That natural process where you just stop wanting to eat. And the whole business behind the drug versions of that, they're fantastic for people that are very much overweight and need to lose a lot of weight. We would never go against a person's choice to do that. But when you do that, a very large percentage of people have digestive problems, and a lot of that comes from gastroparesis, which is the slowing of the emptying of your stomach. So you feel full because you eat and it just sits there. So. And then it slows down your gut motility as well. So the moving of food along your elementary canal changes as well. And the reason why it does it so strongly is because it's a drug. It goes to. It goes to your. Your brain, basically, and initiates all of those downstream effects. And I often call it a hammer. So if you're. If your endocrine system is kind of like an orchestra or a piano, you want to play a beautiful piece where there's a lot of strings being played and there's resonance and they're readjusting with each other. And often when you intercede with something that's like a GLP1 agonist, that stays on, it goes on, stays on forever. It's like playing the piano with a hammer. Um, and so it's not pretty. It gets the job done, it does what it's supposed to do, but it's not how you're supposed to be interacting with your endocrine system.
- [26:03]
A
So for the average person that maybe just wants to lose a little bit of weight or tighten up, instead of jumping to that, you could jump into something like this and achieve some of the same effects that that drug is doing. But without going straight to the brain and taking to your words a hammer to it, you could go, you could take a more natural approach to that same kind of GLP1 production.
- [26:20]
D
Exactly. Yeah. I mean, the other issue with GLP1s, again, they work for a lot of people, but there's the muscle wasting side of it. And so one of our Partners is a MD and he was like, Guys, let's develop a GLP1 alternative. Not necessarily as a substitute, but if people come off of GLP1 because they get sick and they can't eat, or let's say they lose their insurance and it's expensive, you know, having an option. And so we, we came up with one that has berberine for that reason, but it also has green tea extracts called egcg and that turns off your hunger hormone ghrelin. And so you have the same satiety issue or effect as GLP1s, but instead of maybe not being able to eat because your gut is full, you're not hungry, so you don't have like the incessant snacking, but you can eat because your, your gut's emptied. And John, maybe you can touch about this about the myostatin.
- [27:24]
B
Oh. So the biggest problem a lot of people, at least health influencers have with GL GLP agonists and is, is that they make you lose muscle weight. So that was the primary reason of how we formulated it was myostatin. A lot of people know what myostatin is by the fact that there's these cows or dogs that look like Arnold Schwarzenegger. They're just super muscular. That's a myostatin knockout. And so it's the way that you, if you can inhibit myostatin in any way, you'll make it easier to put on muscle. And so one of the components in RGL Perfect is called ec, one of the sub components of green tea. And it actually directly reduces the expression of myostatin. So there's that angle. And then berberine itself increases a protein called follistatin, which it then inhibits. Directly inhibits.
- [28:32]
C
I'm sold myostatin. I'll take two right now.
- [28:34]
A
So the intention is. The intention is that you could increase GLP1 production naturally, but also not trigger the massive muscle shedding.
- [28:42]
D
Not just. Not trigger it. It's protective. It increases.
- [28:45]
C
It's not my first meal. It says to take one with my first meal. Can I take one now?
- [28:49]
D
Can you take two?
- [28:49]
C
Take two now.
- [28:50]
D
Yeah.
- [28:52]
A
Okay. Wow.
- [28:53]
C
Interesting, guys.
- [28:54]
D
Jeez. It's awesome.
- [28:56]
A
So for somebody that is worried about losing muscle mass, they could take this and guard that.
- [29:04]
D
Yeah.
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A
And then still achieve the GLP1 production that they're looking for. Interesting.
- [29:09]
B
It's more like the, the piano concerto where it's not a, it's not a hammer, it's. It's cycling like GLP1 is close to.
- [29:17]
C
It's not like a heavy pill. It just goes down real quick, easy, efficient.
- [29:21]
A
So microplastics and invisible toxins. Are we living in the most toxic time ever or is this just what people.
- [29:26]
C
Are we really swallowing a credit card a month?
- [29:30]
D
Yeah, that's a great question. Hopefully not, but some people certainly are. I mean, I'd say it's a pretty easy. Yes. As far as being the most toxic. And it depends on where you live. Right. If you're in the city. Yeah. If your municipal water is chock filled with stuff. And then if you're in the country and you're on a. Well, maybe less. But I mean, microplastics, a huge issue that are everywhere. We just touched on glyphosate, Huge issue that's everywhere. And you know, they're, they're, they, you know, are big, big problems.
- [30:06]
A
And so what do you guys think about in terms of guarding yourself or ridding yourself of these microplastics that we're exposed to on a daily basis?
- [30:13]
D
Yeah, I mean, I think, you know, to just take a step back, you know, micro. What are microplastics? They're micron kind of microscopic sized plastic particles, even nano sized, so even smaller, that can be in your. The liquid you drink, they can be in the food you eat, they can be in the air you breathe. In fact, most of our exposure comes through air.
- [30:36]
C
Oh, wow. I did not know that.
- [30:38]
D
Yeah. And so, you know, if you want to start thinking, okay, what are some things I can do to mitigate to lessen microplastic exposure? First thing would be, are you microwaving your foods in plastic? That heating of the food, that plastic can leach into the food. So frozen dinner? No, no. If you have a. Reheating your dinner, put it in a Tupperware or a ceramic, put it in metal Reheat it. That way it's easy, it takes a little bit more time, but you're not going to get the same.
- [31:15]
C
Do you know what I did?
- [31:16]
D
What?
- [31:16]
C
You don't even know this. In my microwave, I have a note, a post it that says, don't even try it.
- [31:24]
B
Thinking about it.
- [31:24]
C
So anyone that opens that, because you're not opening that, it says, don't even
- [31:28]
A
try a big microwave guy.
- [31:29]
C
Good. I don't. Don't even try it. And our new house. I'm taking the microwave out of the house.
- [31:34]
A
Well, the question is like, you know, I mean, I think we, you know, we jumped into these easy, convenient things. We've done that with a lot of different human technology.
- [31:40]
D
Sure, but.
- [31:42]
A
But to your point, you can achieve the same result maybe not as quickly, but with the same effect in a. Maybe a healthier way with other cooking methods in heating.
- [31:50]
D
Yeah, but I mean, there are things like. Do you know those shiny teabags that are like the pyramids?
- [31:57]
A
Yep.
- [31:58]
D
So those are made of nylon. And those. Just one teabag, one drink can leach up to 2 billion microplastics.
- [32:09]
C
This is why I use peak tea. Code skinny. I use my ginger peak tea. You just open it at the top and pour it in. And then I also have loose leaves.
- [32:18]
A
Right.
- [32:18]
C
No, you just. It's like it's all squished up.
- [32:22]
A
That's what I'm saying. It doesn't sit in the pot.
- [32:24]
C
No, you just pour it in and it's. You're so right. You really, you have to be, I think, your own, like, investigator. Even in the baby bottles. I was looking at my son's bottle, it's glass, but there's a plastic thing in it that he's drinking every day. And when that heats up because we heat his bottle, I'm like, wait, that's heating up the plastic thing. So now I'm like, I told my nanny, I'm like, please just. Just do it room temperature. And that's what Michael and I are going to do too, is room temperature. Because it's. You really just have to look at every little thing you're doing on a daily basis.
- [33:00]
D
Yeah, I mean, we just. Another great example, we're at a hotel and there's a plastic water bottle next to the coffee maker which has a plastic pod which has paper cups, which is good. Right. But those paper cups are lined with plastic. And so just the simple idea of drinking a coffee, you're getting three different exposures.
- [33:22]
C
And then you put the straw in the hot coffee and you drink it out of the straw. I mean it's on and on and on. Yeah, I think that you do have to take a self inventory though. You can't expect other people to do it for you because clearly that's not happening. You have to just look at your own habits.
- [33:37]
A
So this topic is obviously becoming more prominent and I think more it's being received now in a different way. But you know, when we started kind of having people on and talking about these subjects four, five, six years ago, you catch a lot of flak. Are you guys starting to see people in, I guess the medical and community, scientific community be more open to this perspective? Because I, I'll just tell you like, you know, we've, when, when I say when I'm joking about press, like I would say even the, the mainstream media sometimes when you say things like this you get these kind of like bad articles or bad headlines saying like oh you're fear mongering or you're you know, this or that or woo woo, no science. And, and so I wonder how, how you guys respond to that now as these conversations become more prominent.
- [34:20]
D
Yeah.
- [34:22]
B
From my perspective, when you pull all those pieces together and then knowing what it, how it works inside your body, I'm pretty confident I could scare just about anybody about them being inside your, inside your body and pretty convincingly, even though it's a new subject. So the way I usually start talking about this is that you know, a long time ago everything started being made from plastic. Right. And they said it would last forever and then now we know it doesn't like anybody that has put some plastic outside, you see, it degrades. So the plasticizers that are in the plastic used to be thought of, that's what the bad stuff is. There's endocrine disruptors in there and all kinds of things like that. But as that as those plasticizers that make the plastic soft leave, they become brittle. So anything, wind, abrasion time, they become smaller and smaller and to the point where the whole crust of the earth is covered with microplastics. And so you stir that up, breathe it in, gets in your food, gets in your water. It's, it's sort of everywhere. So you have to do something related to that to, to decrease your, your burden. And so a good way to start that is where's the, whereas the first one, the highest dose that's coming around, if you're outside, it's not that high. If you're indoors, the indoor microplastics is the biggest problem. So Getting a HEPA filter in your air, especially where you sleep is the most important thing. Should be the first thing you do. And then your water. What's the best water? Water is, you know, Ro water has no microplastics in it at all. And so you just think about reverse osmosis filter.
- [36:10]
C
I'd like one of those. What's the best brand?
- [36:13]
D
There are a number of. Good one I would just. I would source.
- [36:16]
A
You have a reverse osmosis filter on the house?
- [36:18]
C
We do.
- [36:18]
A
Do you even know that?
- [36:19]
D
No.
- [36:19]
C
No.
- [36:19]
B
Man, that's good.
- [36:21]
D
Say, who brand do you have?
- [36:22]
A
I don't know. It's one of those big. It's like out on the. We did the whole thing.
- [36:27]
B
Whole house already.
- [36:27]
C
Yeah, we did.
- [36:28]
A
Wow.
- [36:29]
B
Okay.
- [36:29]
C
Wow.
- [36:30]
D
That's interesting.
- [36:30]
C
I want one.
- [36:30]
A
Well, so we get to. We have the privilege of talking to people like yourself and I feel like we take little chunks. So we had a person who builds air filters named Mike. Just nothing but, you know, Mike from Jasper. So he's been on. We talk. We have a guy that does nothing but test homes and he tests the air and the air filters. We have, you know, the water guy. Like the paint, like even non toxic paints. And so you kind of pick up these things along the way. And the way that I look at it now, because I was a skeptic for sure. Like I grew up in the typical 90s household with all of the. The clean Windex for breakfast. Yeah, it basically got sprayed in the face of Windex before school, tied for lunch.
- [37:07]
D
But frozen dinners, TV dinner.
- [37:10]
A
Over time you start to look at these things and you're like, okay, I have not been able to see the downside in making these swaps. It's like, yeah, what's the harm in having a great AR filter? Why would you not want to clean your ventilator?
- [37:21]
C
But don't you notice that your nervous system is more relaxed since making the swaps? You have to admit it.
- [37:26]
A
Of course. I mean even the cleaning supplies in our house now we use this company called Branch Basics and things like that.
- [37:32]
C
But every idea he just said is my idea. That I've manipulated him too.
- [37:36]
A
Sure. But it's.
- [37:37]
D
That's the beauty of it. Right?
- [37:38]
A
But it's, it's his idea from. And what I, what I tell people is it's not like I'm not scared of the air and I'm not scared of living, but it's this cumulative effect. And so I said if you can remove all of these things and slowly start to add in better Alternatives. It just, the way I think about it is like you're just at such a greater advantage than someone who's maybe not doing those things.
- [37:57]
D
Absolutely. Yeah. And I think it's, you know, you look at just again, public health, the puberty age of girls has gone down. You know, it's, they're a lot younger and for boys, it's. They're older, you know, and it has to do with the fact that people have these microplastics. You can't get rid of them historically. And, you know, the microplastics aren't inert, they're like sponges. So they have toxins in the microplastics. And they could be, it could be like the plasticizers. And probably a lot of them are. They could be metals. And so, you know, let's say you're backed up with these microplastics and the sponge has some of these estrogen mimicking compounds. I mean, it's not rocket science that if, you know, if you have all these estrogen mimicking compounds, a lot of them in your body, that it's sending signals, hey, it's time for puberty, when it's not actually, and I look at it, the hormones are signaling compounds. Estrogen is a signaling compound. It's like you're watching two TV shows on top of each other. You can kind of see maybe what the TV show is. You can recognize some characters. You're not going to know what the plot is. You're not going to be able to understand it. And so it's similar when you have a body that's filled with microplastics, that's some of these BPAs or estrogen mimic compounds are leaching out, that there's this disruption. I mean, and women, even with irregular menstrual cycles, it's another issue.
- [39:45]
A
Do you think over time, future generations will adapt to these microplastics and that our bodies will be able to build them, or do you think it's just going to.
- [39:54]
D
No, because, I mean, what happens is basically you ingest them, they get through your gut lining, they get engulfed in this, I call it the garbage disposal of the cell called the lysosome. And the lysosomes are great at degrading stuff, just not plastics, because they weren't designed to, to degrade plastics. And so you get these buildup of these lysosomes with microplastics in it. And so that was why, like that last about a year ago we were talking about, because our sulforaphan products so good about detox. We're like, I wonder if it's. It would work with microplastics. And so before we could do anything, this guy, this researcher in the Midwest, we read about it a couple months later in June, he did a study and he showed that basically taking our form of sulforaphane, basically mobilized the microplastics in his blood. And so he. I think there's only one microplastics blood test. It's Brian Johnson's test. And he did that test, and they said it was the highest blood microplastics level that they had ever measured up to that time. And then, you know, a day later, it, you know, he did it in stages. A day later, this research. Yeah, yeah, yeah, the guy who did the research. And so, you know, it's. Being able to mobilize the microplastics is the first step to getting them out.
- [41:23]
A
And so when you mobilize them, and this may sound like a very dumb question, where do they mobilize to and how do they come out?
- [41:29]
B
So that series of events is not to get into the weeds of how it does it, but basically sulforaphane turns on a switch. It's known to be this thing called mucolipin that makes the lysosome fuse with the membrane of the cell, and then it just dumps its whole contents outside of the cell. So the only way to move that then is lymphatics. So you can imagine what then gets that out of, you know, the tissue and into the circulation. And so from there, it's still a mystery where. Where it leaves in urine, feces, or skin. And so that's still unknown.
- [42:08]
C
But is there anything you can do to support getting microplastics out in a way that's like, what's the most efficient way to get them out?
- [42:17]
B
So our. Our broccoli product is maybe not as well known about this, but it has stabilized sulforaphane in it, but also has a. Another compound in it called P EITC it's the active ingredient in watercress. And so those two together are synergistic. And so they actually make a bigger punch than just sulforaphane alone, even though that has a lot of punch. So we think that it's that combination that is actually mobilizing that. That plastic and getting it out of the cells. So that's the first step. And then I usually talk about you want to do a one, two punch for the cell itself before you get into the. To how you get rid it from your body. The second one is resveratrol. So we have a really high bioavailable resveratrol. And the analogy there is that it's like upgrading your sewage system. It's like making bigger pipes, it's making a bigger toilet, maybe a professional flush kind of thing. And so sulforaphane gets it out of the cell. And because it's a moving system, it's accumulating there, especially as you get older, because those lysosomes aren't as prominent. So you have to do both. You have to make more lysosomes, you have to make them bigger and stronger, and you have to move them more. So when a cell gobbles up a microplastic, you want better plumbing to get rid of it, to get rid of everything else. Because when you, when you plug it up with a microplastic, all these things that it's very easy to scare someone. But basically, misfolded proteins that are normally degraded by, that are stopped. And so Alzheimer's is a misfolded protein problem. And even worse than that, these misfolded proteins, instead of going into the, into the lysosome and getting degraded, is shuttled out another system called exosomes. And so those misfolded proteins are being shed out in a way that they can infect, transfix other cells. So it's. It's a really bad problem. And so the one, two punch of resveratrol and sulforaphane gets it mobilized.
- [44:33]
A
And then, so if, if we were, if we were, for us personally and for our audience, viewers and listeners, if we were to come to you and say, okay, we want to do this detox protocol with your products, what is the timeline? And I guess what you guys would advise us to do, if I came to you and said, okay, I'm ready to start this, is this a thing you take for a couple weeks, couple months? Is it a couple days? And what will we notice? And how are we going to set ourselves up for the most success if we wanted to do this detox? And then second part of that, and this is just a caveat, is is there any downside for just doing this? Even if you just like, just for anyone to do it, like, you just jump in. And even if you weren't worried about heavy metals.
- [45:15]
D
Yeah. I mean, so the first step would be mitigation. So you actually, you have to decrease your exposure. Right. Because John, what John said, if you're, if you're bringing in more than you're excreting, then you're still behind. And so drink your water, get your air, filter those, you know, those would be two steps.
- [45:34]
A
Clean up your lifestyle.
- [45:35]
D
Clean up your lifestyle. Yeah. And then you have clean food. And then, and then, you know, take the, the broccoli reserve elite. Do lymphatic drainage. You could just do a rebounder. You could just walk.
- [45:48]
A
She loves lymphatic drainage.
- [45:49]
C
I have a dry brush. He asked me what my weird device is that I just got in. I shake on a vibrating plate every morning.
- [45:55]
D
Vibrating plates, power plate.
- [45:58]
C
Oh, my God, just listen to your wife.
- [46:00]
D
So.
- [46:00]
A
But I'm okay. So. But if I'm taking your product.
- [46:03]
D
Yeah.
- [46:04]
A
What's the protocol to get started?
- [46:06]
D
Yeah. And so protocol would be lifestyle cleanup. Your lifestyle. Then you can just, you know, we haven't honed in on the exact measurement, but like this guy took, I think 100 milligrams. Our daily dose suggested is 10. He was like, you know, that would probably do it. So two capsules a day of the, the broccoli. Two capsules a day of the reserve elite would be. You could do that for a week and you'd have. Be well on your way again.
- [46:40]
A
And what would you feel once you do have you. I'm sure you guys have done it. What, what do you kind of notice?
- [46:45]
D
I mean, I, I haven't like, sat and been like, oh, you know, I, I have less estrogen mimics in my body.
- [46:53]
A
So there's no, like, there's no. You don't get like sick or feel like you're.
- [46:57]
D
No, it's the beauty of the sulforaphane is actually works in all three phases of detox. So basically the detox flu that you get when you get sick is. And this is. Most of the detox programs are just heavy. They're just pulling the, like, putting the pedal on the metal to phase one. And so you're mobilizing all these toxins, but you can't get them out of your body. And so it's. Yeah, you get sick. And so broccoli, actually, the sulforaphane, it actually slows that first phase of detox. And it's the best phase two, detoxify of any natural compound. So it speeds that up. And then step three is excretion.
- [47:35]
A
Is there side effects of taking this? Do you.
- [47:38]
C
He wants to know if he's going to shit his pants?
- [47:39]
A
No, no, no. I just want to know, like, as you're going, you know, like, for example, like, if you. Well, I always want to know that, to be honest. But if I'M just asking, like, is there. Is there. Can you overdo it?
- [47:49]
D
Yeah. So yes or no? No, you can't. It's not like if you take too many Advil, it's gonna. And that, in fact, they're protective of your kidneys and so that you can't overdose that way. About 10% of people who take it, especially early on, can have a little nausea. So that's why we suggest taking it with food. We think that there may be some issues with your microbiome shifting and die off of bad bacteria. So.
- [48:19]
A
Okay. The reason I asked is we were talking about GLP1s and those things earlier, and I think in some cases, people can overdo these things.
- [48:24]
D
Oh, yeah, right.
- [48:25]
A
And that's why I just ask.
- [48:26]
D
Yeah. I mean, our. Our Geoperfect, we used to be three capsules a day. We dropped it two after I did. My blood sugar's typically under 100, and this one day, it was 115. I took three capsules and just. Just sat. I just sat and typed for two and a half hours and. And I took it again, and it was 70. I'm like. And I'm like, that's a lot. Like, that's too. You know, unless you're keto adapted and can use ketones as fuel, that. That's enough. So people could. May pass. Maybe pass out. And. And so, yeah, you. Those are like Geoperfect. You don't want to just keep taking because your blood glucose will drop.
- [49:03]
C
I feel like I've gone to Harvard in this conversation.
- [49:07]
D
You know, that's a good thing.
- [49:08]
C
Yeah. You know what's crazy is whenever I go to the farmer's market, I'm drawn to the microgreen booth.
- [49:15]
D
Yes.
- [49:16]
C
And I always get the broccoli sprouts to put on my eggs. But if I go and I buy these sprouts, can I just shove it in my mouth or is enough to put it just on your eggs?
- [49:27]
D
Oh, yeah. So two of our capsules is the equivalent of five pounds of mature broccoli.
- [49:34]
C
Oh, my God. You guys are packing it all in because.
- [49:36]
D
Which you would. And then it's two and a half ounces of sprouts.
- [49:40]
C
The guy who's behind the booth is always trying to tell me all the medicinal benefits. And I feel bad for him because everyone just walks by his booth because they think it's just, like, little decoration. And it's too bad. I'm go to this guy. I want to post him or something.
- [49:54]
D
Microgreens are superfoods. So, yeah, superfoods they're nutrient dense.
- [50:00]
A
She just walks by the guy. I spend a lot of time talking.
- [50:02]
D
You do, you're the one.
- [50:04]
B
So think about eggs. You were talking about eggs in your morning. So that's, that's a single food that can raise a whole organism. So it has everything. It's like a very easy to think about that. So a seed is the same thing. It has everything in there to grow a plant. And so when you, when you in. In the seed world, there's a lot of things in seeds that inhibit, you know, it, it from growing. You have to start it from growing. And that's why the, the issue with sprouting is that it inactivates a lot of anti nutrients in there. And so. But you have the same thing seed like an egg or for, for kids milk. It's a single food that can sustain all of, all of life and growth. It's. It's for sure the most nutrient dense food.
- [50:47]
C
Can you guys make a kid's version so we can sneak in? Because it's very.
- [50:51]
D
We have a kid's version. In fact, you should have.
- [50:53]
C
Can I have the kids version?
- [50:54]
D
Yeah, it's. You have it.
- [50:56]
C
Okay. I have inside.
- [50:57]
A
It's here in this office.
- [50:58]
C
It's here in this office.
- [50:59]
B
You know what I always called it baby broccoli, but it's actually children's broccoli.
- [51:03]
D
It's name. It's children's. And so the issue is like John mentioned attaching the. Adding the P EITC from watercress and that's basically one plus one equals five. It's like five times the effect. And so some adults can't take it, some kids can't take it. And so we just have half the amount of sulforaphane. It's much more gentle. And so that's the kids version.
- [51:26]
C
I think there's sticky fingers going on in this office. It may be because it's like where's my. I want. I want my. Yeah, I want that and I want. I have my GLP1 perfect or GL perfect.
- [51:42]
A
She comes home and starts explaining all these stuff but she, she pronounces it in the ways and I. So I get lost.
- [51:49]
C
You admitted on the show in front of everyone, you are like, oh, she was right. The vibrating plate, she was right. The dry brush, she was right. The micro greens at the photos.
- [51:58]
A
What I realized about her is that she's just way more open to these conversations earlier than most people. What we find doing this show, especially like family members is there's A lot. Even to this day, there's a lot of resistance around a lot of these subjects.
- [52:11]
D
Sure.
- [52:11]
A
I mean, it took me 20 years to convince my dad that Diet Coke was, in fact, not very good for him. He's still.
- [52:18]
C
He's still two doctors that are sitting here telling you he's a cancer. Cancer expert, saying that this specific.
- [52:25]
D
I just play a doctor on tv.
- [52:27]
A
He would listen. Obviously, you know, you don't want to have too much fruit juice in the morning with the sugar. But my dad would sit there and tell me for years that organic orange juice was worse for me than Diet Coke. And we had to listen. He's now backed off. But I think, like, a lot of that generation comes from, you know, they're like, well, we've had these cleaning supplies, and we've had these plastics, and we've had these sugars and these. These chemicals. And it hasn't caused problems. But I think that's. That narrative is kind of breaking down
- [52:56]
D
a little bit now, I have to say. Since you mentioned micro microgreens and farmers markets. I told my boys this was six years ago that before they got a cell phone or a driver's license, they had to have a profitable business. And so they latched onto microgreens and started making microgreens for restaurants in Charlottesville.
- [53:18]
A
That's a really good idea.
- [53:19]
C
What a great idea.
- [53:21]
D
And so they had this thriving microgreens business for years. They retired it last summer, but settled the debate.
- [53:29]
C
Charging your phone in the room.
- [53:32]
D
Well, I'm emf, electromagnetic field sensitive, so the reason I have an OURA ring is I can't do the watches because I can do them for a day.
- [53:41]
C
I can't put anything.
- [53:42]
D
And my wrist hurts. I can't put the phone up to my temple. It hurts, like, now. Does that mean you get cancer? I mean, it's not good for you, that's for sure. And going back to the idea of cancer and stress, I'd say everyone's a little bit different as far as what stress they can. I can clearly cannot take that stress.
- [54:00]
A
Did you see that thing? Do you follow Paul Saladino at all, ever?
- [54:03]
D
I know who he is.
- [54:04]
A
So he just did this thing.
- [54:05]
D
He's not a big Sulforaphane fan.
- [54:07]
A
Okay, well, regardless of that, he did this. He put this post up the other day that I guess The San Francisco 49ers have, like, the most injuries of any NFL team, but recently their stadium was moved next to some field where they have either cell towers, electromagnet. And he says that they're like, he's put a video out of it and I'm butchering it. But I guess from like, torn ACLs or blown Achilles, like, they are like 40 above the average of the entire NFL, and they just move next. That's what you're saying. Like, these things have an impact on our tendons, on our collagen and all these. And so he was basically trying to make the correlation. Like, they do not be the average of what the other NFL teams do. And they're. Right. Their stadiums right next to provocative.
- [54:51]
C
I think you're gonna see an influx of people that are using headphones with wires. And I also think you are going to see. Mark my words, in the next two years, everyone is going to say, charge your cell phone in the other room while you are sleeping. I'm not saying across the room. I'm saying the other room. And we will be doing that in our new house.
- [55:09]
A
I have a cell phone helmet and be fine.
- [55:12]
D
So you can also get, like, what's called a Faraday cage. So it can be, like, even a. Something you can put your cell phone in. And so it's the issue. It's.
- [55:20]
C
My thing is like, can we just leave it downstairs? Like, do you need it?
- [55:23]
A
No, no, I put it.
- [55:24]
D
No, you can actually.
- [55:25]
A
I put it across the room.
- [55:26]
C
Yeah, I think I'm going to take it out of the room.
- [55:27]
B
You can.
- [55:29]
D
Well, what?
- [55:30]
B
Say it. Don't get in the middle of that one.
- [55:34]
D
Yeah, you can actually just wrap it in aluminum foil and it's fine. It will. It'll mitigate all of the electromagnetic.
- [55:40]
A
Have you ever seen Better Call Saul?
- [55:41]
C
I'm in the hat.
- [55:42]
A
The. The Breaking Bad.
- [55:43]
C
I'm in the aluminum hat.
- [55:44]
D
No.
- [55:44]
A
Oh, you should watch it, because there's, like, the brother in Better Call Saul. He, like, is in a full tinfoil.
- [55:49]
C
Like, I should be him for Halloween.
- [55:50]
A
That's. That's. You're. Well, you're gonna be there in about a month. That's you.
- [55:54]
C
I just think we don't need the cell phone in the room. Put it downstairs.
- [55:57]
D
Yeah, you can do that.
- [55:59]
C
No, I'll get my. How about we.
- [56:01]
A
You were talking about stress. Even if I don't have to hear this, it was just my stress.
- [56:04]
C
Desi Arnaz. I think that's his last name from I Love Lucy. Had separate beds. We'll have separate bedrooms. And you can have your cell phone in yours, and I'll have mine. Be so Zen and peaceful with no emf.
- [56:17]
A
What we're talking. I was saying we're if stress is the number one thing like this, we, you know.
- [56:21]
B
Yeah.
- [56:22]
D
There's a lot of ways you can.
- [56:23]
C
I really enjoyed this conversation, and I could have asked you guys a hundred more questions. So please come back on the show. You're both.
- [56:30]
D
Thank you.
- [56:30]
C
Plethora of information. You guys gave us a code, and that is for the next week. You guys can get an exclusive 25% off at mara-labs.com skinny. You can use code skinny at checkout. And the offer ends March 6th.
- [56:50]
D
Yeah. So it's for a week, and then after that, just instead of 25 off, it's just a standard 15% off.
- [56:56]
A
Okay. So the highlight, though, is if you want to manage your weight and your muscle and detox heavy metals and microplastics, we can do it all with you.
- [57:05]
D
We're going to feel good with the broccoli sulforaphane. It's great for skin as well. Super great for skin. Super great. I would be bald if it weren't for broccoli, because it downregulates the dht, which is the bad form of testosterone, the least balding.
- [57:20]
A
So. Okay, we could have led with that. So this can also protect your hair and. And help your hair growth.
- [57:26]
C
Oh, my God. Get your sticky paws out of my stuff hair.
- [57:28]
D
And it's super great for skin. I mean, we are actually. We have a number of testimonials from not necessarily men, but women in their 70s who are like the old ladies who've lost their hair and they comes back and they're like, we love you so much.
- [57:45]
C
You know, Michael, while you've been over at the pastrami sandwich booth at the farmer's market, and I've been talking to the guy with the microgreens, and he's been saying, why can't I get anyone to come to my booth? He should have a line at his booth. Because microgreens are actually gonna say he
- [58:00]
A
should put his booth next to the pastrami sandwich.
- [58:02]
B
Yeah, maybe then you can eat.
- [58:04]
D
Have that be as a condiment.
- [58:05]
B
That's a good combo.
- [58:06]
D
Yeah. He detox the pastrami.
- [58:08]
C
I hate to say it. I told you so.
- [58:09]
A
Listen, what do I know about health and wellness? But as a marketer and as someone building a business, that guy should go next to the thing that you could put the thing on. Because the problem with just standing there with a bunch of micro greens and it's like, okay, but if it's. And if we're standing next to someone's like, hey, you could put this on this great sandwich or this great treat you're gonna get, then you're like, oh, that makes sense.
- [58:29]
D
Yeah.
- [58:29]
A
What do I know, though?
- [58:30]
C
I'm just gonna take my MARA Labs. Five pounds of broccoli?
- [58:34]
D
That's right. Five pounds and two capsules.
- [58:37]
A
Yes.
- [58:38]
D
The equivalent of.
- [58:39]
C
Geez.
- [58:39]
A
I'm gonna start the protocol and report back.
- [58:41]
B
Awesome.
- [58:42]
C
Thank you.
- [58:42]
A
For sure.
- [58:43]
C
Don't take mine. Thank you, guys.
- [58:45]
D
Thank you both. Thanks so much for having us. It's been great.
- [58:47]
B
Yeah. Thank you.