Dr. Rhonda Patrick (30:21)
Than women with the lowest levels of BPA. This is. I'm citing this one study because the statistic is shocking. Six times more likely. That's a very shocking number. But I just want to sort of emphasize that there's not just one study showing this correlation. This is just the big statistic number correlation. There's multiple studies showing this correlation between higher levels of BPA and, and increase autism risk. There's also animal evidence. So if you give pregnant female mice bpa, if you make them exposed to the bpa, they also are more likely to have pups that are, you know, as much as you can, you know, correlate this autistic, like, behavior in these pups. That's what you're seeing in these pups. Right. And again, this, this comes down to the disruption of hormones. And it's particularly during a very, very important time during development, brain development. And so I mentioned, you know, the aromatase enzyme. A lot of men are probably like, oh, aromatase. Well, that's what causes my testosterone to be converted into estrogen. Right? You do want some amount of estrogen. I mean, biology is the way it is for a reason. Right. And so you don't want to be disrupting this delicate balance between hormones. Things are supposed to be. You're supposed to have high levels of estrogen at certain points and periods of development. And it's actually, we were talking about this earlier. It's counterintuitive because BPA is inhibiting that aromatase enzyme. That aromatase enzyme is important for increasing estrogen, particularly during very specific moments of brain development. And what happens is that estrogen is very important for actually masculinizing the male brain. It's counterintuitive, but it's pretty, pretty well known that estrogen plays a role in actually masculinizing the male brain. And so when you're not getting those estrogen surges during brain development, what happens is the connectivity of the Brain, the wiring of the brain, the structure of the brain isn't quite right. And so that's playing a role in. At least that's what's thought to partly play a role in the increase of autism risk in women that are having these high exposures to bpa. And then again, like I said, it's something that's been shown in, replicated in animal studies, which is nice. Again, going to that totality of evidence when you're like, okay, I'm looking at the epidemiological observational data with the correlation that doesn't equal causation. But now I have a mechanism here. I know that the mice are also better exposed to it. We see the same thing, and then we look at the genetic data. And if you look at genetic data in boys that have dysfunctional aromatase enzymes, guess what? They're much more likely to be diagnosed with autism, especially if they also have an environmental insult. So there's this gene environment interaction when you're already sort of vulnerable, and then you add in that insult and you just, you know, get that plastic chemical. So any sort of aromatase function that they, that they were having as low as it was now is like worse. Right. And so that's like that double whammy sort of effect that's also known to be. To play a role in autism as well. And then there's some interesting data on actually children with autism. This is really interesting. They have some sort of dysfunctional mechanism in excreting BPA. So children with autism oftentimes have like, 15 times higher level of BPA than non autistic children. And it has to do with like, the excretion pathway I was talking about. And it's really, really interesting because this is all connected that sulforaphane supplement that I was telling you about. So this is extracted from broccoli sprouts, the richest source of that compound. Right. That sulforaphane compound has been now used in two different clinical studies, placebo controlled trials, one with children with autism spectrum disorder and one with adolescents with autism spectrum disorder. And they were given this sulforaphane compound or a placebo. And the children that got the sulforaphane compound, it improved the whole battery of tests that they do for the autism array of tests that they do to look at improvements and symptoms. And so it was in two studies that it was shown to improve. And again, I mentioned that sulforaphane helps excrete bpa. Kind of interesting that the autistics are having such high levels of bpa. And BPA also is just disrupting the hormones, right? Disrupting the hormones, causing oxidative stress and stuff. So that I thought that was a very interesting connection between sort of all these pieces of the puzzle that we're talking about, like the plastic chemicals, the bpa, the hormone disruption, and then the autism. And by the way, ADHD is another one that's associated with BPA levels as well. So it's all linked. And you know, there's a lot of underlying, I would say there's a lot of common denominators between ADHD and autism spectrum disorder. I'm like, there's so many different commonalities between the two. I mean, that's why it's a spectrum. Right. You know, and I really, truly believe that first of all, that there's over diagnosis, particularly with adhd. I think that's, that's, you can't ignore it. I mean, we were talking about studies that I, you know, read a few years ago where boys that were born in July and August, you know, these are the youngest in the class, are three to four times more likely to be diagnosed with adhd. There's nothing about being born in July or August that makes you have adhd. You're just the younger boy. And so you're moving around more. You're, you know, the teachers are comparing you to the girls or to the older kids that are a little more school ready. Right.