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Welcome to Breakpoint, a daily look at an ever changing culture through the lens of unchanging truth. For the Colson Center, I'm John Stonestreet. Recently, the New York Times reported that scientists at Columbia University are using a new technology called base editing to alter the DNA of early human embryos with unprecedented accuracy. Here's what the Times said. On the one hand, the technology might one day enable parents to safely repair disease causing mutations in embryos, but it might also be used to select desired traits, a practice that some ethicists have argued is nothing short of eugenics. End quote. Well, these recent approaches differ from earlier gene editing methods like crispr, which removed defective genes, not necessarily improve them. So what the Times is reporting is not just a difference in degree, but in kind, though with the same moral questions that still remain unanswered. As Andrew Walker put it over at world, we should recognize that this technology occupies a morally gray zone. Therapeutic intervention differs from genetic enhancement. Base editing enables both. End quote. Well, neither base editing nor CRISPR will be the last foray into this kind of eugenics. In fact, some of us predicted that the imprisonment by the CCP of a Chinese scientist who used CRISPR a few years ago to modify human embryos was. Was basically a distraction, not really a punishment. And if that was the case, it definitely worked, because the public has moved on. The outrage at the doctor has now died down. His work actually continues, even as Columbia researchers have added a degree of academic respectability to these efforts to edit human beings. And it always goes like this. As one of the geneticists from Columbia put it, we need to have a public discussion about gene editing. Really? Do we before or after we do it? Note, these scientists are behaving as if the moral questions are settled or at least somehow a matter of personal interest and preference. And all that's left now is to discuss how best to use the technology. Both history and the Bible warn what happens when our technologies outrun our ethics. Many have now forgotten the US Supreme Court decision in Buck v. Bell. When caught up in the euphoria of the Progressive Era's zeal for scientific improvement, Justice Oliver Wendell Holmes spoke for an 8:1 majority and upheld a compulsory sterilization law of the mentally disabled. The aim of the law was, the court said, and I quote, to prevent those who are manifestly unfit from continuing their kind. According to Holmes, in the case of Carrie Buck being sterilized, and I quote again, three generations of imbeciles are enough lawyers representing the Nazis at the Nuremberg trials after World War II cited that opinion from Buck V. Bell to justify their own eugenics efforts in the Nazi regime. And these new developments in gene editing are just as much plagued by the essential questions regarding human nature. First, is human nature permanently flawed, or are we constantly progressing toward perfection, now in control of it through our technologies? And second, what will stop us from using these technologies not just to repair, but to pursue perfection? Or dare I say, perhaps a master race? Look, these aren't far fetched questions. As one scientist quoted by the Times put it in regular IVF embryos are screened for genetic abnormalities, but baseline editing is providing the baby improvers with a how to manual for forays beyond the ethical pale. End quote. He sounds like C.S. lewis in the Abolition of Man, who foresaw these dangers. And I quote him man's conquest of nature, if the dreams of some scientific planners are realized, means the rule of a few hundreds of men over billions and billions of men. But the man molders of the new age will be armed with the power of an omnicompetent state, an irresistible scientific technique. We shall get at last a race of conditioners who really can cut out all posterity in what shape they please. End quote. And do these Columbia scientists really think that what will govern these conditioners will be a quote, unquote public discussion? No. Without moral standards, we're left to the impulses of those who are in charge. Recently, Christian ethicist Scott Ray argued that those things resulting from the Fall are within the domain of medical treatment like disease, while those things not resulting from the Fall are givens of life and creation and thus should not be left in the realm of enhancement. That includes things like biological sex, eye color, etc. That distinction is helpful despite the real challenge of drawing such an ethical line in a fallen world, especially at big universities with unlimited budget supported by rogue governments. It's going to be real difficult to stop this stuff, much less expect anyone else to comply. Look, Scripture is plain. Every person is made in the image of God and is endowed with eternal dignity, worth and beauty. Any potential value to be found in this new base editing technology will be an added value. But there's no way to add value to the priceless. And that all will be outweighed by the consequences of not recognizing what's true of the human condition, both our value and also our potential for evil. In this case as well, the potential consequences far outweigh any potential benefits. For the Colson Center, I'm John Stonestreet with Breakpoint Today. I thank Kyra of Gig Harbor, Washington for being a Cornerstone Monthly Partner of the Colson Center. Thanks for making this episode a Breakpoint possible. Today's breakpoint was co authored with Andrew Carico. If you're a fan of Breakpoint, leave us a review wherever you download your podcast. And for more resources or to share this commentary with others, go to breakpoint.org
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hi, I'm Adam from Texas and I'm a Cornerstone Partner because now more than ever, all followers of Christ must be able to stand up for their faith and speak truth in love to the hurting world around us. The Colson center has helped not just my wife and I become better apologists, but it has supported us in countless conversations with our children. My prayer is that they will be equipped to boldly engage with the culture and shine brightly for him and the world throughout their lives. If you would like to join myself and over a thousand other people in becoming a CornerStone partner, visit colsoncenter.org monthly.
Host: John Stonestreet (Colson Center)
Date: July 14, 2026
In this episode of Breakpoint, John Stonestreet examines the latest advancements in genetic editing, notably the technology called "base editing" being used at Columbia University to alter human embryos' DNA. He unpacks the ethical, moral, and theological implications of this technology, comparing it to earlier controversies around CRISPR and historical precedents for eugenics. The discussion frames gene editing not only as a technological leap but as a battleground for deeper questions about human nature, dignity, and the limits of scientific "progress" under a Christian worldview.
“We should recognize that this technology occupies a morally gray zone. Therapeutic intervention differs from genetic enhancement. Base editing enables both.” (01:00)
“Three generations of imbeciles are enough.” — Justice Oliver Wendell Holmes, paraphrased by Stonestreet (02:45)
Two core questions are raised:
Stonestreet asserts these aren't hypothetical risks:
“Baseline editing is providing the baby improvers with a how-to manual for forays beyond the ethical pale.” (04:08)
"Man’s conquest of nature... means the rule of a few hundreds of men over billions and billions of men. But the man molders of the new age will be armed with... an irresistible scientific technique. We shall get at last a race of conditioners who really can cut out all posterity in what shape they please.” (04:30)
“Every person is made in the image of God and is endowed with eternal dignity, worth and beauty... there’s no way to add value to the priceless.” (05:34)
Andrew Walker (via Stonestreet):
"We should recognize that this technology occupies a morally gray zone. Therapeutic intervention differs from genetic enhancement. Base editing enables both." (01:00)
Justice Holmes (Buck v. Bell, paraphrased via Stonestreet):
“Three generations of imbeciles are enough.” (02:45)
C.S. Lewis (The Abolition of Man):
"We shall get at last a race of conditioners who really can cut out all posterity in what shape they please.” (04:30)
Stonestreet:
“There’s no way to add value to the priceless.” (05:34)
Stonestreet’s tone throughout is urgent and cautionary, blending historical reference, scriptural interpretation, and philosophical analysis. He frequently attributes his points to other experts (Walker, Rae, Lewis) and uses memorable analogies and quotes to strengthen his argument against the uncritical embrace of genetic editing technologies.
For listeners seeking a thoughtful, Christian perspective on the latest advances in genetic editing, this episode cautions against the allure of technological progress unchecked by ethics or theology. The dangers of repeating eugenic history, the ambivalence of scientists, and the enduring value of every human being are emphasized as central considerations in this ethical frontier.