Jonathan Sporn (CEO + Founder of Gilgamesh Pharma) joins for a deep dive into next-gen psychedelic medicines, why duration matters for real-world clinical use, and what it takes to build these therapies the way large pharma would—culminating in a partnership with AbbVie worth up to $1.2B.

In this episode, we discuss:
• Why Gilgamesh is building psychedelic medicines the way large pharma would
• The thesis behind short-acting psychedelics and why long-duration trips are impractical for real-world psychiatry
• How Gilgamesh designs molecules backwards from clinical needs
• Effective approaches to the challenges of trial designs for psychedelics
• What AbbVie’s deal and Spravato’s trajectory mean for psychedelics
• How psychedelic medicines could reshape mental health

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Matias and Greg
Produced by Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
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Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank