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Narrator
By the time she was just 8 years old, Sharon Berkowitz had already lived a lifetime of stress and trauma. She was a young child growing up during the Iranian revolution. There was genuine fury here.
Dr. Sharon Berkowitz
Thousands of Iranians, most of them young, rampaged through the streets of Tehran, shouting, down with the Shah. Death to the Shah. In 1979, really beginning 1978, the rapid pace at which the country went from a very peaceful situation to just utter, just turmoil. Seven thousand have been killed. Emotions over the dead and the rumors of dead are high. Protests in the streets, food being rationed. It really became very evident that we were not safe. So we left everything and fled as quickly as anybody could get out of a country. I vividly remember being at the airport. We were the last plane to leave before Khomeini came. The airport was incredibly packed. I remember the whole process of trying to get through security and just the mass of people that were there and how we got onto the Runway, every step of it. The plane stopped in Kuwait because we are Jewish. They threatened to kill my father. It was a layover because they were trying to take as many people out of Iran as possible and then take us to our final destination, which was England. The airlines had to intercede on our behalf. So to save my father's life. And at every juncture, they separate men from women and children and threaten to kill the men.
Narrator
Now, that type of stress, I think, for so many of us is just unimaginable. But thankfully, Sharon and her family did make it safely to their final destination and eventually settled in Atlanta, Georgia. But even then, Sharon faced and overcame a new series of setbacks.
Dr. Sharon Berkowitz
In eighth grade, I could not write a paragraph in English without a lot of struggle. It would take me all night. I graduated valedictorian.
Narrator
But what is really amazing to me and the reason I wanted to sit down with Sharon is how she reflects on all of this today.
Dr. Sharon Berkowitz
I view it as a gift to have encountered that in early life because it puts so much in perspective later in life of what is considered a bad day.
Narrator
Sharon says it was those early experiences in childhood, combined with the support of her parents, that made her more resilient. She went on to attend Harvard Medical School, and today she's a stress researcher and a practicing physician who continuously uses what she learned to now help her patients.
Dr. Sharon Berkowitz
And what I've learned from it is something that can help other people, because ultimately it triggered this obsession for me of why is it that some people grow and thrive from these experiences and others don't? And the amazing Part of it is that what we need to become resilient is in all of us. Like, there's nothing special about me or my family. We all have this gift in our DNA to become resilient in the face of stress. Most people just don't know how to summon that ability.
Narrator
She's got a new book called the Stress Paradox. And in it, Dr. Berkowitz goes so far as to say that certain types of stress can help us, help us prevent disease, help us even with aging.
Dr. Sharon Berkowitz
Yes, too much stress harms us, but not enough is actually just as harmful.
Narrator
Look, it's a bold claim and flips a lot of what we have known about stress right on its head. So today I'm gonna ask Dr. Berkowitz to make the case for why stress can be a good thing. I'm Dr. Sanjay Gupta, CNN's chief medical correspondent, and this is chasing life.
Dr. Sanjay Gupta
Just going back to childhood for a second. How much of your career, then your focus on stress, you writing a book about stress does go back to what you experienced as a child?
Dr. Sharon Berkowitz
I think the seeds of it were there. I think in retrospect, when I connect the dots, I think that influence is huge. I don't think I made that realization until in my professional career. I became really interested in this question of is all stress harmful? Because I work with a lot of professionals that are very driven but are also so passionate about what they do. And I would put myself in that category. And so I could not help but wonder, is that a bad thing or is that a good thing?
Dr. Sanjay Gupta
That's a good question. Because as you're saying that I'm thinking that kind of describes me. I live a pretty high stress life, but I'm generally pretty engaged, energetic, and happy. But I would describe myself as stressed.
Dr. Sharon Berkowitz
I would now, knowing what I know, call that good stress, which I think has a very different effect on our bodies than the harmful stress that has become almost synonymous with what people describe as stress. So for me, it's led to a complete reframing of our relationship with stress. I think I can now say at a comfortable level that that type of stress releases a biochemical profile that is actually health promoting. We release, for example, dopamine, serotonin, oxytocin.
Dr. Sanjay Gupta
All in response to stress.
Dr. Sharon Berkowitz
You're saying in the response to stress, and that biochemical response is so different than the simplistic stress response that we.
Dr. Sanjay Gupta
Think of cortisol and adrenaline.
Dr. Sharon Berkowitz
Exactly. Our stress response is so much more complicated. And different types of stress trigger a different biochemical Response. The stressors that are harmful are generally ones that are not predictable and they're just unavoidable because there's so much uncertainty that leads to some of the harmful effect that is downstream. And often these stressors are not brief and intermittent, they're much more chronic, continuous, and those are generally the ones that are harmful. When you look at resilience as this muscle, a lot of childhood events, for example, people have dealt with a lot of different forms of adversity in childhood. And there's a lot of literature on how childhood adversity can lead to long term harm throughout life. But that's your passive resilience. When you choose your stress, you are shape shifting, an active form of resilience. Because resilience is incredibly dynamic, just like building muscle is. So when we take on these good stressors, interestingly enough, the hormones we're talking about here, the dopamine for the reward for doing something meaningful, the serotonin, that joy that comes from accomplishment, the oxytocin from contributing to the greater good, that is the trifecta that mitigates our cortisol level. It literally builds our resilience to stress so we don't have to fear at all.
Dr. Sanjay Gupta
So at the same time you have stress, you're also building more resilience. It's like a workout, I guess, if thinking of it from a muscle metaphor.
Dr. Sharon Berkowitz
Resilience is a muscle. And our ability to shape our resilience and to shape the downstream effect of that passive resilience from those childhood exposures is like one we could not have ever imagined. So I think that we all have this ability to choose some stressors, these good stressors, and that helps us handle the types of stressors that are unavoidable. And it's really a shifting from kind of playing defense, of always trying to curb the chronic stress, fight, wrangle, draw boundaries around stress, to one that is playing offense, right? So we are just going to become stronger so we can handle more stress in the future.
Dr. Sanjay Gupta
If you don't stress yourself at all, that's bad. I mean, you're not gonna get out of bed in the morning, you're not gonna study for an exam, things like that. But the idea that there's all these biochemical processes that are happening in your body that wouldn't be happening if you never challenge yourself at all, I think is the point that you're making. You need this.
Dr. Sharon Berkowitz
I think it's because we understand stress so much better now. In the last two decades, we have cellular and molecular Based technology that is looking at what happens down to a very granular level in our bodies. The stress response we're all familiar with is fight or flight, right? The release of catecholamines, the cortisol. But we have this layer of stress responses in our cells. We actually have seven cellular stress responses. And these stress responses in our cells activate our ability to moderate inflammation. So how we understand stress has changed so much. And the key really is that our stress responses are there to help us. They're there to help us adapt to our world. They've, for our entire human history been how we have survived and thrived. But the things that help us activate those stress responses have been removed from the fabric of our lives. At no time in human history, until the last hundred years have we removed the natural stressors that were in our environment, that were built in, like food scarcity, needing to survive on edible plants, needing to have moments of intense exercise, exposure to extremes of heat and cold, mental challenges that forced you to think beyond the horizon. We have increased our lives in a way that have made our lives very comfortable. And we can get a lot of gratification very instantly. We can have access to food 24, 7. The introduction of a lot of these comforts has removed our connection with the natural environment that we live in and the ultimate need of our physiology to express the genes that activate these cellular stress responses. We are essentially handicapping ourselves because we are not allowing our bodies to do what they are so capable of doing.
Dr. Sanjay Gupta
It's interesting, I think anybody who says, hey, I'm going to read a book about stress, they're probably thinking, I'm going to read a book about how to mitigate or reduce my stress. And in some ways, doctor, you're making the argument that go out and find yourself some but the right amount of stress, the point is the right amount of stress, maybe even more so than calling it good stress or bad stress, because good or bad are attributes that are very much dependent on, on how much you're getting.
Dr. Sharon Berkowitz
That is such a critical point. This science of what I'm calling good stress is hormesis. This is a science of good stress. From this Greek word to excite is how hormesis was derived. And it is mild to moderate stress followed by recovery. It is not. What doesn't kill you makes you stronger. I would actually say that that is not good stress. The goal is to do stress with a small S, not capital S. And it's those little incremental exposures that ultimately make us stronger. Cortisol is not a good or bad hormone. Cortisol is just telling our body we need energy. You know, exercise can evoke it, or we can evoke it through job situations we don't like, financial hardship. I mean, these chronic stressors that lead to your baseline level of cortisol being elevated, which is a very different scenario. So it's not that our body has a moral code again, our body is just responding to the inputs, and if we can just change the inputs, we change the output.
Narrator
Now I want to jump in for a second and make sure you got that. Dr. Berkowitz is saying that when we choose to challenge ourselves with intentional bouts of stress, that can help us become more resilient to future stressors that may be outside of our control. And to be clear, although we've been talking mostly about psychological stress, Dr. Berkowitz also points out that challenging our bodies can be beneficial as well. Like fasting, for example, or intermittent high intensity exercise, hot or cold therapy, like saunas. They can all be ways to harness the power of good stress.
Dr. Sharon Berkowitz
Finding tools that are accessible, that awaken our natural defense against chronic disease. And I mean mental and physical chronic disease, anxiety, depression, diabetes, heart disease. To me, the fact that we can all access our bodies innate defense mechanisms if we just knew how, and that stress is interestingly, the most powerful lever for doing this, became something that I felt more than just my patients needed to know about.
Narrator
Coming up after the break, Dr. Berkowitz helps us create a life full of good stress.
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Dr. Sanjay Gupta
For me, Doc, and I think for probably a lot of people I could experience the same stress on a Tuesday and feel defeated by it, whereas on Wednesday I'm emboldened by it. And I don't always know why that is. It could be that I slept well the night before, I had a good meal, I don't know. But it's the same exact stress. And one day it crushes me and the next day I feel fueled by it. How do I summon, how does anyone summon the resilience when they need it the most?
Dr. Sharon Berkowitz
The recovery is a really big part of this day to day variation. So you hit the nail on the head. It is how much you slept the night before. It is also a combination of what did your body go through that same day, right? If you also exercise that day, you ate fairly healthy. All these variables impact day to day resilience. So how much stress a person can handle is not just different person to person, it's different for the same person from day to day. So I think we can all just make note of what helps us on the days that we can sail through it. The recovery piece, of course, is critical, but looking at other factors, you know, did exercise play a role? Did the amount of sunlight and how you sync your circadian biology make a difference? What was that first meal like? I think we could drill it down. I think most of us don't spend the time doing that kind of human experiment to figure it out.
Dr. Sanjay Gupta
So what do you tell somebody in that situation who comes in, who's probably a pretty high stress individual and yet loves what they do? How do you guide them? Dr.
Dr. Sharon Berkowitz
I think the key is strategic recovery because our bodies are designed for brief, intermittent stress. That is how we grow. But our bodies need that period of recovery. So when we go through brief intermittent stress in stress mode, our bodies are getting the signal down to ourselves to become more efficient. We do a lot of repair, housekeeping functions it is in recovery that we actually reconfigure and reshape our bodies in a way that helps us handle future stress better. If you go through a period of stress and you don't allow yourself that recovery, you miss that opportunity to actually grow from that exposure to stress. So the key for people who are driven and high functioning is, is the stress is okay. Do not fear it, embrace it, but plan for the recovery. And I think that that is ultimately the blueprint of how we become our strongest self. Right? Stress, recover, repeat. Stress, recover, repeat. Because our bodies work through bioplasticity and in the brain, that's neuroplasticity. And we know that when we are exposed to cortisol in a mild to moderate range for a brief transient time, that tells our synapses to make stronger connections. Like, we bind different receptors in our brain depending on the amount of cortisol. The short term, we bind mineralocorticoid receptors that sends a signal to grow within the communications between our neurons. At a high amount in the chronic state of stress or a very intense amount of stress, cortisol starts to bind the glucocorticoid corticoid receptors which actually prune those synaptic connections. So you wanna straddle this kind of Goldilocks amount of stress followed by recovery. So you are benefiting from the stress. And what's really fascinating is yes, too much stress harms us, but not enough is actually just as harmful.
Dr. Sanjay Gupta
That's really fascinating. But how do you know when it is too much stress, though?
Dr. Sharon Berkowitz
I think intuitively we know when it's bad stress. We feel exhausted, depleted, we feel we're on the verge of burnout, we want to escape. When it's good stress, we're energized, we're motivated, we're creative. Like, we just feel like it's effortless. I think we just have to tune into our bodies and I think we just have that knowing. And I think that that's a really good framework for every type of stress. You know, we've been talking so much about psycholog stress, I will extend that to physical stressors, the foods we eat, the type of movement. I mean, stress in a technical sense is anything that challenges your body. And whether your health habit is health promoting or taking away from your health is ultimately, how do you feel afterward.
Dr. Sanjay Gupta
If you feel like you're in a bad stress or call it too much stress? If we're sort of keeping this Goldilocks metaphor that what do you, you wanna make sure that you're going into the stressor as sort of ready as you can be, having slept the night before, eating and all that. But if you're in that situation now where you feel like it's too much stress, intuitively, you know, what do you do in that moment?
Dr. Sharon Berkowitz
I think that is your signal that you need recovery. Like when you reach that point where you feel that, you know, if you pictured your cortisol level as the metric, if you just feel that it's just so high that you're not even functioning effect, you need to step away. I mean, it could be a walk outside, it could be connecting, you know.
Dr. Sanjay Gupta
I read this book which I really loved. I'm sure you've read it as well. It's my second favorite book next to yours. It's called why Zebras don't get Ulcers. Robert Sapolsky. And the point that Robert makes, I'm sure and you read in the book is like for zebras, you know, they can be chased and while they're being chased, their cortisol levels and all this stress stuff goes way up. And then as soon as they're not being chased, milliseconds later, their stress levels come back down, they're happily grazing whatever. We humans don't quite have that luxury in part because of this phone that I'm holding up and just all the various things in our lives so we don't get a break from it. It's that relentless nature of it. Have you seen that worsening in your own practice?
Dr. Sharon Berkowitz
In primary care, 60 to 90% of visits are stress related. Really? Yeah, across the country, national surveys. And I would echo that. That would hold for my practice.
Dr. Sanjay Gupta
60 to 90% stress related.
Dr. Sharon Berkowitz
Stress related illnesses that may manifest as headaches, irritable bowel, it comes in different forms. But that stress plays a big role in the manifestation.
Dr. Sanjay Gupta
And has that gotten worse over time?
Dr. Sharon Berkowitz
I think that it ebbs and flows. I do think that we are at a period of heightened stress right now. I think that is clearly a big contributor to a lot of illnesses that we're seeing.
Dr. Sanjay Gupta
Too much tv, too much politics.
Dr. Sharon Berkowitz
It is. And too much information. And very hard to know how to put the information in a larger perspective of whether it's just current state or whether it's just that we now have the awareness about a lot of things that our parents dealt with, but we just didn't have the same level of awareness. Right. So it's access to that information.
Dr. Sanjay Gupta
Yeah. I mean look, I say this in part in Jess, but also someone who works in the news business, it's a lot, and it's a fire hydrant of information, and a lot of it's not good. And I think just to be completely immersed in that all the time, even as someone who's in the business from a medical standpoint, you can recognize that that's not good. Finding breaks from that. By the way, are your parents still living?
Dr. Sharon Berkowitz
My mom is. My dad passed away November of 2022. He was a man of very few words, but what he would choose to say always carried a lot of weight because it was always very thoughtful and reflective. And the book truly is dedicated to him. It's in his memory because he had this unbelievable acceptance, stoicism and resilience and handled everything that came his way with unbelievable calm. And I now term that resilience because we know at a biochemical level that people who have that kind of resilience emit an energy that invites calm instead of chaos, that attracts rather than repels, that inspires instead of evokes fear. And my father had that. And for me, this is a way of breaking down, defining and putting terms to what is it about people like that that become. You know, people would describe my father as whatever corner of the room he was at, that is where you could find peace and serenity. And people would just gravitate towards him when, you know, people were in a scenario, at a party or an event where they needed that sense of calm. And I feel that now I understand what is it about people who have that and the amount of synchrony in their body, in their soul, that emits that type of energy. And I think we're all capable of it. And I think that we can get to that point if we are willing to go past our comfort zone, even for brief amounts of time, again followed by recovery, because that is the path of getting there. That is how we create this positive, virtuous cycle in our world. And I hope that everyone makes that investment in themselves because ultimately it's an investment in other people.
Narrator
That was Dr. Sharon Berquist and her book the Stress Paradox. It hits bookstores this week. Chasing Life is a production of CNN Audio. Our podcast is produced by Erin Mathewson, Jennifer Lai, Grace Walker, Lori Gallaretta, Jesse Remedios, Sofia Sanchez and Kira Dehring. Andrea Cain is our medical writer. Our senior producer is Dan Bloom. Amanda Seeley is our showrunner. Dan Dezulla is our technical director. And the executive producer of CNN Audio is Steve Lichti, with support from Jamis Andrest, John Dionora Hailey, Thomas, Alex Manasseri, Robert Mathers, Lainey Steinhardt, Nicole Pesaru and Lisa Namoro. Special thanks to Ben Tinker and Nadia Kanang of CNN Health and Katie Hinman.
Published on: March 28, 2025
Host: Dr. Sanjay Gupta, CNN's Chief Medical Correspondent
Guest: Dr. Sharon Berkowitz, Stress Researcher and Author of The Stress Paradox
In the enlightening episode titled "Why We Need To Embrace Stress," Dr. Sanjay Gupta delves into the nuanced understanding of stress with Dr. Sharon Berkowitz, a prominent stress researcher and physician. The conversation challenges conventional perceptions of stress, proposing that not all stress is detrimental and that certain types can be harnessed to enhance resilience and overall well-being. Drawing from her personal experiences and professional expertise, Dr. Berkowitz presents a compelling case for redefining our relationship with stress.
The episode opens with a poignant account of Dr. Sharon Berkowitz’s childhood. By the age of eight, she had already endured significant stress and trauma during the Iranian Revolution.
Dr. Sharon Berkowitz (00:14):
“Thousands of Iranians, most of them young, rampaged through the streets of Tehran, shouting, down with the Shah. Death to the Shah... We fled as quickly as anybody could get out of a country.”
Her harrowing escape from Iran, marked by threats to her family’s safety, exemplifies extreme stress. Despite these early adversities, her family safely settled in Atlanta, Georgia. Even after relocation, Sharon faced challenges, such as struggling with English in eighth grade but eventually graduating as valedictorian.
Dr. Sharon Berkowitz (02:22):
“I view it as a gift to have encountered that in early life because it puts so much in perspective later in life of what is considered a bad day.”
Dr. Berkowitz introduces the revolutionary idea that stress is not universally harmful. Instead, she differentiates between "good stress" and "harmful stress."
Dr. Sharon Berkowitz (05:23):
“I would now, knowing what I know, call that good stress, which I think has a very different effect on our bodies than the harmful stress...”
Good stress, or hormesis, involves mild to moderate stress followed by recovery, leading to beneficial biochemical responses such as the release of dopamine, serotonin, and oxytocin. These responses promote health and resilience.
Dr. Sharon Berkowitz (12:09):
“This science of what I'm calling good stress is hormesis. It is mild to moderate stress followed by recovery. It is not... what doesn't kill you makes you stronger.”
Conversely, harmful stress is typically unpredictable, chronic, and overwhelming, often leading to negative health outcomes like elevated cortisol levels, anxiety, and burnout.
A significant portion of the discussion centers on the body's biochemical responses to different types of stress and how they influence resilience.
Dr. Sharon Berkowitz (08:00):
“Resilience is a muscle. And our ability to shape our resilience...”
Dr. Berkowitz explains that engaging in good stress activates various biochemical pathways that not only mitigate the effects of harmful stress but also strengthen our ability to handle future stressors. This process is akin to exercising a muscle, where intentional, controlled stress leads to growth and enhanced resilience.
She further elaborates on the complexity of the stress response:
Dr. Sharon Berkowitz (09:08):
“We have seven cellular stress responses. And these stress responses in our cells activate our ability to moderate inflammation...”
Modern scientific advancements have revealed that stress responses operate at both cellular and molecular levels, playing a crucial role in regulating inflammation and overall health.
The conversation highlights how contemporary lifestyles have diminished our exposure to natural stressors that our ancestors regularly encountered, leading to a mismatch between our biology and environment.
Dr. Sharon Berkowitz (10:20):
“We have been removed from the fabric of our lives. At no time in human history, until the last hundred years...”
Activities such as food scarcity, physical exertion, and mental challenges were integral to survival and the activation of our natural stress responses. Today’s conveniences and constant access to instant gratification have reduced these necessary stressors, hindering our innate resilience mechanisms.
Dr. Berkowitz provides practical strategies for integrating good stress into daily life to bolster resilience and prevent chronic diseases.
Intentional Stressors:
Strategic Recovery:
Dr. Sharon Berkowitz (18:27):
“The key is strategic recovery because our bodies are designed for brief, intermittent stress. That is how we grow...”
Dr. Gupta echoes the sentiment, sharing his personal struggles with stress variability and the importance of recovery.
The discussion touches on the increasing prevalence of stress-related illnesses in modern society, exacerbated by factors like excessive media consumption and information overload.
Dr. Sharon Berkowitz (23:35):
“Stress related illnesses that may manifest as headaches, irritable bowel...”
Dr. Berkowitz notes a significant rise in stress-related medical visits, underscoring the urgent need to address chronic stress in healthcare.
Dr. Berkowitz shares a heartfelt tribute to her late father, attributing much of her understanding of resilience to his stoic and calm demeanor.
Dr. Sharon Berkowitz (25:03):
“He had this unbelievable acceptance, stoicism and resilience...”
Her father's ability to emit calm and inspire others serves as a living example of the profound impact of resilience, both biochemically and interpersonally.
The episode concludes with a call to action for listeners to embrace good stress intentionally and incorporate strategic recovery into their lives. By doing so, individuals can unlock their inherent resilience, improve mental and physical health, and lead more fulfilling lives.
Dr. Sharon Berkowitz (27:36):
“Ultimately, it's an investment in other people.”
Dr. Berkowitz emphasizes that fostering resilience not only benefits the individual but also creates a positive ripple effect within communities, promoting collective well-being.
Dr. Sharon Berkowitz (02:22):
“I view it as a gift to have encountered that in early life because it puts so much in perspective later in life of what is considered a bad day.”
Dr. Sharon Berkowitz (05:23):
“I would now, knowing what I know, call that good stress...”
Dr. Sharon Berkowitz (12:09):
“This science of what I'm calling good stress is hormesis...”
Dr. Sharon Berkowitz (18:27):
“The key is strategic recovery because our bodies are designed for brief, intermittent stress...”
Dr. Sharon Berkowitz (25:03):
“He had this unbelievable acceptance, stoicism and resilience...”
For those interested in exploring this topic in greater depth, Dr. Sharon Berkowitz’s book, The Stress Paradox, is available in bookstores now. The book delves into the intricate relationship between stress and health, providing actionable insights to transform how we perceive and manage stress in our lives.
Produced by: Erin Mathewson, Jennifer Lai, Grace Walker, Lori Gallaretta, Jesse Remedios, Sofia Sanchez, and Kira Dehring.
Medical Writer: Andrea Cain
Senior Producer: Dan Bloom
Showrunner: Amanda Seeley
Technical Director: Dan Dezulla
Executive Producer: Steve Lichti
Chasing Life is a production of CNN Audio.